scholarly journals EP.FRI.196 The Giant Hoqweed as a rare cause of chemical burns: A Case Series

2021 ◽  
Vol 108 (Supplement_7) ◽  
Author(s):  
Su Kwan Lim ◽  
Jamie Clements ◽  
Khalid Khan
Keyword(s):  
Uv Light ◽  
Case Series ◽  
Health Concern ◽  
Skin Thickness ◽  
Topical Steroids ◽  
Skin Damage ◽  
Chemical Burns ◽  
Severe Injuries ◽  
Heracleum Mantegazzianum ◽  
Prolonged Contact

Abstract Introduction The Giant Hogweed (Heracleum mantegazzianum) is a rare cause for chemical burns in humans and animals and is acquiring growing recognition in mainstream media as a relevant public health concern.  Injuries attributed to this plant range from innocuous superficial irritation to full-thickness chemical burns. A vast majority of cases will resolve with conservative measures and effective first aid, but these case series demonstrate the clinical course of more severe injuries.  Description We present a case series of 2 patients requiring admission to the Royal Group Hospitals for management of mixed thickness hogweed burns. Injuries were sustained by two separate infestations of giant hogweed in the Western Trust Area. Both patients responded to observation and conservative measures, namely effective analgesia, UV light protection, topical hydrocortisone, and dressings.   Discussion Cutaneous burns induced by giant hogweed are caused by contact with its photoactive sap containing plant furocoumarins. On exposure to sunlight, the sap initiates a damaging process known as phytophotodermatitis (PPD). This process can be managed effectively with topical steroids; however, prolonged contact and subsequent sun exposure may lead to more severe skin damage. In extremely rare instances, damage may progress to full skin thickness burns warranting operative intervention.  

scholarly journals 793 The Giant Hogweed as A Rare Cause of Chemical Burns: A Case Series

2021 ◽  
Vol 108 (Supplement_2) ◽  
Author(s):  
S K Lim ◽  
J Clements ◽  
K Khan
Keyword(s):  
Uv Light ◽  
Case Series ◽  
Health Concern ◽  
Topical Steroids ◽  
Full Thickness ◽  
Skin Damage ◽  
Chemical Burns ◽  
Severe Injuries ◽  
Heracleum Mantegazzianum ◽  
Prolonged Contact

Abstract Introduction The Giant Hogweed (Heracleum mantegazzianum) is a rare cause for chemical burns in humans and animals and is acquiring growing recognition in mainstream media as a relevant public health concern. Injuries attributed to this plant range from innocuous superficial irritation to full-thickness chemical burns. A vast majority of cases will resolve with conservative measures and effective first aid, but these case series demonstrate the clinical course of more severe injuries. Description We present a case series of 2 patients requiring admission to the Royal Group Hospitals for management of mixed thickness hogweed burns. Injuries were sustained by two separate infestations of giant hogweed in the Western Trust Area. Both patients responded to observation and conservative measures, namely effective analgesia, UV light protection, topical hydrocortisone, and dressings. Discussion Cutaneous burns induced by giant hogweed are caused by contact with its photoactive sap containing plant furocoumarins. On exposure to sunlight, the sap initiates a damaging process known as phytophotodermatitis (PPD). This process can be managed effectively with topical steroids; however, prolonged contact and subsequent sun exposure may lead to more severe skin damage. In extremely rare instances, damage may progress to full-thickness skin burns warranting operative intervention.

scholarly journals Unusual complications after occupational exposure to giant hogweed (Heracleum mantegazzianum): A case report

2014 ◽  
Vol 27 (1) ◽  
Author(s):  
Piotr Klimaszyk ◽  
Dorota Klimaszyk ◽  
Michał Piotrowiak ◽  
Agnieszka Popiołek
Keyword(s):  
Occupational Exposure ◽  
Skin Lesions ◽  
Skin Thickness ◽  
Occupational Hazard ◽  
Skin Damage ◽  
Skin Changes ◽  
Heracleum Mantegazzianum ◽  
Oral Corticosteroids ◽  
Epidermal Necrosis

