C-46 Assessing Global Delays in Corpus Callosum Agenesis: Infants and Toddlers

2019 ◽  
Vol 34 (6) ◽  
pp. 1075-1075
Author(s):  
G Andrews ◽  
K Eddy ◽  
A Gibson
Keyword(s):  
Corpus Callosum ◽  
Expressive Language ◽  
Receptive Language ◽  
Effect Sizes ◽  
Fine Motor ◽  
Infants And Toddlers ◽  
Fine Motor Skill ◽  
Early Intervention Services ◽  
Corpus Callosum Agenesis ◽  
The Average Range

Abstract Objective Corpus callosum agenesis (ACC) is a congenital birth defect in which the corpus callosum fails to fully form (Badaruddin, et al., 2007). The partial or complete absence of a corpus callosum affects specific functioning (Brown, Jeeves, Dietrich, & Burnison, 1999) resulting in behavioral, social, and cognitive difficulties (Badaruddin, et al., 2007). We evaluated the development of infants and toddlers with ACC in cognition, language, and motor functioning. Methods Boys (n = 6) and girls (n = 4) ages 3 to 41 months were assessed utilizing the Bayley Scales of Infant and Toddler Development-Third Edition, a test designed to assess the developmental functioning in 5 domains: motor, social-emotional, adaptive behavior, cognitive, and language (Bayley, 2006). Volunteers were assessed during ACC conferences. Results Cognitive, language and motor index scores were significantly correlated but not age. Moderate to large effect sizes (Cohens d) were found. Girls had lower Cognitive Index scores and were below average; boys mean score was within the average range. Large effect sizes for receptive and expressive language. Boys scored within the low average range; girls below average for receptive language. For expressive language, girls fell in the borderline range, boys were low average. Gross motor was very low compared to age norms. Girls showed deficits in fine motor skill development; boys within the average range. Conclusions Global developmental deficits and gender differences occurred for infants and toddlers with ACC. Girls show more delays than boys. Outcomes suggest that delays can be measured well before entering school and supports early intervention services.

Development of Infants and Toddlers with Clefts from Birth to Three Years of Age

1997 ◽  
Vol 34 (3) ◽  
pp. 218-225 ◽  
Author(s):  
Gary S. Neiman ◽  
Hallie E. Savage
Keyword(s):  
At Risk ◽  
Cleft Palate ◽  
Cleft Lip ◽  
Expressive Language ◽  
Fine Motor ◽  
Infants And Toddlers ◽  
Developmental Assessment ◽  
Normative Sample ◽  
Self Help ◽  
Delayed Development

Objective The purpose of this study was to use caregiver report measures to describe the developmental status of infants and toddlers with clefts. Method Developmental assessment data were obtained on 186 infants and toddlers with cleft lip (n = 48), cleft palate (n = 46), and cleft lip/palate (n = 92) at one of the following age categories: 5 months (n = 47), 13 months (n = 46), 25 months (n = 47), and 36 months (n = 46). Developmental assessment measures used were the Kent Infant Developmental Scale and the Minnesota Child Development Inventory, both caregiver reports. Data were analyzed in separate 2-between ANOVAs (age x cleft type) for each developmental domain according to developmental assessment measure. Further, results were examined relative to the normative sample. Results The ANOVA results indicated that at 5 months, lower motor and self-help developmental quotients (DQs) were evident compared to the 13-month-old level. When compared to the normative sample, the 5-month-old infants exhibited ‘at-risk/delayed’ development on the motor, self-help, and cognitive domains, and as reflected on their full-scale scores, depending on the cleft type. Infants at 13 and 25 months were within normal limits in all developmental domains, with the exception of the 13-month-old infants with cleft palate, who demonstrate ‘at-risk’ development in the motor domain. At 36 months of age, all toddlers demonstrated significantly lower developmental performance in the fine motor, gross motor, and expressive language domain compared to the 25-month-old toddlers. Toddlers with cleft palate exhibit ‘at-risk/delayed’ development in the expressive language domain at 36 months. Conclusion Data are discussed relative to the events surrounding team management of clefts, Including surgery, middle-ear problems, and feeding difficulty.

scholarly journals Mullen Scales of Early Learning Adaptation for Assessment of Indian Children and Application to Tuberculous Meningitis

2020 ◽  
Author(s):  
Smita Nimkar ◽  
Suvarna Joshi ◽  
Aarti Kinikar ◽  
Chhaya Valvi ◽  
D Bella Devaleenal ◽  
...  
Keyword(s):  
Tuberculous Meningitis ◽  
Expressive Language ◽  
Early Learning ◽  
Receptive Language ◽  
Cultural Bias ◽  
Fine Motor ◽  
Indian Children ◽  
Language And Culture ◽  
Culturally Adapted ◽  
Visual Reception

