SimulTRAC simultaneous radioimmunoassay of thyrotropin and free thyroxin evaluated.

1986 ◽  
Vol 32 (12) ◽  
pp. 2191-2194 ◽  
Author(s):  
S M Gow ◽  
G Caldwell ◽  
A D Toft ◽  
G J Beckett
Keyword(s):  
Thyroid Disease ◽  
Third Trimester ◽  
Nonthyroidal Illness ◽  
Dual Isotope ◽  
The Third ◽  
Analytical Recovery ◽  
Reference Limits ◽  
The Mean ◽  
Small Overlap ◽  
Good Agreement

Abstract We assessed the analytical and diagnostic performance of a dual-isotope RIA for thyrotropin (TSH) and free thyroxin (FT4) in serum. The mean interassay CVs for these analytes were 7.9% and 5.0%, respectively. The mean minimum detection limit for TSH was 0.25 milli-int. unit/L, the mean analytical recovery 110%. There was good agreement with values for TSH and FT4 measured by alternative RIA procedures. Euthyroid patients were well distinguished from those with overt thyroid disease, although there was a small overlap in the case of TSH. Combining the two results better discriminated these categories and identified those patients with subclinical thyroid disease who had abnormal TSH concentrations but FT4 concentrations within reference limits. Euthyroid women taking estrogen-containing oral contraceptives had normal results for TSH and FT4, as did most pregnant women studied. During the third trimester of pregnancy, TSH concentrations of women with low FT4 concentrations were within reference limits. Similarly, euthyroidism was confirmed in patients with low FT4 due to nonthyroidal illness by the simultaneous finding of a normal TSH concentration.

Improved dialysis method for free thyroxin in serum compared with five commercial radioimmunoassays in nonthyroidal illness and subjects with abnormal concentrations of thyroxin-binding globulin.

1983 ◽  
Vol 29 (5) ◽  
pp. 816-822 ◽  
Author(s):  
T Helenius ◽  
K Liewendahl
Keyword(s):  
Clinical Laboratory ◽  
Late Pregnancy ◽  
Third Trimester ◽  
Free T4 ◽  
Nonthyroidal Illness ◽  
Mean Values ◽  
The Third ◽  
Dialysis Method ◽  
The Mean ◽  
Low Serum

Abstract We describe a method for free thyroxin (FT4) in serum, based on radioimmunoassay of T4 in serum dialysate, FT4(D). The method is analytically accurate, sensitive, reproducible, and suitable for routine use in the clinical laboratory. We compared results by this method with those obtained with five commercial FT4 assays (Amerlex, GammaCoat, ImmoPhase, LiquiSol, Spiria) and the free T4 index (FT4I). In several of the patients with nonthyroidal illness FT4(D) was above normal and FT4 as measured with the commercial assays was subnormal. In the third trimester of pregnancy all the FT4 methods gave decreased mean values, though the decreases were of various magnitudes: FT4(D) 32%, Amerlex 44%, GammaCoat 40%, Spiria 19%, LiquiSol 16%, and ImmoPhase 13%, respectively. FT4I was significantly higher than normal during late pregnancy. In women taking oral contraceptives the mean FT4I was increased, but there was no significant effect on the results obtained with the various FT4 methods. All subjects with hereditarily high or low serum thyroxin-binding globulin had normal FT4(D) and abnormal FT4I. Amerlex, ImmoPhase, and LiquiSol misclassified some of the subjects with hereditarily abnormal thyroxin-binding globulin.

Correlations Between the Values of Maternal Glycemia from the Last Trimester of Pregnancy and Fetal Birth Weight

2013 ◽  
Vol 20 (3) ◽  
pp. 259-265
Author(s):  
Monica Vereş ◽  
Aurel Babeş ◽  
Szidonia Lacziko
Keyword(s):  
First Trimester ◽  
Mean Value ◽  
Fetal Macrosomia ◽  
Entire Group ◽  
Third Trimester ◽  
The Third ◽  
Group I ◽  
Fetal Birth Weight ◽  
First Trimester Of Pregnancy ◽  
The Mean