AbstractExposure to giant hogweed brings about the risk of serious skin damage, usually in the form of phytophotodermatitis. Initially, skin changes are signaled by a burning sensation, followed by a vesiculobullous rash and long-term hyperpigmentation. Usually, skin disorders improve after the application of topical and oral corticosteroids. In extremely rare instances, full skin thickness burns or epidermal necrosis occur. The study presents a case of occupational exposure to hogweed, which resulted in extensive skin lesions leading to the disablement of a 27-year-old man. The principles of procedure to be followed when contact with giant hogweed is an occupational hazard are also outlined.

scholarly journals Treatment of vitamin D deficiency with UV light in patients with malabsorption syndromes: a case series

2007 ◽  
Vol 23 (5) ◽  
pp. 179-185 ◽  
Author(s):  
Prakash Chandra ◽  
Linda L. Wolfenden ◽  
Thomas R. Ziegler ◽  
Junqiang Tian ◽  
Menghua Luo ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Uv Light ◽  
Case Series ◽  
Malabsorption Syndromes

scholarly journals When To Start Tacrolimus Ointment For Vernal Keratoconjunctivitis? A Proposed Treatment Protocol

2021 ◽  
Author(s):  
Roee Arnon ◽  
Irit Rozen - Knisbacher ◽  
Tal Yahalomi ◽  
Nir Stanescu ◽  
Yulia Niazov ◽  
...  
Keyword(s):  
Clinical Signs ◽  
Treatment Protocol ◽  
Topical Steroid ◽  
Case Series ◽  
Topical Steroids ◽  
Line Treatment ◽  
Tacrolimus Ointment ◽  
Disease Remission ◽  
The Mean ◽  
Topical Treatments

Abstract PurposeThe aim of this study was to compare treatment regimens of tacrolimus and of topical steroids for VKC and suggest a treatment protocol according to our clinical experience.MethodsThis retrospective, nonrandomized case series enrolled 85 Patients with VKC. Patients were classified clinically according to severity (mild, moderate, severe) and were treated according to a suggested protocol. Analysis was made according to treatment received: tacrolimus ointment as first line treatment (tacrolimus 1st line), tacrolimus ointment after topical steroid drops treatment (tacrolimus 2nd line) and topical steroid drops or artificial tears alone (topical steroid and tears group). Results Significant improvements in clinical signs and symptoms were achieved under tacrolimus treatment 14 months in the moderate group and 5 months in the severe group. The longest duration of treatment was for tacrolimus 2nd line group (p=0.031) and the mean number of visits in the clinic was the highest. The mean number of topical treatments per day was higher in the topical steroid and tears group (2.6 times) than in the two tacrolimus groups (1.3 times for both). The mean time needed to achieve disease remission or relief did not differ between the tacrolimus 1st line and 2nd line groups.ConclusionTacrolimus treatment is effective and safe for VKC. Tacrolimus as 1st line treatment may be preferred for severe cases, for faster disease remission compared to tacrolimus as 2nd line treatment; and with fewer topical treatments per day compared to topical steroids.

Late-term topical tacrolimus for subepithelial infiltrates resistant to topical steroids and ciclosporin secondary to adenoviral keratoconjunctivitis

2020 ◽  
pp. bjophthalmol-2020-316196
Author(s):  
Ceyhun Arici ◽  
Burak Mergen
Keyword(s):  
Topical Steroid ◽  
Case Series ◽  
Topical Steroids ◽  
Efficacy And Safety ◽  
Topical Tacrolimus ◽  
Corrected Visual Acuity ◽  
Baseline Visit ◽  
Ciclosporin A ◽  
Breakup Time ◽  
Oxford Score

