CORTISOL AND CORTISONE IN SALIVA OF PREGNANCY

SUMMARY The concentration of cortisol and cortisone in mixed saliva has been measured in normal non-pregnant women, normal pregnant women in the third trimester of pregnancy and pregnant ones with mild toxaemia in the third trimester. The ratio of cortisol to cortisone was 1:4 for the non-pregnant and 1:5 for the pregnant women. The mean concentration of cortisol for the pregnant subjects was twice that of the non-pregnant and the mean concentration of cortisone three times that of the non-pregnant women. Filtration studies showed no significant binding of cortisol or cortisone in the saliva. It is concluded that the raised concentration of cortisol and cortisone in saliva indicates a raised concentration in the cells of the salivary gland. If this rise is common to the connective tissues generally it provides a reasonable explanation for the remission of rheumatoid arthritis experienced by some patients in the latter months of pregnancy.

Download Full-text

The sFlt-1 to PlGF Ratio in Pregnant Women with Rheumatoid Arthritis: Impact of Disease Activity and Sulfasalazine Use

Rheumatology ◽

10.1093/rheumatology/keab372 ◽

2021 ◽

Author(s):

Rugina I Neuman ◽

Hieronymus T W Smeele ◽

A H Jan Danser ◽

Radboud J E M Dolhain ◽

Willy Visser

Keyword(s):

Rheumatoid Arthritis ◽

Cohort Study ◽

Disease Activity ◽

Pregnant Women ◽

Gestational Age ◽

Third Trimester ◽

Low Disease Activity ◽

The Third ◽

Observational Prospective Cohort Study ◽

Plgf Ratio

Abstract Objectives An elevated sFlt-1/PlGF-ratio has been validated as a significant predictor of preeclampsia, but has not been established in women with rheumatoid arthritis (RA). We explored whether the sFlt-1/PlGF-ratio could be altered due to disease activity in RA, and could be applied in this population to predict preeclampsia. Since sulfasalazine has been suggested to improve the angiogenic imbalance in preeclampsia, we also aimed to examine whether sulfasalazine could affect sFlt-1 or PlGF levels. Methods Making use of a nationwide, observational, prospective cohort study on pregnant women with RA, sFlt-1 and PlGF were measured in the third trimester. A total of 221 women, aged 21–42 years, were included, with a median gestational age of 30 + 3 weeks. Results No differences in sFlt-1 or PlGF were observed between women with high, intermediate or low disease activity (p= 0.07 and p= 0.41), whereas sFlt-1 and PlGF did not correlate with DAS28-CRP score (r=-0.01 and r=-0.05, respectively). Four (2%) women with a sFlt-1/PlGF-ratio ≤38 developed preeclampsia in comparison to three (43%) women with a ratio > 38, corresponding to a negative predictive value of 98.1%. Sulfasalazine users (n = 57) did not show altered levels of sFlt-1 or PlGF in comparison to non-sulfasalazine users (n = 164, p= 0.91 and p= 0.11). Conclusion Our study shows that in pregnant women with RA, the sFlt-1/PlGF-ratio is not altered due to disease activity and a cut-off ≤38 can be used to exclude preeclampsia. Additionally, sulfasalazine use did not affect sFlt-1 or PlGF levels in this population.

Download Full-text

PRENATAL YOGA TERHADAP TINGKAT KECEMASAN PRIMIGRAVIDA TRIMESTER III

Jurnal Sains Kebidanan ◽

10.31983/jsk.v2i1.5788 ◽

2020 ◽

Vol 2 (1) ◽

pp. 29-34

Author(s):

Riza Amalia ◽

Rusmini Rusmini ◽

Diki Retno Yuliani

Keyword(s):

Pregnant Women ◽

Alternative Therapy ◽

P Value ◽

Third Trimester ◽

The Third ◽

Before And After ◽

Change In The Mean ◽

Prolonged Labor ◽

The Mean ◽

Anxiety Levels

Anxiety in pregnant women often occurs in the third trimester. Anxiety results in prolonged labor, premature birth, LBW (Low Birth Weight). To prevent and reduce anxiety, prenatal yoga as an alternative therapy is given to primigravida pregnant women in the third trimester.The puropose of this study is to find out the influence of prenatal yoga toward anxiety level primigravida in the third trimester in Puskesmas I Kembaran, Banyumas District. This study used quasy experimental with pretest posttest design. The sample in this study are all of primigravida in third trimester, there are 24 pregnant woman in Puskesmas 1 Kembaran. The results showed there were differences in primigravida in third trimester anxiety levels before and after prenatal yoga with p value = 0,000 (p 0.05). There is an influence of prenatal yoga on the level of anxiety primigravida in third trimester. There is a change in the mean level of anxiety of 11,3.

