The Effects of Lower Versus Higher Cell Number of Platelet-Rich Plasma (PRP) in Hair Density and Diameter in Androgenetic Alopecia (AGA): A Randomized, Double-Blinded, Placebo, Paralleled Group Half-Scalp IRB Study

2021 ◽  
Author(s):  
Gordon H Sasaki
Keyword(s):  
Adverse Reactions ◽  
Platelet Rich Plasma ◽  
Cell Number ◽  
Lower Number ◽  
Androgenetic Alopecia ◽  
Hair Density ◽  
Treatment Protocols ◽  
Evaluation Period ◽  
Terminal Hair ◽  
Double Blinded

Abstract Background Androgenetic alopecia (AGA) is a common disorder in male and female patients that may benefit from the use of platelet-rich plasma. Objectives To compare the safety, efficacy, and satisfaction of a lower or higher number of platelets over 6 months. Methods A prospective randomized, double-blinded, placebo, paralleled group, half-scalp IRB study among eight subjects with moderate AGA. Participants received intradermal PRP injections (baseline and month 3), according to two treatment protocols (high vs low platelet numbers) to the frontal and crown portions of the hemi-scalp and normal saline to control sites. Phototrichoscans were measured at baseline and six months, while global photography and subject and investigator satisfaction questionnaires were obtained at baseline, 3, and 6 months. Results At the end of 6-month evaluation period, both groups demonstrated numerical increases in total hair densities, follicle diameters and terminal hair densities, as well as absolute and percent changes at the frontal and crown targeted sites compared to baseline. These improvements tended to occur more often in areas treated with higher platelet numbers than with lower numbers. Vellus hair densities did not exhibit any significant changes to either PRP dosages. Treatments were assessed by investigator and subjects as “satisfied” at month-3 and were associated with no adverse reactions. Conclusions Intradermal injections with two therapeutic quantities of platelets were equally safe and efficacious among men and women with androgenetic alopecia. Findings suggest that higher numbers of platelets may have a greater effect than lower number of platelets in regard to hair densities, follicle diameters and terminal hair densities but exhibited minimal effects on vellus hair densities at the month-6 evaluation period. Further studies are required to determine whether any significant advantages occur when delivering either lower or higher numbers of platelets in AGA treatments as long as therapeutic levels are administered.

Comparison of efficacy of topical 5% minoxidil alone versus topical 5% minoxidil with autologous Platelet Rich Plasma (PRP) therapy in treatment of androgenetic alopecia: A randomised open label study

2021 ◽  
Vol 7 (2) ◽  
pp. 107-114
Author(s):  
Bela Padhiar ◽  
Sruthy Raveendran
Keyword(s):  
Platelet Rich Plasma ◽  
Androgenetic Alopecia ◽  
Androgenic Alopecia ◽  
Open Label ◽  
Hair Density ◽  
Convenience Sample ◽  
Double Spin ◽  
Autologous Platelet Rich Plasma ◽  
Group B ◽  
Autologous Platelet

Androgenic alopecia (AGA) is a type of progressive hairloss, where there is androgen mediated conversion of susceptible terminal hairs into vellus hairs, in genetically predisposed individuals. To compare efficacy of Topical 5% Minoxidil alone versus Topical 5% Minoxidil with Autologous Platelet Rich Plasma (PRP) therapy in patients with Androgenetic Alopecia.This is aProspective study conducted in Department of Dermatology GMERS Medical College, Gandhinagar, Gujarat. A convenience sample of 62 men in the age group of 20-40 with Grade 2-5 AGA according to Hamilton- Norwood Grading were selected and was divided into 2 groups of 31 each. Presitting digital photographs and dermoscopic photos were taken. Autologous PRP was prepared using 18 ml of patients blood after double spin centrifugation and injected by Nappage technique. Results were assessed at the baseline and at the end of each sitting on the basis of change in hair density, photographic evaluation and patient’s self satisfaction. Highly significant increase in hair density was achieved after 4 months of treatment. At T4 (Fourth Session of treatment) Group B showed higher hair density (42.97± 8.96) as compared to Group A (36.94 ± 11.57) which was statistically significant at P = 0.03Group B showed better improvement as compared to Group A.PRP treatment has a positive therapeutic effect on male Androgenetic alopecia without major side effects.

scholarly journals Evaluation of using stromal vascular fraction and platelet rich plasma in the treatment of androgenetic alopecia