Abstract Background and aims: Gestational diabetes represents a form of diabetes diagnosed during pregnancy that is not clearly overt diabetes. In the last trimester of gestation the growth of fetoplacental unit takes place, thus maternal hyperglycemia will determine an increased transplacental passage, hyperinsulinemia and fetal macrosomia. The aim of our study was that o analyzing the effect of maternal glycemia from the last trimester of pregnancy over fetal weight. Material and method: We run an observational study on a group of 46 pregnant women taken into evidence from the first trimester of pregnancy, separated in two groups according to blood glucose determined in the third trimester (before birth): group I normoglycemic and group II with hyperglycemia (>92mg/dl). Results: The mean value of third trimester glycemia for the entire group was of 87.13±22.03. The mean value of the glycemia determined in the third trimester of pregnancy was higher in the second group (109.17 mg/dl) in comparison to the first group (74.,21 mg/dl). The ROC curve for third trimester glycemia as fetal macrosomia appreciation test has an AUC of 0.517. Conclusions: Glycemia determined in the last trimester of pregnancy cannot be used alone as the predictive factor for fetal macrosomia.

scholarly journals Platelet counts during pregnancy in Chinese women

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Li-Xia Zhang ◽  
Ning Dong ◽  
Rui-Xia Yang ◽  
Ang Li ◽  
Xuan-Mei Luo ◽  
...  
Keyword(s):  
Chinese Women ◽  
Third Trimester ◽  
Bleeding Events ◽  
Common Cause ◽  
Platelet Counts ◽  
The Third ◽  
Uncomplicated Pregnancy ◽  
Gestational Thrombocytopenia ◽  
The Mean ◽  
Medical University

AbstractObjectivesGestational thrombocytopenia (GT) is the most common cause of thrombocytopenia during pregnancy. However, the occurrence and severity of thrombocytopenia throughout pregnancy in Chinese women are not fully defined.MethodsWe analyzed platelet counts in Chinese women who received prenatal care and/or delivered at the First Affiliated Hospital with Nanjing Medical University between January 2, 2018 and July 19, 2018 in China. These platelet counts were compared with those of nonpregnant women in the same study period.ResultsThe platelet counts of all women continued to decrease significantly each trimester (p < 0.0001). The mean platelet counts of the 818 women who had pregnancy-related complications were lower than those of the 796 women who had uncomplicated pregnancies during the third trimester (p = 0.047). At the time of delivery, platelet counts less than 150 × 109/L were more common in women with pregnancy-related complications than in women with uncomplicated pregnancy (26.7% vs. 19.7%, p = 0.03).ConclusionsPlatelet counts decrease throughout pregnancy in Chinese women and platelet counts less than 150 × 109/L were more common in women with pregnancy-related complications than in women with uncomplicated pregnancy. The pregnant women should be paid more attention for thrombocytopenia to avoid the occurrence of bleeding events.

scholarly journals Fetal Heart Rate Regresses toward the Mean in the Third Trimester

2012 ◽  
Vol 27 (7) ◽  
pp. 794 ◽  
Author(s):  
Young-Sun Park ◽  
Jeong-Kyu Hoh ◽  
Moon-Il Park
Keyword(s):  
Heart Rate ◽  
Fetal Heart Rate ◽  
Fetal Heart ◽  
Third Trimester ◽  
The Third ◽  
The Mean

Free thyroxin by radioimmunoassay: evaluation of a new direct method involving a radiolabeled thyroxin analog.

1983 ◽  
Vol 29 (10) ◽  
pp. 1781-1786 ◽  
Author(s):  
N P Kubasik ◽  
P A Lundberg ◽  
R G Brodows ◽  
G D Hallauer ◽  
D G Same ◽  
...  
Keyword(s):  
Performance Evaluation ◽  
Oral Contraceptives ◽  
Thyroid Disease ◽  
Direct Method ◽  
Age Effect ◽  
Free T4 ◽  
Nonthyroidal Illness ◽  
Serum Free ◽  
Normal Individuals ◽  
The Mean

Abstract We present here the first performance evaluation of a new direct method for free thyroxin (T4) in serum by radioimmunoassay, with use of coated tubes and a radiolabeled T4 analog (Diagnostic Products Corp.). The assay is precise and robust: within-run imprecision (CV), 3.1-6.6%; between-run imprecision, 4.0-7.9%; no demonstrable variation between technologists irrespective of experience with the method. No outliers were observed when we compared the free T4 results with serum total T4. Reference values are reported for a total of 1243 euthyroid subjects; there was no significant age effect on serum free T4 in women 26 to 72 years old. The biological variation was about +/- 35% of the mean (2 SD). Free T4 results are the same for serum and plasma. The assay performs well in hypothyroidism and hyperthyroidism, and distinguishes individuals with thyroid disease from normal individuals. Free T4 values in women taking oral contraceptives are normal. Depressed results were often observed in acute nonthyroidal illness and continuing pregnancy. These results were directly comparable with those of another commercial direct radiolabeled-T4 analog kit for free T4.

