Sex-dependent association between day-by-day morning blood pressure variability and common carotid artery intima-media thickness: the J-HOP study

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
M Nagai ◽  
S Hoshide ◽  
K Kario
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
High Risk ◽  
Carotid Artery ◽  
Common Carotid Artery ◽  
Blood Pressure Variability ◽  
Intima Media Thickness ◽  
Home Blood Pressure ◽  
Media Thickness ◽  
Day By Day

Abstract Background Day-by-day home systolic blood pressure variability (BPV) was shown to be associated with increased common carotid artery (CCA) intima-media thickness (IMT) in the hypertensives. Recently, 24 hour ambulatory BPV was revealed to serve as an indicator of higher CCA-IMT only in males. However, there have been no studies that reported the sex-dependent relationship between day-by-day BPV and CCA-IMT. Purpose We assessed the hypothesis that day-by-day BPV was associated with higher CCA-IMT in the Japanese males at high-risk of cardiovascular disease. Methods Among 4310 patients with one or more cardiovascular risks recruited for the Japan Morning Surge-Home Blood Pressure Study, carotid ultrasound in CCA was performed in the 1365 patients (mean age 65.6 years old, male 52%). The home blood pressure (BP) readings during mean 11.2 days were used to calculate home mean levels and variability in morning systolic BP (SBP). Day-by-day BPV was measured as standard deviation [SD] and delta (maximum-minimum) in SBP. Results Average mean CCA-IMT of left and right side was 1.046±0.4mm. Mean (r=0.118, p<0.0001), SD (r=0.120, p<0.0001) and delta (r=0.149, p<0.0001) in morning SBP were significantly correlated with CCA-IMT. In the multiple regression analysis adjustment for confounders including age, gender, body mass index, total cholesterol, high density lipoprotein and mean morning SBP, SD (B: 0.008, 95% CI: 0.001–0.015, p<0.05) or delta (B: 0.004, 95% CI: 0.002–0.006, p<0.001) in morning SBP each had a significant association with CCA-IMT. According to the gender, SD (p<0.01) or delta (p<0.01) in morning SBP each was significantly associated with CCA-IMT only in the male group while neither SD (p=0.4) nor delta (p=0.4) in morning SBP was associated with CCA-IMT in the female group. Conclusions In addition to the conventional risk factors, day-by-day morning SBP variability was a significant indicator of increased CCA-IMT in the high-risk Japanese population. The significant relationship between day-by-day morning SBP variability and CCA-IMT was observed only in the males. Gender specific impact of day-by-day morning home systolic BPV on carotid artery atherosclerosis should be taken into account in the high-risk elderly at cardiovascular disease. Funding Acknowledgement Type of funding source: None

scholarly journals Age, gender and hypertension as major risk factors in development of subclinical atherosclerosis

2013 ◽  
Vol 3 (1) ◽  
pp. 26-29
Author(s):  
Ajla Rahimić Ćatić ◽  
Sandra Vegar Zubović ◽  
Jasminka Ðelilović Vranić ◽  
Svjetlana Lozo
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Carotid Artery ◽  
Early Detection ◽  
Common Carotid Artery ◽  
Carotid Atherosclerosis ◽  
Heart Diseases ◽  
Subclinical Atherosclerosis ◽  
Intima Media Thickness ◽  
Media Thickness

Introduction: Intima-media thickness (IMT) measurement of the common carotid artery (CCA) is considered as useful indicator of carotid atherosclerosis. Early detection of atherosclerosis and its associated risk factors is important to prevent stroke and heart diseases. The aim of the present study was to investigate which risk factors are better determinants of subclinical atherosclerosis, measured by common carotidartery intima media thickness (CCA-IMT).Methods: A total of 74 subjects were randomly selected in this cross – sectional study. Information on the patient’s medical history and laboratory fi ndings were obtained from their clinical records. Risk factors relevant to this study were age, gender, cigarette smoking status, diabetes, hypertension and dyslipidemia. Ultrasound scanning of carotid arteries was performed with a 7,5 MHz linear array transducer (GE Voluson730 pro). The highest value of six common carotid artery measurements was taken as the fi nal IMT. Increased CCA-IMT was defi ned when it was > 1 mm.Results: Our data demonstrated higher CCA-IMT values in male patients compared with female patients. Increased CCA-IMT was the most closely related to age (P<0.001), followed by systolic blood pressure (P=0.001), diastolic blood pressure (P=0.003) and glucose blood level (P=0.048).Conclusion: Age, gender and hypertension are the most important risk factors in development of carotid atherosclerosis. Early detection of atherosclerosis among high-risk populations is important in order to prevent stroke and heart diseases, which are leading causes of death worldwide.

scholarly journals Time Rate of Blood Pressure Variation Is Associated With Increased Common Carotid Artery Intima-Media Thickness

