scholarly journals Left atrial stiffness index is associated with metabolic syndrome and independently related to urine albumin-creatinine ratio in young subjects with hypertension

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
E.I Bazdyreva ◽  
N Ezhova ◽  
I.A Khomova ◽  
E.K Shavarova ◽  
Z.D Kobalava
Keyword(s):  
Blood Pressure ◽  
Regression Analysis ◽  
Left Atrial ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Left Ventricular ◽  
Stiffness Index ◽  
Albumin Creatinine Ratio ◽  
Young Subjects ◽  
Left Atrial Stiffness

Abstract Background and objective Left atrial (LA) functional decline seems to be the earliest sign of hypertension-related heart damage detectable with echocardiography for the moment. Left atrial stiffness index (LASI) is a novel index reflecting both LA function and LA–left ventricular (LV) coupling. Early detection of hypertension-mediated organ damage (HMOD) is critically important in clinical decision making in certain groups of patients, such as young persons with first time diagnosed HTN. We intended to analyze the relations of LASI with office and 24 hours blood pressure levels and HMOD characteristics in subjects with HTN aged of 18 to 45 years. Methods We included 78 young subjects (median of age 23 [21; 25] years, mean BMI 25,9±4,7 kg/m2, median 24 hours systolic blood pressure (SBP) and diastolic blood pressure (DBP) 134,0 [128,8; 143,3] and 79,5 [74,0; 88,0] mm Hg, respectively) with HTN diagnosed with 24-hours ambulatory blood pressure monitoring (ABPM) according to ESH guidelines criteria (2018). Most patients (73%) had masked HTN. We performed routine clinical evaluation, including registration of anthropometric characteristics and blood and urine tests, central pulse wave assessment with applanation tonometry and echocardiography including two-dimensional speckle tracking. LASI was calculated as E/e$'$ to left atrial longitudinal strain during reservoir phase (LASr) ratio. We performed correlation analysis and multiple linear regression analysis to investigate the relationship between LASI, LASr and variables indicating presence of HMOD. Results Correlation analysis did not reveal any significant associations of LASI and LASR with office and ambulatory BP values. Both LASI and LASr were correlated with age, body mass index (BMI), waist circumference (WC) (r=0,312, p<0,05 and (−0,354), p<0,01) and HOMA-IR (r=0,551, p<0,001 and (−0,345), p<0,01). LASI had stronger correlation with albumin-creatinine ratio (ACR) than LASr (r=0,550, p<0,001 vs (−0,288), p<0,05, respectively). Glomerular filtration rate (GFR) was associated with LASI: r=−0,329, p<0,01 but not with LASr. Left ventricular mass index (LVMI) also had a significant correlation with LASI only: r=0,284, p<0,05 as had carotid-femoral pulse wave velocity (cfPWV): r=0,275, p<0,05. We performed multiple linear regression analysis in which LASI remained related to ACR independently of age, sex, BMI, WC, HOMA-IR, GFR and 24 hours SBP and DBP (β=0,306, p<0,05) while LASr lost the association. The link between LASI and other HMOD markers (GFR, cfPWV, LVMI) got insignificant in multiple regression analysis. Conclusion Early left atrial functional impairment is associated with overweight, abdominal obesity and insulin resistance in young never treated patients with HTN, while impact of elevated BP in HTN of low grades seems to be not so important. LASI in contrast with LASr is independently related to albuminuria but not with other HMOD markers FUNDunding Acknowledgement Type of funding sources: Public grant(s) – National budget only. Main funding source(s): RFBRRUDN University program 5-100

Abstract MP68: The Correlation Between Left Atrial-left Ventricular-arterial Coupling And Circadian Rhythm Of Blood Pressure In Hypertension

Hypertension ◽  
2021 ◽  
Vol 78 (Suppl_1) ◽  
Author(s):  
Yan Liu ◽  
Qiaobing Sun ◽  
Yixiao Zhao ◽  
Yinong Jiang
Keyword(s):  
Blood Pressure ◽  
Regression Analysis ◽  
Circadian Rhythm ◽  
Linear Regression ◽  
Left Atrial ◽  
Linear Regression Analysis ◽  
Left Ventricular ◽  
Multivariate Linear Regression ◽  
Multivariate Linear Regression Analysis ◽  
Left Ventricular Arterial Coupling