Abstract Introduction Tuberculous meningitis (TBM) results in significant morbidity and mortality among children worldwide. Associated neurocognitive complications are common but not well characterized. The Mullen Scales of Early Learning (MSEL), a well-established measure for assessment of neurodevelopment, has not yet been adapted for use in India. This study’s goal was to adapt the MSEL for local language and culture to assess neurocognition among children in India, and apply the adapted measure for assessment of children with TBM. Methods Administration of MSEL domains was culturally adapted. Robust translation procedures for instructions took place for three local languages: Marathi, Hindi and Tamil. Multilingual staff compared instructions against the original version for accuracy. The MSEL stimuli and instructions were reviewed by psychologists and pediatricians in India to identify items concerning for cultural bias. Results MSEL stimuli unfamiliar to children in this setting were identified and modified within Visual Reception, Fine-Motor, Receptive Language and Expressive Language Scales. Item category was maintained for adaptations of items visually or linguistically different from those observed in daily life. Adjusted items were administered to six typically developing children to determine modification utility. Two children diagnosed with confirmed TBM (ages 11 and 29 months) were evaluated with the adapted MSEL before receiving study medications. Skills were below age-expectation across visual reception, fine motor and expressive language domains. Conclusions This is the first study to assess children with TBM using the MSEL adapted for use in India. Future studies in larger groups of Indian children are warranted to validate the adapted measure.

Neurologic Aspects of the Smith-Magenis Syndrome

2010 ◽  
Author(s):  
Andrea L. Gropman ◽  
Ann C. M. Smith
Keyword(s):  
Mental Retardation ◽  
Behavioral Problems ◽  
Expressive Language ◽  
Fine Motor ◽  
Older Children ◽  
Fine Motor Skill ◽  
History Of ◽  
Molecular Cytogenetic Techniques ◽  
Integration Problems ◽  
First Year Of Life

The Smith-Magenis syndrome (SMS) is a multiple congenital anomaly and mental retardation syndrome (Greenberg et al. 1996). The clinical phenotype includes distinctive craniofacial and skeletal features that change with age, a history of infantile hypotonia, significant expressive language delay, mental retardation, stereotypies, behavioral problems, and a sleep disorder (Potocki et al., 2000; De Leersynder et al. 2001). Two genetic mechanisms can cause SMS: an interstitial deletion involving chromosome 17p11.2 (including the retinoic acid–induced 1 [RAI1] gene) or a mutation in the RAI1 gene (Smith et al. 1986; Seranski et al. 2001; Slager et al. 2003). First described by Smith and colleagues in 1982, in two severely impaired patients (Smith et al. 1982), the phenotypic spectrum has been expanded by the recognition of additional cases (Smith et al. 1986; Stratton et al., 1986). The estimated prevalence of SMS deletion cases was reported to be 1 in 25,000 (Greenberg et al. 1991). However, new cases identified in the last decade as a result of improved molecular cytogenetic techniques (including microarray technology) now suggest the incidence to be closer to 1 in 15,000 births (Elsea and Girirajian 2008). Despite this improvement in technology accounting for new cases identified in the last several years, clinical diagnosis based on phenotypic recognition is often delayed. The phenotype of SMS becomes more pronounced and recognizable with advancing age both in terms of the physical and dysmorphic characteristics, as well as in the behavioral features (Gropman et al. 2006). Infants with SMS present with hypotonia, weak hoarse cry, decreased vocalization, and complacency (Gropman et al. 1998; 2006; Martin et al. 2006; Wolters et al.,2009). Gross and fine motor skill development is delayed in the first year of life. Sensory integration problems are frequently noted. Social skills are often age appropriate, delaying diagnosis in some cases. In older children, developmental delay, in particular expressive language delays, as well as emerging behavioral difficulties (Gropman et al. 2006; Martin et al. 2006; Madduri et al. 2006) and sleep disturbance may bring patients to clinical attention.

