scholarly journals Kinetic Studies of Fibrinogen in Pregnant Rabbits

1977 ◽  
Author(s):  
R.-M. Moeller ◽  
I. Mahn ◽  
G. Müller-Berqhaus

During gestation increased concentrations of fibrin (ogen)derivatives are observed indicative of intravascular action of thrombin. The aim of this study was to elucidate the kinetics of fibrinogen during gestation. The elimination of homologous 1-125-fibrinogen was studied in 14 pregnant rabbits during the first as well as during the third trimesters of gestation. Control studies were performed with 10 non-pregnant rabbits.The mean distribution volume of labeled fibrinogen did not significantly differ between pregnant and non-pregnant rabbits. During the third trimester pregnant rabbits demonstrated a pronounced shortening of T 1/2 of labeled fibrinogen from a mean of 55.3 hr during the first to a mean of 29.7 hr during the third trimester. The experiments showed a significant increase in the fractional catabolic rate from 45.0 to 69.9% per day in the course of gestation. The shortening of T 1/2 of labeled fibrinogen correlated to the number of fetusses per litter.This study indicates an average acceleration of the fibrinogen turnover during gestation of about 50%. These direct quantitative measurements demonstrate that fibrinogen catabolism is pronouncedly accelerated during pregnancy.

2013 ◽  
Vol 20 (3) ◽  
pp. 259-265
Author(s):  
Monica Vereş ◽  
Aurel Babeş ◽  
Szidonia Lacziko

Abstract Background and aims: Gestational diabetes represents a form of diabetes diagnosed during pregnancy that is not clearly overt diabetes. In the last trimester of gestation the growth of fetoplacental unit takes place, thus maternal hyperglycemia will determine an increased transplacental passage, hyperinsulinemia and fetal macrosomia. The aim of our study was that o analyzing the effect of maternal glycemia from the last trimester of pregnancy over fetal weight. Material and method: We run an observational study on a group of 46 pregnant women taken into evidence from the first trimester of pregnancy, separated in two groups according to blood glucose determined in the third trimester (before birth): group I normoglycemic and group II with hyperglycemia (>92mg/dl). Results: The mean value of third trimester glycemia for the entire group was of 87.13±22.03. The mean value of the glycemia determined in the third trimester of pregnancy was higher in the second group (109.17 mg/dl) in comparison to the first group (74.,21 mg/dl). The ROC curve for third trimester glycemia as fetal macrosomia appreciation test has an AUC of 0.517. Conclusions: Glycemia determined in the last trimester of pregnancy cannot be used alone as the predictive factor for fetal macrosomia.


2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Li-Xia Zhang ◽  
Ning Dong ◽  
Rui-Xia Yang ◽  
Ang Li ◽  
Xuan-Mei Luo ◽  
...  

AbstractObjectivesGestational thrombocytopenia (GT) is the most common cause of thrombocytopenia during pregnancy. However, the occurrence and severity of thrombocytopenia throughout pregnancy in Chinese women are not fully defined.MethodsWe analyzed platelet counts in Chinese women who received prenatal care and/or delivered at the First Affiliated Hospital with Nanjing Medical University between January 2, 2018 and July 19, 2018 in China. These platelet counts were compared with those of nonpregnant women in the same study period.ResultsThe platelet counts of all women continued to decrease significantly each trimester (p < 0.0001). The mean platelet counts of the 818 women who had pregnancy-related complications were lower than those of the 796 women who had uncomplicated pregnancies during the third trimester (p = 0.047). At the time of delivery, platelet counts less than 150 × 109/L were more common in women with pregnancy-related complications than in women with uncomplicated pregnancy (26.7% vs. 19.7%, p = 0.03).ConclusionsPlatelet counts decrease throughout pregnancy in Chinese women and platelet counts less than 150 × 109/L were more common in women with pregnancy-related complications than in women with uncomplicated pregnancy. The pregnant women should be paid more attention for thrombocytopenia to avoid the occurrence of bleeding events.


