scholarly journals Applicability of the German Food Based Dietary Guidelines for Infancy to Estimate Exposure to Substances in Food – The Example of Erucic Acid

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 764-764
Author(s):  
Hermann Kalhoff ◽  
Mathilde Kersting ◽  
Bernd Honermeier ◽  
Kathrin Jansen ◽  
Thomas Lücke
Keyword(s):  
Public Health ◽  
Erucic Acid ◽  
Rapeseed Oil ◽  
Daily Intake ◽  
Formula Feeding ◽  
Erucic Acid Content ◽  
German Market ◽  
High Exposure ◽  
Potential Exposure ◽  
Infant Diet

Abstract Objectives The objective of this study was to use the recommended total daily food amounts of the German ‘Dietary Scheme for the first year of life’ (for the first time) to calculate the potential exposure of substances in the infant diet from a public health perspective. Erucic acid was taken as a concrete example, because the European Food Safety Agency (EFSA) recently issued a Tolerable Daily Intake (TDI) for erucic acid with a special note that vulnerable groups, especially young children, may be particularly at risk of exceeding the TDI. Methods The age of about 1 month with the highest consumption per kg body weight was chosen for scenarios for the phase of exclusive milk feeding, the age of about 8 months for the CF phase. Principle of calculation was: erucic acid exposure = food consumption volume per kg bodyweight per day x erucic acid concentration in food (from European studies for breastmilk, EFSA food samples for formula, current German market analysis for rapeseed oil, EU food law). We calculated 6 scenarios for the milk phase (4 formula-feeding, 2 breastfeeding) and 8 scenarios for the CF phase (5 CF + formula-feeding, 3 CF + breastfeeding). Results Out of the 14 scenarios, only 3 resulted in exposures in the safe range below the TDI (range 4.4.– 6.0 mg/kg BW). All scenarios assuming either high consumption (p95) or high concentration led to high exceedances of the TDI (range 7.5–26.2 mg/kg BW), especially when using maximum values of EU law for formula or vegetable oils (33.6 and 43.2 mg/kg BW respectively). Conclusions The Dietary Scheme proved to be a suitable frame to calculate the potential exposure of substances in foods forming the daily infant diet. The results give cause for concern, as the calculated high exposure to erucic acid in the scenarios occurs during infancy as a particularly sensitive developmental period and results from the food-based recommendations as public health guidelines. Considering the scarcity of data, in addition to the proven low erucic acid concentrations in rapeseed oil in Germany, it is imperative to analyze the erucic acid content of mature breast milk and formula as well. Funding Sources Union for the Promotion of Oil and Protein Plants (UFOP, Berlin, Germany).

scholarly journals Erucic Acid (22:1n-9) in Fish Feed, Farmed, and Wild Fish and Seafood Products

Nutrients ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1443 ◽  
Author(s):  
Nini Sissener ◽  
Robin Ørnsrud ◽  
Monica Sanden ◽  
Livar Frøyland ◽  
Sofie Remø ◽  
...  
Keyword(s):  
Fish Oil ◽  
Erucic Acid ◽  
Current Knowledge ◽  
Daily Intake ◽  
Wild Fish ◽  
Erucic Acid Content ◽  
Fish Feed ◽  
Farmed Fish ◽  
Marine Research ◽  
Seafood Products

The European Food Safety Authority (EFSA) published a risk assessment of erucic acid (22:1n-9) in 2016, establishing a Tolerable Daily Intake (TDI) for humans of 7 mg kg−1 body weight per day. This report largely excluded the contribution of erucic acid from fish and seafood, due to this fatty acid often not being reported separately in seafood. The Institute of Marine Research (IMR) in Norway analyzes erucic acid and has accumulated extensive data from analyses of fish feeds, farmed and wild fish, and seafood products. Our data show that rapeseed oil (low erucic acid varieties) and fish oil are the main sources of erucic acid in feed for farmed fish. Erucic acid content increases with total fat content, both in farmed and wild fish, and it is particularly high in fish liver, fish oil, and oily fish, such as mackerel. We show that the current TDI could be exceeded with a 200 g meal of mackerel, as at the maximum concentration analyzed, such a meal would contribute 143% to the TDI of a 60 kg person. These data cover a current knowledge gap in the scientific literature regarding the content of erucic acid in fish and seafood.

