Serum Zinc, Iron, and Copper Concentrations during Typhoid Fever in Man: Effect of Chloramphenicol Therapy

1975 ◽  
Vol 21 (4) ◽  
pp. 528-532 ◽  
Author(s):  
Robert S Pekarek ◽  
R M Kluge ◽  
H L DuPont ◽  
R W Wannemacher ◽  
R B Hornick ◽  
...  
Keyword(s):  
Typhoid Fever ◽  
Serum Iron ◽  
Iron Concentration ◽  
Serum Zinc ◽  
Salmonella Typhi ◽  
Serum Copper ◽  
Related Phenomenon ◽  
Iron And Zinc ◽  
Zinc Concentrations ◽  
Metal Monitoring

Abstract In volunteers experimentally infected with Salmonella typhi, serum iron and zinc concentrations became significantly depressed and there was a concomitant rise in serum copper before the onset of overt clinical illness. However, after several days of fever and the initiation of chloramphenicol therapy, serum iron and zinc concentrations significantly increased. Additional studies—in volunteers with typhoid fever treated with chloramphenicol, in a volunteer with typhoid fever receiving cefazolin and gentamicin, and in untreated rhesus monkeys infected with Salmonella typhimurium—provided evidence that the increase in serum iron concentration during the febrile phase was the result of chloramphenicol therapy, whereas the increase in serum zinc concentrations was a disease-related phenomenon. The importance of trace-metal monitoring during infectious disease and chemotherapy is discussed

Copper Deficiency with Cow's Milk Diet

PEDIATRICS ◽  
1981 ◽  
Vol 68 (3) ◽  
pp. 397-400
Author(s):  
Yehezkel Naveh ◽  
Anna Hazani ◽  
Moshe Berant
Keyword(s):  
Serum Iron ◽  
Copper Deficiency ◽  
Iron Concentration ◽  
Bone Age ◽  
Serum Copper ◽  
Term Infant ◽  
Deficiency Anemia ◽  
Cow’S Milk ◽  
Cow's Milk ◽  
Iron Folic Acid

A 6-month-old full-term infant had severe anemia and neutropenia. The patient was being fed cow's milk and a diet of corn flour. Thorough investigation revealed low serum iron concentration, severe hypocupremia, low ceruloplasmin, retardation of bone age, and metaphysial irregularities and spurring. Bone marrow aspirate revealed cytoplasmic vacuolization in precursors of the erythroid and myeloid series and ringed sideroblasts. Therapy with oral iron, folic acid, and vitamin C was futile. Administration of copper sulfate resulted in brisk increase in neutrophils and reticulocytes. The child maintained normal levels of hemoglobin, neutrophils, serum copper and ceruloplasmin, and serum iron one year after copper therapy was discontinued. The probable role of unrecognized copper deficiency in causing anemia in infants more than 6 months of age is discussed, and the importance of serum copper examination in refractory iron deficiency anemia and neutropenia is stressed. To the best of our knowledge, no such case has previously been described in the literature.

scholarly journals The subsequent newborn effects of stillbirth and abortion, a longitudinal study.

2020 ◽  
Author(s):  
Berhanu Elfu Feleke ◽  
Teferi Elfu Feleke
Keyword(s):  
Birth Weight ◽  
Serum Iron ◽  
Survival Curve ◽  
Previous History ◽  
Serum Zinc ◽  
Sampling Technique ◽  
Simple Random Sampling ◽  
Iron And Zinc ◽  
History Of ◽  
Zinc Levels

Abstract Introduction This study was conducted to assess the effects of stillbirth and abortion on the health of the subsequent newborn. Methods A prospective cohort study was implemented. The data were collected from January 2015 to August 2019. The study participants were selected using the simple random sampling technique. The data were collected using interviewing the pregnant mothers, reviewing medical charts, analyzing the blood samples from the newborn, and scheduled medical checkups. General linear model was used to assess the effects of stillbirth and abortion on the health of the newborn, Poisson regression was used to identify predictors of childhood infectious diseases episodes and Kaplan Meier survival curve were used to estimate time to childhood pneumonia and diarrhea. Results 2872 infants were included giving for the response rate of 88.97%. Neonate born from mothers with a previous history of stillbirth or abortion had low birth weight, low serum iron, and zinc levels. High infection episodes of diarrhea and pneumonia were observed among infants born from a previous history of stillbirth and abortion mothers. The infection episodes during the childhood period were determined by serum zinc level [IRR 0.71; 95% CI: 0.61- 0.83], birth weight [IRR 0.86; 95% CI: 0.81 – 0.91], breastfeeding frequency [IRR 0.9; 95% CI: 0.87-0.93]. Conclusion The birth weight, serum iron and zinc levels of neonates born from the previous history of stillbirth and abortion were lower. The infection episodes of newborns born from mothers with previous history stillbirth or abortion were higher.

