P5339Association between high-sensitive troponin I and subclinical coronary atherosclerosis in well-controlled HIV-infected adults

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
M Vassara ◽  
S Siwamogsatham ◽  
W Buddhari ◽  
M Tumkosit ◽  
C Ketloy ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Coronary Artery ◽  
Coronary Artery Calcification ◽  
Coronary Atherosclerosis ◽  
Troponin I ◽  
Cardiac Computed Tomography ◽  
Agatston Score ◽  
Cross Sectional ◽  
Potential Biomarker ◽  
High Sensitive Troponin

Abstract Background and objectives Patients with human immunodeficiency virus (HIV) infection live longer and the prevalence of coronary heart disease is increasing among them. High-sensitive troponin I (hs-TnI) is associated with coronary artery calcification as determined by non-contrast cardiac computed tomography (CT) in general population without established cardiovascular disease (CVD). Nevertheless, the relationship in well-controlled HIV-infected patients has not been validated. Design and methods A cross-sectional study among HIV-infected adults aged >50 years free from known CVDs. All subjects underwent non-contrast cardiac CT and blood test for serum hs-TnI was concomitantly performed. Relationship between Agatston score, a parameter used to quantify coronary artery calcification and serum hs-TnI level was analysed using spearman correlation and logistic regression models. Results A total of 338 HIV-infected adults (median age 54 years, 62% men) were included. All of them were in antiretroviral therapy with a median 18 years of exposure. The median CD4 cell count was 614 cell/mm3, 98% were virologically suppressed. Hs-TnI was correlated with coronary artery calcification with the correlation coefficient of 0.287 (p<0.0001). Multivariated logistic regression analysis demonstrated that serum hs-TnI concentration was associated with an increased odd of coronary artery calcification (Agatston score>0) (OR 1.64; 95% CI, 1.05–2.56, p=0.029). To detect coronary artery calcification, using the hs-TnI in addition to Thai CV risk score slightly increased the ROCAUC from 0.6827 to 0.692 (p=0.45). Distribution of CAC score over hs-TnI Conclusion Among well-controlled HIV-infected patients without established CVDs, hs-TnI concentration was associated with coronary artery calcification. This could be a potential biomarker for an early risk stratification of subclinical coronary atherosclerosis in this population. The association with long-term adverse cardiovascular outcome needs to be validated in the future study.

Sport specific incidence and progression of coronary artery calcification among amateur athletes: a follow-up of the Measuring Athletes Risk of Cardiovascular events (MARC) study

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
V Aengevaeren ◽  
A Mosterd ◽  
T.L Braber ◽  
H.M Nathoe ◽  
T.M.H Eijsvogels ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Calcification ◽  
Cardiovascular Events ◽  
Coronary Atherosclerosis ◽  
Sport Performance ◽  
Funding Source ◽  
Cross Sectional ◽  
Amateur Athletes ◽  
Entire Cohort

Abstract Background Emerging evidence indicates increased coronary atherosclerosis in amateur athletes. However, previous studies were limited by its cross-sectional design and limited sample size, preventing the exploration of sport specific associations with coronary atherosclerosis. Purpose We aimed to compare the incidence and progression of coronary artery calcification (CAC) between runners, cyclists and other types of athletes using a prospective cohort study with repetitive measurements. Methods Asymptomatic middle-aged men, who previously underwent a sports medical evaluation without abnormalities, were recruited in the Measuring Athlete's Risk of Cardiovascular events (MARC) study (n=318) and were asked to participate in this follow-up study. CT imaging was performed to assess CAC scores. Data was collected between 2012–2014 (i.e. baseline) and 2019–2020 (i.e. follow-up). We categorized participants as runners, cyclists or “other” sports (e.g. water polo, tennis, hockey, etc.) based on their dominant sport performance at baseline. Results We included 260 men in this interim analysis, with an average follow-up time of 6.3±0.5 years. Age (61.4±6.4 years), systolic blood pressure (143±20 mmHg), BMI (25.2±2.8 kg/m2), LDL-cholesterol (3.2±0.9 mmol/L), smoking (0.3 [0–8] pack years) and family history of coronary heart disease (28%) did not differ between runners (n=64), cyclists (n=75) and other athletes (n=121, all p&gt;0.05). CAC was present in 137 (53%) men at baseline, which increased to 181 (70%) at follow-up. CAC scores increased from 1 [0–33] to 33 [0–129]. Cyclists had a lower CAC prevalence and CAC scores compared to individuals performing other sports at follow-up (Figure 1). Of those without CAC at baseline (n=123, 47%), cyclists less often developed CAC during follow-up compared with runners (adjusted OR=0.36 [0.17–0.79], p=0.01). In the entire cohort, CAC progression (ln delta CAC+1) was less prominent in cyclists than runners (adjusted B=−0.75 [−1.39 to −0.11], p=0.02), whereas progression of CAC in participants performing other sports did not differ from the runners. In participants with CAC at baseline, cyclists also had less CAC progression than runners (B=−0.49 [−0.95 to −0.02], p=0.04). Conclusion Cyclists have a lower incidence and less progression of CAC during 6 years of follow-up compared with runners and individuals performing other sports. Figure 1. Sport specific CAC prevalence and scores Funding Acknowledgement Type of funding source: Foundation. Main funding source(s): Hartstichting