Download Full-text

Comparison of Salivary Alpha-Amylase, Sialic Acid, and pH in Pregnant and Nonpregnant Subjects

European Journal of General Dentistry ◽

10.1055/s-0041-1732771 ◽

2021 ◽

Author(s):

Masoomeh Shirzaiy ◽

Zohreh Dalirsani

Keyword(s):

Sialic Acid ◽

Pregnant Women ◽

First Trimester ◽

Control Group ◽

Case Group ◽

Third Trimester ◽

The Third ◽

Significant Difference ◽

Salivary Ph ◽

The Mean

Abstract Objectives During pregnancy, systemic physiological alterations lead to some changes in the oral cavity, which could prepare the mouth environment for oral and dental problems. This study was aimed to investigate salivary α-amylase, sialic acid levels, and pH levels in pregnant and nonpregnant females. Materials and Methods In this analytical, case–control study, unstimulated saliva samples were collected with spiting method from 35 pregnant women (case group) and 35 nonpregnant women (control group) and transferred to the laboratory to assess salivary α-amylase, sialic acid, and pH levels. Data were analyzed by SPSS (version: 19) software through statistical methods of independent t-test and analysis of variance. Results The mean sialic acid levels were 2.285 ± 1.230 mg/dL in pregnant and 2.744 ± 1.326 in nonpregnant women without any significant difference (p = 0.138). The mean salivary α-amylase concentrations were 2.461 ± 1.869 U/L and 2.439 ± 2.058 U/L, respectively, in pregnant and nonpregnant women, with no significant difference (p = 0.963).The mean salivary pH in nonpregnant women was significantly more than that in pregnant women (7.845 ± 0.430 and 6.868 ± 0.413, respectively) (p < 0.001). Also, the mean salivary pH levels in pregnant women were 7.474 ± 0.420 in the first trimester, 6.868 ± 0.413 in the second trimester, and 6.568 ± 0.387 in the third trimester, which were significantly different (p < 0.001). Conclusion Salivary sialic acid and α-amylase levels among pregnant women were no different from those of other subjects. During pregnancy, the salivary pH significantly reduced, and the mean salivary pH during pregnancy had a decreasing trend from the first trimester to the third trimester.

Download Full-text

Measurement of Gallbladder Volume with Ultrasonography in Pregnant Women

Canadian Journal of Gastroenterology ◽

10.1155/2000/561739 ◽

2000 ◽

Vol 14 (5) ◽

pp. 403-405 ◽

Cited By ~ 6

Author(s):

Sait Kapicioglu ◽

Sevgi Gürbüz ◽

Ahmet Danalioglu ◽

Ömer Sentürk ◽

Mehmet Uslu

Keyword(s):

Pregnant Women ◽

Test Meal ◽

Cholesterol Gallstone ◽

Gallstone Formation ◽

Control Group ◽

Third Trimester ◽

Gallbladder Volume ◽

The Third ◽

Baseline Values ◽

The Mean

Fasting and postprandial gallbladder volumes were investigated using ultrasonography in three groups (10 subjects in each) of healthy women: third trimester pregnant women, postpartum women up to 10 days after giving birth and nonpregnant controls. The scans were performed at 09:00 after a 12 h fast. After the basal measurement was taken, gallbladder volumes were rescanned in 15 min intervals for 60 mins. At the end of this period, all volunteers received a standard liquid test meal, and scans were performed again for 1 h. The mean basal gallbladder volume was 22.2±4.2 mL in the nonpregnant (control) group. In the third trimester group, the basal volume was 37.8±10.5 mL – 70.5% higher than in the nonpregnant group (P<0.001). In the postpartum group, the mean basal volume was 37.9% lower (27.4±6.5 mL) than that of the third trimester group (P<0.02). This basal volume was 23.6% greater than that of the control group (P<0.05). After administration of a test meal, the postprandial gallbladder volumes decreased during the first few minutes compared with baseline values. The volumes decreased by 10.2% to 39.8% (23.5±7.3 to 34.0±10.2; P<0.01) in the third trimester group, by 14.9% to 43.2% (16.6±4.3 to 23.3±5.5; P<0.01, 0.001) in the postpartum group and by 19.2% to 51.6% (11.9±3.5 to 17.9±3.6; P<0.02, 0.05, 0.01, 0.001) in the control group. Postprandial mean gallbladder volumes of the third trimester (P<0.02) and postpartum groups (P<0.02 to 0.01) were significantly different from those of the control group. In conclusion, incomplete emptying of the gallbladder after eating during the third trimester of pregnancy may contribute to cholesterol-gallstone formation, and pregnancy may thus increase the risk of gallstones.

