Changes in Serum Trace Elements after Surgery: Value of Copper and Zinc in Predicting Post-Operative Fatigue

1992 ◽  
Vol 20 (1) ◽  
pp. 12-19 ◽  
Author(s):  
A Cordova Martinez ◽  
J F Escanero Marcen
Keyword(s):  
Trace Elements ◽  
Total Protein ◽  
Serum Zinc ◽  
Serum Copper ◽  
Serum Total Protein ◽  
Muscular Performance ◽  
Skin Fold ◽  
Triceps Skin Fold ◽  
Zinc Concentrations ◽  
Serum Trace Elements

Triceps skin fold, arm muscular performance and fatigue were quantified, haematocrit measured and haemoglobin, serum total protein, albumin, transferrin, zinc and copper concentrations determined in 60 patients (36 women, 24 men) before and 3–45 days after surgery. On days 3 and 9 after surgery, there was a significant ( P < 0.05) decrease in serum zinc concentrations but by 45 days concentrations had return to pre-operative values. In contrast, serum copper concentrations were significantly ( P < 0.05) elevated until day 45. Haematocrit and haemoglobin and albumin concentrations were decreased significantly ( P < 0.05) 3 and 9 days after surgery, whereas serum total protein concentrations remained significantly ( P < 0.05) lower for 45 days compared with concentrations prior to surgery.

Influence of Myocardial Infarction on Serum Manganese, Copper, and Zinc Concentrations

1975 ◽  
Vol 21 (4) ◽  
pp. 578-581 ◽  
Author(s):  
Jacques Versieck ◽  
Fabrice Barbler ◽  
Albert Speecke ◽  
Julien Hoste
Keyword(s):  
Myocardial Infarction ◽  
Trace Elements ◽  
Neutron Activation Analysis ◽  
Serum Zinc ◽  
Serum Copper ◽  
Aminotransferase Activity ◽  
Copper And Zinc ◽  
Serum Aspartate Aminotransferase ◽  
Zinc Concentrations ◽  
Manganese Concentrations

Abstract Reportedly, serum manganese concentrations increase after myocardial infarction, closely correlated with increased serum aspartate aminotransferase activity. However, these conclusions are apparently based on analyses of contaminated samples. Serum manganese concentrations after myocardial infarction have been re-investigated by neutron activation analysis, and no significant increase could be demonstrated. Because serum copper and zinc could be determined simultaneously, analyses for these trace elements are also reported, which confirm the findings of others. After myocardial Infarction a statistically significant (0.02 &lt; P &lt; 0.05) increase in serum copper and a statistically significant (0.001 &lt; P &lt; 0.01) decrease in serum zinc were observed.

Estimation of Trace Elements in Gingival Crevicular Fluid and Serum-Comparative Study in Healthy and Periodontitis

2017 ◽  
Vol 9 (5) ◽  
Author(s):  
Bhagavathami Meenaksh ◽  
Chitraa R. Chandran ◽  
Aravindhan Thathchari Ranganathan ◽  
Kavindapadi Venkateswaran Rama ◽  
Valarmathy Srinivasan
Keyword(s):  
Trace Elements ◽  
Inductively Coupled Plasma ◽  
Gingival Crevicular Fluid ◽  
Serum Zinc ◽  
Cross Sectional Study ◽  
Serum Copper ◽  
Cross Sectional ◽  
Inductively Coupled ◽  
Significant Difference ◽  
Copper Zinc

Background: This study aims to determine and compare the levels of trace elements copper, zinc, selenium and chromium in GCF and serum of patients with periodontitis and healthy individuals. Methods: This cross sectional study includes 24 study subjects recruited from the patients reporting to the Department of Periodontics , Tagore Dental College Chennai. All the selected patients were subjected to a clinical examination done by a single examiner. The estimation of trace elements Copper, Zinc, Selenium and Chromium in GCF and serum is performed using Perkin Elmer optima 5300 Inductively Coupled Plasma Emission Spectrometer (ICPOES). Results: GCF and serum copper levels showed no significant difference in both periodontitis and healthy groups . Selenium levels tend to be the same in both groups. Serum zinc levels are more in periodontitis patients than healthy subjects (p less than 0.01). GCF chromium levels are found to be more in patients with periodontitis than healthy. Conclusions : More research is therefore needed to monitor the role of these trace elements C with an increased sample size to ascertain whether they are associated with a reduced risk of periodontitis.

