scholarly journals Impact of body mass index on left atrial dimension in HOCM patients

Open Medicine ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. 207-216
Author(s):  
Yue Zhou ◽  
Miao Yu ◽  
Jingang Cui ◽  
Shengwen Liu ◽  
Jiansong Yuan ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Regression Analysis ◽  
Body Mass ◽  
Left Atrial ◽  
Independent Predictor ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Hypertrophic Obstructive Cardiomyopathy ◽  
Left Ventricular ◽  
Normal Weight

Abstract Background Substantial studies have demonstrated that left atrial (LA) enlargement was a robust predictor of atrial fibrillation (AF) and obesity was a modifiable risk factor for cardiovascular diseases. However, the role of body mass index (BMI) on LA dimension in hypertrophic obstructive cardiomyopathy (HOCM) remains unclear. Methods A total of 423 HOCM patients (average BMI 25.4 ± 3.4 kg/m2) were recruited for our study. Participants were stratified into three groups based on BMI: normal weight (BMI < 23 kg/m2), overweight (BMI 23–27.5 kg/m2), and obesity (BMI ≥ 27.5 kg/m2). Results Compared with normal weight, patients with obesity had significantly lower prevalence of syncope (p = 0.007) and moderate or severe mitral regurgitation (p = 0.014), and serum NT-proBNP (p = 0.004). Multiple linear regression analysis indicated that BMI (β = 0.328, p < 0.001), log NT-proBNP (β = 0.308, p < 0.001), presence of AF (β = 0.209, p = 0.001), and left ventricular diastolic diameter index (β = 0.142, p = 0.019) were independently related with LA diameter. However, BMI was not an independent predictor of the presence of AF on multivariable binary logistical regression analysis. Conclusions BMI was independently associated with LA diameter; however, it was not an independent predictor of prevalence of AF. These results suggest that BMI may promote incidence of AF through LA enlargement in HOCM.

scholarly journals Left Atrial Deformation And Risk of Transient Ischemic Attack And Stroke In Paroxysmal Atrial Fibrillation

2021 ◽  
Author(s):  
Jian Chen ◽  
Ying Zhao ◽  
Changsheng Ma ◽  
Xin Du ◽  
Yihua He
Keyword(s):  
Atrial Fibrillation ◽  
Body Mass Index ◽  
Regression Analysis ◽  
Linear Regression ◽  
Body Mass ◽  
Left Atrial ◽  
Speckle Tracking ◽  
Linear Regression Analysis ◽  
Volume Index ◽  
Chamber View

Abstract Left atrial (LA) remodeling is closely related to cerebral stroke, but the relationship between impaired deformability of LA in early stages and stroke/TIA is not clear. The aim of this study was to evaluate the changes of LA deformability and its relationship with stroke/TIA events by using Speckle Tracking echocardiography. In 365 patients with paroxysmal atrial fibrillation (AF) (318, Non stroke/TIA; 47, stroke/TIA), comprehensive echocardiography was performed by using speckle tracking imaging to calculate mean LA longitudinal strain and strain rate values from apical four chamber view, apical two chamber view and apical three cavity view. The patients in stroke/TIA group had greater ages, a greater proportion of men and lower LA strain rate during left ventricular (LV) early diastole (SRE), and the difference was statistically significant(p<0.05). In the univariate linear regression analysis, the following clinical and conventional echocardiographic parameters each had a significant linear correlation with SRE(p<0.001), they were E/A ratio, LA volume index, body mass index, mean E/e′, LV ejection fraction, age, proportion of hypertension. Through a multiple linear regression analysis, the results show that there is a linear dependence between SRE and E/A ratio, LA volume index and Body mass index. The regression equation is y=-1.430-0.394X1+0.012X2+0.019X3(p<0.001) (y,SRE; X1,E/A ratio; X2,LA volume index; X3,Body mass index).In the multivariate logistic regression analyses, SRE and Sex ratio were independently risk factors stroke/TIA. (SRE, OR 2.945, 95% CI 1.092-7.943, p= 0.033; Sex, OR 0.462, 95% CI 0.230-0.930, p = 0.031)In patients with paroxysmal AF, SRE could reflect the impaired deformability of LA in early stages, and it was associated with the risk of stroke/TIA.

