scholarly journals Maternal Prenatal Psychosocial Stress and Prepregnancy BMI Associations with Fetal Iron Status

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Rebecca K Campbell ◽  
Marcela Tamayo-Ortiz ◽  
Alejandra Cantoral ◽  
Lourdes Schnaas ◽  
Erika Osorio-Valencia ◽  
...  
Keyword(s):  
Cord Blood ◽  
Perceived Stress ◽  
Life Stress ◽  
Psychosocial Stress ◽  
Maternal Stress ◽  
Iron Status ◽  
Overweight And Obesity ◽  
Prepregnancy Bmi ◽  
Psychological Dysfunction ◽  
Domains Of Life

ABSTRACT Background Iron accrued in utero is critical for fetal and infant neurocognitive development. Psychosocial stress and obesity can each suppress fetal iron accrual. Their combined effects and differences by fetal sex are not known. In an observational pregnancy cohort study in Mexico City, we investigated associations of maternal prenatal life stressors, psychological dysfunction, and prepregnancy BMI with fetal iron status at delivery. Objectives We hypothesized that greater maternal prenatal psychosocial stress and prepregnancy overweight and obesity are associated with lower cord blood ferritin and hemoglobin (Hb), with stronger associations in boys than girls. Methods Psychosocial stress in multiple domains of life stress (negative life events, perceived stress, exposure to violence) and psychological dysfunction symptoms (depression, generalized anxiety, and pregnancy-specific anxiety) were assessed with validated questionnaires during pregnancy. Prepregnancy BMI was predicted with a validated equation and categorized as normal/overweight/obese. Cord blood ferritin and Hb associations with prenatal psychosocial stress and BMI were modeled in multivariable linear regressions adjusted for maternal age, socioeconomic status, child sex, and prenatal iron supplementation. Interactions with child sex and 3-way stress-overweight/obesity-sex interactions were tested with product terms and likelihood ratio tests. Results In 493 dyads, median (IQR) cord blood ferritin and Hb concentrations were 185 µg/L (126–263 g/dL) and 16 g/dL (14.7–17.1 g/dL), respectively. Ferritin was lower in infants of mothers with higher prenatal perceived stress (−23%; 95% CI: −35%, −9%), violence exposure (−28%; 95% CI: −42%, −12%), anxiety symptoms (−16%; 95% CI: −27%, −4%), and obesity (−17%; 95% CI: −31%, 0.2%). Interaction models suggested sex differences and synergism between maternal stress and overweight/obesity. No associations were observed between stress or BMI and Hb. Conclusions Multiple prenatal psychosocial stressors and excess prepregnancy BMI were each inversely associated with fetal iron status at birth. Pregnancies and infants at elevated risk of impaired fetal iron accrual may be identifiable according to observed synergism between maternal stress and obesity and differential associations with fetal iron status by infant sex.

scholarly journals Maternal Prenatal Psychosocial Stress and BMI Predict Lower Fetal Iron Status in a Mexico City Cohort (FS01-07-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Rebecca Campbell ◽  
Marcela Tamayo-Ortiz ◽  
Alejandra Cantoral ◽  
Rosalind Wright ◽  
Martha Tellez-Rojo ◽  
...  
Keyword(s):  
Cord Blood ◽  
Mexico City ◽  
Perceived Stress ◽  
Prenatal Stress ◽  
Psychosocial Stress ◽  
Overweight And Obesity ◽  
Depression Symptoms ◽  
Psychological Function ◽  
Neurocognitive Development ◽  
Maternal Prenatal Stress