2012 ◽  
Vol 27 (7) ◽  
pp. 794 ◽  
Author(s):  
Young-Sun Park ◽  
Jeong-Kyu Hoh ◽  
Moon-Il Park

The main recombination reactions in the sulphur dioxide afterglow are shown to be O + SO 2 + M = SO 3 + M (1) and O + SO + M = SO 2 + M , (2) with rate constants of (4·7 ± 0·8) x 10 15 and (3·2 ± 0·4) x 10 17 cm 6 mole -2 s -1 respectively at 300°K for M = Ar. Reaction (2) is the dominant process removing sulphur monoxide (SO) which is otherwise remarkably unreactive. The absolute intensity of the sulphur dioxide afterglow is found to be I = 1·5 x 10 8 [O] [SO] cm 3 mole -1 s -1 for argon carriers at pressures between 0·25 an d 3·0 mmHg. The afterglow emission comes from three excited states of SO 2 . Spectroscopic and kinetic studies show that these are populated subsequent to or by the third order combination reaction (2). Excited SO 2 is removed mainly by electronic quenching.


Blood ◽  
2001 ◽  
Vol 98 (9) ◽  
pp. 2745-2751 ◽  
Author(s):  
Harry W. Schroeder ◽  
Liming Zhang ◽  
Joseph B. Philips

Abstract The mean distribution of lengths in the third complementarity-determining region of the heavy chain (HCDR3) serves as a measure of the development of the antibody repertoire during ontogeny. To determine the timing and pattern of HCDR3 length maturation during the third trimester of pregnancy, the mean distribution of HCDR3 lengths among variable-diversity-joining-constant–μ (VDJCμ) transcripts from the cord blood was analyzed from 138 infants of 23 to 40 weeks' gestation, including 3 sets of twins, 2 of which were of dizygotic origin. HCDR3 maturation begins at the start of the third trimester; follows a slow, continuous expansion over a 5-month period; and is unaffected by race or sex. The range and mean distribution of lengths may vary in dizygotic twins, indicating individual rates of development. The mean HCDR3 length distribution in 10 premature infants with documented bacterial sepsis was then followed for 2 to 12 weeks after their first positive blood culture. HCDR3 spectrotype analysis demonstrated oligoclonal B-cell activation and expansion after sepsis, but maturation of the repertoire was not accelerated even by the systemic exposure to external antigen represented by bacteremia. Antibody repertoire development appears to be endogenously controlled and adheres to an individualized developmental progression that probably contributes to the relative immaturity of the neonatal immune response.


The addition of molecular oxygen was found to increase the rate of rem oval of hydrogen atoms in a flow system at and below room temperature. Kinetic studies of this process using argon carrier showed that the rate-determining step is the third-order reaction H + O2 + Ar = HO 2 + Ar. (2) Atomic oxygen in small concentrations is produced in the system. Product analysis and measurements of oxygen atom concentrations indicated that the principal reactions removing HO 2 under these conditions are H+HO 2 = H 2 +O 2 , (12a) H+HO 2 = OH+OH, (12b) H+HO 2 = H 2 O+O 2 , (12c) A value for k 2 of 2.2 x 10 -32 cm 6 molecule -2 s -1 was determined at 293 °K. Reaction (2) was found to have a small negative temperature coefficient. These data and values of k 2 from explosion limit studies can be represented by the expression k 2 = 1.3 x 10 -33 exp (+ 1600 + 700/ RT ) cm 6 molecule -2 s -1 in the range 250 to 800 °K. The third-body efficiencies in reaction (2) at 293 °K of He and H 2 O relative to Ar are similar to those obtained from data on the second explosion limit at higher temperatures.


1963 ◽  
Vol 26 (2) ◽  
pp. 189-195 ◽  
Author(s):  
M. S. GREAVES ◽  
H. F. WEST

SUMMARY The concentration of cortisol and cortisone in mixed saliva has been measured in normal non-pregnant women, normal pregnant women in the third trimester of pregnancy and pregnant ones with mild toxaemia in the third trimester. The ratio of cortisol to cortisone was 1:4 for the non-pregnant and 1:5 for the pregnant women. The mean concentration of cortisol for the pregnant subjects was twice that of the non-pregnant and the mean concentration of cortisone three times that of the non-pregnant women. Filtration studies showed no significant binding of cortisol or cortisone in the saliva. It is concluded that the raised concentration of cortisol and cortisone in saliva indicates a raised concentration in the cells of the salivary gland. If this rise is common to the connective tissues generally it provides a reasonable explanation for the remission of rheumatoid arthritis experienced by some patients in the latter months of pregnancy.


Author(s):  
Maryam Hasani ◽  
Afsaneh Keramat ◽  
Raziyeh Maasoumi ◽  
Maryam Farjamfar ◽  
Masud Yunesian ◽  
...  