Positive Association Between Body Mass Index and Hematologic Parameters, Including RBC, WBC and Platelet Count, in Korean Children and Adolescent

2021 ◽  
Author(s):  
Hwal Rim Jeong ◽  
Young Seok Shim
Keyword(s):  
Body Mass Index ◽  
Children And Adolescents ◽  
Body Mass ◽  
Linear Regression Analysis ◽  
Positive Association ◽  
Multiple Linear Regression Analysis ◽  
Normal Weight ◽  
Overweight And Obesity ◽  
Korean Children ◽  
Children And Adolescent

Abstract Objective: To investigate the associations between hematologic parameters and obesity in children and adolescents.Methods: A total of 7,997 subjects (4,259 boys, 3,738 girls) aged 10–18 years was enrolled and hematologic parameters, including WBC, RBC, Hb, Hct, and platelet levels, were recorded and compared against body mass index (BMI) classified into normal-weight, overweight, and obesity groups.Results : The obesity group had significantly higher mean levels of WBC (7.16 vs. 6.16 (x103/mm3), p<0.001), RBC (4.90 vs. 4.82 (x106/mm3), p<0.001), Hb (14.07 vs. 13.99 (g/dL), p<0.05), Hct (42.31 vs. 41.91 (%), p<0.001) and platelets (311.87 vs. 282.66 (x103/mm3), p<0.001) than the normal-weight group after adjusting for obesity and sex. BMI SDS was significantly positively associated with WBC (β=0.275, p<0.001), RBC (β=0.028, p<0.001), Hb (β=0.034, p<0.001), Hct (β=0.152, p<0.001), and platelets (β=8.372, p<0.001) after adjusting for age, sex, and possible socioeconomic confounders in a multiple linear regression analysis.Conclusion: Higher BMI is associated with elevated WBC, RBC, Hb, Hct and platelet counts in children and adolescents. Because higher hematologic parameters are potential risk factors for obesity-related morbidity, more attention should be paid to evaluating and interpreting hematologic parameters in children and adolescents with obesity

scholarly journals Left atrial stiffness index is associated with metabolic syndrome and independently related to urine albumin-creatinine ratio in young subjects with hypertension

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
E.I Bazdyreva ◽  
N Ezhova ◽  
I.A Khomova ◽  
E.K Shavarova ◽  
Z.D Kobalava
Keyword(s):  
Blood Pressure ◽  
Regression Analysis ◽  
Left Atrial ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Left Ventricular ◽  
Stiffness Index ◽  
Albumin Creatinine Ratio ◽  
Young Subjects ◽  
Left Atrial Stiffness

Abstract Background and objective Left atrial (LA) functional decline seems to be the earliest sign of hypertension-related heart damage detectable with echocardiography for the moment. Left atrial stiffness index (LASI) is a novel index reflecting both LA function and LA–left ventricular (LV) coupling. Early detection of hypertension-mediated organ damage (HMOD) is critically important in clinical decision making in certain groups of patients, such as young persons with first time diagnosed HTN. We intended to analyze the relations of LASI with office and 24 hours blood pressure levels and HMOD characteristics in subjects with HTN aged of 18 to 45 years. Methods We included 78 young subjects (median of age 23 [21; 25] years, mean BMI 25,9±4,7 kg/m2, median 24 hours systolic blood pressure (SBP) and diastolic blood pressure (DBP) 134,0 [128,8; 143,3] and 79,5 [74,0; 88,0] mm Hg, respectively) with HTN diagnosed with 24-hours ambulatory blood pressure monitoring (ABPM) according to ESH guidelines criteria (2018). Most patients (73%) had masked HTN. We performed routine clinical evaluation, including registration of anthropometric characteristics and blood and urine tests, central pulse wave assessment with applanation tonometry and echocardiography including two-dimensional speckle tracking. LASI was calculated as E/e$'$ to left atrial longitudinal strain during reservoir phase (LASr) ratio. We performed correlation analysis and multiple linear regression analysis to investigate the relationship between LASI, LASr and variables indicating presence of HMOD. Results Correlation analysis did not reveal any significant associations of LASI and LASR with office and ambulatory BP values. Both LASI and LASr were correlated with age, body mass index (BMI), waist circumference (WC) (r=0,312, p&lt;0,05 and (−0,354), p&lt;0,01) and HOMA-IR (r=0,551, p&lt;0,001 and (−0,345), p&lt;0,01). LASI had stronger correlation with albumin-creatinine ratio (ACR) than LASr (r=0,550, p&lt;0,001 vs (−0,288), p&lt;0,05, respectively). Glomerular filtration rate (GFR) was associated with LASI: r=−0,329, p&lt;0,01 but not with LASr. Left ventricular mass index (LVMI) also had a significant correlation with LASI only: r=0,284, p&lt;0,05 as had carotid-femoral pulse wave velocity (cfPWV): r=0,275, p&lt;0,05. We performed multiple linear regression analysis in which LASI remained related to ACR independently of age, sex, BMI, WC, HOMA-IR, GFR and 24 hours SBP and DBP (β=0,306, p&lt;0,05) while LASr lost the association. The link between LASI and other HMOD markers (GFR, cfPWV, LVMI) got insignificant in multiple regression analysis. Conclusion Early left atrial functional impairment is associated with overweight, abdominal obesity and insulin resistance in young never treated patients with HTN, while impact of elevated BP in HTN of low grades seems to be not so important. LASI in contrast with LASr is independently related to albuminuria but not with other HMOD markers FUNDunding Acknowledgement Type of funding sources: Public grant(s) – National budget only. Main funding source(s): RFBRRUDN University program 5-100

