scholarly journals Dorsal Hump Reduction Based on the New Ethmoidal Point Classification: A Clinical and Radiological Study of the Keystone Area in 138 Patients

2020 ◽  
Vol 40 (9) ◽  
pp. 950-959 ◽  
Author(s):  
Miguel Gonçalves Ferreira ◽  
David Rodrigues Dias ◽  
Luis Cardoso ◽  
Mariline Santos ◽  
Cecília A Sousa ◽  
...  
Keyword(s):  
Septal Cartilage ◽  
Control Group ◽  
Level Of Evidence ◽  
Primary Rhinoplasty ◽  
Computed Tomography Scans ◽  
Study Population ◽  
Caucasian Patients ◽  
The Mean ◽  
Hump Reduction ◽  
Hump Resection

Abstract Background Hump resection often requires reorganization of the keystone area. Objectives The authors sought to describe the importance of the point where the perpendicular plate of ethmoid joins the septal cartilage (SC) and the nasal bones (NB) (Ethmoidal point [E-point]) for hump resection surgical planning. Methods Measurements from mid-sagittal slices in nasal computed tomography scans taken in adult Caucasian patients between January 2015 and December 2018 were compared between patients seeking primary rhinoplasty due to a nasal hump and patients not seeking rhinoplasty (control group). Patients with previous nasal surgery or trauma, genetic or congenital facial disorders, and high septal deviation were excluded. The length of overlap between NB and SC was compared between the 2 groups. The location of the E-point in relation to the beginning of the nasal hump in the cephalocaudal direction was documented in the patients seeking rhinoplasty. Results The study population included 138 patients, 69 seeking and 69 not seeking rhinoplasty (96 females). The mean age was 32.9 years (range, 18-55 years). The length of overlap between NB and SC was similar between both groups (11.7 ± 3.3 vs 10.8 ± 3.3; P = 0.235). The E-point was located before the beginning of the nasal hump in 97% (67/69) of nasal hump patients, and it could be found a mean distance of 2.3 (±2.3) mm cephalic to the latter. Conclusions As a rule, the perpendicular plate of the ethmoid does not contribute to the nasal hump; therefore, only in exceptional cases should this be addressed while performing dorsal reduction. Level of Evidence: 3

scholarly journals Association between Psoriasis and Obesity

2018 ◽  
Vol 16 (2) ◽  
pp. 58-61
Author(s):  
Sumit Pandey ◽  
Smita Jha ◽  
Shyam Kumar B.K ◽  
Shyam Kumar B.K. ◽  
Kumar Pokharel
Keyword(s):  
College Teaching ◽  
Control Group ◽  
Medical College ◽  
Pasi Score ◽  
Prevalence Of Obesity ◽  
Study Population ◽  
Duration Of Disease ◽  
The Mean ◽  
Chronic Skin ◽  
Chronic Skin Disease

Background: Psoriasis is primarily a chronic skin disease, the course being punctuated by remissions and relapses. Research has shown that hypertension, obesity, heart failure and diabetes are significantly more common in patients with psoriasis. Obesity is associated with severe psoriasis and is reported about twice as frequently among psoriasis patients as in the general population. In recent years many reports have demonstrated an association between psoriasis and metabolic syndrome. Objectives: The aim of this study was to identify the prevalence of obesity in patients with psoriasis and compare it with that of non-psoriatic population. Material and Method: This study is a case control hospital based study conducted in the Department of Dermatology, Venereologyand Leprology of Nepalgunj Medical College Teaching Hospital, Kohalpur between May 2017 to October 2018.Total 56 cases of psoriasis and similar number of healthy age and sex matched controls were enrolled in the study after taking written consent. Detailed history and physical examination was performed with measurement of body mass index which was recorded. Statistical analysis was done using SPSS 20. Result: The results of the study which included 56 patients with psoriasis and 56 subjects without psoriasis. Among them 26 male and 30 female in study population and 25 male and 31 female in control group. The mean age was41.68±19.04 years in study population and 39.46 ±16.27 years in control group. Duration of disease ranged from 2 months to 360months and PASI score ranged from 4.4 to 28.2 with mean PASI score 11.02±5.4. BMI in cases ranged from 16.7 to 34.2 with mean24.3±4.3 and in controls it ranged from 15.5 to 29.1 with mean 21.9±3. Mean BMI was significantly higher in cases than controls. Conclusion: The result of this study supports the significantly higher prevalence of obesity in study population than control group.