scholarly journals Serum Trace Elements Profile in Graves’ Disease Patients with or without Orbitopathy in Northeast China

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Yongping Liu ◽  
Shanshan Liu ◽  
Jinyuan Mao ◽  
Sichen Piao ◽  
Jing Qin ◽  
...  
Keyword(s):  
Trace Elements ◽  
Northeast China ◽  
Thyroid Autoimmunity ◽  
Serum Copper ◽  
High Serum ◽  
Graves Disease ◽  
Serum Selenium ◽  
Specific Antibodies ◽  
Euthyroid Status ◽  
Serum Trace Elements

Objective. The purpose of the present study was to investigate serum trace elements in Graves’ disease (GD) patients with or without orbitopathy in Northeast China. Methods. Patients with newly diagnosed Graves’ disease (HyGD) (n=66), GD patients with euthyroid status or subclinical thyroidism after treatment (EUGD) (n=55), GO patients with euthyroid status or subclinical thyroidism after treatment (GO) (n=57), and normal controls (NC) (n=66) were enrolled in this study. Serum trace elements were measured with ICP-MS. Results. Serum selenium (Se) levels in EUGD group (median: 7.53 µg/dL), HyGD group (median: 6.76 µg/dL), and GO group (median: 7.40 µg/dL) were significantly lower than those in NC group (median: 9.20 µg/dL, all P<0.01). Serum copper (Cu) levels in GO group (median: 95.93 µg/dL) were significantly lower than those in the NC group (median: 113.59 µg/dL, P=0.015). After being adjusted for multivariables, thyroid-specific antibodies grade was associated with low Se levels. Hyperthyroidism and thyroid-specific antibodies grade were associated with high Cu levels. In addition, orbitopathy was associated with low Cu levels. Conclusions. Thyroid autoimmunity was associated with low Se levels. Hyperthyroidism and thyroid autoimmunity may be associated with relatively high serum Cu levels. Alternatively, ophthalmopathy may be related to low serum Cu levels.

scholarly journals TRACE METALS IN CANCER PATIENTS AND THEIR CORRELATION WITH RENAL FUNCTION

2003 ◽  
Vol 42 (146) ◽  
pp. 71-73
Author(s):  
Shankhar Majhi ◽  
B D Toora ◽  
S K Sen ◽  
K Anantha ◽  
N Anantha
Keyword(s):  
Trace Elements ◽  
Trace Metals ◽  
Cancer Patients ◽  
Serum Zinc ◽  
Serum Copper ◽  
The Body ◽  
Significant Elevation ◽  
Super Oxide Dismutase ◽  
Carcinoma Stomach ◽  
Cu And Zn

ABSTRACTTwo trace elements, copper (Cu) and zinc (Zn) in serum are elevated in cancer patients since both areconstituents of super oxide dismutase (SOD) as metalloenzyme, the enzyme that scavenge free radicals andactivated oxygen species in the body. The study of 52 cancer patients comprising of 31 carcinoma stomachand 21 breast cancer showed the elevation of both of these trace elements in serum when compared to 32healthy controls and effected the kidney functions as a consequences. Serum Cu and Zn were estimated byAtomic Absorption Spectrometer (AAS), analyzed statistically by student "t" test and marked elevationwas observed in cancer patient compared to healthy controls. Serum Cu and Zn values were 98.13 ± 17.49μg/dl 99..57 ± 13.91 μg /dl respectively in 38 healthy subjects and these trace metals were 156.23 ± 31.02 μg/dl and 171.86 ± 35.15 μg/dl in 52 cancer patients showing significant elevation (P <0.001). These elevatedelements were routed through kidneys and damaged nephrons since both of them are cationic heavy metals.Nephrotoxicity of these trace metals was reflected as elevated level of blood urea and creatinine and werefound to be 27.44 ± 7.72 mg /dl and 0.83 ± 0.30 mg/dl in control groups and 64.49 ± 49 mg /dl and 1.60 ± 0.72mg/dl in cancer patients respectively, a significant elevation (P<0.001) in study group. The elevation ofthese parameters may indicate renal origin.Key Words: Serum copper, serum zinc, super oxide dismutase, carcinoma stomach, carcinoma breastand nephrotoxicity.