scholarly journals Body mass index and weight status misperception among a sample of college students in Yogyakarta, Indonesia

2017 ◽  
Vol 16 (2) ◽  
pp. 225-232
Author(s):  
Janatin Hastuti ◽  
Neni Trilusiana Rahmawati ◽  
Rusyad Adi Suriyanto
Keyword(s):  
College Students ◽  
Body Mass Index ◽  
Regression Analysis ◽  
Body Mass ◽  
Weight Control ◽  
Weight Status ◽  
Medical Science ◽  
Normal Weight ◽  
Ordinal Regression ◽  
Ordinal Regression Analysis

Background: Weight status perception associates with objective weight status and is important in the management of weight control. To date, perception of weight status among Indonesian youths has not been reported.Objectives: This study aimed to examine the association between body mass index and weight status perception in a sample of college students in Yogyakarta Province.Materials and Methods: A sample of 209 boys and 269 girls of college students in Yogyakarta Province were measured for their stature and body weight. Body mass index was calculated (BMI). Data of demographic, exercise, and diet were collected. Weight status perception was based on participant responses to a question regarding how they classified their own body size as underweight, normal, overweight, or obese. Ordinal regression analysis was performed to evaluate factors associated with weight status misperception among boys and girls.Results: Overall, 43.5% of boys and 37.5% of girls misclassified their own weight status by actual BMI. Of particular note, 75.9% of obese boys and 78.6% of obese girls underestimated their weight status as overweight or normal weight. Whereas, 9.1% and 23.4% of normal weight boys and girls respectively, overestimated their weight status. Ordinal regression analysis revealed that, weight status misperception from others was significantly contributed (p<0.01) to misperception of weight status among boys and girls with OR of 10.31 and 8.13 respectively. Diet practicing was significantly correlated with weight status misperception in boys (p<0.05) with an OR of 19.57.Conclusions: Weight status misperception was prevalent among normal weight and obese students. Obese students of both gender and normal weight boys tended to underestimate their weight status, whereas normal weight girls were likely to overestimate their weight status.Bangladesh Journal of Medical Science Vol.16(2) 2017 p.225-232

Aerobic Capacity, Obesity, and Atherosclerotic Risk Factors in Male Adolescents

PEDIATRICS ◽  
1985 ◽  
Vol 75 (5) ◽  
pp. 813-818
Author(s):  
Raymond R. Fripp ◽  
James L. Hodgson ◽  
Peter O. Kwiterovich ◽  
John C. Werner ◽  
H. Gregg Schuler ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Regression Analysis ◽  
Body Mass ◽  
Linear Regression Analysis ◽  
Density Lipoprotein ◽  
Plasma Triglyceride ◽  
Lipoprotein Cholesterol ◽  
Atherosclerotic Risk Factors