Download Full-text

Associations between Maternal Dietary Patterns and Infant Birth Weight in the NISAMI Cohort: A Structural Equation Modeling Analysis

Nutrients ◽

10.3390/nu13114054 ◽

2021 ◽

Vol 13 (11) ◽

pp. 4054

Author(s):

Jerusa da Mota Santana ◽

Valterlinda Alves de Oliveira Queiroz ◽

Marcos Pereira ◽

Enny S. Paixão ◽

Sheila Monteiro Brito ◽

...

Keyword(s):

Birth Weight ◽

Pregnant Women ◽

Dietary Patterns ◽

Dietary Pattern ◽

Structural Equation ◽

Third Trimester ◽

The Third ◽

Dietary Consumption ◽

The Mean ◽

Infant Birth

The mother’s diet during pregnancy is associated with maternal and child health. However, there are few studies with moderation analysis on maternal dietary patterns and infant birth weight. We aim to analyse the association between dietary patterns during pregnancy and birth weight. A prospective cohort study was performed with pregnant women registered with the prenatal service (Bahia, Brazil). A food frequency questionnaire was used to evaluate dietary intake. Birth weight was measured by a prenatal service team. Statistical analyses were performed using factor analysis with a principal component extraction technique and structural equation modelling. The mean age of the pregnant women was 27 years old (SD: 5.5) and the mean birth weight was 3341.18 g. It was observed that alcohol consumption (p = 0.05) and weight-gain during pregnancy (p = 0.05) were associated with birth weight. Four patterns of dietary consumption were identified for each trimester of the pregnancy evaluated. Adherence to the “Meat, Eggs, Fried Snacks and Processed foods” dietary pattern (pattern 1) and the “Sugars and Sweets” dietary pattern (pattern 4) in the third trimester directly reduced birth weight, by 98.42 g (Confidence interval (CI) 95%: 24.26, 172.59) and 92.03 g (CI 95%: 39.88, 165.30), respectively. It was also observed that insufficient dietary consumption in the third trimester increases maternal complications during pregnancy, indirectly reducing birth weight by 145 g (CI 95%: −21.39, −211.45). Inadequate dietary intake in the third trimester appears to have negative results on birth weight, directly and indirectly, but more studies are needed to clarify these causal paths, especially investigations of the influence of the maternal dietary pattern on the infant gut microbiota and the impacts on perinatal outcomes.

Download Full-text

Assessment of D-Dimer Levels in Southwestern Nigerian Pregnant Women

Advances in Research ◽

10.9734/air/2020/v21i930233 ◽

2020 ◽

pp. 60-68

Author(s):

E. O. Bamisaye ◽

M. A. Okungbowa ◽

D. T. Alade ◽

O. Brown- West ◽

G. T. Oluwasuji

Keyword(s):