Serum Zinc, Iron, and Copper Concentrations during Typhoid Fever in Man: Effect of Chloramphenicol Therapy

1975 ◽  
Vol 21 (4) ◽  
pp. 528-532 ◽  
Author(s):  
Robert S Pekarek ◽  
R M Kluge ◽  
H L DuPont ◽  
R W Wannemacher ◽  
R B Hornick ◽  
...  
Keyword(s):  
Typhoid Fever ◽  
Serum Iron ◽  
Iron Concentration ◽  
Serum Zinc ◽  
Salmonella Typhi ◽  
Serum Copper ◽  
Related Phenomenon ◽  
Iron And Zinc ◽  
Zinc Concentrations ◽  
Metal Monitoring

Abstract In volunteers experimentally infected with Salmonella typhi, serum iron and zinc concentrations became significantly depressed and there was a concomitant rise in serum copper before the onset of overt clinical illness. However, after several days of fever and the initiation of chloramphenicol therapy, serum iron and zinc concentrations significantly increased. Additional studies—in volunteers with typhoid fever treated with chloramphenicol, in a volunteer with typhoid fever receiving cefazolin and gentamicin, and in untreated rhesus monkeys infected with Salmonella typhimurium—provided evidence that the increase in serum iron concentration during the febrile phase was the result of chloramphenicol therapy, whereas the increase in serum zinc concentrations was a disease-related phenomenon. The importance of trace-metal monitoring during infectious disease and chemotherapy is discussed

scholarly journals Serum Copper and Plasma Protein Status in Normal Pregnancy

2013 ◽  
Vol 7 (2) ◽  
pp. 66-71 ◽  
Author(s):  
Nushrat Noor ◽  
Nasim Jahan ◽  
Nayma Sultana
Keyword(s):  
Pregnant Women ◽  
Plasma Protein ◽  
Total Protein ◽  
Serum Copper ◽  
Copper Level ◽  
Serum Total Protein ◽  
Cross Sectional ◽  
Protein Levels ◽  
Control Serum ◽  
Significant Difference

Background: Gradual alteration of serum copper and some plasma protein levels may occur with advancement of pregnancy, which is associated with increased maternal and infant morbidity and mortality. Objective: To observe serum copper and plasma protein levels in normal pregnant women of different trimesters in order to find out their nutritional status. Methods: This cross sectional study was carried out in the Department of Physiology, Sir Salimullah Medical College (SSMC), Dhaka, between 1st January 2010 and December 2010. Ninety normal pregnant women of different trimesters with age 20-30 years were included in the study group. They were selected from Out Patient Department of Obstetrics and Gynaecology, SSMC. Age matched 30 non-pregnant women were taken as control. Serum copper level was measured by Spectrophotometric method, serum total protein and albumin levels were estimated by standard method. Statistical analysis was done by one way ANOVA, Bonferroni and Pearson’s correlation coefficient test as applicable. Results: Serum Cu levels were significantly higher in all trimesters of pregnant women compared to control. Again, this value was significantly higher in 3rd trimester than that of in 1st and 2nd trimester and also in 2nd trimester than that of in 1st trimester. In addition, mean serum total protein level was significantly lower in 3rd trimester than control but no statistically significant difference was observed among different trimesters. Again, mean serum albumin level was significantly lower in 2nd and 3rd trimester than 1st trimester and control. In addition, serum Cu concentration showed significant positive correlation with different trimesters of gestation. Conclusion: This study reveals that hypercupremia along with hypoproteinemia occur in pregnant women from 1st to 3rd trimester of gestation. This gradual alteration of micro and macronutrients become more profound with advancement of pregnancy. DOI: http://dx.doi.org/10.3329/jbsp.v7i2.14452 J Bangladesh Soc Physiol. 2012, December; 7(2): 66-71

