scholarly journals ECG-AI: electrocardiographic artificial intelligence model for prediction of heart failure

2021 ◽  
Author(s):  
Oguz Akbilgic ◽  
Liam Butler ◽  
Ibrahim Karabayir ◽  
Patricia P Chang ◽  
Dalane W Kitzman ◽  
...  
Keyword(s):  
Neural Network ◽  
Artificial Intelligence ◽  
Heart Failure ◽  
Convolutional Neural Network ◽  
Prediction Models ◽  
Smoking Status ◽  
Characteristic Curve ◽  
Gradient Boosting ◽  
Model Output ◽  
Light Gradient

Abstract Aims Heart failure (HF) is a leading cause of death. Early intervention is the key to reduce HF-related morbidity and mortality. This study assesses the utility of electrocardiograms (ECGs) in HF risk prediction. Methods and results Data from the baseline visits (1987–89) of the Atherosclerosis Risk in Communities (ARIC) study was used. Incident hospitalized HF events were ascertained by ICD codes. Participants with good quality baseline ECGs were included. Participants with prevalent HF were excluded. ECG-artificial intelligence (AI) model to predict HF was created as a deep residual convolutional neural network (CNN) utilizing standard 12-lead ECG. The area under the receiver operating characteristic curve (AUC) was used to evaluate prediction models including (CNN), light gradient boosting machines (LGBM), and Cox proportional hazards regression. A total of 14 613 (45% male, 73% of white, mean age ± standard deviation of 54 ± 5) participants were eligible. A total of 803 (5.5%) participants developed HF within 10 years from baseline. Convolutional neural network utilizing solely ECG achieved an AUC of 0.756 (0.717–0.795) on the hold-out test data. ARIC and Framingham Heart Study (FHS) HF risk calculators yielded AUC of 0.802 (0.750–0.850) and 0.780 (0.740–0.830). The highest AUC of 0.818 (0.778–0.859) was obtained when ECG-AI model output, age, gender, race, body mass index, smoking status, prevalent coronary heart disease, diabetes mellitus, systolic blood pressure, and heart rate were used as predictors of HF within LGBM. The ECG-AI model output was the most important predictor of HF. Conclusions ECG-AI model based solely on information extracted from ECG independently predicts HF with accuracy comparable to existing FHS and ARIC risk calculators.

scholarly journals Convolutional Neural Network Classifies Pathological Voice Change in Laryngeal Cancer with High Accuracy

2020 ◽  
Vol 9 (11) ◽  
pp. 3415
Author(s):  
HyunBum Kim ◽  
Juhyeong Jeon ◽  
Yeon Jae Han ◽  
YoungHoon Joo ◽  
Jonghwan Lee ◽  
...  
Keyword(s):  
Neural Network ◽  
Convolutional Neural Network ◽  
Sensitivity And Specificity ◽  
Laryngeal Cancer ◽  
Healthy Subjects ◽  
Gradient Boosting ◽  
Support Vector ◽  
Vowel Sound ◽  
Light Gradient ◽  
Extreme Gradient Boosting

Voice changes may be the earliest signs in laryngeal cancer. We investigated whether automated voice signal analysis can be used to distinguish patients with laryngeal cancer from healthy subjects. We extracted features using the software package for speech analysis in phonetics (PRAAT) and calculated the Mel-frequency cepstral coefficients (MFCCs) from voice samples of a vowel sound of /a:/. The proposed method was tested with six algorithms: support vector machine (SVM), extreme gradient boosting (XGBoost), light gradient boosted machine (LGBM), artificial neural network (ANN), one-dimensional convolutional neural network (1D-CNN) and two-dimensional convolutional neural network (2D-CNN). Their performances were evaluated in terms of accuracy, sensitivity, and specificity. The result was compared with human performance. A total of four volunteers, two of whom were trained laryngologists, rated the same files. The 1D-CNN showed the highest accuracy of 85% and sensitivity and sensitivity and specificity levels of 78% and 93%. The two laryngologists achieved accuracy of 69.9% but sensitivity levels of 44%. Automated analysis of voice signals could differentiate subjects with laryngeal cancer from those of healthy subjects with higher diagnostic properties than those performed by the four volunteers.