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
A B Osama ◽  
Elfeky K Ahdallah ◽  
E K M Ali ◽  
N A Mamdouh
Keyword(s):  
Side Effects ◽  
Clinical Improvement ◽  
Platelet Rich Plasma ◽  
Stromal Vascular Fraction ◽  
Androgenetic Alopecia ◽  
Serious Adverse Events ◽  
Terminal Hair ◽  
Significant Difference ◽  
Potential Therapeutic Application ◽  
Fraction Versus

Abstract Background Platelet Rich Plasma (PRP) is based on the release of growth factors stimulating the initiation/extension of anagen phase as well as promoting vascularization, Adipose Derived Stem Cell (AT-ADSCs) treatment through injection of stromal vascular fraction were recently introduced as an alternative potential therapeutic application for hair growth. Purpose This study aims to compare the efficacy, safety and adverse effects of using lipo-aspirate stromal vascular fraction versus Platelet Rich Plasma injection in the treatment of Androgenetic Alopecia (AGA). Patients And Methods Forty randomized patients were treated by PRP, and SVF. Each patient was evaluated. And each lesion was treated by those modalities, patients received three sessions with one month interval for 3 months, follow up after 3 months. Results A highly significant improvement <0.001 in terminal hair count of SVF group evaluated by videodermoscopy assessment of AGA. That were confirmed by highly significant improvement in inter-mediate hair count and mean caliber (<0.001) associated with high incidence of side effects especially headache and erythema. In contrast. PRP group showed significant improvement 0.048 in terminal hair count and non-significant improvement in inter-mediate hair count and of mean caliber with minimum side effects. SVF group showed a significant improvement in terminal hair count than PRP and a highly significant improvement in Inter-mediate hair count. Regard the clinical improvement and photographic assessment, SVF evoked upper hand of clinical improvement than PRP without statistically difference. Also, side effects of SVF showed highly significant pain, headache and erythema but no serious adverse events. Our study suggests that was significant improvement in AGA after PRP and highly significant after SVF therapy, with significant difference of SVF in terminal hair count and highly significant in vellus hair. Both modalities could effectively and safely he used to treat AGA. Conclusion our study suggested that there was significant improvement in AGA after both PRP and highly significant after SVF therapy. The results indicated a significant difference between PRP and SVF regarding terminal hair count and highly significant for vellus hair count, but non-significant difference in hair diameter. Both modalities could effectively and safely be used to treat AGA and there was statistically improvement in AGA after both PRP and SVF therapies.

scholarly journals Morphological substantiation of clinical efficacy of platelet rich plasma in males with androgenic alopecia

2018 ◽  
Vol 20 (3) ◽  
pp. 67-71
Author(s):  
E E Pakhomova ◽  
I O Smirnova ◽  
I N Telichko
Keyword(s):  
Clinical Efficacy ◽  
Growth Parameters ◽  
Platelet Rich Plasma ◽  
Hair Follicles ◽  
Androgenetic Alopecia ◽  
Sweat Glands ◽  
Androgenic Alopecia ◽  
Hair Density ◽  
Plasma Therapy ◽  
Four Levels

Morphological substantiation of the clinical efficacy of platelets rich plasma was carried out in the treatment of 22 men with androgenetic alopecia from the 1st to the 4th stage according to the Norwood-Hamilton scale were included. All patients received intradermal injections of platelets rich plasma 0,15 ml per injection. The course of treatment consisted of 4 procedures with an interval of 4 weeks. Clinical efficacy was assessed by the dynamics of morphometric indices of hair growth. Histological examination was carried out on horizontal sections, stained with hematoxylin and eosin, the morphology of the hair was counted at four levels. Evaluation of morphometric growth parameters conducted before treatment and 4 months after the onset of it. It was established that the therapy of platelet-rich plasma has a pronounced clinical efficacy, consisting in a significant (p=0,00025) increase in hair density by 11% and average hair diameter by 10% (p=0,00766), a 14% decrease in the share of hair follicles (p=0,00959). Histologically, the increase in hair density was significant at the level of the bulb of the hair follicles by 148% (p=0,0034) and at the level of the sweat glands by 65% (p=0,0326), and also by the tendency to increase their number at the level of the sebaceous glands. This was combined with a significant decrease in the proportion of telogen hair at 47% (p=0,0153). Thus, the positive clinical effect of plasma-rich plasma therapy in men suffering from androgenetic alopecia is based on reliable morphofunctional changes in the hair follicles.

scholarly journals Effectiveness of Platelet-Rich Plasma in the Treatment of Androgenetic Alopecia - A Prospective Cohort Study from Guntur, Andhra Pradesh