Prediction of Fine Motor Skills of Children Having Language and Speech Disorders

1988 ◽  
Vol 67 (1) ◽  
pp. 63-72 ◽  
Author(s):  
Ronald K. Sommers
Keyword(s):  
Motor Skills ◽  
Receptive Language ◽  
Speech Disorders ◽  
Fine Motor ◽  
Fine Motor Skills ◽  
Auditory Comprehension ◽  
Fine Motor Skill ◽  
Language Tests ◽  
Cas A ◽  
Fine Motor Performance

Relationships between the fine motor skills and linguistic abilities of 37 developmentally delayed children, ages 5 to 9 yr., were studied using a battery of expressive and receptive language tests, a measure of fine motor performance, a dichotic listening test, and individual intelligence tests. While IQs and MAs were not related to fine motor skills, both expressive and receptive language test scores showed moderate to moderately high correlations, the highest single relationship being the Test for the Auditory Comprehension of Language. In concert with CAs, a dichotic right-ear test score, the Auditory Comprehension Test, predicted fine motor-skill indices substantially; R = .80. Strong relationships appear between linguistic and fine motor skills in an age group not previously investigated and at higher levels than reported in studies of infants and very young children. Dichotic results were abnormal in a majority of the children.

scholarly journals Beyond Stunting: Mechanisms Linking Length to Early Child Development Among Infants in Rural India (P10-003-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Maureen Black ◽  
Doris Yimgang ◽  
Kristen Hurley ◽  
Kimberly Harding ◽  
Silvia Fernandez-Rao ◽  
...  
Keyword(s):  
Child Development ◽  
Maternal Education ◽  
Expressive Language ◽  
Receptive Language ◽  
Rural India ◽  
Fine Motor ◽  
Early Child Development ◽  
Blood Draw ◽  
Early Child ◽  
Visual Reception

Abstract Objectives In low and middle-income countries, early child development (ECD) is associated with stunting, but the association with length-for-age z-scores (LAZ) is understudied. The objective is to examine whether the association with ECD among infants extends beyond stunting to LAZ and whether it is altered by nurturance or inflammation. Methods Sample: 513 infants (mean age 8.6 months, SD 2.2), 20% stunted (LAZ < -2) participated in a randomized controlled trial of micronutrient powder (MNP) in rural India. Following baseline, infants were re-evaluated at 6- and 12-months. LAZ was calculated from measured length, inflammation (C-reactive protein, CRP) from blood draw; nurturance from home observation (HOME Inventory), and ECD from Mullens Early Learning Scale (visual reception, fine/gross motor and receptive/expressive language). Linear mixed effects models were conducted, accounting for repeated measures and clustering, adjusted for child age, anemia, maternal education, household assets, and intervention. LAZ interactions with CRP and HOME scores were tested. Results LAZ was significantly positively associated with all ECD domains over time. HOME was positively associated with visual reception and expressive language (Table 1). HOME interactions were marginal for fine motor (P = 0.058) and significant for receptive language (P = 0.015). For HOME scores < -1 SD, LAZ was positively related to fine motor and receptive language, for HOME scores >1 SD, LAZ was not related to ECD (Figure 1). CRP was not related to ECD and CRP interaction was not significant. Conclusions The positive association between LAZ and ECD illustrates vulnerability prior to the threshold of stunting. Maternal nurturance is positively associated with multiple domains of infants’ ECD and attenuates relations between LAZ and receptive language and fine motor. Inflammation (measured by CRP) is not associated with ECD. Linear growth within normal and nurturant caregiving are needed to promote ECD. Funding Sources Mathile Institute for the Advancement of Human Nutrition, Nutrition International, Sackler Institute for Nutrition Science of the New York Academy of Sciences.

Brief Report: Performance of Australian Children at One Year of Age on the Bayley Scales of Infant and Toddler Development (Version III)

2010 ◽  
Vol 27 (1) ◽  
pp. 54-58 ◽  
Author(s):  
Karen Walker ◽  
Nadia Badawi ◽  
Robert Halliday ◽  
Sharon Laing
Keyword(s):  
Cultural Context ◽  
Expressive Language ◽  
Receptive Language ◽  
Fine Motor ◽  
Australian Population ◽  
Gross Motor ◽  
Toddler Development ◽  
One Year ◽  
Bayley Scales

AbstractThis article reports mean scores on the Bayley Scales of Infant and Toddler Development (Version III) for 211 randomly selected healthy term (≥ 37 weeks gestation) Australian infants at one year of age. Mean scores were significantly different from standardised norms in all subscales except fine motor. Australian infants scored higher on cognitive and receptive language (p < .01) and lower on expressive language and gross motor (ps < .01) subscales. These findings raise questions regarding the validity of this test in the Australian population and suggest that the test be re-normed on Australian children for valid interpretation of scores in this cultural context.

scholarly journals Effects of Fine Motor Development in the Subsequent Expressive and Receptive Language Skills of Children with Special Needs

2020 ◽  
Vol 3 (2) ◽  
pp. 143-144
Author(s):  
David Karlo I. Equipaje ◽  
Deborah Natalia E. Singson
Keyword(s):  
Special Needs ◽  
Motor Skills ◽  
Motor Development ◽  
Language Skills ◽  
Expressive Language ◽  
Development Program ◽  
Receptive Language ◽  
Fine Motor ◽  
International Studies ◽  
Fine Motor Skills