Abstract Objectives Insufficient iron in utero may impair neurocognitive development. Prenatal physiological stress, as in obesity, inhibits fetal iron accumulation. Emerging evidence suggests prenatal psychosocial stress may similarly suppress fetal iron, a novel potential mechanism linking prenatal stress and child neuro-cognition. In a pregnancy cohort in Mexico City, Mexico, we investigated associations between maternal prenatal stress and psychological function, pre-pregnancy BMI and fetal iron at delivery. We hypothesized that maternal prenatal psychosocial stress and psychological dysfunction and pre-pregnancy BMI would be associated with lower cord blood Hb and ferritin. Methods Psychosocial stress and psychological function were assessed with validated questionnaires in mid-pregnancy: depression symptoms (CES-D), trait anxiety (STI), perceived stress (PSS-4), lifetime exposure to violence (ETV), and negative life events (NLEs, CRISYS). Pre-pregnancy BMI was calculated from self-reported height and weight. Cord blood was collected at delivery and ferritin (ferr.) and hemoglobin (Hb) measured. Regression models were developed for Hb and log-transformed ferr. as functions of dichotomized stress scores (CES-D ≥ 13, STI > median, PSS-4 > 4th quartile, ETV > 0.5, CRISYS > 1st quartile) and pre-pregnancy overweight and obesity in separate models, each adjusted for maternal age, SES, child sex and maternal prenatal iron supplementation (yes/no). Results In 455 dyads with complete data, median (IQR) ferr. and Hb were 186 µg/L (125, 265) and 16 g/dL (14.7, 17), respectively. In adjusted models, lower ferr. was associated with prenatal depression symptoms (11%, 95% CI: −0.26, 0.01), elevated perceived stress (23%, −0.35, −0.09), high lifetime violence (21%, −0.33, −0.06) and high NLEs count (10%, −0.22, 0.02), as well as maternal pre-pregnancy obesity (17%, −0.31, −0.00). Interaction models suggested possible stronger prenatal stressor effects among overweight and obese mothers. No associations with cord blood Hb were observed. Conclusions In Mexico City pregnant women, excess pre-pregnancy BMI and multiple prenatal psychosocial stressors were each associated with fetal iron stores at birth. Insufficient fetal iron accrual may explain links between maternal prenatal stress and child neurocognitive development, but more research is needed. Funding Sources National Institutes of Health, Office of the Director; National Institute of Environmental Health Sciences.

scholarly journals Maternal Prenatal Psychosocial Stress and BMI Predict Lower Fetal Iron Status in a Mexico City Cohort (FS01-07-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Rebecca Campbell ◽  
Marcela Tamayo-Ortiz ◽  
Alejandra Cantoral ◽  
Rosalind Wright ◽  
Martha Tellez-Rojo ◽  
...  
Keyword(s):  
Cord Blood ◽  
Mexico City ◽  
Perceived Stress ◽  
Prenatal Stress ◽  
Psychosocial Stress ◽  
Overweight And Obesity ◽  
Depression Symptoms ◽  
Psychological Function ◽  
Neurocognitive Development ◽  
Maternal Prenatal Stress

Abstract Objectives Insufficient iron in utero may impair neurocognitive development. Prenatal physiological stress, as in obesity, inhibits fetal iron accumulation. Emerging evidence suggests prenatal psychosocial stress may similarly suppress fetal iron, a novel potential mechanism linking prenatal stress and child neuro-cognition. In a pregnancy cohort in Mexico City, Mexico, we investigated associations between maternal prenatal stress and psychological function, pre-pregnancy BMI and fetal iron at delivery. We hypothesized that maternal prenatal psychosocial stress and psychological dysfunction and pre-pregnancy BMI would be associated with lower cord blood Hb and ferritin. Methods Psychosocial stress and psychological function were assessed with validated questionnaires in mid-pregnancy: depression symptoms (CES-D), trait anxiety (STI), perceived stress (PSS-4), lifetime exposure to violence (ETV), and negative life events (NLEs, CRISYS). Pre-pregnancy BMI was calculated from self-reported height and weight. Cord blood was collected at delivery and ferritin (ferr.) and hemoglobin (Hb) measured. Regression models were developed for Hb and log-transformed ferr. as functions of dichotomized stress scores (CES-D ≥ 13, STI > median, PSS-4 >4th quartile, ETV >0.5, CRISYS >1st quartile) and pre-pregnancy overweight and obesity in separate models, each adjusted for maternal age, SES, child sex and maternal prenatal iron supplementation (yes/no). Results In 455 dyads with complete data, median (IQR) ferr. and Hb were 186 µg/L (125, 265) and 16 g/dL (14.7, 17), respectively. In adjusted models, lower ferr. was associated with prenatal depression symptoms (11%, 95% CI: -0.26, 0.01), elevated perceived stress (23%, -0.35, -0.09), high lifetime violence (21%, -0.33, -0.06) and high NLEs count (10%, -0.22, 0.02), as well as maternal pre-pregnancy obesity (17%, -0.31, -0.00). Interaction models suggested possible stronger prenatal stressor effects among overweight and obese mothers. No associations with cord blood Hb were observed. Conclusions In Mexico City pregnant women, excess pre-pregnancy BMI and multiple prenatal psychosocial stressors were each associated with fetal iron stores at birth. Insufficient fetal iron accrual may explain links between maternal prenatal stress and child neurocognitive development, but more research is needed. Funding Sources National Institutes of Health, Office of the Director; National Institute of Environmental Health Sciences.