Pregnant Women ◽

Teaching Hospital ◽

First Trimester ◽

Elevated Concentration ◽

Third Trimester ◽

Southwestern Nigeria ◽

Blood Samples ◽

The Third ◽

The Mean ◽

D Dimer

Aim: This study evaluated D-dimer level in pregnant and non-pregnant women in Southwestern Nigeria in order to provide more information on the concentration and liable risks in this region. Study Design: This is a cross sectional study where convenience sampling method was applied in sample collection. Place and Duration of Study: Blood samples were collected from pregnant women attending the antenatal clinics of Federal Teaching Hospital Ido-Ekiti (FETHI), Ekiti; Federal Medical Centre (FMC), Owo; and LAUTECH Teaching Hospital (LTH), Osogbo in Southwestern Nigeria. Methodology: Exactly three hundred pregnant (300) and one hundred and fifty (150) apparently healthy non pregnant women were recruited for this study. The blood samples were analysed for haematocrit (HCT) and platelet count using Sysmex KX-2IN (Japan); prothrombin time (PT) and activated partial thromboplastin time (APTT) by Diagen reagents (Diagnostic Ltd., UK); the international normalized ratio (INR) was calculated from the PT results; and D-dimer quantitative assay using Tina Quant Gen 2 on Cobas C111 (Roche). Data analysis was performed using IBM-SPSS version 25.0; mean and standard deviation was used to summarize continuous variables and descriptive and Inferential statistical tests were employed with level of statistical significance was determined at p<0.05. Results: The mean D-dimer levels were significantly higher in the pregnant women (0.87 ± 1.00 ugFEU/ml) than in controls (0.31 ± 0.22 ugFEU/ml) with 42% of the pregnant population having elevated concentration while the mean PT, INR and HCT were significantly higher in controls than the subjects (p<0.05).Furthermore, the HCT, platelet, PT and INR were observed to be highest at first trimester; 36.04±5.09 (L/L), 182.72±35.11 (x109/L), 11.80±1.86 (seconds) and 0.35±0.15 respectively, decreasing across the second and the third trimester. On the other hand, the D-dimer and APTT increased exponentially from the first trimester; 0.42±0.18 (ugFEU/ml) and 30.80±3.30 (seconds), through the second and third trimesters respectively (p>0.05). Conclusion: This study shows a significant increase in D-dimer in the pregnant subjects when compared with the control and an exponential increase in the third trimester, also a significant reduction in some other baseline coagulation profile hence depicting D-dimer as a notable significant marker of coagulation and fibrinolysis. This therefore emphasizes the hypercoagulable state of pregnancy and a need for adequate monitoring.

Download Full-text

Appraisal of A1c% level in healthy Sudanese pregnant women in reference to body mass index

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20191928 ◽

2019 ◽

Vol 8 (5) ◽

pp. 1835

Author(s):

Abdelgadir Ali Elmugadam ◽

Marwan Ismail ◽

Abdelgadir Eltom

Keyword(s):

Body Mass Index ◽

Pregnant Women ◽

Body Mass ◽

First Trimester ◽

The Body ◽

Control Group ◽

Third Trimester ◽

Significant Difference ◽

The Mean ◽

Mean Concentration

Background: Pregnancy is a major endocrine event in the female lifespan, involving wide-ranged and often dramatic changes in the metabolism of various hormones. Cross sectional, case control, analytical quantitative study was conducted in Sudan, Khartoum state in Yastabsheron obstetric hospital during the period from March to August 2011. Analytical and statistical methods were applied to measure the concentration of A1c% in healthy pregnant women as well as in healthy non-pregnant women to assess the difference in the results.Methods: Blood samples were taken from a total of 90 healthy pregnant women (case group) and 30 healthy non-pregnant women (control group), then samples were analyzed for A1c% by using affinity chromatography technique, and results were recorded in addition to their age, body mass index and the number of pregnancies.Results: showed that, the mean concentration of the A1c% in cases group was (4.407±1.054%) in first trimester, (4.797±0.631) % in second trimester and (4.833±0.626) % in third trimester, and (5.670±0.471%) in control group with a P value of 0.00, indicating the highly significant difference between the two groups. Others finding showed that the mean concentration of A1c% of the first trimester is lower than that of the second and third trimesters, also there was no significant difference between the mean concentration of the second and third trimester. A significant weak positive correlation between A1c% concentration with body mass index and the age of pregnant women.Conclusions: Healthy normal pregnant women have lower A1c% concentrations than non-pregnant women which can be impute to the reduce in plasma glucose values and to the shortened erythrocyte life span that can occur during pregnancy. The body mass index and age affect the concentration of A1c% c, but it is not affected by gravida.

Download Full-text

Circulating Platelet Aggregates in Normal Pregnancy and Rpeeclampsia

10.1055/s-0039-1684257 ◽

1979 ◽

Author(s):

I. Rákóczi ◽

F. Tallián ◽

I. Cseh ◽

I. Gáti

Keyword(s):

Pregnant Women ◽

Platelet Activation ◽

Normal Pregnancy ◽

Third Trimester ◽

The Third ◽

Platelet Aggregate ◽

Circulating Platelet Aggregates ◽

Platelet Aggregates ◽

The Mean

Circulating platelet aggregates have been observed in various thromboembolic states. It is known that severe preeclamsia is associated with features of intravascular coagulation. To evaluate the role of platelets in this disorder we have determined circulating platelet aggregates in 10 patients with severe preeclampsia, in 30 patients in the third trimester of uncomplicated pregnancies and in 35 healthy nonpregnant volunteers. Platelet aggregate ratio /P.A.R./ was measured by a modification of a method described by Wu and Hoak, The mean P.A.R. of severe preeclamptic patients /0.732 ± 0,063 SEM/ was significantly lower than that of the uncomplicated pregnant women /0,860 ± 0,052 SEM/ and of the nonpregnant volunteers /0.880 ± 0,061 SEM/.The results indicate that severe preeclamptic patients have increased levels of circulating platelet aggregates and platelet activation is a feature of preeclampsia.