scholarly journals Significant inverse association of equol-producer status with coronary artery calcification but not dietary isoflavones in healthy Japanese men

2017 ◽  
Vol 117 (2) ◽  
pp. 260-266 ◽  
Author(s):  
Vasudha Ahuja ◽  
Katsuyuki Miura ◽  
Abhishek Vishnu ◽  
Akira Fujiyoshi ◽  
Rhobert Evans ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Calcification ◽  
Coronary Atherosclerosis ◽  
Population Based ◽  
Inverse Association ◽  
Multiple Logistic Regression ◽  
Cross Sectional ◽  
Japanese Men ◽  
Key Factor ◽  
Multivariable Adjustment

AbstractEquol, a metabolite of the dietary isoflavone daidzein, is produced by the action of gut bacteria in some individuals who are termed as equol-producers. It is proposed to have stronger atheroprotective properties than dietary isoflavones. We examined a cross-sectional association of dietary isoflavones and equol-producer status with coronary artery calcification (CAC), a biomarker of coronary atherosclerosis, among men in Japan. A population-based sample of 272 Japanese men aged 40–49 years recruited from 2004 to 2007 was examined for serum isoflavones, serum equol, CAC and other factors. Equol-producers were classified as individuals having a serum level of equol >83 nm. The presence of CAC was defined as a coronary Ca score ≥10 Agatston units. The associations of dietary isoflavones and equol-producers with CAC were analysed using multiple logistic regression. The median of dietary isoflavones, equol and CAC were 512·7 (interquartile range (IQR) 194·1, 1170·0), 9·1 (IQR 0·10, 33·1) and 0·0 (IQR 0·0, 1·0) nm, respectively. Prevalence of CAC and equol-producers was 9·6 and 16·0 %, respectively. Dietary isoflavones were not significantly associated with CAC. After multivariable adjustment, the OR for the presence of CAC in equol-producers compared with equol non-producers was 0·10 (95 % CI 0·01, 0·90, P<0·04). Equol-producers had significantly lower CAC than equol non-producers, but there was no significant association between dietary isoflavones and CAC, suggesting that equol may be a key factor for atheroprotective properties of isoflavones in Japanese men. This finding must be confirmed in larger studies or clinical trials of equol that is now available as a dietary supplement.

scholarly journals Long-Term Prognostic Significance of High-Sensitive Troponin I Increase during Hospital Stay in Patients with Acute Myocardial Infarction and Non-Obstructive Coronary Arteries

Medicina ◽  
2020 ◽  
Vol 56 (9) ◽  
pp. 432
Author(s):  
Magdalena Jędrychowska ◽  
Rafał Januszek ◽  
Wojciech Wańha ◽  
Krzysztof Piotr Malinowski ◽  
Piotr Kunik ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery ◽  
Clinical Outcomes ◽  
Coronary Atherosclerosis ◽  
Prognostic Value ◽  
Troponin I ◽  
Mortality Rates ◽  
Cerebral Stroke ◽  
All Cause Mortality ◽  
High Sensitive Troponin