Diurnal Variation of Serum Copper and Zinc in Epileptics Receiving Anti-Convulsants

1986 ◽  
Vol 5 (3) ◽  
pp. 195-200 ◽  
Author(s):  
A. Taylor ◽  
K. Ghose
Keyword(s):  
Diurnal Variation ◽  
Reference Range ◽  
Serum Zinc ◽  
Serum Copper ◽  
Copper Level ◽  
Copper And Zinc ◽  
Urinary Copper ◽  
Zinc Concentrations ◽  
Zinc Levels ◽  
Patients With Epilepsy

1 Serial measurements of copper and zinc concentrations in serum were made at 06.00, 14.00, 22.00 and again at 06.00 hours in 37 male patients with epilepsy, aged between 9 and 19 years. Anti-convulsant drugs were administered at 08.00 and 20.00 hours, and standard hospital meals were allowed at 07.30, 12.00, 16.00 and 19.00 hours. 2 Similar to our previous results, eight patients (21.6%) had serum copper levels greater than the reference range (11.0–20.5 μmol/l) and this hypercupraemia was associated with carbamazapine and/or phenytoin medication. 3 No diurnal variation in serum copper level was observed. Serum copper concentration had no correlation with either 24 h urinary copper excretion or serum anti-convulsant drug levels. 4 Serum zinc concentrations were within the reference range (10–16.5 μmol/l), confirming our previous report. No relation with anti-convulsant medication or serum copper levels was found. 5 Diurnal variations in serum zinc levels with peak and trough concentrations at 06.00 and 14.00 hours, respectively, were observed. 6 It is proposed that these variations in serum zinc concentrations are a normal physiological process and is unlikely to be related to anti-convulsant drugs or epilepsy.

scholarly journals Administration of zinc to preterm infants with hypozincemia does not reduce serum copper concentrations in most cases: a single-center retrospective observational study

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Toshikazu Ito ◽  
Kazuya Uenoyama ◽  
Kazuhiro Kobayashi ◽  
Mikio Kakumoto ◽  
Hiroshi Mizumoto ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Zinc Acetate ◽  
Zinc Concentration ◽  
Zinc Acetate Dihydrate ◽  
Serum Zinc ◽  
Serum Copper ◽  
Acetate Dihydrate ◽  
Serum Zinc Concentration ◽  
Postmenstrual Age ◽  
Zinc Concentrations

Abstract Background Zinc is an essential trace element involved in various physiological functions. In Japan, zinc acetate dihydrate is administered to neonates and infants with hypozincemia. Since serum copper concentrations are reduced by the administration of zinc, we retrospectively investigated changes in serum zinc and copper concentrations in preterm infants with hypozincemia receiving zinc acetate dihydrate. Methods Sixty-three preterm infants were included in the present study. Serum zinc and copper concentrations, doses, and other clinical characteristics were retrieved from electronic medical records. Results The medians and interquartile ranges of the dosage and duration of zinc acetate dihydrate were 2.1 (1.8–2.5) mg/kg/day and 12.0 (10.0–13.0) days, respectively. Its administration increased serum zinc concentrations in 39 patients (61.9%) and to more than 70 μg/dL in 16 patients (25.4%). The group with a serum zinc concentration of 70 μg/dL or higher after administration had a significantly higher zinc dose of 2.5 mg/kg/day than the group with a serum zinc concentration of less than 70 μg/dL. Serum copper concentrations did not decrease in 44 patients (69.8%). In the group with a decreased serum copper concentration, postmenstrual age and body weight were significantly lower, while serum zinc concentrations were significantly higher at the start of administration. Conclusion The present results showed that when zinc acetate dihydrate was administered to preterm infants with hypozincemia, it was possible to increase serum zinc concentrations without decreasing serum copper concentrations in many cases. However, caution may be required when administering zinc to preterm infants with a lower postmenstrual age or milder hypozincemia because serum copper concentrations may decrease.

scholarly journals Serum Copper and Serum Zinc in Preeclampsia: Cause or Effect?

