Plasma enzyme activities in primary hypothyroidism.

1984 ◽  
Vol 30 (2) ◽  
pp. 323-325 ◽  
Author(s):  
G H White ◽  
R N Walmsley
Keyword(s):  
Enzyme Activities ◽  
Medical Staff ◽  
Laboratory Tests ◽  
Clinical Chemistry ◽  
Primary Hypothyroidism ◽  
Diagnostic Problem ◽  
Plasma Enzyme ◽  
Professional Assistance ◽  
Clinical Chemistry Tests

Abstract Results of clinical chemistry tests are often initially interpreted by relatively inexperienced junior medical staff, and therefore a major role of clinical chemists is to ensure that their laboratory tests are utilized and interpreted appropriately. The cases described below demonstrate the interaction of a diagnostic problem and clinical inexperience in an area where clinical chemists can, and should be, of professional assistance.

Accuracy in clinical chemistry--does anybody care?

1994 ◽  
Vol 40 (6) ◽  
pp. 859-861 ◽  
Author(s):  
N W Tietz
Keyword(s):  
Laboratory Tests ◽  
Serum Iron ◽  
Clinical Chemistry ◽  
Analytical Techniques ◽  
Optimal Performance ◽  
Diagnostic Process ◽  
Serum Lipase ◽  
Clinical Laboratories

Abstract The role of clinical chemistry in the diagnostic process has been enhanced by the evolution of better instrumentation and analytical techniques. The quality of some laboratory tests, however, has not kept pace with these advances. I present three examples--serum iron, serum lipase, and nonisotopic immunoassays--assays where some currently used methodologies are highly flawed. Causes for the less than optimal performance of some clinical laboratories are discussed.

The Role of Expert Systems in Improving the Test Requesting Patterns of Clinicians

1993 ◽  
Vol 30 (1) ◽  
pp. 52-59 ◽  
Author(s):  
Margaret Peters ◽  
P M G Broughton
Keyword(s):  
Expert Systems ◽  
Clinical Chemistry ◽  
Clinical Settings ◽  
Out Of Hours ◽  
Laboratory Staff ◽  
Testing Strategies ◽  
Laboratory Utilization ◽  
The Many ◽  
Clinical Chemistry Tests

The many strategies proposed for influencing the test requesting patterns of clinicians have had only limited success, largely because they are labour intensive and depend on motivation and commitment. Clinical protocols which have been locally agreed between laboratory staff and clinicians are potentially one of the more successful strategies, but detailed study of their application in different clinical settings has been limited by practical problems. Expert systems offer a way of implementing locally agreed protocols and, consequently, of assisting the identification, audit and refinement of laboratory testing strategies. Where these systems have been applied in specialist units they have resulted in savings in time by both clinical and laboratory staff, and an overall reduction in the number of clinical chemistry tests done within and out of hours. These systems offer promise as a method of improving laboratory utilization.

Tryptophan-Niacin Metabolism in Rat with Puromycin Aminonucleoside-Induced Nephrosis

2006 ◽  
Vol 76 (1) ◽  
pp. 28-33 ◽  
Author(s):  
Yukari Egashira ◽  
Shin Nagaki ◽  
Hiroo Sanada
Keyword(s):  
Body Weight ◽  
Urinary Excretion ◽  
Enzyme Activities ◽  
Treated Group ◽  
Control Group ◽  
Puromycin Aminonucleoside ◽  
Low Level ◽  
Key Enzyme

We investigated the change of tryptophan-niacin metabolism in rats with puromycin aminonucleoside PAN-induced nephrosis, the mechanisms responsible for their change of urinary excretion of nicotinamide and its metabolites, and the role of the kidney in tryptophan-niacin conversion. PAN-treated rats were intraperitoneally injected once with a 1.0% (w/v) solution of PAN at a dose of 100 mg/kg body weight. The collection of 24-hour urine was conducted 8 days after PAN injection. Daily urinary excretion of nicotinamide and its metabolites, liver and blood NAD, and key enzyme activities of tryptophan-niacin metabolism were determined. In PAN-treated rats, the sum of urinary excretion of nicotinamide and its metabolites was significantly lower compared with controls. The kidneyα-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) activity in the PAN-treated group was significantly decreased by 50%, compared with the control group. Although kidney ACMSD activity was reduced, the conversion of tryptophan to niacin tended to be lower in the PAN-treated rats. A decrease in urinary excretion of niacin and the conversion of tryptophan to niacin in nephrotic rats may contribute to a low level of blood tryptophan. The role of kidney ACMSD activity may be minimal concerning tryptophan-niacin conversion under this experimental condition.

‘Thank you for giving me my wife back’ – the role of liothyronine (T3) in primary hypothyroidism

2020 ◽  
Author(s):  
Bonnie Grant ◽  
Nirupam Purkayastha ◽  
Raj Tanday ◽  
Anna Hawkins ◽  
Nancy Enriquez ◽  
...  
Keyword(s):  
Primary Hypothyroidism
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