Background and Objectives: A topic already widely investigated is the negative prognostic value regarding the extent of high sensitive troponin I (hs-TnI) increases among patients with myocardial infarction (MI) and obstructive coronary atherosclerosis compared to a group of patients with MI and non-obstructive coronary atherosclerosis (MINOCA). Thus, the aim of this study was to evaluate the prognostic value concerning the extent of hs-TnI increase on clinical outcomes among patients with a MINOCA working diagnosis. Materials and Methods: We selected 337 consecutive patients admitted to hospital with a working diagnosis of MINOCA. The patients were divided in three groups according to the extent of hs-TnI increase during hospitalization (increase ≤5-times above the limit of the upper norm, >5 and ≤20-times, and >20-times). The study endpoints included all-cause mortality and major adverse cardiac and cerebrovascular events (MACCE; cerebral stroke and transient ischemic attacks, MI, coronary artery revascularization, either percutaneous coronary intervention or coronary artery bypass grafting and all-cause mortality). Results: During the mean follow-up period of 516.1 ± 239.8 days, using Kaplan–Meier survival curve analysis, significantly higher mortality rates were demonstrated among patients from the group with the greatest hs-TnI increase compared to the remaining groups (p = 0.01) and borderline values for MACCE (p = 0.053). Multivariable cox regression analysis did not confirm hs-TnI among factors related to increased MACCE or all-cause mortality rates. Conclusion: While a relationship between clinical outcomes and the extent of the hs-TnI increase among patients with a MINOCA working diagnosis remains, it does not seem to be not as strong as it is in patients with obstructive coronary atherosclerosis.

Abstract 3126: Coronary Artery Calcification as a Predictor of Subsequent Coronary Artery Disease Events

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Tina Costacou ◽  
Trevor J Orchard
Keyword(s):  
Coronary Artery Disease ◽  
Type 1 Diabetes ◽  
Coronary Artery ◽  
Coronary Artery Calcification ◽  
Diabetes Duration ◽  
Glucose Disposal ◽  
Agatston Score ◽  
Cross Sectional ◽  
Artery Disease

Coronary artery calcification (CAC) as measured by electron beam computed tomography (EBCT) can be used as an indicator of atherosclerotic burden. We have previously reported a cross sectional association between the presence of CAC and history of clinical coronary artery disease (CAD) in type 1 diabetes. In this analysis, we assessed the ability of CAC to predict the incidence of CAD events. Participants from the Pittsburgh Epidemiology of Diabetes Complications Study of childhood onset type 1 diabetes who underwent an EBCT screening (1996–98) and were free of clinical CAD were selected for study (n=236). Mean age at EBCT screening was 36.6 years and diabetes duration 28 years. CAC was calculated using the Agatston score and was used both as a continuous variable (after log transformation) and as a categorical variable. CAD was defined as non-fatal MI (n=4), ischemic ECG changes (Minnesota codes 1.3, 4.1, 4.2, 4.3, 5.1, 5.2, 5.3, 7.1) (n=9), hospitalized unstable angina (n=1), new onset angina leading to revascularization (n=2) or fatal CAD (n=4). Glucose disposal rate (eGDR-insulin sensitivity) was estimated by a regression equation derived from hyperinsulinemic euglycemic clamp studies with terms for waist to hip ratio, HbA 1c , and hypertension. During a mean follow-up of 7.4 years, 20 (8.5%) individuals had an incident event. Individuals who had an event were older, with a greater diabetes duration, systolic blood pressure, HbA 1c , and WBC count, a lower eGDR (all p-values <0.05), and a higher CAC score (p<0.0001). Thus, approximately 24% of persons with CAC ≥200 had a subsequent CAD event compared to only 3% of those with a zero score. In multivariable Cox proportional hazard models with backward elimination, a CAC score greater than zero was a significant predictor of CAD incidence (HR=4.07, 95% CI=1.38–11.96). Other significant predictors comprised diabetes duration (HR=1.07, 95% CI=1.01–1.14) and HbA 1c (HR=1.39, 95% CI=1.10–1.76). The area under the ROC curve increased from 0.720 to 0.784 with the inclusion of CAC score. In this cohort of individuals with type 1 diabetes, CAC is a significant predictor of subsequent CAD status and adds to the prediction beyond standard risk factors. Thus, CAC may be used as a screening tool for CAD risk in type 1 diabetes.

Abstract P184: Is Home Blood Pressure More Strongly Associated with Coronary Artery Calcification Than Clinic Blood Pressure Measured Under an Appropriate Condition?

Circulation ◽  
2016 ◽  
Vol 133 (suppl_1) ◽  
Author(s):  
Atsushi Satoh ◽  
Hisatomi Arima ◽  
Atsushi Hozawa ◽  
Takashi Hisamatsu ◽  
Sayaka Kadowaki ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Coronary Artery ◽  
Coronary Artery Calcification ◽  
Home Blood Pressure ◽  
Agatston Score ◽  
Ideal Condition ◽  
Clinic Blood Pressure ◽  
Cross Sectional ◽  
Electrical Device ◽  
The Mean