scholarly journals Maternal stress and depressive symptoms and adolescents’ body mass index: a prospective study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Maaike Koning ◽  
Jacqueline Vink ◽  
Tommy L. S. Visscher ◽  
Junilla Larsen
Keyword(s):  
Mental Health ◽  
Depressive Symptoms ◽  
Prospective Study ◽  
Perceived Stress ◽  
Maternal Stress ◽  
Maternal Mental Health ◽  
Cross Sectional ◽  
Domain Specific ◽  
General Stress ◽  
Adolescent Offspring

Abstract Background Growing evidence suggests that maternal mental health issues are associated with (young) children’s weight outcomes. However, most studies have been limited by cross-sectional designs and have been aimed at (younger) children. The current prospective study focuses on the link between maternal mental health (i.e., psychological stress and depressive symptoms) and adolescents’ zBMI development. Methods The participants in the present study were part of wave 1 and 2 of a longitudinal study on Dutch adolescents’ and their parents’ health behavior. Adolescents (aged 10–14) and their parents were recruited through six secondary schools in the South and the East of the Netherlands. For this study, we only included biological mothers and their adolescent children who participated in both waves, with data on the main measures in both waves, leaving a final sample of 336 biological mother-child dyads. Adolescents height and weight were measured, and both parents and adolescents filled in validated questionnaires on perceived stress and depressive symptoms and answered additional questions concerning domain-specific stress. Regression analyses were performed in R to examine longitudinal links between maternal stress and depressive symptoms at baseline (T1) and adolescents’ BMI standard deviation scores (zBMI) 6 months later (T2), corrected for baseline zBMI and covariates. Results Maternal general perceived stress (β = .20, p = .002) at T1 preceded higher adolescents’ zBMI at T2, after controlling for baseline zBMI and other covariates, whereas maternal depressive symptoms at T1 (β = −.05, p = .44) and other domain-specific stress did not (maternal financial stress, maternal stress at work, maternal stress at home). Additionally, lower educational level among adolescents (β = .16, p = .001) and adolescent depressive symptoms (β = .16, p = .001) was associated with a higher zBMI at T2. Conclusions Results suggest that maternal general stress, but not depressive symptoms, may influence adolescents’ weight development. Our findings warrant future investigation on whether and how general stress among mothers may predict weight increases of their adolescent offspring.

scholarly journals Recent Perceived Stress, Amygdala Reactivity to Acute Psychosocial Stress, and Alcohol and Cannabis Use in Adolescents and Young Adults With Bipolar Disorder

2021 ◽  
Vol 12 ◽  
Author(s):  
Vanessa Le ◽  
Dylan E. Kirsch ◽  
Valeria Tretyak ◽  
Wade Weber ◽  
Stephen M. Strakowski ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Substance Use ◽  
Young Adults ◽  
Perceived Stress ◽  
Psychosocial Stress ◽  
Acute Stress ◽  
Cannabis Use ◽  
Typically Developing ◽  
Amygdala Activation ◽  
Amygdala Reactivity

