scholarly journals Peri-operative risk factors for acute lung injury after elective oesophagectomy †

2001 ◽  
Vol 86 (5) ◽  
pp. 633-638 ◽  
Author(s):  
S. Tandon ◽  
A. Batchelor ◽  
R. Bullock ◽  
A. Gascoigne ◽  
M. Griffin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Operative Risk

scholarly journals Analysis of Risk Factors Associated with Outcomes in Road Traffic Injury Patients with Acute Lung Injury

2009 ◽  
Vol 37 (3) ◽  
pp. 835-840
Author(s):  
L Sheng ◽  
J-S Wu ◽  
M Zhang ◽  
S-W Xu ◽  
J-X Gan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Road Traffic ◽  
Road Traffic Injury ◽  
Apache Ii Score ◽  
Factors Associated ◽  
Traffic Injury ◽  
Short And Long Term

Over 50% of road traffic injury (RTI) patients experience post-traumatic acute lung injury (ALI) and it is, therefore, extremely important to identify the risk factors related to the poor outcomes associated with ALI in RTI populations. This study evaluated 19 potential risk factors associated with the outcomes of ALI in 366 RTI patients. They were divided into two groups: a ‘favourable outcomes group’ and an ‘unfavourable outcomes group’. The results indicated that the Acute Physiology and Chronic Health Evaluation II (APACHE II) score and the presence of gastrointestinal haemorrhage may help predict the outcomes of ALI in the early post-trauma phase of treatment. The duration of trauma and sepsis were shown to impact strongly on both the short- and long-term outcomes of ALI. Age (≥ 65 years) and disseminated intravascular coagulation in the early RTI phase were also independent risk factors for a poorer short- and long-term outcome in ALI.

scholarly journals Risk Factors for Transfusion-Related Acute Lung Injury in Critical Patients Admitted in Intensive Care Unit: A Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
Lunyang Hu ◽  
Baoli Wang ◽  
Yong Jiang ◽  
Banghui Zhu ◽  
Chen Wang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Mechanical Ventilation ◽  
Acute Lung Injury ◽  
Blood Transfusion ◽  
Lung Injury ◽  
Chronic Alcohol ◽  
Related Factors ◽  
Chronic Alcohol Abuse ◽  
Related Risk ◽  
Critical Patients

Abstract Background: Until now, transfusion-related acute lung injury (TRALI) has been considered to be the leading cause of blood transfusion-related diseases and death. And there is no clinically effective treatment plan for TRALI. The aim of this study was to systematically summarize the literature on risk factors for TRALI in critical patients. Methods: Electronic searches (up to March 2020) were performed in the Cochrane Library, Web of Knowledge, Embase, and PubMed databases. We included studies reporting on the risk factors of TRALI for critical patients and extracted the risk factors. Finally, third studies met the inclusion criteria. Results: We summarized and analyzed the potential risk factors of TRALI for critical patients in 13 existing studies. The host-related factors were age (odds ratio (OR) [95% confidence interval] = 1.16 [1.08-1.24]), sex (OR = 1.26 [1.16-1.38]), tobacco use status (OR = 3.82 [1.91-7.65]), chronic alcohol abuse (OR = 3.82 [2.97-26.83]), fluid balance (OR = 1.24 [1.08-1.42]), shock before transfusion (OR = 4.41 [2.38-8.20]), and ASA score of the recipients (OR = 2.72 [1.43-5.16]). The transfusion-related factors were the number of transfusions (OR = 1.40 [1.14-1.72]) and fresh frozen plasma (FFP) units (OR = 1.21 [1.01-1.46]). The device-related factor was mechanical ventilation (OR = 4.13 [2.20-7.76]). Conclusions: The risk factors for TRALI in this study included age, sex, tobacco use, chronic alcohol abuse, fluid balance, shock before transfusion, ASA score, number of transfusions, FFP units and mechanical ventilation. Our study suggests that host-related risk factors play a more important role in the occurrence and development of TRALI than blood transfusion-related risk factors.

scholarly journals Risk factors, management and prevention of transfusion-related acute lung injury: a comprehensive update

2019 ◽  
Vol 12 (9) ◽  
pp. 773-785 ◽  
Author(s):  
Susan A. Kuldanek ◽  
Marguerite Kelher ◽  
Christopher C. Silliman
Keyword(s):  
Risk Factors ◽  
Acute Lung Injury ◽  
Lung Injury

scholarly journals Risk factors of postoperative acute lung injury following lobectomy for nonsmall cell lung cancer