Correlations between aerobic capacity, obesity, and atherosclerotic risk factors were evaluated in adolescents with low-to-moderate levels of physical fitness. Subjects with higher levels of fitness had a more favorable risk profile with decreased body mass index, lower systolic and diastolic blood pressure and plasma triglyceride levels, and higher plasma high-density lipoprotein-cholesterol levels. Simple linear regression analysis revealed an association between body mass index and blood pressure, plasma triglyceride and plasma highdensity lipoprotein-cholesterol. The level of aerobic fitness as determined by exercise duration was also associated with the same atherosclerotic risk factors. However, multiple linear regression analysis demonstrated that body mass index provided the largest explanation, by those variables examined, of the interindividual variance in blood pressure, plasma triglyceride, and high-density lipoprotein-cholesterol. Aerobic fitness contributed only minimally to the variation in these risk factors. These findings suggest that if aerobic conditioning is used to modify atherosclerotic risk factors, it should be accompanied by a reduction in weight in adolescents with low-to-moderate levels of physical fitness.

Serum myonectin is increased after laparoscopic sleeve gastrectomy

2020 ◽  
Vol 57 (5) ◽  
pp. 360-364
Author(s):  
Lei Li ◽  
Qianqian Wang ◽  
Chengkun Qin
Keyword(s):  
Body Mass Index ◽  
Regression Analysis ◽  
Sleeve Gastrectomy ◽  
Linear Regression ◽  
Laparoscopic Sleeve Gastrectomy ◽  
Body Mass ◽  
Linear Regression Analysis ◽  
Acid Uptake ◽  
Model Assessment ◽  
Obese Patients

Objective Myonectin, a newly discovered myokine, enhances fatty acid uptake in cultured adipocytes and hepatocytes and suppresses circulating levels of free fatty acids in mice. Recent studies showed that serum myonectin concentration is negatively correlated with obesity. This study was undertaken to evaluate the change of serum myonectin in obese patients after laparoscopic sleeve gastrectomy. Methods This study was performed in a population of 42 obese and 58 control subjects from April of 2018 to December of 2019. All obese subjects underwent laparoscopic sleeve gastrectomy. Anthropometric measurements, lipid profiles, HbA1c and serum myonectin were assessed at baseline and six months after laparoscopic sleeve gastrectomy. Results Serum myonectin concentrations were significantly lower in the obese patients than in the controls. Serum myonectin concentrations were increased at six months after laparoscopic sleeve gastrectomy. Simple linear regression analysis indicated that serum myonectin was negatively correlated with weight, waist circumference, hip circumference, body mass index, fasting plasma glucose, homeostasis model assessment of insulin resistance and HbA1c. Only body mass index was still inversely correlated with serum myonectin after multiple linear regression analysis. Conclusion Serum myonectin is correlated with obesity and increased after laparoscopic sleeve gastrectomy.

scholarly journals Effect of weight loss on early left atrial myopathy in obese patients without known cardiovascular disease

2021 ◽  
Vol 22 (Supplement_2) ◽  
Author(s):  
O Deal ◽  
J Rayner ◽  
A Stracquadanio ◽  
R Wijesurendra ◽  
S Neubauer ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Body Mass Index ◽  
Weight Loss ◽  
Body Mass ◽  
Left Atrial ◽  
Normal Weight ◽  
Obese Patients ◽  
Weight Loss Intervention ◽  
Reservoir Function ◽  
Lv Mass

