scholarly journals T11. CORONARY ARTERY CALCIFICATION IN PEOPLE WITH SCHIZOPHRENIA

2020 ◽  
Vol 46 (Supplement_1) ◽  
pp. S235-S235
Author(s):  
Trine Trab ◽  
René Ernst Nielsen ◽  
Jens Broendum Froekjaer ◽  
Svend Eggert Jensen
Keyword(s):  
Coronary Artery ◽  
General Population ◽  
Coronary Artery Calcification ◽  
Smoking Status ◽  
Cardiac Computed Tomography ◽  
Premature Mortality ◽  
Research Society ◽  
Agatston Score ◽  
Chronic Group ◽  
Icd 10

Abstract Background Coronary artery disease (CAD) is one of the major causes of premature mortality in patients with schizophrenia. Coronary artery calcification (CAC) is an independent predictor of cardiac mortality and CAD in the general population, but has not yet been investigated in patients with schizophrenia. The aim of the present study is to compare CAC quantified by cardiac computed tomography (CT) in patients with schizophrenia to the general population. Methods Baseline data from an ongoing prospective cohort study including 200 patients with schizophrenia (ICD-10 diagnoses F20 or F25) diagnosed at least 10 years prior to inclusion (chronic group) and 86 patients with schizophrenia diagnosed within two years prior to inclusion (debut group). Patients in the debut group were matched 1:1 on age, gender and smoking status with psychiatrically healthy controls (PHC). All participants underwent cardiac CT and the CAC was quantified using Agatston Score. Mean CAC in the chronic group was compared to reference CAC scores whilst mean CAC in the debut group was compared to PHC. Information on cardiovascular risk factors, illness history, social and psychiatric conditions were obtained at baseline. Results Data is currently being analyzed and results will be presented at the Congress of International Schizophrenia Research Society. Discussion If the CAC quantified by CT in patients with schizophrenia differs from the PHC population, it might act as a tool for early detection of CAD in these patients. Thus, the findings of this study might contribute to preventive strategies in order to decrease cardiovascular mortality.

P5339Association between high-sensitive troponin I and subclinical coronary atherosclerosis in well-controlled HIV-infected adults

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
M Vassara ◽  
S Siwamogsatham ◽  
W Buddhari ◽  
M Tumkosit ◽  
C Ketloy ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Coronary Artery ◽  
Coronary Artery Calcification ◽  
Coronary Atherosclerosis ◽  
Troponin I ◽  
Cardiac Computed Tomography ◽  
Agatston Score ◽  
Cross Sectional ◽  
Potential Biomarker ◽  
High Sensitive Troponin

Abstract Background and objectives Patients with human immunodeficiency virus (HIV) infection live longer and the prevalence of coronary heart disease is increasing among them. High-sensitive troponin I (hs-TnI) is associated with coronary artery calcification as determined by non-contrast cardiac computed tomography (CT) in general population without established cardiovascular disease (CVD). Nevertheless, the relationship in well-controlled HIV-infected patients has not been validated. Design and methods A cross-sectional study among HIV-infected adults aged >50 years free from known CVDs. All subjects underwent non-contrast cardiac CT and blood test for serum hs-TnI was concomitantly performed. Relationship between Agatston score, a parameter used to quantify coronary artery calcification and serum hs-TnI level was analysed using spearman correlation and logistic regression models. Results A total of 338 HIV-infected adults (median age 54 years, 62% men) were included. All of them were in antiretroviral therapy with a median 18 years of exposure. The median CD4 cell count was 614 cell/mm3, 98% were virologically suppressed. Hs-TnI was correlated with coronary artery calcification with the correlation coefficient of 0.287 (p<0.0001). Multivariated logistic regression analysis demonstrated that serum hs-TnI concentration was associated with an increased odd of coronary artery calcification (Agatston score>0) (OR 1.64; 95% CI, 1.05–2.56, p=0.029). To detect coronary artery calcification, using the hs-TnI in addition to Thai CV risk score slightly increased the ROCAUC from 0.6827 to 0.692 (p=0.45). Distribution of CAC score over hs-TnI Conclusion Among well-controlled HIV-infected patients without established CVDs, hs-TnI concentration was associated with coronary artery calcification. This could be a potential biomarker for an early risk stratification of subclinical coronary atherosclerosis in this population. The association with long-term adverse cardiovascular outcome needs to be validated in the future study.

scholarly journals Plasma F2-Isoprostanes and Coronary Artery Calcification: The CARDIA Study