Medicine ◽  
2019 ◽  
Vol 98 (13) ◽  
pp. e15078 ◽  
Author(s):  
Hyun Jung Kim ◽  
Seung Ick Cha ◽  
Chang-Ho Kim ◽  
Jaehee Lee ◽  
Joon Yong Cho ◽  
...  
Keyword(s):  
Risk Factors ◽  
Lung Cancer ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Cell Lung Cancer ◽  
Nonsmall Cell Lung Cancer

scholarly journals Animal models of acute lung injury

2008 ◽  
Vol 295 (3) ◽  
pp. L379-L399 ◽  
Author(s):  
Gustavo Matute-Bello ◽  
Charles W. Frevert ◽  
Thomas R. Martin
Keyword(s):  
Risk Factors ◽  
Acute Lung Injury ◽  
Animal Models ◽  
Lung Injury ◽  
Animal Studies ◽  
Ischemia Reperfusion ◽  
Alveolar Epithelium ◽  
Acid Aspiration ◽  
Advantages And Disadvantages ◽  
Clinical Risks

Acute lung injury in humans is characterized histopathologically by neutrophilic alveolitis, injury of the alveolar epithelium and endothelium, hyaline membrane formation, and microvascular thrombi. Different animal models of experimental lung injury have been used to investigate mechanisms of lung injury. Most are based on reproducing in animals known risk factors for ARDS, such as sepsis, lipid embolism secondary to bone fracture, acid aspiration, ischemia-reperfusion of pulmonary or distal vascular beds, and other clinical risks. However, none of these models fully reproduces the features of human lung injury. The goal of this review is to summarize the strengths and weaknesses of existing models of lung injury. We review the specific features of human ARDS that should be modeled in experimental lung injury and then discuss specific characteristics of animal species that may affect the pulmonary host response to noxious stimuli. We emphasize those models of lung injury that are based on reproducing risk factors for human ARDS in animals and discuss the advantages and disadvantages of each model and the extent to which each model reproduces human ARDS. The present review will help guide investigators in the design and interpretation of animal studies of acute lung injury.

scholarly journals ACUTE LUNG INJURY COMPLICATING BLOOD TRANSFUSION IN POST-PARTUM HEMORRHAGE: INCIDENCE AND RISK FACTORS.

2014 ◽  
Vol 6 (1) ◽  
pp. e2014069 ◽  
Author(s):  
Luciana Teofili ◽  
Maria Bianchi ◽  
Bruno A Zanfini ◽  
Stefano Catarci ◽  
Rossella Sicuranza ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Gestational Hypertension ◽  
Post Partum ◽  
Univariate Analysis ◽  
High Risk Population ◽  
Post Partum Hemorrhage ◽  
Hypertensive Disorders ◽  
Clinical Records

Background. We retrospectively investigated the incidence and risk factors for transfusion-related acute lung injury (TRALI) among patients transfused for post-partum hemorrhage (PPH). Methods. We identified a series of 71 consecutive patients with PPH requiring the urgent transfusion of three or more red blood cell (RBC) units, with or without fresh frozen plasma (FFP) and platelet (PLT) transfusion. Clinical records were then retrieved and examined for respiratory distress events. According to the 2004 consensus definition, cases of new-onset hypoxemia within 6 hours after transfusion, with bilateral pulmonary changes in the absence of cardiogenic pulmonary edema  were identified as TRALI; if an alternative risk factor for acute lung injury was present,  possible TRALI was diagnosed.Results. Thirteen cases of TRALI and 1 case of possible TRALI were identified (overall incidence 19.7%).  At univariate analysis, patients with TRALI received higher number of RBC, PLT and FFP units and had a longer post-partum hospitalization. Among several pregnancy-related diseases (including hypertensive disorders, anemia, intrahepatic cholestasis, gestational diabetes) and various pre-existing comorbidities, only gestational hypertension and pre-eclampsia   significantly increased the risk to develop  TRALI (p = 0.006). At multivariate analysis, including both transfusion- and patient-related risk factors, pregnancy-related hypertensive disorders were confirmed to be the only predictors for TRALI, with an odds ratio of 27.7 ( 95% CI 1.27-604.3, p=0.034).Conclusions. Patients suffering from PPH represent a high-risk population for TRALI. In particular, patients with gestational hypertension and pre-eclampsia   have the highest risk, particularly if they are not receiving anti-hypertensive therapy. A careful monitoring of these patients after transfusions is therefore recommended.

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