scholarly journals Kinetic Studies of Fibrinogen in Pregnant Rabbits

1977 ◽  
Author(s):  
R.-M. Moeller ◽  
I. Mahn ◽  
G. Müller-Berqhaus
Keyword(s):  
Kinetic Studies ◽  
Distribution Volume ◽  
Fractional Catabolic Rate ◽  
Third Trimester ◽  
The Third ◽  
Quantitative Measurements ◽  
Catabolic Rate ◽  
Average Acceleration ◽  
The Mean ◽  
Kinetics Of

During gestation increased concentrations of fibrin (ogen)derivatives are observed indicative of intravascular action of thrombin. The aim of this study was to elucidate the kinetics of fibrinogen during gestation. The elimination of homologous 1-125-fibrinogen was studied in 14 pregnant rabbits during the first as well as during the third trimesters of gestation. Control studies were performed with 10 non-pregnant rabbits.The mean distribution volume of labeled fibrinogen did not significantly differ between pregnant and non-pregnant rabbits. During the third trimester pregnant rabbits demonstrated a pronounced shortening of T 1/2 of labeled fibrinogen from a mean of 55.3 hr during the first to a mean of 29.7 hr during the third trimester. The experiments showed a significant increase in the fractional catabolic rate from 45.0 to 69.9% per day in the course of gestation. The shortening of T 1/2 of labeled fibrinogen correlated to the number of fetusses per litter.This study indicates an average acceleration of the fibrinogen turnover during gestation of about 50%. These direct quantitative measurements demonstrate that fibrinogen catabolism is pronouncedly accelerated during pregnancy.

Slow, programmed maturation of the immunoglobulin HCDR3 repertoire during the third trimester of fetal life

Blood ◽  
2001 ◽  
Vol 98 (9) ◽  
pp. 2745-2751 ◽  
Author(s):  
Harry W. Schroeder ◽  
Liming Zhang ◽  
Joseph B. Philips
Keyword(s):  
Cell Activation ◽  
Length Distribution ◽  
Systemic Exposure ◽  
Antibody Repertoire ◽  
Fetal Life ◽  
B Cell Activation ◽  
Third Trimester ◽  
The Third ◽  
Developmental Progression ◽  
The Mean

Abstract The mean distribution of lengths in the third complementarity-determining region of the heavy chain (HCDR3) serves as a measure of the development of the antibody repertoire during ontogeny. To determine the timing and pattern of HCDR3 length maturation during the third trimester of pregnancy, the mean distribution of HCDR3 lengths among variable-diversity-joining-constant–μ (VDJCμ) transcripts from the cord blood was analyzed from 138 infants of 23 to 40 weeks' gestation, including 3 sets of twins, 2 of which were of dizygotic origin. HCDR3 maturation begins at the start of the third trimester; follows a slow, continuous expansion over a 5-month period; and is unaffected by race or sex. The range and mean distribution of lengths may vary in dizygotic twins, indicating individual rates of development. The mean HCDR3 length distribution in 10 premature infants with documented bacterial sepsis was then followed for 2 to 12 weeks after their first positive blood culture. HCDR3 spectrotype analysis demonstrated oligoclonal B-cell activation and expansion after sepsis, but maturation of the repertoire was not accelerated even by the systemic exposure to external antigen represented by bacteremia. Antibody repertoire development appears to be endogenously controlled and adheres to an individualized developmental progression that probably contributes to the relative immaturity of the neonatal immune response.

CORTISOL AND CORTISONE IN SALIVA OF PREGNANCY

1963 ◽  
Vol 26 (2) ◽  
pp. 189-195 ◽  
Author(s):  
M. S. GREAVES ◽  
H. F. WEST
Keyword(s):  
Rheumatoid Arthritis ◽  
Salivary Gland ◽  
Pregnant Women ◽  
Connective Tissues ◽  
Third Trimester ◽  
The Third ◽  
Reasonable Explanation ◽  
The Mean ◽  
Mixed Saliva ◽  
Mean Concentration