PurposeInvestigation of the efficacy and safety of 12 months of topical tacrolimus 0.03% ointment treatment against the subepithelial infiltrates (SEIs) due to adenoviral keratoconjunctivitis (AKC) resisting at least 2 years was aimed.MethodsThis case series included consecutive patients with SEIs secondary to AKC who were resistant to topical steroid and ciclosporin-A (CSA) treatment and treated with topical 0.03% tacrolimus (Protopic; Fujisawa Healthcare, Teva, Deerfield, Illinois, USA) for 12 months, at least 2 years after AKC. For the evaluation of treatment efficacy, best-corrected visual acuity (BCVA), Fantes score, corneal subepithelial infiltrate score (CSIS), Oxford score, Schirmer and tear breakup time results were evaluated. Intraocular pressure and complaints of the patients were followed for evaluating the safety profile of the treatment. The patients were followed after the baseline visit at the 1st, 3rd, 6th and 12th month.Results15 eyes of 11 patients with SEIs and 16 eyes of 16 healthy controls were included in this study. 1 patient (9.1%) could not tolerate the treatment. Significant improvements in BCVA, CSIS, Fantes score and Schirmer results were observed in the study group starting from the 3rd-month visit, and the improvements persisted until the end of 12 months of treatment.ConclusionTopical 0.03% tacrolimus might show efficacy against the SEIs persisting at least 2 years despite corticosteroid and/or CSA treatment without any prominent side effect. While at least a period of 3 months was necessary for a significant improvement in the BCVA, SEIs and Schirmer results, a period of 6 months was necessary for a decrease in Oxford score.

Promising Efficacy with the 308 Nm Excimer Laser Phototherapy in Early Stage Mycosis Fungoides

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 4990-4990
Author(s):  
Darcie Deaver ◽  
Ashley Cauthen ◽  
George Cohen ◽  
Lubomir Sokol ◽  
L. Frank Glass
Keyword(s):  
Mycosis Fungoides ◽  
Excimer Laser ◽  
Conflicts Of Interest ◽  
Uv Light ◽  
Short Pulse ◽  
Early Stage ◽  
Common Type ◽  
Topical Steroids ◽  
Serious Adverse Events ◽  
Early Stage Disease

Abstract Abstract 4990 Background: Mycosis fungoides is the most common type of cutaneous T-cell lymphoma. Early stage disease is effectively managed with skin directed therapies such as UV light and topical steroids. Excimer laser (EL) delivers monochromatic, UVB light at a wavelength of 308 nm via hand held device that covers an area of 2 × 2 cm. It generates a short-pulse radiation that is concentrated on an affected area of skin, thereby allowing a delivery of higher dose on precisely targeted tissue. In contrast to other phototherapy techniques such as narrow band UV light, the EL is ideally suited for patients with small number of patch lesions. Although EL was successfully utilized in the management of psoriasis and vitiligo, there is not extensive experience with this modality in patients with CTCL. Objectives: To assess safety and efficacy of EL therapy in patients with early stage MF who failed ≥1 skin directed therapy. Design and Methods: This is a retrospective analysis of seven consecutive patients with stage 1 MF treated with EL phototherapy between January 2011 and August 2011 in a single institution. Seven patients with histologically confirmed common type MF, and one patient with folliculotropic MF received 308 nm EL therapy after failure of at least one prior skin directed therapy. The median age was 48 years (range 24–77 yrs). Four (57%) were male, 3 (43%) were female, six (86%) were Caucasian, and 1(14%) were African American. Biopsies and photos were obtained at diagnosis and after the completion of 24 treatments. Results: Treatment was initiated at a dose of 200 millijoules (mJ) and was increased by 10–15% each subsequent treatment. The max dose of treatment ranged from 240 mJ to 850 mJ. The total number of administered treatments was 24 delivered over period of 3 months. The median number of treated lesions was 2 (range 1–5). The surface area of treated lesions was <10%. Six patients achieved clinical improvement in appearance of lesions and intensity of pruritis; 2 (29%) achieved clinical remission as confirmed with photos and post-treatment biopsies. One (14%) patient developed first degree burn and 1 (14%) patient developed pruritis. These resolved by the second treatment with EL. There were no treatment-related serious adverse events observed. Conclusion: Our results suggest that EL is effective and well tolerated skin-directed treatment modality for selected patients with early stage MF. However, longer follow-up will be required to assess durability of responses. Advantages of this approach include shorter treatment duration and lower risk of carcinogenesis in the non-affected areas of skin. Prospective study with a larger cohort of patients is necessary to further assess efficacy and safety of this approach. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Multifocal Breast Cancer in Young Women with Prolonged Contact between Their Breasts and Their Cellular Phones