scholarly journals Automatic Detection of Small Intestinal Hookworms in Capsule Endoscopy Images Based on a Convolutional Neural Network

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Tao Gan ◽  
Yulin Yang ◽  
Shuaicheng Liu ◽  
Bing Zeng ◽  
Jinlin Yang ◽  
...  
Keyword(s):  
Neural Network ◽  
Artificial Intelligence ◽  
Small Bowel ◽  
Convolutional Neural Network ◽  
Capsule Endoscopy ◽  
High Speed ◽  
Characteristic Curve ◽  
Area Under The Curve ◽  
Intelligence System ◽  
Sensitivity Specificity

Ancylostomiasis is a fairly common small bowel parasite disease identified by capsule endoscopy (CE) for which a computer-aided clinical detection method has not been established. We sought to develop an artificial intelligence system with a convolutional neural network (CNN) to automatically detect hookworms in CE images. We trained a deep CNN system based on a YOLO-V4 (You Look Only Once-Version4) detector using 11236 CE images of hookworms. We assessed its performance by calculating the area under the receiver operating characteristic curve and its sensitivity, specificity, and accuracy using an independent test set of 10,529 small-bowel images including 531 images of hookworms. The trained CNN system required 403 seconds to evaluate 10,529 test images. The area under the curve for the detection of hookworms was 0.972 (95% confidence interval (CI), 0.967-0.978). The sensitivity, specificity, and accuracy of the CNN system were 92.2%, 91.1%, and 91.2%, respectively, at a probability score cut-off of 0.485. We developed and validated a CNN-based system for detecting hookworms in CE images. By combining this high-accuracy, high-speed, and oversight-preventing system with other CNN systems, we hope it will become an important supplement for detecting intestinal abnormalities in CE images. This trial is registered with ChiCTR2000034546 (a clinical research of artificial-intelligence-aided diagnosis for hookworms in small intestine by capsule endoscope images).

scholarly journals Development and Evaluation of an AI System for COVID-19 Diagnosis

2020 ◽  
Author(s):  
Cheng Jin ◽  
Weixiang Chen ◽  
Yukun Cao ◽  
Zhanwei Xu ◽  
Xin Zhang ◽  
...  
Keyword(s):  
Neural Network ◽  
Artificial Intelligence ◽  
Early Detection ◽  
Convolutional Neural Network ◽  
Operating Characteristic ◽  
Characteristic Curve ◽  
Chest Ct ◽  
Large Dataset ◽  
Operating Characteristic Curve ◽  
Timely Treatment

AbstractEarly detection of COVID-19 based on chest CT will enable timely treatment of patients and help control the spread of the disease. With rapid spreading of COVID-19 in many countries, however, CT volumes of suspicious patients are increasing at a speed much faster than the availability of human experts. Here, we propose an artificial intelligence (AI) system for fast COVID-19 diagnosis with an accuracy comparable to experienced radiologists. A large dataset was constructed by collecting 970 CT volumes of 496 patients with confirmed COVID-19 and 260 negative cases from three hospitals in Wuhan, China, and 1,125 negative cases from two publicly available chest CT datasets. Trained using only 312 cases, our diagnosis system, which is based on deep convolutional neural network, is able to achieve an accuracy of 94.98%, an area under the receiver operating characteristic curve (AUC) of 97.91%, a sensitivity of 94.06%, and a specificity of 95.47% on an independent external verification dataset of 1,255 cases. In a reader study involving five radiologists, only one radiologist is slightly more accurate than the AI system. The AI system is two orders of magnitude faster than radiologists and the code is available at https://github.com/ChenWWWeixiang/diagnosis_covid19.

scholarly journals Convolutional Neural Network-Based Artificial Intelligence for Classification of Protein Localization Patterns