The Correlation between Left Atrial-Left Ventricular-Arterial Coupling and Circadian Rhythm of Blood Pressure in Hypertension Objective: Hypertension induces left atrial (LA) and left ventricular (LV) dysfunction, and arterial stiffness increased. In this study, we further investigated the association between LA-LV-arterial coupling and circadian rhythm of blood pressure (BP) in essential hypertension (HT). Design and Methods: We enrolled 289 HT patients which were evaluated by 2 dimensional speckle tracking echocardiography (2D-STE), ambulatory 24-hour BP monitoring (ABPM) and carotid-femoral pulse wave velocity (PWV). According to BP patterns, these patients were divided into two groups, which included dippers (n=109), patients with a >10% reduction in BP at nighttime; non-dippers (n=180), patients with a <10% reduction in BP at nighttime. 2D-STE based LA and LV strains were studied and the following parameters were measured, LV global longitudinal strain (GLS), LA reservoir strain (LA S-S ), LA conduit strain (LA S-E ), and LA booster pump strain (LA S-A ). LA stiffness index (LASI) defined as the ratio of E/e' to LA S-S , and PWV-to-GLS ratio (PWV/GLS) were calculated to reflect LA-LV-arterial coupling. Furthermore, we also explored the correlation between LASI (or PWV/GLS) and ambulatory blood pressure indexes. The related factors were evaluated by multivariate linear regression analysis to find the independent factors. Results: LASI was significantly higher in non-dippers (0.35±0.24) than dippers (0.29±0.12) ( p <0.05). PWV/GLS was significantly higher in non-dippers (-90.30±34.13) than dippers (-79.62±25.84) ( p <0.05). LA S-S , LA S-A and LV GLS were significantly lower in non-dippers than dippers ( p <0.05). Multivariate linear regression analysis revealed that LV mass index (LVMI), PWV/GLS, nighttime mean SBP (n-SBP) and nighttime mean DBP (n-DBP) were independently correlated with LASI; LASI and n-SBP were independently correlated with PWV/GLS. Conclusions: LA and LV myocardial mechanics, and LA-LV-arterial coupling were associated with circadian rhythm of BP. Nocturnal systolic BP was the independent risk factor of abnormal LA-LV-arterial coupling in HT.

scholarly journals Gender is a determinant of carotid artery stiffness independent of age and blood pressure

2021 ◽  
Vol 94 (1119) ◽  
pp. 20200796
Author(s):  
Zhenzhen Wang ◽  
Wei Li ◽  
Wei Liu ◽  
Jiawei Tian
Keyword(s):  
Blood Pressure ◽  
Regression Analysis ◽  
Carotid Artery ◽  
Linear Regression ◽  
Arterial Stiffness ◽  
Multiple Linear Regression ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Stiffness Index ◽  
Males And Females

Objective: To identify the gender-specific differences in carotid artery structural and stiffening parameters by radiofrequency ultrasound (RFU) with an automatic arterial stiffness analyzing system. Methods: Seventy-two consecutive individuals (32 males and 40 females, age range from 36 to 62 years) with no history of significant cardiovascular diseases or carotid artery plaques were enrolled between September and December 2017. Quality intima-media thickness (QIMT) and quality arterial stiffness (QAS) parameters were automatically computed, including pulse wave velocity (PWV), vascular distension, compliance coefficient (CC), distensibility coefficient (DC), stiffness index α and β, augmentation pressure (AP), and augmentation index (AIx). Those parameters were compared between males and females. Multiple linear regression analysis was performed to assess the independent association between gender and RFU parameters. Results: The mean age had no difference between males and females (47.8 ± 3.3 vs 50.0 ± 8.5 years, p = 0.19). Females had higher systolic blood pressure (134.53 ± 9.65 vs 127.78 ± 6.12 mm Hg) and diastolic blood pressure (85.83 ± 3.94 vs 78.03 ± 5.22 mm Hg), greater carotid QIMT (598.73 ± 72.16 vs 550.84 ± 29.37 µm), advanced PWV (8.08 ± 1.60 vs 6.24 ± 0.70 m/s), higher stiffness index α (6.21 ± 1.94 vs 3.95 ± 0.78) and β (9.43 ± 3.17 vs 6.38 ± 0.78), higher AP (6.68 ± 2.24 vs 3.64 ± 1.22 mm Hg) and AIx (7.42 ± 2.08 vs 4.69 ± 1.26%), all p < 0.001. Multiple linear regression analysis demonstrated gender was independently associated with carotid structural and elastic parameters. Conclusion: Gender independently impacts carotid structure and function, with females more vulnerable to the progression of arterial aging. Awareness of the gender differences on the risk stratification of carotid artery disease will benefit reliable assessments and specific management recommendations in clinical practice. Advances in knowledge: (1) RFU provides an μm-unit quality IMT measurement and multiple quality arterial stiffness parameters. (2) Gender is an independent determinant in both the arterial structural and elastic aspects, with females of stiffer arteries in low CVD risk individuals.