PERFORMANCE OF MYOCARDIAL AND BLOOD SERAL CHANGES IN PIGS FED DIETS CONTAINING HIGH OR LOW ERUCIC ACID RAPESEED OILS

1976 ◽  
Vol 56 (2) ◽  
pp. 275-284 ◽  
Author(s):  
F. X. AHERNE ◽  
J. P. BOWLAND ◽  
R. T. HARDIN ◽  
R. G. CHRISTIAN
Keyword(s):  
Left Ventricle ◽  
Erucic Acid ◽  
Rapeseed Oil ◽  
Control Diet ◽  
Heart Tissue ◽  
Erucic Acid Content ◽  
Feed Conversion ◽  
Serum Glutamic Oxaloacetic Transaminase ◽  
Tissue Samples ◽  
Low Erucic Acid

Eighty crossbred pigs (barrows and gilts), 4–5 wk old and averaging 7.9 kg were fed diets containing 15% rapeseed oil of either high (34.2%) or low (1.2%) erucic acid content, or a control diet to which no oil was added. Tissue samples were taken from the left ventricle of pigs slaughtered after 4, 16 and 23 wk on experiment, at which time they averaged 19, 87 and 130 kg liveweight. Differences in growth rate were not significant for any of the five treatments. Feed conversion efficiency was poorest (P < 0.01) for pigs fed the control diet. Significant differences between treatments were detected at one or more slaughter weights for serum cholesterol, albumin, alkaline phosphatase, blood urea nitrogen, glucose, protein-bound iodine and serum glutamic oxaloacetic transaminase. Total backfat and area of loin were not significantly affected by either source or level of rapeseed oil. Most of the carcass measurements recorded were significantly (P < 0.01) influenced by sex and slaughter weight. Histological examination of heart tissue from the left ventricle showed no significant effect of rapeseed oil on the incidence of cardiac lipidosis and myopathy.

FAE1 Sequence Characteristics and Its Relationship with Erucic Acid Content in Brassica juncea

2010 ◽  
Vol 36 (5) ◽  
pp. 794-800 ◽  
Author(s):  
Ai-Xia XU ◽  
Zhen HUANG ◽  
Chao-Zhi MA ◽  
En-Shi XIAO ◽  
Xiu-Sen ZHANG ◽  
...  
Keyword(s):  
Erucic Acid ◽  
Brassica Juncea ◽  
Acid Content ◽  
Erucic Acid Content ◽  
Sequence Characteristics

Improving Erucic Acid Content in Rapeseed through Biotechnology: What Can the Arabidopsis FAE1 and the Yeast SLC1-1 Genes Contribute?1, 2

Crop Science ◽  
2001 ◽  
Vol 41 (3) ◽  
pp. 739-747 ◽  
Author(s):  
Vesna Katavic ◽  
Winnie Friesen ◽  
Dennis L. Barton ◽  
Kalie K. Gossen ◽  
E.Michael Giblin ◽  
...  
Keyword(s):  
Erucic Acid ◽  
Acid Content ◽  
Erucic Acid Content

scholarly journals Aspartame and cancer – new evidence for causation

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Philip J. Landrigan ◽  
Kurt Straif
Keyword(s):  
Public Health ◽  
Cancer Risk ◽  
Malignant Tumors ◽  
Daily Intake ◽  
Immunohistochemical Analysis ◽  
International Agency ◽  
Advisory Group ◽  
Malignant Neoplasms ◽  
Acceptable Daily Intake ◽  
New Findings