Objectives: Sexual life may change during pregnancy. Due to negative attitudes toward having sex, unpleasant feeling, and fear of several issues, women might avoid vaginal intercourse during pregnancy. Therefore, the present systematic review aimed to investigate the frequency of vaginal intercourse in pregnancy. Materials and Methods: Comprehensive literature review was conducted to find the relevant articles published (from December 1990 to April 2018) on the issue including observational studies (e.g., cross-sectional and cohort studies) that certainly determined the mean frequency of vaginal sex throughout pregnancy. In this regard, online international databases such as ISI, PubMed, Scopus, Cochrane, and Google Scholar were independently explored and checked by two authors. Duplicate articles were removed by the EndNote X7 Reference Manager. The results were analyzed using RevMan 5.3 software. The P < 0.05 was considered significant. Results: Totally, after excluding the duplicate and irrelevant articles based on having the mean frequency of vaginal intercourse during pregnancy, 13 articles were obtained. The range of vaginal intercourse frequency varied from 6.01 to 21 times every month pre-pregnancy, 3.67-9.87 times monthly in the first trimester, 2.78-7.21 times monthly in the second trimester, and 1.35-5.9 times monthly in the third trimester. Five out of the 13 selected articles reporting the mean and standard deviation were entered the current meta-analysis. The frequency of vaginal intercourse was obtained 7.75 (7.13-8.38) times monthly prior to pregnancy, 4.16 (3.86-4.46) times in the first trimester, 6.37 (5.60-7.14) times monthly in the second trimester, and 1.81 (1.49-2.13) times monthly in the third trimester. Conclusions: Generally, the frequency of vaginal intercourse decreased in the first trimester while increasing in the second trimester. However, a sharp decline was observed between the second and third trimesters of pregnancy.


2020 ◽  
Vol 2 (1) ◽  
pp. 29-34
Author(s):  
Riza Amalia ◽  
Rusmini Rusmini ◽  
Diki Retno Yuliani

Anxiety in pregnant women often occurs in the third trimester. Anxiety results in prolonged labor, premature birth, LBW (Low Birth Weight). To prevent and reduce anxiety, prenatal yoga as an alternative therapy is given to primigravida pregnant women in the third trimester.The puropose of this study is to find out the influence of prenatal yoga toward anxiety level primigravida in the third trimester in Puskesmas I Kembaran, Banyumas District. This study used quasy experimental with pretest posttest design. The sample in this study are all of primigravida in third trimester, there are 24 pregnant woman in Puskesmas 1 Kembaran. The results showed there were differences in primigravida in third trimester anxiety levels before and after prenatal yoga with p value = 0,000 (p 0.05). There is an influence of prenatal yoga on the level of anxiety primigravida in third trimester. There is a change in the mean level of anxiety of 11,3. 


Author(s):  
Masoomeh Shirzaiy ◽  
Zohreh Dalirsani

Abstract Objectives During pregnancy, systemic physiological alterations lead to some changes in the oral cavity, which could prepare the mouth environment for oral and dental problems. This study was aimed to investigate salivary α-amylase, sialic acid levels, and pH levels in pregnant and nonpregnant females. Materials and Methods In this analytical, case–control study, unstimulated saliva samples were collected with spiting method from 35 pregnant women (case group) and 35 nonpregnant women (control group) and transferred to the laboratory to assess salivary α-amylase, sialic acid, and pH levels. Data were analyzed by SPSS (version: 19) software through statistical methods of independent t-test and analysis of variance. Results The mean sialic acid levels were 2.285 ± 1.230 mg/dL in pregnant and 2.744 ± 1.326 in nonpregnant women without any significant difference (p = 0.138). The mean salivary α-amylase concentrations were 2.461 ± 1.869 U/L and 2.439 ± 2.058 U/L, respectively, in pregnant and nonpregnant women, with no significant difference (p = 0.963).The mean salivary pH in nonpregnant women was significantly more than that in pregnant women (7.845 ± 0.430 and 6.868 ± 0.413, respectively) (p < 0.001). Also, the mean salivary pH levels in pregnant women were 7.474 ± 0.420 in the first trimester, 6.868 ± 0.413 in the second trimester, and 6.568 ± 0.387 in the third trimester, which were significantly different (p < 0.001). Conclusion Salivary sialic acid and α-amylase levels among pregnant women were no different from those of other subjects. During pregnancy, the salivary pH significantly reduced, and the mean salivary pH during pregnancy had a decreasing trend from the first trimester to the third trimester.


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