Background: Psychosocial stress negatively affects the clinical course of bipolar disorder. Studies primarily focused on adults with bipolar disorder suggest the impact of stress is progressive, i.e., stress response sensitizes with age. Neural mechanisms underlying stress sensitization are unknown. As stress-related mechanisms contribute to alcohol/substance use disorders, variation in stress response in youth with bipolar disorder may contribute to development of co-occurring alcohol/substance use disorders. This study investigated relations between psychosocial stress, amygdala reactivity, and alcohol and cannabis use in youth with bipolar disorder, compared to typically developing youth.Methods: Forty-two adolescents/young adults [19 with bipolar disorder, 23 typically developing, 71% female, agemean ± SD = 21 ± 2 years] completed the Perceived Stress Scale (PSS), Daily Drinking Questionnaire modified for heaviest drinking week, and a modified Montreal Imaging Stress functional MRI Task. Amygdala activation was measured for both the control and stress conditions. Main effects of group, condition, total PSS, and their interactions on amygdala activation were modeled. Relationships between amygdala response to acute stress with recent alcohol/cannabis use were investigated.Results: Greater perceived stress related to increased right amygdala activation in response to the stress, compared to control, condition in bipolar disorder, but not in typically developing youth (group × condition × PSS interaction, p = 0.02). Greater amygdala reactivity to acute stress correlated with greater quantity and frequency of alcohol use and frequency of cannabis use in bipolar disorder.Conclusion: Recent perceived stress is associated with changes in amygdala activation during acute stress with amygdala reactivity related to alcohol/cannabis use in youth with bipolar disorder.

Perceived stress at work is associated with attenuated DHEA-S response during acute psychosocial stress

2013 ◽  
Vol 38 (9) ◽  
pp. 1650-1657 ◽  
Author(s):  
Anna-Karin Lennartsson ◽  
Töres Theorell ◽  
Mark M. Kushnir ◽  
Jonas Bergquist ◽  
Ingibjörg H. Jonsdottir
Keyword(s):  
Perceived Stress ◽  
Psychosocial Stress ◽  
Stress At Work ◽  
Acute Psychosocial Stress

scholarly journals Maternal Stress Before Conception Is Associated with Shorter Gestation

2020 ◽  
Author(s):  
N E Mahrer ◽  
C M Guardino ◽  
C Hobel ◽  
C Dunkel Schetter
Keyword(s):  
Birth Outcomes ◽  
Perceived Stress ◽  
Interpersonal Violence ◽  
Maternal Stress ◽  
Stress Test ◽  
Stress Factors ◽  
Latent Factors ◽  
Acute And Chronic Stress ◽  
Stress Appraisals ◽  
Length Of Gestation

Abstract Background Stress in pregnancy predicts adverse birth outcomes. Stressors occurring prior to conception may also pose risk for the mother and child. The few published studies on preconception stress test a single stress measure and examine only linear associations with birth outcomes. Purpose Guided by findings in the prenatal stress literature, the current study aimed to (i) identify latent factors from a set of preconception stress measures and (ii) examine linear and curvilinear associations between these stress factors and length of gestation. Methods Study 1 utilized a sample of 2,637 racially/ethnically diverse women to develop a measurement model of maternal stress from assessments of seven acute and chronic stress measures. Factor analysis revealed three latent factors representing stressors (life events, financial strain, interpersonal violence, discrimination), stress appraisals (perceived stress, parenting stress), and chronic relationship stress (family, partner stress). Study 2 examined the associations of these three latent preconception stress factors with the length of gestation of a subsequent pregnancy in the subset of 360 women who became pregnant within 4.5 years. Results Controlling for prenatal medical risks, there was a significant linear effect of stress appraisals on the length of gestation such that more perceived stress was associated with shorter gestation. There was a curvilinear effect of stressors on the length of gestation with moderate levels associated with longer gestation. Conclusions These results have implications for research on intergenerational origins of developmental adversities and may guide preconception prevention efforts. Findings also inform approaches to the study of stress as a multidimensional construct.

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