scholarly journals Association of Hypertension and Smoking with Ischaemic Stroke

2013 ◽  
Vol 3 (1) ◽  
pp. 16-18
Author(s):  
K Kirtania ◽  
N Sultana ◽  
S Ahmed ◽  
A Khatun
Keyword(s):  
Cigarette Smoking ◽  
Ischaemic Stroke ◽  
Matched Control ◽  
Strong Relationship ◽  
Control Group ◽  
Case Group ◽  
Medical College ◽  
Study Population ◽  
The Mean ◽  
Control Study

Hypertension is one of the most important modifiable risk factors for ischemic stroke. Cigarette smoking is a risk factor for atherosclerotic disease. There is a strong relationship between hypertension and cigarette smoking with ischaemic stroke. A case control study was undertaken to see the association of hypertension and cigarette smoking with ischaemic stroke. The study was done from January to December 2009 in the Department of Biochemistry, Dhaka Medical College, Dhaka. A total of 60 subjects were selected as study population. Among them 30 were diagnosed case of ischaemic stroke and 30 were age-and sex-matched control subjects. It was found that 60% patients of case group and 20% respondents of control group were hypertensive and diffrence was significant. Study showed that 56.66% of cases and 53.33% of controls were smoker and the findings were insignificant. The mean duration of smoking was 27.41 ± 2.98 years in cases and 15.63 ± 2.85 years in controls which was significant. The study suggests that hypertension is significantly associated with ischaemic stroke and longer duration of smoking also associated with ischaemic stroke. DOI: http://dx.doi.org/10.3329/bjmb.v3i1.13802 Bangladesh J Med Biochem 2010; 3(1): 16-18

scholarly journals Cytokines Level (Il8 and Il17) in Pregnant Women with Toxoplasmosis in Khartoum State

2019 ◽  
Vol 1 (1) ◽  
pp. 8-12
Author(s):  
Wahaj M. M ◽  
Satti, A. B ◽  
Abdalla H.S ◽  
Ahmed S. Kabbashi
Keyword(s):  
Toxoplasma Gondii ◽  
Serum Level ◽  
Pregnant Women ◽  
Venous Blood ◽  
Control Group ◽  
Cross Sectional ◽  
Study Population ◽  
Patient’S Information ◽  
The Mean ◽  
Toxoplasma Gondii Infection

Toxoplasmosis is one of the most important zoonotic diseases worldwide caused by Toxoplasma gondii that leads to abortion or hydrocephalus during pregnancy. It’s a comparative cross-sectional one designed to assess immunoglobulins and cytokines in pregnant women. A total of 300 venous blood samples were collected from each pregnant woman and centrifuged to obtain serum. Patient’s information was recorded in a questionnaire previously designed for the purpose of analysis. In addition, 40 uninfected women were enrolled in the study as control group to assess the level of IL8 and IL17 cytokines. The overall seropositive rate of Toxoplasma gondii infection was 22.6%. Within the positive cases of study population, only 16 and 13 showed positive results of IL8, IL17 respectively. The results showed highly significant increase in the mean serum level of IL8 (210.25pg/ml) and IL17 (203.15 pg/ml) when compared to the control group who showed 68.9 pg/ml and 54.8 pg/ml respectively. The serum level of proinflammatory cytokines investigated in this study seems to be increased in patients with serological evidence of Toxoplasma gondii infection. Our study concludes that IL-17 and IL-8 involved in the induction of inflammation and toxoplasmosis disease.

scholarly journals Apolipoprotein A-I and B levels in Bangladeshi patients with coronary artery disease