2021 ◽  
Vol 8 (20) ◽  
pp. 1510-1515
Author(s):  
Santosh Reddy Mandadi ◽  
Krishna Rajesh Kilaru ◽  
Venkateswara Rao G
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Platelet Rich Plasma ◽  
Treatment Options ◽  
Androgenetic Alopecia ◽  
Hair Density ◽  
Patient’S Satisfaction ◽  
Pull Test ◽  
Number Of Patients

BACKGROUND Androgenetic alopecia (AGA) is a genetically determined disorder characterized by the gradual conversion of terminal hairs into indeterminate, and finally into vellus hairs. It is the most common cause of hair loss affecting more men and occasionally women. Platelet-rich plasma (PRP) therapy is one of the newer treatment options and has shown promising results. We wanted to evaluate the safety and efficacy of PRP in the treatment of AGA. METHODS A prospective cohort study was done on thirty patients of AGA. The stage of alopecia was evaluated according to the Hamilton-Norwood scale (males) and the Ludwig scale (females). All patients were treated with six intradermal PRP sittings with an interval of 4 weeks between each sitting and were evaluated at the end of 6 months using global photography, hair pull test, patient’s satisfaction rating and hair density. RESULTS Out of 30 patients, majority were in the age group of 21 - 25 years (40 %). 23 were males and 7 were females. Among male patients, maximum number of patients (39.13 %) were having grade 4 AGA followed by grade 3 (30.43 %). Among females, maximum number of patients (57.14 %) were having grade 1 AGA. At baseline, 66.67 % patients showed positive hair pull test whereas all patients showed negative hair pull test at the end of study. Baseline mean hair density was 78.96 ± 9.66 hairs / cm2 and at the end of study it was 105. 46 ± 9.21 hairs / cm2 . On an analogue scale ranging from 0 to 10, the overall mean change in the clinical rating of patient satisfaction was 6.83, which denoted satisfactory for most patients. CONCLUSIONS All patients treated with PRP showed increase in hair density in dermoscopic photomicrographs at the end of the study. PRP is a simple, effective and safe treatment for AGA. KEYWORDS Androgenetic Alopecia, Platelet-Rich Plasma

scholarly journals The Effect of Platelet-Rich Plasma on the Intra-Articular Microenvironment in Knee Osteoarthritis

2021 ◽  
Vol 22 (11) ◽  
pp. 5492
Author(s):  
Dawid Szwedowski ◽  
Joanna Szczepanek ◽  
Łukasz Paczesny ◽  
Jan Zabrzyński ◽  
Maciej Gagat ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Operative Treatment ◽  
Animal Studies ◽  
Platelet Rich Plasma ◽  
Treatment Options ◽  
Treatment Protocols ◽  
Metabolic Functions ◽  
Inflammatory Drugs ◽  
Positive Effect

Knee osteoarthritis (KOA) represents a clinical challenge due to poor potential for spontaneous healing of cartilage lesions. Several treatment options are available for KOA, including oral nonsteroidal anti-inflammatory drugs, physical therapy, braces, activity modification, and finally operative treatment. Intra-articular (IA) injections are usually used when the non-operative treatment is not effective, and when the surgery is not yet indicated. More and more studies suggesting that IA injections are as or even more efficient and safe than NSAIDs. Recently, research to improve intra-articular homeostasis has focused on biologic adjuncts, such as platelet-rich plasma (PRP). The catabolic and inflammatory intra-articular processes that exists in knee osteoarthritis (KOA) may be influenced by the administration of PRP and its derivatives. PRP can induce a regenerative response and lead to the improvement of metabolic functions of damaged structures. However, the positive effect on chondrogenesis and proliferation of mesenchymal stem cells (MSC) is still highly controversial. Recommendations from in vitro and animal research often lead to different clinical outcomes because it is difficult to translate non-clinical study outcomes and methodology recommendations to human clinical treatment protocols. In recent years, significant progress has been made in understanding the mechanism of PRP action. In this review, we will discuss mechanisms related to inflammation and chondrogenesis in cartilage repair and regenerative processes after PRP administration in in vitro and animal studies. Furthermore, we review clinical trials of PRP efficiency in changing the OA biomarkers in knee joint.

16004 Meta-analysis of platelet-rich plasma for androgenetic alopecia

2020 ◽  
Vol 83 (6) ◽  
pp. AB167
Author(s):  
A.K. Gupta ◽  
J.L. Carviel ◽  
C.J. Puig DO ◽  
Jeffrey Rapaport ◽  
N.H. Shear ◽  
...  
Keyword(s):  
Platelet Rich Plasma ◽  
Meta Analysis ◽  
Androgenetic Alopecia
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