2005 ◽  
Vol 51 (1) ◽  
pp. 125-131 ◽  
Author(s):  
Myron Gross ◽  
Michael Steffes ◽  
David R Jacobs ◽  
Xinhua Yu ◽  
Linda Lewis ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Early Development ◽  
Coronary Artery Calcification ◽  
Continuous Variable ◽  
Oxidation Products ◽  
Gas Chromatography Mass Spectrometry ◽  
Agatston Score ◽  
Reactive Protein ◽  
Increased Risk ◽  
Coronary Artery Atherosclerosis

Abstract Background: Oxidation of lipids in lipoproteins and cells may initiate and enhance the early development of cardiovascular disease. Method and Results: We assayed F2-isoprostanes, oxidation products of arachidonic acid, by gas chromatography–mass spectrometry in a biracial cohort of 2850 young healthy adult men and women. Coronary artery calcification (CAC), a component of coronary artery atherosclerosis, was detectable in 10% of the cohort and appeared to be in its initial stages (Agatston scores &lt;20 in 47% and &lt;100 in 83% of CAC-positive participants). After adjusting for sex, clinical site, age, and race, the presence of any CAC was 24% more likely among those with high vs low concentrations of F2-isoprostanes [odds ratio (OR) = 1.24 per 92.2 pmol/L (32.7 ng/L; 1 SD of F2-isoprostanes); 95% confidence interval (CI), 1.09–1.41]. The OR was only slightly attenuated [1.18 per 92.2 pmol/L (32.7 ng/L); CI, 1.02–1.38] after further adjustment for body mass index, smoking, serum lipids, C-reactive protein, antioxidant supplementation use, diabetes, and blood pressure. As a continuous variable, the Agatston score increased by 6.9% per 92.2 pmol/L (32.7 ng/L) of F2-isoprostane concentration (P &lt;0.01). Whereas CAC prevalence was lower in women than men, mean (SD), F2-isoprostanes were higher in women {190 (108.9) pmol/L [67.4 (38.6) ng/L]} than in men {140.4 (55.6) pmol/L [49.8 (19.7) ng/L]}. Nevertheless, F2-isoprostanes were associated with an increased risk of CAC in both sexes. Conclusion: This association between increased concentrations of circulating F2-isoprostanes and CAC in young healthy adults supports the hypothesis that oxidative damage is involved in the early development of atherosclerosis.

scholarly journals Evaluation of Breast Vascular Calcifications as a Predictor for Coronary Artery Calcification

2021 ◽  
Vol 102 (3) ◽  
pp. 196-202
Author(s):  
D. A. Bazhenova ◽  
O. S. Puchkova ◽  
E. A. Mershina ◽  
V. E. Sinitsyn
Keyword(s):  
Coronary Artery ◽  
Cardiovascular Diseases ◽  
Coronary Artery Calcification ◽  
Cardiac Computed Tomography ◽  
Calcium Score ◽  
Vascular Calcifications ◽  
Increased Risk ◽  
Wall Calcification ◽  
Made In

Background. Cardiovascular diseases are one of the main causes of death among women, and current prevention paradigms may not be sufficient in this group. In this context, it has been suggested that the detection of breast vascular calcifications can improve the screening and assessment of the risk of cardiovascular diseases in apparently healthy women.Objective: to study the role of breast vascular calcifications as a potential predictor for coronary artery calcification. Material and methods. Examinations were made in 123 patients who underwent digital mammography and cardiac computed tomography to estimate a coronary artery calcium score.Results. The use of the Wilcoxon-Mann-Whitney W-test for abnormal distribution showed a relationship between the presence of breast vascular calcifications and calcium score (p< 0.001), and that between aortic wall calcification and calcium score (p< 0.001).Conclusion. Breast vascular calcifications detected by mammography are an indicator of a higher frequency of coronary artery calcification and, apparently, a predictor for the increased risk of cardiovascular disease.

scholarly journals Acromegaly per se does not increase the risk for coronary artery disease

2010 ◽  
Vol 162 (5) ◽  
pp. 879-886 ◽  
Author(s):  
Hiroyoshi Akutsu ◽  
Jürgen Kreutzer ◽  
Gerald Wasmeier ◽  
Dieter Ropers ◽  
Christian Rost ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Risk Score ◽  
Successful Treatment ◽  
Cardiac Computed Tomography ◽  
Agatston Score ◽  
Per Se ◽  
Artery Disease ◽  
Cad Risk ◽  
Gh Excess