2020 ◽  
pp. 52-57
Author(s):  
Anjum A. K. Sayyed ◽  
Alka N. Sontakke
Keyword(s):  
Trace Elements ◽  
Case Control Study ◽  
Serum Zinc ◽  
Serum Copper ◽  
Total Serum ◽  
Control Group ◽  
Multisystem Disorder ◽  
Mean Values ◽  
Copper And Zinc ◽  
Control Study

Background: Preeclampsia is multisystem disorder. Despite its prevalence and severity, the pathophysiology of this multisystem disorder is poorly understood. In concern regarding the increasing number of preeclamptic cases and lack of data about the levels of trace elements in preeclampsia, a case-control study was conducted with aim to determine the trace elements like serum total copper and serum total zinc in preeclampsia. Aims: To estimate alterations in serum copper and serum zinc in preeclampsia and to compare them with normal pregnant women. Study Design: This is a case control study, carried out in the Department of Biochemistry, MIMER Medical College, Talegaon Dabhade, Pune. Methods: The present study consisted of 120 study participants. These were divided into two groups. Group I - normal pregnant women as control (n=60) and Group II - preeclamptic group (n=60). The serum levels of copper and zinc were determined by inductively coupled plasma atomic emission spectrometry (ICP- AES) technique at IIT Mumbai. Results: Analysis revealed that mean values of total serum copper and total serum zinc were 196.20 ± 25.9 and 77.15 ± 14.5 (µg/dl) respectively in control group. In preeclamptic group, the mean values of copper and zinc were 213.13± 38.6 and 76.23 ± 13.13 (µg/dl) respectively. Copper was significantly increased in preeclamptic group, while non-significant reduction in levels of zinc levels was observed when compared to control group. Conclusion: In the present study, significantly high serum copper was observed in preeclamptic patients. Presence of high copper levels may be related factor in the etiopathogenesis of preeclampsia. Estimation of trace elements like copper and zinc may help clinicians in early diagnosis and minimizing or delaying complications of preeclampsia, hence preventing harm to both mother & fetus.

scholarly journals Circulating Zinc and Copper Levels are Associated with Sperm Quality in Obese Men after Metabolic Surgery: A Pilot Study

Nutrients ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3354
Author(s):  
Berniza Calderón ◽  
Jesús M. Gómez-Martín ◽  
Marta Cuadrado-Ayuso ◽  
Pilar Cobeta ◽  
Belén Vega-Piñero ◽  
...  
Keyword(s):  
Trace Elements ◽  
Metabolic Surgery ◽  
Sperm Quality ◽  
Serum Zinc ◽  
Serum Testosterone ◽  
Serum Copper ◽  
Reproductive Hormones ◽  
Positive Correlation ◽  
Sperm Analysis ◽  
Sperm Volume

(1) Background: Inadequate levels of several trace elements and vitamins may impair spermatogenesis in men. Although weight loss after metabolic surgery normalizes male reproductive hormones, sperm quality seems to not improve. We hypothesized that circulating concentrations of zinc, copper and other trace elements and vitamins might be involved. (2) Methods: We studied 20 men submitted to metabolic surgery at baseline and after two years. Hormone profiles, serum trace elements and vitamins were studied together with sperm analysis. (3) Results: At follow-up, serum testosterone, follicle-stimulating hormone and inhibin B concentrations increased showing a beneficial hormonal response for spermatogenesis. Conversely, serum copper, zinc and ferritin showed a decline after surgery. In total, 33% of men showed zinc deficiency, 27% copper deficiency and 20% iron deficiency, among others. Sperm analysis showed that all revaluated patients had at least one abnormal parameter. Serum zinc concentrations showed a positive correlation with progressive motility (r = 0.577, p = 0.031), and serum ferritin a positive correlation with sperm volume (ρ = 0.535, p = 0.049). Serum copper showed a weak and near significant correlation with motility (r = 0.115, p = 0.051). (4) Conclusions: The lack of improvement in sperm quality in obese men after metabolic surgery may be related to nutrient malabsorption, especially zinc, copper and iron.

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