Hypertension ◽  
2005 ◽  
Vol 45 (4) ◽  
pp. 505-512 ◽  
Author(s):  
Nikos A. Zakopoulos ◽  
Georgios Tsivgoulis ◽  
Gerassimos Barlas ◽  
Christos Papamichael ◽  
Konstantinos Spengos ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Carotid Artery ◽  
Common Carotid Artery ◽  
Intima Media Thickness ◽  
Pressure Variation ◽  
Time Rate ◽  
Media Thickness ◽  
Blood Pressure Variation

Effects of blood pressure lowering with amlodipine or lisinopril on vascular structure of the common carotid artery

2001 ◽  
Vol 101 (5) ◽  
pp. 455-464 ◽  
Author(s):  
Alice V. STANTON ◽  
Jeremy N. CHAPMAN ◽  
Jamil MAYET ◽  
Peter S. SEVER ◽  
Neil R. POULTER ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Carotid Artery ◽  
Common Carotid Artery ◽  
Enzyme Inhibitor ◽  
Intima Media Thickness ◽  
Treated Group ◽  
Treatment Regimens ◽  
Media Thickness ◽  
Increased Risk ◽  
The Common

Increased intima-media thickness of the common carotid artery predicts increased risk of myocardial infarction and stroke. Preliminary evidence suggests that a decrease in blood pressure (BP) is associated with diminished wall thickness. It is not known if all classes of anti-hypertensive agents have similar protective effects. In this double-blind parallel-group clinical trial, 69 previously untreated patients with hypertension were allocated randomly to 1 year of treatment with either amlodipine (5-10mg daily) or lisinopril (5-20mg daily). Doxazosin and bendrofluazide were added if required to achieve BP control. After 12 months of treatment, clinic BP, ambulatory BP and cardiac mass were reduced similarly by the two treatment regimens. Common carotid artery intima-media thickness decreased by 0.048mm (95% confidence intervals -0.066, -0.031mm) in the amlodipine-treated group, but decreased by only 0.027 mm (-0.046, -0.007mm) in the lisinopril-treated group (P < 0.05 for difference between treatments). Common carotid artery lumen diameter declined significantly only in patients treated with lisinopril [amlodipine, -0.02mm (-0.14, 0.10mm); lisinopril, -0.21mm (-0.32, -0.11mm); P < 0.02], while intima-media area declined similarly in the two treatment groups [amlodipine -1.32mm2 (-1.91, -0.74mm2), lisinopril -1.26mm2 (-1.80, -0.72mm2); not significant]. The results confirm that a decrease in BP causes regression of structural changes in the carotid artery in hypertensive patients. The nature of the structural regression differed markedly between the two treatment regimens, in spite of similar decreases in BP. The calcium channel blocker induced greater regression of common carotid artery intima-media thickness than the angiotensin-converting enzyme inhibitor. However, carotid artery wall mass, as indicated by intima-media area, was reduced to a similar extent by the two treatments. It remains to be established whether such differences confer a prognostic advantage.

Application of the Measurement of Carotid Intima-Media Thickness for Prediction of the Essential Hypertension in Children

2018 ◽  
Vol 69 (6) ◽  
pp. 1550-1553
Author(s):  
Rosana Manea ◽  
Bianca Elena Popovici ◽  
Carmen Daniela Neculoiu ◽  
Dan Minea ◽  
Alina Calin
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Carotid Artery ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Diagnostic Methods ◽  
Control Group ◽  
Study Group ◽  
Media Thickness ◽  
Hypertension In Children

Hypertension is a major risk factor for progression of the atherosclerotic process and for developing of degenerative cardiovascular diseases in adulthood. The aim of this study is to evaluate how the measurement of carotid intima - media thickness for prediction of essential hypertension in children can be used.The study group included 81 children and the control group 61 children, all aged between 5 - 17 years and 11 months old, and admitted in Children Hospital Brasov in the period of 2009 � 2014. The study protocol included: BMI, blood pressure and Doppler echography of the common carotid artery for each group. Mean age of the patients from the study group was 13.67 years, 43.20 % girls and 56.80 % boys, while in the control group, the mean age was 14.07 years, 54.10% girls and 45.90 % boys. 70.37% of the children from the study group presented obesity, while in the control group 40.98% were obese. The IMTC study group ranged from 0.52 - 0.69 mm and the limits of the normotensive subjects were 0.32 -0.54 mm. In both groups the obese patients were found to have increased carotid artery intima-media, which means that IMTC was positively correlated with BMI (p=0.000001).It is necessary to identify diagnostic methods easily applicable for children, allowing involvement of the characteristics of the arterial wall in the degenerative pathological processes. Increased intima-media ratio is positively correlated with high values of blood pressure.

Short-term beat-to-beat but not ambulatory blood pressure variability is correlated to carotid intima-media thickness

2014 ◽  
Vol 19 (5) ◽  
pp. 288-293 ◽  
Author(s):  
Efstathios Manios ◽  
Fotios Michas ◽  
Kimon Stamatelopoulos ◽  
Gerasimos Barlas ◽  
Eleni Koroboki ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Ambulatory Blood Pressure ◽  
Blood Pressure Variability ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Short Term ◽  
Media Thickness
Sign in / Sign up

Export Citation Format

Share Document