Background / Objective: A number of studies have shown that home blood pressure (HBP) is more strongly associated with atherosclerotic diseases than clinic blood pressure (CBP). In previous studies, however, measurement of CBP under suboptimal conditions might have undermined the usefulness of CBP for prediction of atherosclerotic diseases. Therefore, we conducted a cross-sectional analysis to clarify whether HBP is more strongly associated with coronary artery calcification (CAC) than strictly measured CBP among a general population of Japanese men. Methods: From 2006 to 2008, we recruited 1094 male participants randomly selected from the residents in Kusatsu City, Shiga, Japan. CBP was measured twice consecutively by a trained physician using electrical device after 5 minutes of complete rest in a sitting position in a silent room. The participants were asked to measure HBP with an electrical device once in the morning during the consecutive 7 days. HBP was measured in seated position after 2 minutes of rest, within an hour after waking up, after urination and before breakfast. The mean of 2 measurements of CBP and the mean of 7 days of HBP were used in the analysis. CAC was assessed using computed tomography. Presence of CAC was defined as Agatston score >10. After exclusion of 175 participants with missing data on HBP, CBP, or CAC, a total of 919 people were included into the present analysis. We calculated multivariable-adjusted odds ratios (ORs) for presence of CAC per one standard deviation (SD) increase of CBP and HBP, then compared by adding interaction terms to the statistical model. ORs were adjusted for age, body mass index, history of cardiovascular diseases, smoking, ethanol consumption, blood sugar, serum total cholesterol, high density lipoprotein cholesterol, and use of medication (hypertension, dyslipidemia, and diabetes mellitus). Results: The mean systolic CBP (SD) and HBP (SD) were 136.8 (19.0) mmHg and 137.2 (18.5) mmHg, respectively. CBP and HBP were highly correlated (r = 0.74 P <0.001). The difference between CBP and HBP was not significant (P = 0.595). CAC was found in 454 (49.4%) participants. Multivariable-adjusted ORs (95% confidence interval) for presence of CAC were comparable between CBP (1.34 (1.14 - 1.58) per 1SD increase) and HBP (1.37 (1.16 - 1.62) per 1SD increase) (P heterogeneity = 0.819). When mean value of the first 2 days of HBP was used as a sensitivity analysis, we found almost the same results (P heterogeneity = 0.992). Similar results were also obtained for diastolic CBP and HBP (P heterogeneity = 0.968 for 7 days of HBP, 0.566 for 2 days of HBP). Conclusion: In conclusion, the association of CBP measured in an ideal condition with CAC was comparable with that of HBP.

Association between high-sensitive troponin I and coronary artery calcification in a Danish general population

2016 ◽  
Vol 245 ◽  
pp. 88-93 ◽  
Author(s):  
Fredrik Olson ◽  
Jonathan Engborg ◽  
Mette H. Grønhøj ◽  
Niels P. Sand ◽  
Jess Lambrechtsen ◽  
...  
Keyword(s):  
Coronary Artery ◽  
General Population ◽  
Coronary Artery Calcification ◽  
Troponin I ◽  
High Sensitive Troponin

scholarly journals Serum uric acid is associated with coronary artery calcification in early chronic kidney disease: a cross-sectional study

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Miyeun Han ◽  
Hyunsuk Kim ◽  
Hyo Jin Kim ◽  
Eunjeong Kang ◽  
Yong-Soo Kim ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Logistic Regression ◽  
Uric Acid ◽  
Regression Analysis ◽  
Risk Factor ◽  
Coronary Artery ◽  
Kidney Disease ◽  
Logistic Regression Analysis ◽  
Coronary Artery Calcification ◽  
Cross Sectional

Abstract Background Although uric acid (UA) is regarded as a risk factor for cardiovascular disease, whether UA is an independent risk factor contributing to coronary artery calcification in chronic kidney disease (CKD) is not well known. We evaluated whether UA level is associated with coronary artery calcium (CAC) score in a predialysis CKD cohort. Methods A total of 1,350 subjects who underwent coronary computed tomography as part of the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease were analysed. We conducted a logistic regression analysis to evaluate the association between UA and the presence of CAC. Results CAC was detected in 705 (52.2 %) patients, and the level of UA was significantly higher in CAC > 0 patients. UA showed a positive relationship with CAC > 0 in age- and sex-adjusted logistic regression analysis (Odds ratio (OR) 1.11, 95 % confidence interval (CI) 1.04–1.19, P = 0.003). However, UA showed no association with CAC > 0 in multivariate analysis. Further analysis showed that UA showed a positive association with CAC > 0 only in estimated glomerual filtration rate (eGFR) > 60 ml/min/1.73 m2 (OR 1.23, 95 % CI 1.02–1.49, P = 0.036) but not in eGFR 30–59 ml/min/1.73 m2 (OR 0.92, 95 % CI 0.78–1.08, P = 0.309) or < 30 ml/min/1.73 m2 (OR 0.92, 95 % CI 0.79–1.08, P = 0.426). Conclusions UA level was significantly associated with CAC in early CKD, but not in advanced CKD.