scholarly journals Impact of body mass index on left atrial dimension in HOCM patients

Open Medicine ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. 207-216
Author(s):  
Yue Zhou ◽  
Miao Yu ◽  
Jingang Cui ◽  
Shengwen Liu ◽  
Jiansong Yuan ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Regression Analysis ◽  
Body Mass ◽  
Left Atrial ◽  
Independent Predictor ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Hypertrophic Obstructive Cardiomyopathy ◽  
Left Ventricular ◽  
Normal Weight

Abstract Background Substantial studies have demonstrated that left atrial (LA) enlargement was a robust predictor of atrial fibrillation (AF) and obesity was a modifiable risk factor for cardiovascular diseases. However, the role of body mass index (BMI) on LA dimension in hypertrophic obstructive cardiomyopathy (HOCM) remains unclear. Methods A total of 423 HOCM patients (average BMI 25.4 ± 3.4 kg/m2) were recruited for our study. Participants were stratified into three groups based on BMI: normal weight (BMI < 23 kg/m2), overweight (BMI 23–27.5 kg/m2), and obesity (BMI ≥ 27.5 kg/m2). Results Compared with normal weight, patients with obesity had significantly lower prevalence of syncope (p = 0.007) and moderate or severe mitral regurgitation (p = 0.014), and serum NT-proBNP (p = 0.004). Multiple linear regression analysis indicated that BMI (β = 0.328, p < 0.001), log NT-proBNP (β = 0.308, p < 0.001), presence of AF (β = 0.209, p = 0.001), and left ventricular diastolic diameter index (β = 0.142, p = 0.019) were independently related with LA diameter. However, BMI was not an independent predictor of the presence of AF on multivariable binary logistical regression analysis. Conclusions BMI was independently associated with LA diameter; however, it was not an independent predictor of prevalence of AF. These results suggest that BMI may promote incidence of AF through LA enlargement in HOCM.

scholarly journals Comparing differences and correlation between 24-hour ambulatory blood pressure and office blood pressure monitoring in patients with untreated hypertension

2021 ◽  
Vol 49 (6) ◽  
pp. 030006052110161
Author(s):  
Zhenhong Zhang ◽  
Shunyin Wang ◽  
Junru Yan ◽  
Zhiwen Xu ◽  
Dongliang Liang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Regression Analysis ◽  
Linear Regression ◽  
Ambulatory Blood Pressure ◽  
Blood Pressure Monitoring ◽  
Linear Regression Analysis ◽  
Fasting Blood Glucose ◽  
Left Ventricular ◽  
Office Blood Pressure ◽  
Pressure Index