ContextInformation about the risk and course of coronary artery disease (CAD) in acromegaly is limited.ObjectiveTo evaluate CAD risk in acromegalic patients at diagnosis and after successful treatment during follow-up.Subjects and methodsTwenty-five consecutive patients (age 45.1±10.6 years, 15 women) were studied at the time of diagnosis, and 19 patients were re-evaluated after 4.6±1.1 years. The European Society of Cardiology (ESC) risk score was calculated, and a cardiac computed tomography was performed for detection and quantification (Agatston score (AS)) of coronary artery calcium (CACs). Fifty age-, sex-, and CAD risk-matched subjects and CAC data from the population-based Heinz Nixdorf Recall (HNR) study served as controls.ResultsIn 21 of the 25 patients, the 10-year risk of developing CAD according to the ESC risk score was low (<10%) and high (>20%) in four patients. The AS was lower than in controls (2.6±7.9 vs 66±182;P=0.014) and less patients had a positive CAC (AS>0) (20 vs 48%,P=0.024), which in the acromegalic patients was less than expected from the HNR study. The AS did not correlate with GH excess or disease duration. In 19 acromegalic patients, who were in remission and re-evaluated after 4.6±1.1 years, the ESC risk (P=0.102) and the AS (P=0.173) did not change significantly and no symptomatic CAD event occurred.ConclusionCAD risk in newly diagnosed acromegalic patients was low and remained stable after successful treatment. CAC was lower than in controls suggesting that GH excessper sedoes not carry an additional CAD risk.

Abstract P270: Associations of Lipoprotein-associated Phospholipase A 2 Mass and Activity with Coronary Artery Calcium: The Multi-Ethnic Study of Atherosclerosis (MESA)

Circulation ◽  
2013 ◽  
Vol 127 (suppl_12) ◽  
Author(s):  
Nancy S Jenny ◽  
Robyn McClelland ◽  
Neal Jorgensen ◽  
Parveen Garg ◽  
Gregory Burke ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Calcium ◽  
Cardiac Computed Tomography ◽  
Prevalence Ratio ◽  
Hdl Cholesterol ◽  
Phospholipase A ◽  
Lipid Lowering ◽  
Agatston Score ◽  
Ethnic Study

Background: Lipoprotein-associated phospholipase A 2 (Lp-PLA 2 ) is an inflammatory enzyme localized in atherosclerotic lesions. However, associations of Lp-PLA 2 with coronary artery calcium (CAC), used as a marker of lesion progression, have not been extensively studied and may vary by sex and type of Lp-PLA 2 assay. Methods: We examined these associations in 5486 White, Black, Chinese and Hispanic men and women in the Multi-Ethnic Study of Atherosclerosis (MESA). At baseline, mean age was 62 years; all were free of clinical cardiovascular disease. CAC, by cardiac computed tomography, was assessed at baseline (2000-02) and follow-up; half the cohort at exam 2 (2002-04), the remainder at exam 3 (2004-05). 2758 had CAC (Agatston score>0) at baseline; of those with no baseline CAC, 372 (13.6%) had incident CAC (CAC>0) at follow-up. Lp-PLA 2 mass and activity were measured by immunoassay and enzymatic assay, respectively. Longitudinal models were adjusted for age, sex, ethnicity, smoking, diabetes, obesity, total and HDL cholesterol, blood pressure, hypertension, lipid-lowering medications and time between CAC measures. Results: Each standard deviation (SD 36.5 nmol/min/ml) increase in Lp-PLA 2 activity was associated with CAC presence (prevalence ratio 1.03; p=0.01) in the whole group at baseline and incidence in those with no CAC at baseline (odds ratio 1.17; p=0.02). Activity was not associated with CAC progression (increase in Agatston score over time) in the whole group (β=1.32; p>0.4). Lp-PLA 2 mass was not associated with CAC presence or incidence (SD 45.6 ng/ml; associations p>0.2). The only association that differed significantly by sex was that for mass and progression (p interaction 0.01). Mass was associated with CAC progression in women (β=4.99; p=0.004) but not men (β=-0.20; p>0.9). Conclusions: In this multi-ethnic cohort, associations of Lp-PLA 2 with CAC varied by sex and Lp-PLA 2 assay type. Lp-PLA 2 activity was associated with CAC presence and incidence, but not progression. Mass was associated with CAC progression in women only. Additional research is needed to support the clinical utility of Lp-PLA 2 in monitoring atherosclerosis progression.

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