A simple method for estimating association constants between monoclonal antibodies and derivatized or native antigens
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Abstract We describe a simple method for estimating the association constant between an antibody and an antigen, based on a theoretical treatment of experimental dose-response data. We used this method to calculate the association constants of an anti-progesterone monoclonal antibody for native progesterone and for progesterone 11 alpha-hemisuccinate. These association constants provide a quantitative measure of the bridging-group recognition by the antibody.
1986 ◽
Vol 32
(10)
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pp. 1873-1878
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2000 ◽
Vol 41
(4-5)
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pp. 301-308
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2020 ◽
Vol 20
(16)
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pp. 1895-1907
2021 ◽
Vol 21
(2)
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pp. 320-347
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1994 ◽
Vol 21
(2)
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pp. 171-178
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2004 ◽
Vol 67
(9)
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pp. 2024-2032
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