Influence of Myocardial Infarction on Serum Manganese, Copper, and Zinc Concentrations

1975 ◽  
Vol 21 (4) ◽  
pp. 578-581 ◽  
Author(s):  
Jacques Versieck ◽  
Fabrice Barbler ◽  
Albert Speecke ◽  
Julien Hoste
Keyword(s):  
Myocardial Infarction ◽  
Trace Elements ◽  
Neutron Activation Analysis ◽  
Serum Zinc ◽  
Serum Copper ◽  
Aminotransferase Activity ◽  
Copper And Zinc ◽  
Serum Aspartate Aminotransferase ◽  
Zinc Concentrations ◽  
Manganese Concentrations

Abstract Reportedly, serum manganese concentrations increase after myocardial infarction, closely correlated with increased serum aspartate aminotransferase activity. However, these conclusions are apparently based on analyses of contaminated samples. Serum manganese concentrations after myocardial infarction have been re-investigated by neutron activation analysis, and no significant increase could be demonstrated. Because serum copper and zinc could be determined simultaneously, analyses for these trace elements are also reported, which confirm the findings of others. After myocardial Infarction a statistically significant (0.02 < P < 0.05) increase in serum copper and a statistically significant (0.001 < P < 0.01) decrease in serum zinc were observed.

scholarly journals High serum iron and zinc decrease glutathione S-transferase among women with breast cancer

2018 ◽  
Vol 37 (1) ◽  
pp. 25 ◽  
Author(s):  
Nendyah Roestijawati ◽  
Dwi Arini Ernawati ◽  
Diah Krisnansari
Keyword(s):  
Breast Cancer ◽  
Trace Elements ◽  
Serum Iron ◽  
Pearson Correlation ◽  
Serum Zinc ◽  
Iron Level ◽  
Research Subjects ◽  
Glutathione S Transferase ◽  
Iron And Zinc ◽  
Gst Activity

BACKGROUND<br />Breast cancer in Indonesia ranks second as the most common cancer found in women after cervical cancer. Tumor cells express increased levels of antioxidant proteins to detoxify reactive oxygen species (ROS). Glutathione S-transferase (GST) is known to play a key role in the detoxification and reduction of ROS. Trace elements have nutritional benefits as essential cofactors for physiologic processes, but some can be toxic to humans. Accumulated evidence suggests that deficiency or excess of certain trace elements may be associated with risk of chronic diseases including cardiovascular diseases, diabetes and cancer. The aim of this research was to determine the correlation of the trace elements iron and zinc with the oxidative stress level of GST activity in women with breast cancer.<br /><br />METHODS<br />An observational analytic study with cross sectional design was conducted involving 35 breast cancer women. Research subjects were women with breast cancer diagnosed by biopsy. Measurements of iron and zinc levels were performed using atomic absorption spectrometry, GST activity was measured using spectrophotometry. Data analysis was done with the Pearson correlation test.<br /><br />RESULTS<br />The results showed that there was a significant relationship of serum iron with GST (r=-0.487; p&lt;0.05) and serum zinc with GST (r=-0.409; p&lt;0.01).<br /><br />CONCLUSION<br />Our study demonstrated that the higher zinc and iron level, the lower GST level among breast cancer women. It is recommended to use zinc, iron and GST levels as biomarkers for breast cancer and its progression.