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
John G. West ◽  
Nimmi S. Kapoor ◽  
Shu-Yuan Liao ◽  
June W. Chen ◽  
Lisa Bailey ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Family History ◽  
Young Women ◽  
Breast Imaging ◽  
Safety Data ◽  
Case Series ◽  
Striking Similarity ◽  
Cellular Phones ◽  
Multifocal Breast Cancer ◽  
Prolonged Contact

Breast cancer occurring in women under the age of 40 is uncommon in the absence of family history or genetic predisposition, and prompts the exploration of other possible exposures or environmental risks. We report a case series of four young women—ages from 21 to 39—with multifocal invasive breast cancer that raises the concern of a possible association with nonionizing radiation of electromagnetic field exposures from cellular phones. All patients regularly carried their smartphones directly against their breasts in their brassieres for up to 10 hours a day, for several years, and developed tumors in areas of their breasts immediately underlying the phones. All patients had no family history of breast cancer, tested negative for BRCA1 and BRCA2, and had no other known breast cancer risks. Their breast imaging is reviewed, showing clustering of multiple tumor foci in the breast directly under the area of phone contact. Pathology of all four cases shows striking similarity; all tumors are hormone-positive, low-intermediate grade, having an extensive intraductal component, and all tumors have near identical morphology. These cases raise awareness to the lack of safety data of prolonged direct contact with cellular phones.

scholarly journals Unveiling the dermatological manifestations of nCOVID-19

2020 ◽  
Vol 6 (4) ◽  
pp. 597
Author(s):  
Dheemant M. ◽  
Sushmitha E. S. ◽  
Madhan Jeyaraman ◽  
Ajay S. S. ◽  
Rashmi Jain
Keyword(s):  
Preventive Measures ◽  
Respiratory Illness ◽  
Health Concern ◽  
Personal Hygiene ◽  
Target Cells ◽  
Alveolar Type ◽  
Public Health Concern ◽  
Prolonged Contact ◽  
Skin Conditions ◽  
The City

<p class="abstract">Coronaviruses are RNA viruses that have become a major public health concern since the severe acute respiratory syndrome CoV (SARS-CoV-2) outbreak in 2002. The continuous evolution of coronaviruses was further highlighted with the emergence of the middle east respiratory syndrome CoV (MERS-CoV) outbreak in 2012. The spike glycoprotein of SARS-CoV-2 plays a pivotal role in the entry of virus into the cell and it further interacts with ACE-II receptors which are widely distributed on the human cell surface especially on alveolar type II cells (AT-2) and endothelium. Currently, the world is concerned about the 2019 novel CoV (SARS-CoV-2) that was initially identified in the city of Wuhan, China in December 2019. Patients presented with severe viral pneumonia and respiratory illness. Despite the virus not being dermatotropic, several skin conditions have emerged mainly as a result of prolonged contact with personal protective equipment and excessive personal hygiene. In this review, we discuss structure, genome organisation, entry of CoVs into target cells, probable cutaneous manifestation that dermatologists may be aware of skin complications and the preventive measures, outcome of the disease and the management.</p>

Definitive reconstruction of complex maxillofacial trauma with wide-spread soft-tissue defects: A case series

2021 ◽  
Author(s):  
Hong Loi Nguyen
Keyword(s):  
Soft Tissue ◽  
Tissue Injury ◽  
Soft Tissue Injury ◽  
Case Series ◽  
Maxillofacial Trauma ◽  
Soft Tissue Defects ◽  
Wide Spread ◽  
Severe Injuries ◽  
Tissue Defects

The mаnаgement of soft tissue injury аfter complex fаciаl trаumа poses unique chаllenges to the plаstic surgeon, given the speciаlized nаture of fаciаl tissue аnd the аesthetic importаnce of the fаce. We report 8 cаses with wide-spreаd soft-tissue defects due to complex fаciаl trаumаwho presented аt Odontostomаtology center - Hue centrаl hospitаl during the yeаr 2018.Of these cаses were surgicаlly mаnаged by fixаtion аnd fаciаl reconstructionаt Odonto-stomаtology center - Hue centrаl hospitаl;аnd they were very well recovery in function аnd аesthetics. The generаl principles of trаumа mаnаgement аnd wound cаre аre аpplied in аll cаses. The mаnаgement of severe injuries to the fаce is discussed in relаtion to the locаtion аnd the mechаnism of injury.

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