Objective We assessed differences and correlations between 24-hour ambulatory blood pressure (ABP) and office blood pressure (OBP) monitoring. Methods We conducted an observational study among 85 untreated patients with essential hypertension and measured 24-hour ABP, OBP, target organ damage (TOD) markers, and metabolism indexes. Variance analysis and the Pearson method were used to compare differences and correlation between the two methods. The Spearman or Pearson method was applied to compare the correlation between TOD markers, blood pressure index, and metabolism index. Linear regression analysis was applied to estimate the quantitative relationship between the blood pressure index and TOD markers. Results There were significant differences in the mean and variance of systolic blood pressure (SBP) and diastolic blood pressure and a positive correlation between ABP and OBP. Correlations between the left ventricular mass index (LVMI) and average ambulatory SBP, daytime ambulatory SBP, nighttime ambulatory SBP, and fasting blood glucose were significant. Correlations between left intima-media thickness (IMT) and average ambulatory SBP, nighttime ambulatory SBP, right IMT, and nighttime ambulatory SBP were significant. In linear regression analysis of the LVMI (y) and ambulatory SBP (x), the equation was expressed as y = 0.637*x. Conclusion Nighttime ambulatory SBP may be an optimal predictor of TOD.

scholarly journals Analysis of the chemerin and resistin adipokines in children and adolescents

2020 ◽  
Vol 66 (3) ◽  
pp. 300-306
Author(s):  
Vanessa S. Fontes ◽  
Kácia Mateus ◽  
Michele P. Netto ◽  
Renata M. S. Oliveira ◽  
George L. L. Machado-Coelho ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Regression Analysis ◽  
Linear Regression ◽  
Children And Adolescents ◽  
Blood Pressure Measurement ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Excess Weight ◽  
Cross Sectional ◽  
Significance Level

SUMMARY OBJECTIVES To compare the serum concentrations of adipokines resistin and chemerin in children and adolescents with eutrophic and overweight and to evaluate their relationship with anthropometric, biochemical, and blood pressure variables. METHODS a cross-sectional epidemiological study was conducted with 234 students enrolled in public elementary schools in the city of Juiz de Fora / MG. Anthropometric evaluation, biochemistry, and blood pressure measurement were performed. Statistical analyzes included the Student-t or Mann-Whitney tests, Pearson or Spearman correlation, used according to the distribution of the variables, and linear regression analysis, by means of the evaluation of the effect of the independent variables on the serum levels of chemerin and resistin, adjusted for age and sex. For the data analysis, SPSS® software version 21.0 and STATA® version 10.1 were used, assuming a significance level of 5%. RESULTS the concentrations of chemerin were higher in eutrophic individuals than in those with excess weight (p> 0.05). In contrast, levels of resistin were higher in the young with excess weight than in the eutrophic ones (p <0.05). In the multiple linear regression analysis, the levels of chemerin were associated with the values of resistin, systolic, and diastolic blood pressure. Resistance levels maintained association only with BMI and chemerin values. CONCLUSION the adipokines analyzed presented a distinct profile in the groups of children and adolescents with eutrophic and overweight.

scholarly journals Effect of slow breathing on the blood pressure and the Valsalva ration in prehypertensive Indian students

Biologija ◽  
2019 ◽  
Vol 65 (2) ◽  
Author(s):  
Iryna Oleksandrivna Yepryntseva ◽  
Larisa Semyonovna Shchyrova ◽  
Vera Evgenievna Shekh
Keyword(s):  
Blood Pressure ◽  
Regression Analysis ◽  
Linear Regression ◽  
Linear Regression Analysis ◽  
Surrogate Marker ◽  
Multiple Linear Regression Analysis ◽  
Valsalva Manoeuvre ◽  
Stepwise Multiple Linear Regression ◽  
Slow Breathing ◽  
Indian Students

The purpose of this study was to evaluate the effect of slow breathing and prehypertension (PHT) on cardiovascular and HRV variables and on the Valsalva ratio (VR). ECG was recorded in 39 normotensives and 35 prehypertensives at 5 min resting and slow breathing (6 breaths/min) stages to obtain HR, LF and HF power; SBP and DBP were recorded at the end of each stage. The Valsalva manoeuvre was performed after resting and slow breathing stages. Two-way repeated MANOVA was used to test for the effects of PHT and slow breathing. Stepwise multiple linear regression analysis was used to reveal predictors of HR, SBP and DBP. The normotensives and the prehypertensives demonstrated reduction of SBP during slow breathing (117.95 ± 0.73 vs. 115.18 ± 0.91 mm Hg, P = 0.001 and 130.09 ± 0.08 vs. 125.91 ± 0.96 mm Hg, P < 0.001, respectively). At rest, the VR was lower in prehypertensives (1.69 ± 0.05 vs. 1.87 ± 0.05, P = 0.009). After slow breathing, the VR increased significantly only in prehypertensives (P = 0.008), it was no longer different from that of normotensives (1.82 ± 0.06 vs. 1.90 ± 0.06, P = 0.346). The LnLF power, interpreted according to our hypothesis described previously as sympathoinhibition, increased in both groups. Slow breathing reduced SBP in normotensives and prehypertensives as a result of an increase in sympathoinhibition in both groups and VR, considered as a surrogate marker of the baroreflex activity, in prehypertensives.