Changes in Serum Trace Elements after Surgery: Value of Copper and Zinc in Predicting Post-Operative Fatigue

1992 ◽  
Vol 20 (1) ◽  
pp. 12-19 ◽  
Author(s):  
A Cordova Martinez ◽  
J F Escanero Marcen
Keyword(s):  
Trace Elements ◽  
Total Protein ◽  
Serum Zinc ◽  
Serum Copper ◽  
Serum Total Protein ◽  
Muscular Performance ◽  
Skin Fold ◽  
Triceps Skin Fold ◽  
Zinc Concentrations ◽  
Serum Trace Elements

Triceps skin fold, arm muscular performance and fatigue were quantified, haematocrit measured and haemoglobin, serum total protein, albumin, transferrin, zinc and copper concentrations determined in 60 patients (36 women, 24 men) before and 3–45 days after surgery. On days 3 and 9 after surgery, there was a significant ( P < 0.05) decrease in serum zinc concentrations but by 45 days concentrations had return to pre-operative values. In contrast, serum copper concentrations were significantly ( P < 0.05) elevated until day 45. Haematocrit and haemoglobin and albumin concentrations were decreased significantly ( P < 0.05) 3 and 9 days after surgery, whereas serum total protein concentrations remained significantly ( P < 0.05) lower for 45 days compared with concentrations prior to surgery.

Serum Copper, Iron and Zinc Concentrations During Gestation and Early Lactation in Sangamneri Goats

2016 ◽  
Vol 22 (2) ◽  
pp. 243
Author(s):  
K.Y. Kamble ◽  
V.R. Patodkar ◽  
V.M. Sardar ◽  
P.V. Mehere ◽  
U.R. Patil
Keyword(s):  
Serum Copper ◽  
Early Lactation ◽  
Iron And Zinc ◽  
Zinc Concentrations

Responses of baboons to traditionally pyrogenic agents

1987 ◽  
Vol 65 (6) ◽  
pp. 1402-1407 ◽  
Author(s):  
Y. Zurovsky ◽  
Helen Laburn ◽  
D. Mitchell ◽  
A. P. MacPhail
Keyword(s):  
Staphylococcus Aureus ◽  
Body Temperature ◽  
Bovine Serum Albumin ◽  
Bovine Serum ◽  
Serum Iron ◽  
Interleukin 1 ◽  
Iron Concentration ◽  
Salmonella Typhi ◽  
Papio Ursinus ◽  
Serum Iron Concentration

It is not clear whether baboons develop fever in response to endotoxin or other pyrogens. We injected various pyrogens intravenously in 12 unrestrained baboons (Papio ursinus) and measured their body temperature using intra-abdominal radio-telemeters. Serum iron concentration was also measured. The baboons developed fever after injection of killed Staphylococcus aureus (5 × 107 organisms/kg). No significant fever was measured after injection of lipopolysaccharide (Salmonella typhosa) (0.1, 8, 40, and 100 μg/kg), bovine serum albumin (4 mg/kg), killed Salmonella minnesota (5 × 107 organisms/kg), and killed Salmonella typhi (5 × 107 organisms/kg). A significant decrease in serum iron concentration was found only after injection of S. aureus and lipopolysaccharide, 100 μg/kg. The phagocytic synthesis of interleukin-1 following pyrogen stimulation in baboons and some other primates appears to differ from that in man and in nonprimates.

Diurnal Variation of Serum Copper and Zinc in Epileptics Receiving Anti-Convulsants

1986 ◽  
Vol 5 (3) ◽  
pp. 195-200 ◽  
Author(s):  
A. Taylor ◽  
K. Ghose
Keyword(s):  
Diurnal Variation ◽  
Reference Range ◽  
Serum Zinc ◽  
Serum Copper ◽  
Copper Level ◽  
Copper And Zinc ◽  
Urinary Copper ◽  
Zinc Concentrations ◽  
Zinc Levels ◽  
Patients With Epilepsy

1 Serial measurements of copper and zinc concentrations in serum were made at 06.00, 14.00, 22.00 and again at 06.00 hours in 37 male patients with epilepsy, aged between 9 and 19 years. Anti-convulsant drugs were administered at 08.00 and 20.00 hours, and standard hospital meals were allowed at 07.30, 12.00, 16.00 and 19.00 hours. 2 Similar to our previous results, eight patients (21.6%) had serum copper levels greater than the reference range (11.0–20.5 μmol/l) and this hypercupraemia was associated with carbamazapine and/or phenytoin medication. 3 No diurnal variation in serum copper level was observed. Serum copper concentration had no correlation with either 24 h urinary copper excretion or serum anti-convulsant drug levels. 4 Serum zinc concentrations were within the reference range (10–16.5 μmol/l), confirming our previous report. No relation with anti-convulsant medication or serum copper levels was found. 5 Diurnal variations in serum zinc levels with peak and trough concentrations at 06.00 and 14.00 hours, respectively, were observed. 6 It is proposed that these variations in serum zinc concentrations are a normal physiological process and is unlikely to be related to anti-convulsant drugs or epilepsy.