Biomolecules ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 264
Author(s):  
Kaisa Liimatainen ◽  
Riku Huttunen ◽  
Leena Latonen ◽  
Pekka Ruusuvuori
Keyword(s):  
Neural Network ◽  
Artificial Intelligence ◽  
Convolutional Neural Network ◽  
High Throughput ◽  
Protein Function ◽  
Protein Localization ◽  
Convolutional Network ◽  
High Throughput Analysis ◽  
Fully Convolutional Network

Identifying localization of proteins and their specific subpopulations associated with certain cellular compartments is crucial for understanding protein function and interactions with other macromolecules. Fluorescence microscopy is a powerful method to assess protein localizations, with increasing demand of automated high throughput analysis methods to supplement the technical advancements in high throughput imaging. Here, we study the applicability of deep neural network-based artificial intelligence in classification of protein localization in 13 cellular subcompartments. We use deep learning-based on convolutional neural network and fully convolutional network with similar architectures for the classification task, aiming at achieving accurate classification, but importantly, also comparison of the networks. Our results show that both types of convolutional neural networks perform well in protein localization classification tasks for major cellular organelles. Yet, in this study, the fully convolutional network outperforms the convolutional neural network in classification of images with multiple simultaneous protein localizations. We find that the fully convolutional network, using output visualizing the identified localizations, is a very useful tool for systematic protein localization assessment.

scholarly journals Comparison of deep learning with traditional models to predict preventable acute care use and spending among heart failure patients

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
M Lewis ◽  
J Figueroa
Keyword(s):  
Heart Failure ◽  
Deep Learning ◽  
Prediction Models ◽  
Evaluation Metrics ◽  
Gradient Boosting ◽  
Learning Models ◽  
Private Company ◽  
Preventable Hospitalizations ◽  
Targeted Interventions ◽  
Ed Visits

Abstract   Recent health reforms have created incentives for cardiologists and accountable care organizations to participate in value-based care models for heart failure (HF). Accurate risk stratification of HF patients is critical to efficiently deploy interventions aimed at reducing preventable utilization. The goal of this paper was to compare deep learning approaches with traditional logistic regression (LR) to predict preventable utilization among HF patients. We conducted a prognostic study using data on 93,260 HF patients continuously enrolled for 2-years in a large U.S. commercial insurer to develop and validate prediction models for three outcomes of interest: preventable hospitalizations, preventable emergency department (ED) visits, and preventable costs. Patients were split into training, validation, and testing samples. Outcomes were modeled using traditional and enhanced LR and compared to gradient boosting model and deep learning models using sequential and non-sequential inputs. Evaluation metrics included precision (positive predictive value) at k, cost capture, and Area Under the Receiver operating characteristic (AUROC). Deep learning models consistently outperformed LR for all three outcomes with respect to the chosen evaluation metrics. Precision at 1% for preventable hospitalizations was 43% for deep learning compared to 30% for enhanced LR. Precision at 1% for preventable ED visits was 39% for deep learning compared to 33% for enhanced LR. For preventable cost, cost capture at 1% was 30% for sequential deep learning, compared to 18% for enhanced LR. The highest AUROCs for deep learning were 0.778, 0.681 and 0.727, respectively. These results offer a promising approach to identify patients for targeted interventions. FUNDunding Acknowledgement Type of funding sources: Private company. Main funding source(s): internally funded by Diagnostic Robotics Inc.

scholarly journals Pemanfaatan Asynchronous Advantage Actor-Critic Dalam Pembuatan AI Game Bot Pada Game Arcade

2019 ◽  
Vol 1 (2) ◽  
pp. 74-84
Author(s):  
Evan Kusuma Susanto ◽  
Yosi Kristian
Keyword(s):  
Neural Network ◽  
Artificial Intelligence ◽  
Reinforcement Learning ◽  
Convolutional Neural Network ◽  
Short Term Memory ◽  
Trial And Error ◽  
Short Term ◽  
Term Memory ◽  
Memory Network ◽  
Long Short Term Memory