2016 ◽  
Vol 9 (1) ◽  
pp. 31-33
Author(s):  
Ashesh K Chowdhury ◽  
Abu Mohammed Shafique ◽  
Zeenat F Rahman
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Large Scale ◽  
Control Group ◽  
Total Study Population ◽  
Apo B ◽  
Apolipoprotein A ◽  
Study Population ◽  
The Mean ◽  
Artery Disease

Coronary arteay disease (CAD) is an important cause of morbidity and mortality in developed as well as developing countries like Bangladesh. In this study, the status of serum apolipoprotein A-I (Apo A-1) and apolipoprotein B (Apo B) levels were assessed in Bangladeshi patients with coronary artery diseases. The study was carried out in the Department of Cardiology, University Cardiac Centre (UCC), Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka. Total study population was 100, of which 50 were patients with CAD and 50 were individuals without CAD (control). The patients with CAD and controls were enrolled following the inclusion and exclusion criteria. About 5 ml blood was collected by venepuncture from each individual and apolipoprotein A-1 and B were determined by automated nephelometry. The mean age of total study population was 51.4 ± 10.8 years while the mean age of the patients and control was 51.3 ± 10.9 and 51.4 ± 10.9 years respectively. The Apo A-I level was significantly (p<0.01) different in CAD patients compared to control group (95.10 ± 20.50 mg/dl vs 113.47 ± 20.96 mg/dl). The ratio of Apo B and Apo A1 was also significantly higher (p<0.01) in CAD patients than that of controls (1.25 ± 0.40 vs 0.95 ± 0.26 while Apo B levels was not different among the two groups. The study revealed significant alteration of serum Apo A-I level and Apo B/Apo A-I ratio in patients with CAD compared to those without CAD. Further large-scale study is needed to evaluate the exact influence of apolipoproteins on coronary artery disease in Bengali ethnic population.Ibrahim Med. Coll. J. 2015; 9(1): 31-33

scholarly journals Failure Rates of 5-Strand and 6-Strand vs Quadrupled Hamstring Autograft ACL Reconstruction: A Comparative Study of 413 Patients With a Minimum 2-Year Follow-up

2020 ◽  
Vol 8 (8) ◽  
pp. 232596712094632
Author(s):  
Ahmed Khalil Attia ◽  
Hazem Nasef ◽  
Kareem Hussein ElSweify ◽  
Mohammed A. Adam ◽  
Faris AbuShaaban ◽  
...  
Keyword(s):  
Cruciate Ligament ◽  
Control Group ◽  
Failure Rates ◽  
Hamstring Autograft ◽  
Level Of Evidence ◽  
Increased Risk ◽  
The Mean ◽  
Anterior Cruciate ◽  
Graft Diameter

Background: Anterior cruciate ligament reconstruction (ACLR) with hamstring autograft has gained popularity. However, an unpredictably small graft diameter has been a drawback of this technique. Smaller graft diameter has been associated with increased risk of revision, and increasing the number of strands has been reported as a successful technique to increase the graft diameter. Purpose: To compare failure rates of 5-strand (5HS) and 6-strand (6HS) hamstring autograft compared with conventional 4-strand (4HS) hamstring autograft. We describe the technique in detail, supplemented by photographs and illustrations, to provide a reproducible technique to avoid the variable and often insufficient 4HS graft diameter reported in the literature. Study Design: Cohort study; Level of evidence, 3. Methods: We retrospectively reviewed prospectively collected data of all primary hamstring autograft ACLRs performed at our institution with a minimum 2-year follow-up and 8.0-mm graft diameter. A total of 413 consecutive knees met the study inclusion and exclusion criteria. The study population was divided into 5HS and 6HS groups as well as a 4HS control group. The primary outcome was failure of ACLR, defined as persistent or recurrent instability and/or revision ACLR. Results: The analysis included 224, 156, and 33 knees in the 5HS, 6HS, and 4HS groups, respectively. The overall ACLR failure rate in this study was 11 cases (8%): 5 cases for 5HS, 3 cases for 6HS, and 3 cases for 4HS. No statistically significant differences were found among groups ( P = .06). The mean graft diameter was 9 mm, and the mean follow-up was 44.27 months. Conclusion: The 5HS and 6HS constructs have similar failure rates to the conventional 4HS construct of 8.0-mm diameter and are therefore safe and reliable to increase the diameter of relatively smaller hamstring autografts. We strongly recommend using this technique when the length of the tendons permits to avoid failures reportedly associated with inadequate graft size.