Abstract Background Aspartame is one of the world’s most widely used artificial sweeteners and is an ingredient in more than 5000 food products globally. A particularly important use is in low-calorie beverages consumed by children and pregnant women. The Ramazzini Institute (RI) reported in 2006 and 2007 that aspartame causes dose-related increases in malignant tumors in multiple organs in rats and mice. Increased cancer risk was seen even at low exposure levels approaching the Acceptable Daily Intake (ADI). Prenatal exposures caused increased malignancies in rodent offspring at lower doses than in adults. These findings generated intense controversy focused on the accuracy of RI’s diagnoses of hematopoietic and lymphoid tissue tumors (HLTs). Critics made the claim that pulmonary lesions observed in aspartame-exposed animals were inflammatory lesions caused by Mycoplasma infection rather than malignant neoplasms. Methods To address this question, RI subjected all HLTs from aspartame-exposed animals to immunohistochemical analysis using a battery of markers and to morphological reassessment using the most recent Internationally Harmonized Nomenclature and Diagnostic (INHAND) criteria. Findings This immunohistochemical and morphological re-evaluation confirmed the original diagnoses of malignancy in 92.3% of cases. Six lesions originally diagnosed as lymphoma (8% of all HLTs) were reclassified: 3 to lymphoid hyperplasia, and 3 to chronic inflammation with fibrosis. There was no evidence of Mycoplasma infection. Interpretation These new findings confirm that aspartame is a chemical carcinogen in rodents. They confirm the very worrisome finding that prenatal exposure to aspartame increases cancer risk in rodent offspring. They validate the conclusions of the original RI studies. These findings are of great importance for public health. In light of them, we encourage all national and international public health agencies to urgently reexamine their assessments of aspartame’s health risks - especially the risks of prenatal and early postnatal exposures. We call upon food agencies to reassess Acceptable Daily Intake (ADI) levels for aspartame. We note that an Advisory Group to the International Agency for Research on Cancer has recommended high-priority reevaluation of aspartame’s carcinogenicity to humans.

scholarly journals In Vitro Production of Somaclones with Decreased Erucic Acid Content in Indian Mustard [Brassica juncea (Linn.) Czern&Coss]

Plants ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1297
Author(s):  
Chitralekha Shyam ◽  
Manoj Tripathi ◽  
Sushma Tiwari ◽  
Niraj Tripathi ◽  
Ravindra Solanki ◽  
...  
Keyword(s):  
Erucic Acid ◽  
Acid Content ◽  
Indian Mustard ◽  
Mother Plant ◽  
Erucic Acid Content ◽  
Oilseed Crop ◽  
In Vitro Production ◽  
Somaclonal Variations ◽  
Low Erucic Acid

Brassica junceais a crucial cultivated mustard species and principal oilseed crop of India and Madhya Pradesh, grown for diverse vegetables, condiments, and oilseeds. Somaclonal variation was explored as a probable source of additional variability for the manipulation of fatty acids, especially low erucic acid contents that may be valuable for this commercially important plant species. The plantlets regenerated from tissue cultures (R0), their R1 generation and respective parental lines were compared for morpho-physiological traits and fatty acid profile for the probable existence of somaclonal variations. The first putative somaclone derived from genotype CS54 contained 5.48% and 5.52% erucic acid in R0 and R1 regenerants, respectively, compared to the mother plant (41.36%). In comparison, the second somaclone acquired from PM30 exhibited a complete absence of erucic acid corresponding to its mother plant (1.07%). These putative somaclones present a source of variation for exploitation in the development of future mustard crops with low erucic acid content.

Utilization of Rapeseed Oils of High and Low Erucic Acid Content

1974 ◽  
Vol 17 (3) ◽  
pp. 136-147 ◽  
Author(s):  
H. Vogtmann ◽  
D.R. Clandinin ◽  
R.T. Hardin
Keyword(s):  
Erucic Acid ◽  
Acid Content ◽  
Erucic Acid Content ◽  
Low Erucic Acid

THE EFFECTS OF DIFFERENT VARIETIES OF RAPESEED OIL ON WEIGHT GAIN, AND OF GOLDEN RAPESEED OIL ON REPRODUCTION, OF THE RAT

1959 ◽  
Vol 37 (10) ◽  
pp. 1191-1195 ◽  
Author(s):  
Joyce L. Beare ◽  
E. R. W. Gregory ◽  
J. A. Campbell
Keyword(s):  
Weight Gain ◽  
Erucic Acid ◽  
Rapeseed Oil ◽  
Corn Oil ◽  
Retarding Effect ◽  
Wistar Strain ◽  
Weanling Rats ◽  
Weight Gains ◽  
Reproduction Study

Rapeseed oil of the Polish, Golden, or Swedish varieties, corn oil, or mixtures of corn oil and ethyl erucate were fed to weanling rats of the Wistar strain for 9 weeks. Weight gains were inversely related to the content of erucic acid in the diet, confirming previous indications that the growth retarding effect of rapeseed oil is due to its erucic acid. In general, the differences in weight gains could be explained by the effect of rapeseed oil on food consumption.Golden rapeseed oil and corn oil were compared in a reproduction study involving three litters of one generation. Although the young of rats fed rapeseed oil were of lesser weanling weight, there was no difference in the number of animals successfully weaned.

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