scholarly journals Association Between Muscle Quality Measured by Abdominal Computed Tomography and Subclinical Coronary Atherosclerosis

2020 ◽  
Author(s):  
Min Jung Lee ◽  
Hong-Kyu Kim ◽  
Eun Hee Kim ◽  
Sung Jin Bae ◽  
Kyung Won Kim ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Coronary Artery ◽  
Coronary Artery Calcification ◽  
Coronary Atherosclerosis ◽  
Abdominal Muscle ◽  
Muscle Quality ◽  
Muscle Area ◽  
Cross Sectional

Objective: Low muscle mass was known to be associated with cardiovascular diseases. However, only few studies investigated the association between muscle quality and subclinical coronary atherosclerosis. Thus, we evaluated whether muscle quality measured by abdominal computed tomography is associated with the risk of coronary artery calcification. Approach and Results: We conducted a cross-sectional study on 4068 subjects without cardiovascular disease who underwent abdominal and coronary computed tomography between 2012 and 2013 during health examinations. The cross-sectional area of the skeletal muscle was measured at the L3 level (total abdominal muscle area, total abdominal muscle area) and segmented into normal attenuation muscle area, low attenuation muscle area, and intramuscular adipose tissue. We calculated the normal attenuation muscle area/total abdominal muscle area index, of which a higher value reflected a higher proportion of good quality muscle (normal attenuation muscle area) and a lower proportion of myosteatosis (low attenuation muscle area and intramuscular adipose tissue). In women, as the normal attenuation muscle area/total abdominal muscle area quartiles increased, the odds ratios (95% CIs) for significant coronary artery calcification (>100) consistently decreased (0.44 [0.24–0.80], 0.39 [0.19–0.81], 0.34 [0.12–0.98]; P =0.003) after adjusting for cardiovascular risk factors including visceral fat area and insulin resistance. In men, the odds ratios in the Q2 group were significantly lower than those in the Q1, but the association was attenuated in Q3–4 after adjustment. Conclusions: A higher proportion of good quality muscle was strongly associated with a lower prevalence of significant coronary artery calcification after adjustment, especially in women. Poor skeletal muscle quality may be an important risk factor for subclinical coronary atherosclerosis.

scholarly journals T11. CORONARY ARTERY CALCIFICATION IN PEOPLE WITH SCHIZOPHRENIA

2020 ◽  
Vol 46 (Supplement_1) ◽  
pp. S235-S235
Author(s):  
Trine Trab ◽  
René Ernst Nielsen ◽  
Jens Broendum Froekjaer ◽  
Svend Eggert Jensen
Keyword(s):  
Coronary Artery ◽  
General Population ◽  
Coronary Artery Calcification ◽  
Smoking Status ◽  
Cardiac Computed Tomography ◽  
Premature Mortality ◽  
Research Society ◽  
Agatston Score ◽  
Chronic Group ◽  
Icd 10

Abstract Background Coronary artery disease (CAD) is one of the major causes of premature mortality in patients with schizophrenia. Coronary artery calcification (CAC) is an independent predictor of cardiac mortality and CAD in the general population, but has not yet been investigated in patients with schizophrenia. The aim of the present study is to compare CAC quantified by cardiac computed tomography (CT) in patients with schizophrenia to the general population. Methods Baseline data from an ongoing prospective cohort study including 200 patients with schizophrenia (ICD-10 diagnoses F20 or F25) diagnosed at least 10 years prior to inclusion (chronic group) and 86 patients with schizophrenia diagnosed within two years prior to inclusion (debut group). Patients in the debut group were matched 1:1 on age, gender and smoking status with psychiatrically healthy controls (PHC). All participants underwent cardiac CT and the CAC was quantified using Agatston Score. Mean CAC in the chronic group was compared to reference CAC scores whilst mean CAC in the debut group was compared to PHC. Information on cardiovascular risk factors, illness history, social and psychiatric conditions were obtained at baseline. Results Data is currently being analyzed and results will be presented at the Congress of International Schizophrenia Research Society. Discussion If the CAC quantified by CT in patients with schizophrenia differs from the PHC population, it might act as a tool for early detection of CAD in these patients. Thus, the findings of this study might contribute to preventive strategies in order to decrease cardiovascular mortality.

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