scholarly journals The effects of cigarette smoking on ventricular repolarization in adolescents

2017 ◽  
Vol 15 (3) ◽  
pp. 251-255 ◽  
Author(s):  
Seyma Kayali ◽  
Fadime Demir
Keyword(s):  
Body Mass Index ◽  
Cigarette Smoking ◽  
Ventricular Arrhythmias ◽  
Control Group ◽  
Adolescent Smokers ◽  
Blood Pressures ◽  
Study Population ◽  
The Mean ◽  
Electrocardiographic Parameters ◽  
And Control

ABSTRACT Objective To assess the association between cigarette smoking and ventricular arrhythmias in adolescents. Novel electrocardiographic parameters –Tp-e interval, as well as Tpe/QT and Tpe/QTc ratios – were used to make this assessment. Methods The study population consisted of 87 subjects aged between 16-19 years. Fifty-one adolescent smokers with no risk of arrhythmia comprised the Smoker Group, and 36 adolescents who had never smoked cigarettes comprised the Control Group. Smokers were defined as patients smoking more than three cigarettes per day, for at least 1 year. Body mass index, systolic, diastolic and mean blood pressures were measured, and electrocardiograms were performed on all subjects. Heart rate, PR and Tp-e intervals, and Tpe/QT, Tpe/QTc ratio were digitally measured. Results Adolescents in Smoker Group had smoked cigarettes for 2.9±1.4 years (range 1 to 6 years). The mean age at starting smoking was 13.8±1.4 years. There were no differences between smokers and Control Group as to baseline clinical variables (p>0.05). The PR, QT and QTc intervals were similar in all groups. Tp-e interval (98.4±12.7ms and 78.3±6.9 ms; p<0.001), Tpe/QT (0.28±0.04 and 22±0.03; p<0.01), Tpe/QTc (0.24±0.03 and 0.19±0.01; p<0.001) ratios were significantly higher in Smoker Group. There were no correlations between years of smoking, number of cigarettes per day, Tpe interval, Tpe/QT or Tpe/QTc ratios. Conclusion Cigarette smoking is associated with risk of ventricular arrhytmogenesis with prolonged Tp-e interval and increased Tpe/QT and Tpe/QTc ratios in adolescents.

The Combined Auricular Graft: A New Technique for Mestizo Nasal Tip Surgery

2018 ◽  
Vol 39 (12) ◽  
pp. 1297-1308
Author(s):  
Paulo A Escobar ◽  
Simon Zimmermann ◽  
Lukas Lunger
Keyword(s):  
Rotation Angle ◽  
Alar Cartilage ◽  
Cartilage Graft ◽  
Level Of Evidence ◽  
Tip Rotation ◽  
Nasal Tip ◽  
Primary Rhinoplasty ◽  
The Mean ◽  
Mean Differences ◽  
The Aesthetic