Download Full-text

Pengaruh pemberian makanan tambahan (PMT) pada ibu hamil terhadap berat lahir bayi

Jurnal Gizi Klinik Indonesia ◽

10.22146/ijcn.18998 ◽

2014 ◽

Vol 11 (2) ◽

pp. 61

Author(s):

Hana Shafiyyah Zulaidah ◽

Istiti Kandarina ◽

Mohammad Hakimi

Keyword(s):

Birth Weight ◽

Treatment Group ◽

Antenatal Care ◽

Pregnant Women ◽

Comparison Group ◽

Supplementary Feeding ◽

Health Centers ◽

Third Trimester ◽

The Third ◽

The Mean

Background: Anemia causes fetal growth disorders that affect birth weight. Antenatal care (ANC) coverage and provision of high Fe if not followed by a decrease in the incidence of anemia can result indirectly in the risk of low birth weight. Supplementary feeding is expected to resolve the issue.Objective: To assess the effect of supplementary feeding on the third trimester of pregnancy on birth weight.Method: This was a quantitative study with a study design of quasi-experiment and non-equivalent control group. The given intervention was fish-processed feeding for 30 days. The study population was pregnant women in the third trimester in all health centers in the City of Yogyakarta and the samples were 104 pregnant women in some health centers with convenience sampling technique. The subjects were divided into two, namely the treatment group (PMT) and the comparison group (non-PMT). Birth weight was weighed immediately after the baby was born. Statistical analysis used t-test and logistic regression. Results: The mean birth weight of infants in the treatment group and the comparison group was 3248 g and 2974 g, respectively, so that the difference in the mean birth weight of both groups was 274 g (p=0.0002; 95%C:131-416). Thus, supplementary feeding was shown significantly affect the birth weight. The extraneous variables that significantly influenced birth weight were pregnancy interval. Other extraneous variables were age, mid-upper-arm circumference (MUAC), education, occupation, economic status, parity, protein intake, compliance of Fe tablet intake, antenatal care, gestational age at delivery and anemia status were not proven statistically significant to affect birth weight. Conclusion: Supplementary feeding effect on birth weight.

Download Full-text

Kombinasi Teknik Effleurage Massage dan Terapi Akupresur terhadap Nyeri Punggung Ibu Hamil Trimester III

Jurnal Bidan Cerdas (JBC) ◽

10.33860/jbc.v3i4.565 ◽

2021 ◽

Vol 3 (4) ◽

pp. 137-145

Author(s):

Arini Purnama Sari ◽

Farida Farida

Keyword(s):

Back Pain ◽

Data Collection ◽

Pregnant Women ◽

Wilcoxon Test ◽

Test Results ◽

Third Trimester ◽

Analog Scale ◽

The Third ◽

Quasi Experimental ◽

The Mean

Introduction: One of the complaints that is often felt by pregnant women in the third trimester is back pain. Back pain occurs in the lumbar sacral area and usually the pain will increase with gestational age. There are several non-pharmacological therapies that are often used to minimize pain, namely effleurage massage techniques and acupressure therapy. Purpose: This study was to determine the effect of the combination of effleurage massage technique and acupressure therapy on back pain in third trimester pregnant women. Methods: Quasi-experimental research method, one group pretest and posttest design. Samples were taken by purposive sampling obtained 24 third trimester pregnant women with back pain. Data collection was carried out in May-August 2021. Data collection used a numerical pain intensity questionnaire VAS (Visual Analog Scale) intensity (0-10). The effleurage massage technique was carried out in a right tilted position, then continued with acupressure therapy by pressing the BL 23 meridian point 3 times a week. Data analysis using Wilcoxon test. Results: There was a decrease in the mean of back pain before that was 2.83 and after 1.46 with a mean difference of 1.37. Wilcoxon test results obtained sig value is <0.0001. Conclusion: The combination of effleurage massage technique and acupressure therapy is effective in reducing back pain in third trimester pregnant women.

Download Full-text