SUMMARY The concentration of cortisol and cortisone in mixed saliva has been measured in normal non-pregnant women, normal pregnant women in the third trimester of pregnancy and pregnant ones with mild toxaemia in the third trimester. The ratio of cortisol to cortisone was 1:4 for the non-pregnant and 1:5 for the pregnant women. The mean concentration of cortisol for the pregnant subjects was twice that of the non-pregnant and the mean concentration of cortisone three times that of the non-pregnant women. Filtration studies showed no significant binding of cortisol or cortisone in the saliva. It is concluded that the raised concentration of cortisol and cortisone in saliva indicates a raised concentration in the cells of the salivary gland. If this rise is common to the connective tissues generally it provides a reasonable explanation for the remission of rheumatoid arthritis experienced by some patients in the latter months of pregnancy.

scholarly journals The Frequency of Vaginal Intercourse During Pregnancy: A Systematic and Meta-Analysis Stud

2018 ◽  
Vol 7 (1) ◽  
pp. 1-9
Author(s):  
Maryam Hasani ◽  
Afsaneh Keramat ◽  
Raziyeh Maasoumi ◽  
Maryam Farjamfar ◽  
Masud Yunesian ◽  
...  
Keyword(s):  
Meta Analysis ◽  
First Trimester ◽  
Sexual Life ◽  
Vaginal Intercourse ◽  
Second Trimester ◽  
Third Trimester ◽  
Mean Frequency ◽  
The Third ◽  
Reference Manager ◽  
The Mean

Objectives: Sexual life may change during pregnancy. Due to negative attitudes toward having sex, unpleasant feeling, and fear of several issues, women might avoid vaginal intercourse during pregnancy. Therefore, the present systematic review aimed to investigate the frequency of vaginal intercourse in pregnancy. Materials and Methods: Comprehensive literature review was conducted to find the relevant articles published (from December 1990 to April 2018) on the issue including observational studies (e.g., cross-sectional and cohort studies) that certainly determined the mean frequency of vaginal sex throughout pregnancy. In this regard, online international databases such as ISI, PubMed, Scopus, Cochrane, and Google Scholar were independently explored and checked by two authors. Duplicate articles were removed by the EndNote X7 Reference Manager. The results were analyzed using RevMan 5.3 software. The P < 0.05 was considered significant. Results: Totally, after excluding the duplicate and irrelevant articles based on having the mean frequency of vaginal intercourse during pregnancy, 13 articles were obtained. The range of vaginal intercourse frequency varied from 6.01 to 21 times every month pre-pregnancy, 3.67-9.87 times monthly in the first trimester, 2.78-7.21 times monthly in the second trimester, and 1.35-5.9 times monthly in the third trimester. Five out of the 13 selected articles reporting the mean and standard deviation were entered the current meta-analysis. The frequency of vaginal intercourse was obtained 7.75 (7.13-8.38) times monthly prior to pregnancy, 4.16 (3.86-4.46) times in the first trimester, 6.37 (5.60-7.14) times monthly in the second trimester, and 1.81 (1.49-2.13) times monthly in the third trimester. Conclusions: Generally, the frequency of vaginal intercourse decreased in the first trimester while increasing in the second trimester. However, a sharp decline was observed between the second and third trimesters of pregnancy.

scholarly journals PRENATAL YOGA TERHADAP TINGKAT KECEMASAN PRIMIGRAVIDA TRIMESTER III

2020 ◽  
Vol 2 (1) ◽  
pp. 29-34
Author(s):  
Riza Amalia ◽  
Rusmini Rusmini ◽  
Diki Retno Yuliani
Keyword(s):  
Pregnant Women ◽  
Alternative Therapy ◽  
P Value ◽  
Third Trimester ◽  
The Third ◽  
Before And After ◽  
Change In The Mean ◽  
Prolonged Labor ◽  
The Mean ◽  
Anxiety Levels

Anxiety in pregnant women often occurs in the third trimester. Anxiety results in prolonged labor, premature birth, LBW (Low Birth Weight). To prevent and reduce anxiety, prenatal yoga as an alternative therapy is given to primigravida pregnant women in the third trimester.The puropose of this study is to find out the influence of prenatal yoga toward anxiety level primigravida in the third trimester in Puskesmas I Kembaran, Banyumas District. This study used quasy experimental with pretest posttest design. The sample in this study are all of primigravida in third trimester, there are 24 pregnant woman in Puskesmas 1 Kembaran. The results showed there were differences in primigravida in third trimester anxiety levels before and after prenatal yoga with p value = 0,000 (p 0.05). There is an influence of prenatal yoga on the level of anxiety primigravida in third trimester. There is a change in the mean level of anxiety of 11,3. 

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