scholarly journals Administration of zinc to preterm infants with hypozincemia does not reduce serum copper concentrations in most cases: a single-center retrospective observational study

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Toshikazu Ito ◽  
Kazuya Uenoyama ◽  
Kazuhiro Kobayashi ◽  
Mikio Kakumoto ◽  
Hiroshi Mizumoto ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Zinc Acetate ◽  
Zinc Concentration ◽  
Zinc Acetate Dihydrate ◽  
Serum Zinc ◽  
Serum Copper ◽  
Acetate Dihydrate ◽  
Serum Zinc Concentration ◽  
Postmenstrual Age ◽  
Zinc Concentrations

Abstract Background Zinc is an essential trace element involved in various physiological functions. In Japan, zinc acetate dihydrate is administered to neonates and infants with hypozincemia. Since serum copper concentrations are reduced by the administration of zinc, we retrospectively investigated changes in serum zinc and copper concentrations in preterm infants with hypozincemia receiving zinc acetate dihydrate. Methods Sixty-three preterm infants were included in the present study. Serum zinc and copper concentrations, doses, and other clinical characteristics were retrieved from electronic medical records. Results The medians and interquartile ranges of the dosage and duration of zinc acetate dihydrate were 2.1 (1.8–2.5) mg/kg/day and 12.0 (10.0–13.0) days, respectively. Its administration increased serum zinc concentrations in 39 patients (61.9%) and to more than 70 μg/dL in 16 patients (25.4%). The group with a serum zinc concentration of 70 μg/dL or higher after administration had a significantly higher zinc dose of 2.5 mg/kg/day than the group with a serum zinc concentration of less than 70 μg/dL. Serum copper concentrations did not decrease in 44 patients (69.8%). In the group with a decreased serum copper concentration, postmenstrual age and body weight were significantly lower, while serum zinc concentrations were significantly higher at the start of administration. Conclusion The present results showed that when zinc acetate dihydrate was administered to preterm infants with hypozincemia, it was possible to increase serum zinc concentrations without decreasing serum copper concentrations in many cases. However, caution may be required when administering zinc to preterm infants with a lower postmenstrual age or milder hypozincemia because serum copper concentrations may decrease.

Zinc and Manganese of serum were negatively, but Copper positively influenced by Iron elevation in diet of male Wistar rats

2018 ◽  
Vol 88 (1-2) ◽  
pp. 50-57
Author(s):  
Ali Zolfaghari ◽  
Hamid Reza Gheisari ◽  
Arash Omidi ◽  
Saeed Nazifi
Keyword(s):  
Serum Iron ◽  
Wistar Rats ◽  
Graphite Furnace ◽  
Serum Zinc ◽  
The Body ◽  
Control Group ◽  
Dietary Iron ◽  
Flame Atomic Absorption ◽  
Iron And Zinc ◽  
Male Wistar Rats

Abstract. The purpose of the study was to determine the effect of dietary iron on distribution of zinc, manganese, copper, calcium and magnesium in the body of Wistar rats. Commercial Sangak, an Iranian traditional flat bread was used in this study. It was prepared by additionof yeast and sourdough. Different doses of iron (35, 70, 140, and 210 mg/kg per diet) were added to bread vehicle for 30 days with or without baking soda (250 mg/kg per diet). The concentrations of the above elements were determined by graphite furnace and flame atomic absorption spectroscopy. Serum zinc and manganese concentrations were significantly lower (P < 0.05) in rats that received higher concentrations of iron compared to the controls. Serum iron, and copper concentrations increased significantly (P < 0.05) with an increase in dietary iron compared to the controls. Increments of dietary concentrations of iron raised the concentration of iron, zinc and manganese in the feces, and lowered the concentration of copper and calcium in the feces (P < 0.05). Diets that contained baking soda showed a statistically significant increase in phytic acid (P < 0.05). Lower serum iron was seen in rats that received baking soda with diet of the control group. Conversely, feces iron and zinc were increased in this group. It is concluded that iron absorption might interfere with zinc and manganese because of similar physicochemical properties. Knowledge about these interactions is essential when supplementation of some elements is recommended in populations with a high risk of some deficiencies such as iron and zinc.

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