Asynchronous Advantage Actor-Critic (A3C) adalah sebuah algoritma deep reinforcement learning yang dikembangkan oleh Google DeepMind. Algoritma ini dapat digunakan untuk menciptakan sebuah arsitektur artificial intelligence yang dapat menguasai berbagai jenis game yang berbeda melalui trial and error dengan mempelajari tempilan layar game dan skor yang diperoleh dari hasil tindakannya tanpa campur tangan manusia. Sebuah network A3C terdiri dari Convolutional Neural Network (CNN) di bagian depan, Long Short-Term Memory Network (LSTM) di tengah, dan sebuah Actor-Critic network di bagian belakang. CNN berguna sebagai perangkum dari citra output layar dengan mengekstrak fitur-fitur yang penting yang terdapat pada layar. LSTM berguna sebagai pengingat keadaan game sebelumnya. Actor-Critic Network berguna untuk menentukan tindakan terbaik untuk dilakukan ketika dihadapkan dengan suatu kondisi tertentu. Dari hasil percobaan yang dilakukan, metode ini cukup efektif dan dapat mengalahkan pemain pemula dalam memainkan 5 game yang digunakan sebagai bahan uji coba.

scholarly journals A hybrid of convolutional neural network and long short-term memory network approach to predictive maintenance

2022 ◽  
Vol 12 (1) ◽  
pp. 721
Author(s):  
Ahmed Nasser ◽  
Huthaifa AL-Khazraji
Keyword(s):  
Neural Network ◽  
Convolutional Neural Network ◽  
Short Term Memory ◽  
Predictive Maintenance ◽  
Fault Prediction ◽  
Gradient Boosting ◽  
Short Term ◽  
Term Memory ◽  
Memory Network ◽  
Long Short Term Memory

<p>Predictive maintenance (PdM) is a successful strategy used to reduce cost by minimizing the breakdown stoppages and production loss. The massive amount of data that results from the integration between the physical and digital systems of the production process makes it possible for deep learning (DL) algorithms to be applied and utilized for fault prediction and diagnosis. This paper presents a hybrid convolutional neural network based and long short-term memory network (CNN-LSTM) approach to a predictive maintenance problem. The proposed CNN-LSTM approach enhances the predictive accuracy and also reduces the complexity of the model. To evaluate the proposed model, two comparisons with regular LSTM and gradient boosting decision tree (GBDT) methods using a freely available dataset have been made. The PdM model based on CNN-LSTM method demonstrates better prediction accuracy compared to the regular LSTM, where the average F-Score increases form 93.34% in the case of regular LSTM to 97.48% for the proposed CNN-LSTM. Compared to the related works the proposed hybrid CNN-LSTM PdM approach achieved better results in term of accuracy.</p>

scholarly journals Algorithmic and data modeling: Will algorithmic modeling improve predictions of traits evaluated on ordinal scales?

2020 ◽  
Author(s):  
Zhanyou Xu ◽  
Andreomar Kurek ◽  
Steven B. Cannon ◽  
Williams D. Beavis
Keyword(s):  
Support Vector Machine ◽  
Random Forest ◽  
Ridge Regression ◽  
Genomic Prediction ◽  
Ordinal Data ◽  
Prediction Models ◽  
Characteristic Curve ◽  
Gradient Boosting ◽  
Support Vector ◽  
Data Types

AbstractSelection of markers linked to alleles at quantitative trait loci (QTL) for tolerance to Iron Deficiency Chlorosis (IDC) has not been successful. Genomic selection has been advocated for continuous numeric traits such as yield and plant height. For ordinal data types such as IDC, genomic prediction models have not been systematically compared. The objectives of research reported in this manuscript were to evaluate the most commonly used genomic prediction method, ridge regression and it’s equivalent logistic ridge regression method, with algorithmic modeling methods including random forest, gradient boosting, support vector machine, K-nearest neighbors, Naïve Bayes, and artificial neural network using the usual comparator metric of prediction accuracy. In addition we compared the methods using metrics of greater importance for decisions about selecting and culling lines for use in variety development and genetic improvement projects. These metrics include specificity, sensitivity, precision, decision accuracy, and area under the receiver operating characteristic curve. We found that Support Vector Machine provided the best specificity for culling IDC susceptible lines, while Random Forest GP models provided the best combined set of decision metrics for retaining IDC tolerant and culling IDC susceptible lines.

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