Abstract Background Current literature lacks a single cartilage graft to address problems in projection, rotation, and/or definition in mestizo patients that considers the alar cartilage structure, length, and shape characteristics of this population. Objectives The authors sought to describe a novel technique and evaluate the aesthetic outcomes of the combined auricular graft in mestizo patients undergoing primary rhinoplasty. Methods A retrospective cohort study of consecutive patients who underwent primary rhinoplasty using the combined auricular graft between January 2015 and June 2017 was performed. The minimum duration of follow-up was 6 months. Main outcomes were nasal tip projection and tip rotation angle. Results Among the 61 patients (38 women [62.2%] and 23 men [37.8%]; mean age, 29.3 ± 10.8 years), the mean differences in projection were statistically significant between T0 and T1, T0 and T2, and T0 and T3 (1.63, 1.39, and 1.32 mm, respectively). Thus, 80.9% of the increase in projection that had been achieved at T1 was maintained at T3 (P < 0.001). The relapse ratio measured 19.1% (mean difference T1-T3, 0.31 ± 0.10 mm). The mean tip rotation angle at T0 (111.69 ± 3.59°) significantly increased by 2.37 ± 3.13° (T3, 114.06 ± 2.50°, P < 0.001). Conclusions One single auricular cartilage graft can significantly improve projection and/or rotation by simultaneously addressing structure, length, and shape of lower lateral cartilages. Misbalance between the medial and lateral crura is avoided and retraction risks are prevented. Consequently, a more natural, precise, and accurate tip position is obtained. Level of Evidence: 4

scholarly journals Non-tuberculous Mycobacterial Pulmonary Diseases in France: An 8 Years Nationwide Study

2021 ◽  
Author(s):  
Nicolas Veziris ◽  
Claire Andréjak ◽  
Stéphane Bouée ◽  
Corinne Emery ◽  
Marko Obradovic ◽  
...  
Keyword(s):  
Marrow Transplant ◽  
Charlson Comorbidity Index Score ◽  
Control Group ◽  
Treatment Regimens ◽  
Main Driver ◽  
Study Population ◽  
Annual Total ◽  
Comorbidity Index ◽  
The Mean ◽  
Lower Respiratory Disease

Abstract Background: The objective of the study was to describe the epidemiology, management and cost of non-tuberculous mycobacteria lung disease (NTM-PD) in France.Methods: A retrospective analysis was performed using the SNDS database over 2010-2017. Patients with NTM-PD were identified based on the ICD10 codes during hospitalizations and/or specific antibiotics treatment regimens. The study population was matched (age, gender and region) to a control group (1: 3) without NTM-PD.Results: 5,628 patients with NTM-PD (men: 52.9%, mean age=60.9 years) were identified over the study period and 1,433 (25.5%) were treated with antibiotics. The proportion of patients still receiving treatment at 6 and 12 months was 40% and 22%, respectively.Patients with NTM-PD had more co-morbidities compared to controls: corticoids (57.3% versus 33.8%), chronic lower respiratory disease (34.4% vs. 2.7%), other infectious pneumonia (24.4% vs. 1.4%), malnutrition (22.0% vs. 2.0%), tuberculosis (14.1% vs. 0.1%), HIV (8.7% vs 0.2%), lung cancer and graft (5.7% vs 0.4%), cystic fibrosis (3.2% vs 0.0%), gastro-esophageal reflux disease (2.9% vs 0.9%) and bone marrow transplant (1.3% vs 0.0%) (p<0.0001). The mean Charlson comorbidity index score was 1.6 (versus 0.2 for controls; p <0.0001). NTM-PD was independently associated with an increased mortality rate with a hazard ratio of 2.8 (95% CI: 2.53; 3.11). Mortality was lower for patients treated with antibiotics compared to untreated patients (HR=0.772 (95% CI [0.628; 0.949]).Annual total expenses the year following the infection in a societal perspective were € 24,083 (SD: 29,358) in NTM-PD subjects versus € 3,402 (SD: 8,575) in controls (p<0.0001). Main driver of the total expense for NTM-PD patients was hospital expense (>50% of the total expense).Conclusion: Patients with NTM-PD in France were shown to have many comorbidities, their mortality risk is high and mainly driven by NTM-PD, and their management costly. Only a minority of patients got treated with antibiotics and of those patients treated, many stopped their therapy prematurely. These results underline the high burden associated with NTM-PD and the need for improvement of NTM-PD management in France.