scholarly journals Association of serum and aqueous humor myonectin concentrations with diabetic retinopathy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Huibo Sun ◽  
Zhongtao Li ◽  
Wenchao Hu ◽  
Wenjie Ma
Keyword(s):  
Blood Pressure ◽  
Diabetic Retinopathy ◽  
Regression Analysis ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Aqueous Humor ◽  
Proliferative Diabetic Retinopathy ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Duration Of Disease

AbstractMyonectin, a newly discovered myokine, enhances fatty acid uptake in cultured adipocytes and hepatocytes and suppresses circulating levels of free fatty acids in mice. This study is performed to evaluate the association between serum and aqueous humor myonectin concentrations with diabetic retinopathy (DR). This study was performed in a population of 228 patients with type 2 diabetes (T2DM) and 72 control subjects. Diabetic patients were then divided into T2DM patients without DR, non-proliferative diabetic retinopathy (NPDR) patients, and proliferative diabetic retinopathy (PDR) patients. Serum and aqueous humor myonectin concentrations were significantly lower in the case group than in the control group. PDR patients showed significantly decreased serum and aqueous humor myonectin concentrations than in the other two T2DM patients. In addition, NPDR patients showed significantly lower serum and aqueous humor myonectin concentrations than T2DM patients without DR. Logistic regression analysis demonstrated that serum and aqueous humor myonectin was correlated with a decreased risk of T2DM and DR. Simple linear regression analysis showed that serum myonectin was negatively correlated with duration of disease, body mass index (BMI), and HbA1c. Duration of disease and BMI were still correlated with the serum myonectin after a multiple linear regression analysis. Aqueous humor myonectin was negatively correlated with duration of disease, systolic blood pressure (SBP), and diastolic blood pressure. Duration of disease and SBP was still correlated with the aqueous humor myonectin after a multiple linear regression analysis. Our investigation indicates an inverse association of serum and aqueous humor myonectin with DR.

ANALISIS PENGARUH INFLASI, KURS DAN IHSG TERHADAP RETURN REKSA DANA SAHAM PT NIKKO SECURITIES INDONESIA PERIODE 2014-2017

2019 ◽  
Vol 2 (2) ◽  
pp. 103
Author(s):  
Muhammad Rois Rois ◽  
Manarotul Fatati Fatati ◽  
Winda Ihda Magfiroh
Keyword(s):  
Regression Analysis ◽  
Exchange Rate ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Stock Price ◽  
Price Index ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Equity Fund ◽  
Stock Price Index

This study aims to determine the effect of Inflation, Exchange Rate and Composite Stock Price Index (IHSG) to Return of PT Nikko Securities Indonesia Stock Fund period 2014-2017. The study used secondary data obtained through documentation in the form of PT Nikko Securities Indonesia Monthly Net Asset (NAB) report. Data analysis is used with quantitative analysis, multiple linear regression analysis using eviews 9. Population and sample in this research are PT Nikko Securities Indonesia. The result of multiple linear regression analysis was the coefficient of determination (R2) showed the result of 0.123819 or 12%. This means that the Inflation, Exchange Rate and Composite Stock Price Index (IHSG) variables can influence the return of PT Nikko Securities Indonesia's equity fund of 12% and 88% is influenced by other variables. Based on the result of the research, the variables of inflation and exchange rate have a negative and significant effect toward the return of PT Nikko Securities Indonesia's equity fund. While the variable of Composite Stock Price Index (IHSG) has a negative but not significant effect toward Return of Equity Fund of PT Nikko Securities Indonesia

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