Studies related to developmental psychology have long recognized the importance of motor development but have recently begun to systematically map out its subsequent developmental pathways.  In many international studies, finding evidence on the effects of fine motor skills development on children's language skills with special needs (CSNs) has significantly grown much interest.  Fine motor skills and language skills play a vital role in a child's early development.  Hence, the study describes the level of performance in the fine motor domain, expressive language domain, and receptive language domain of preschool-aged CSNs of a private intervention center in Bacolod City during the school year 2019-2020. Likewise, it explores the existing relationship of the fine motor skills and language skills between the CSN's age and sex before and after participating in a fine motor development program.  Also, it determines the subsequent consequences of the fine motor development program on the expressive language skills and receptive language skills of the CSNs.

scholarly journals A Comparison of Children Born Preterm and Full-Term on the Autism Spectrum in a Prospective Community Sample

2020 ◽  
Vol 11 ◽  
Author(s):  
Jenny Luu ◽  
Rachel Jellett ◽  
Maya Yaari ◽  
Melissa Gilbert ◽  
Josephine Barbaro
Keyword(s):  
Expressive Language ◽  
Community Sample ◽  
Receptive Language ◽  
Autism Spectrum ◽  
Full Term ◽  
Fine Motor ◽  
Community Based ◽  
Extremely Preterm ◽  
Social Affect ◽  
Visual Reception

Introduction: Previous research suggests children diagnosed with autism spectrum disorder (ASD or “autism”) born extremely and very preterm face substantially delayed development than their peers born full-term. Further, children born preterm are proposed to show a unique behavioral phenotype, which may overlap with characteristics of autism, making it difficult to disentangle their clinical presentation. To clarify the presentation of autism in children born preterm, this study examined differences in key indicators of child development (expressive language, receptive language, fine motor, and visual reception) and characteristics of autism (social affect and repetitive, restricted behaviors).Materials and Methods: One fifty-eight children (136 full-term, twenty-two preterm) diagnosed with autism, aged 22–34 months, were identified prospectively using the Social Attention and Communication Surveillance tools during community-based, developmental surveillance checks in the second year of life. Those identified at “high likelihood” of an autism diagnosis were administered the Mullen Scales of Early Learning and the Autism Diagnostic Observation Schedule.Results: The children born preterm and full-term did not differ significantly in their fine motor, visual reception, expressive language, or receptive language skills. No significant differences in social affect and repetitive and restrictive behavior traits were found.Discussion: The findings of this study differs from previous research where children diagnosed with autism born very or extremely preterm were developmentally delayed and had greater autistic traits than their term-born peers. These null findings may relate to the large proportion of children born moderate to late preterm in this sample. This study was unique in its use of a community-based, prospectively identified sample of children diagnosed with autism at an early age. It may be that children in these groups differ from clinic- and hospital-based samples, that potential differences emerge later in development, or that within the autism spectrum, children born preterm and full-term develop similarly. It was concluded that within the current sample, at 2 years of age, children diagnosed with autism born preterm are similar to their peers born full-term. Thus, when clinicians identify characteristics of autism in children born preterm, it is important to refer the child for a diagnostic assessment for autism.

The Concurrent Validity of the Minnesota Child Development Inventory as a Measure of Young Children's Language Development

1989 ◽  
Vol 54 (1) ◽  
pp. 101-105 ◽  
Author(s):  
J. Bruce Tomblin ◽  
Cynthia M. Shonrock ◽  
James C. Hardy
Keyword(s):  
Child Development ◽  
Language Development ◽  
Expressive Language ◽  
Strong Predictor ◽  
Receptive Language ◽  
Strongly Correlated ◽  
Language Measure ◽  
The Mean ◽  
Child Development Inventory ◽  
Mean Length Of Utterance

The extent to which the Minnesota Child Development Inventory (MCDI), could be used to estimate levels of language development in 2-year-old children was examined. Fifty-seven children between 23 and 28 months were given the Sequenced Inventory of Communication Development (SICD), and at the same time a parent completed the MCDI. In addition the mean length of utterance (MLU) was obtained for each child from a spontaneous speech sample. The MCDI Expressive Language scale was found to be a strong predictor of both the SICD Expressive scale and MLU. The MCDI Comprehension-Conceptual scale, presumably a receptive language measure, was moderately correlated with the SICD Receptive scale; however, it was also strongly correlated with the expressive measures. These results demonstrated that the Expressive Language scale of the MCDI was a valid predictor of expressive language for 2-year-old children. The MCDI Comprehension-Conceptual scale appeared to assess both receptive and expressive language, thus complicating its interpretation.

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