Nerve Blocks Prior to Microfocused Ultrasound Treatment are Safe and Reduce Patient Discomfort

2020 ◽  
Vol 40 (8) ◽  
pp. 887-891
Author(s):  
Marc A Polacco ◽  
Daniel R Butz ◽  
Rachel Bass ◽  
Teresa Luu ◽  
Esra Kurum ◽  
...  
Keyword(s):  
Adverse Events ◽  
Pain Score ◽  
Ultrasound Treatment ◽  
Patient Comfort ◽  
Control Group ◽  
Level Of Evidence ◽  
Nerve Blocks ◽  
Patient Discomfort ◽  
The Mean ◽  
Split Face

Abstract Background Microfocused ultrasound with visualization has become one of the more popular nonsurgical facial rejuvenation therapies available. Although the treatment has gained wide acceptance, providing adequate pain relief during the procedure can be challenging. Objectives The aim of this study was to test our hypothesis that nerve blocks prior to treatment would be well tolerated and significantly reduce patient discomfort. Methods Subjects undergoing microfocused ultrasound were offered the choice of participating in a split face nerve block, bilateral block, or a control group. Nerves targeted included infraorbital, supratrochlear, supraorbital, zygomaticofrontal, mental, great auricular, and cervical plexus. Pain assessment was based on a 10-point Wong-Backer FACES Pain score. Results A total of 65 patients were included in the study: 28 in the split face group, 19 in the bilateral block group, and 18 without a block. The mean [standard deviation] pain score of the bilateral block cohort was 3.9 [1.2], and that of the control group was 5.1 [1.7] (P = 0.001). Patients in the split face cohort reported a higher pain score on the unblocked side of the face (7.5 [1.3]) than on the blocked side (2.9 [1.0]) (P &lt; 0.001). The mean pain score for local anesthetic injection was 2.7 and 1.4 for the split face and the bilateral groups, respectively. There were no adverse events. Conclusions Nerve blocks are well tolerated and significantly improve patient comfort during microfocused ultrasound treatment without compromising outcomes or increasing adverse events. Level of Evidence: 2

scholarly journals Diffusion-weighted imaging of normal appearing corticospinal tracts in patients with multiple sclerosis

2017 ◽  
Vol 31 (2) ◽  
pp. 142-146
Author(s):  
Kadihan Yalçın-Şafak ◽  
Ahmet Akça ◽  
Özlem Elibol ◽  
İrem Sarı
Keyword(s):  
Corticospinal Tract ◽  
Internal Capsule ◽  
Control Group ◽  
Corticospinal Tracts ◽  
Significant Difference ◽  
Adc Values ◽  
Study Population ◽  
The Mean ◽  
The Right ◽  
And Control

Aim To determine if there are differences in ADC values between normal appearing corticospinal tracks in patients with MS compared to ADC values in controls. Material and methods The study population comprised 62 consecutive MS patients (36 women and 26 men; mean age 36.45±8.63 years). 50 control subjects with no neurological disabilities or intracranial were included the study (32 women and 18 men; mean age 40.18±12.25 years). All ADC maps were independently evaluated by two experienced radiologists. ROI of approximately 15–18 mm2 in capsula interna and 10–12 mm2 in mesencephalon were placed bilaterally for measurement of ADC values. Three circular ROIs were placed-one each side for internal capsule-and 6 total ROIs from right and left internal capsule were averaged for each patient. Mesencephelon ADC measurements were performed similarly. Result The mean ADC values of the left internal capsule in MS patients were significiantly lower than the control group (p:0.002). No statistically significant difference was found between the MS patients and control group mean ADC values of the right internal capsule (p>0.05). The mean ADC values of the right and left mesencephalon in MS patients were significiantly lower than the control group (respectively; p:0.031, p<0.001). The mean ADC values of the left internal capsule were significiantly lower than the right internal capsule in MS patients (p<0.001). The mean ADC values of the left mesencephalon were significiantly lower than the right mesencephalon in MS patients (p<0.001). Conclusion The mean ADC values of the normal-appearing corticospinal tract in MS patients were significantly lower than the control group except for the right internal capsule.

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