Abstract Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): BHF & NIHR BRC Introduction Obesity is strongly associated with increased risk of heart failure and ischaemic stroke independently of associated co-morbidities. Left atrial (LA) reservoir dysfunction, a marker of atrial distensibility and compliance, is an early pathophysiological change which precedes the onset of cardiovascular disease in patients with obesity. It is unclear whether a weight loss intervention may be sufficient to reverse LA reservoir dysfunction. Purpose To longitudinally assess whether a weight loss intervention normalizes LA reservoir function by cardiac magnetic resonance (CMR) feature-tracking in patients with obesity and only subclinical cardiovascular disease and compared this age and sex matched non-obese normal weight controls. Methods A total of 45 patients with severe obese (age = 45 ± 11 years, body mass index = 39.1 ± 6.7 kg/m2, 51 ± 18 kg of excess body weight [EBW], 67% female) underwent CMR for quantification of LA and left ventricular (LV) size and function before and a median of 373 days following weight loss intervention. Weight loss was achieved by means of a very-low calorie diet (N = 28; 800 kcal/day) or by bariatric surgery (N = 17). A total of N = 27 non-obese healthy controls (age = 41 ± 12 years, body mass index = 22.3 ± 2.4 kg/m2, 75% female) underwent the same CMR protocol once. Results At baseline, patients with obesity displayed signs of atrial myopathy with increased LA volume and reduced LA reservoir function as compared to normal-weight controls (both P &lt; 0.05, Figure 1) alongside increased LV mass and hyper-normal LV ejection fraction [LVEF] (both p &lt; 0.01). As expected, weight loss led to a significant reduction of LA volume and LV mass with normalization of LVEF regardless of the degree of weight loss achieved (all P &lt; 0.05, Figure 2). By contrast, only a large weight loss (&gt;46.6% EBW, in red in Figure 2) was sufficient to improve and normalize the LA reservoir function (P &lt; 0.05, Figure 2).  On the other hand, moderate or milder weight loss (in orange and red) had no significant effect on LA reservoir function (both P &gt; 0.05). Conclusion Successful weight loss can completely revert early LA myopathic phenotype in obese patients without known cardiovascular disease although this can be achieved only with larger weight loss targets.

Abstract MP68: The Correlation Between Left Atrial-left Ventricular-arterial Coupling And Circadian Rhythm Of Blood Pressure In Hypertension

Hypertension ◽  
2021 ◽  
Vol 78 (Suppl_1) ◽  
Author(s):  
Yan Liu ◽  
Qiaobing Sun ◽  
Yixiao Zhao ◽  
Yinong Jiang
Keyword(s):  
Blood Pressure ◽  
Regression Analysis ◽  
Circadian Rhythm ◽  
Linear Regression ◽  
Left Atrial ◽  
Linear Regression Analysis ◽  
Left Ventricular ◽  
Multivariate Linear Regression ◽  
Multivariate Linear Regression Analysis ◽  
Left Ventricular Arterial Coupling

The Correlation between Left Atrial-Left Ventricular-Arterial Coupling and Circadian Rhythm of Blood Pressure in Hypertension Objective: Hypertension induces left atrial (LA) and left ventricular (LV) dysfunction, and arterial stiffness increased. In this study, we further investigated the association between LA-LV-arterial coupling and circadian rhythm of blood pressure (BP) in essential hypertension (HT). Design and Methods: We enrolled 289 HT patients which were evaluated by 2 dimensional speckle tracking echocardiography (2D-STE), ambulatory 24-hour BP monitoring (ABPM) and carotid-femoral pulse wave velocity (PWV). According to BP patterns, these patients were divided into two groups, which included dippers (n=109), patients with a >10% reduction in BP at nighttime; non-dippers (n=180), patients with a <10% reduction in BP at nighttime. 2D-STE based LA and LV strains were studied and the following parameters were measured, LV global longitudinal strain (GLS), LA reservoir strain (LA S-S ), LA conduit strain (LA S-E ), and LA booster pump strain (LA S-A ). LA stiffness index (LASI) defined as the ratio of E/e' to LA S-S , and PWV-to-GLS ratio (PWV/GLS) were calculated to reflect LA-LV-arterial coupling. Furthermore, we also explored the correlation between LASI (or PWV/GLS) and ambulatory blood pressure indexes. The related factors were evaluated by multivariate linear regression analysis to find the independent factors. Results: LASI was significantly higher in non-dippers (0.35±0.24) than dippers (0.29±0.12) ( p <0.05). PWV/GLS was significantly higher in non-dippers (-90.30±34.13) than dippers (-79.62±25.84) ( p <0.05). LA S-S , LA S-A and LV GLS were significantly lower in non-dippers than dippers ( p <0.05). Multivariate linear regression analysis revealed that LV mass index (LVMI), PWV/GLS, nighttime mean SBP (n-SBP) and nighttime mean DBP (n-DBP) were independently correlated with LASI; LASI and n-SBP were independently correlated with PWV/GLS. Conclusions: LA and LV myocardial mechanics, and LA-LV-arterial coupling were associated with circadian rhythm of BP. Nocturnal systolic BP was the independent risk factor of abnormal LA-LV-arterial coupling in HT.

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