scholarly journals 152 Effects of nutraceuticals on the control of the lipid-glycaemic structure and on endothelial protection, in patients with low cardiovascular risk profile

2021 ◽  
Vol 23 (Supplement_G) ◽  
Author(s):  
Angelica Cersosimo ◽  
Ludovica Amore ◽  
Giuliana Cimino ◽  
Mara Gavazzoni ◽  
Enrico Vizzardi ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Arterial Stiffness ◽  
Endothelial Function ◽  
Coenzyme Q10 ◽  
Risk Profile ◽  
Red Yeast Rice ◽  
Monacolin K ◽  
Cardiovascular Risk Profile ◽  
Red Rice ◽  
Low Cardiovascular Risk

Abstract Aims Nutraceuticals are dietary supplements that contain a concentrated form of a presumed bioactive substance originally derived from a food. There is a relationship between the consumption of monacolin K from red yeast rice and maintenance of normal blood low density lipoprotein cholesterol (LDL-C) concentrations recognized by the European Agency on Food Safety. The present study evaluates the effects of a therapeutical association of nutraceuticals (a combination of containing fermented red rice, named Monacolin K and Coenzyme Q10) on lipo-glycaemic profile and on the vascular function evaluated as endothelial function and arterial stiffness (using the non-invasive methods of EndoPAT and SphygmoCOR). Methods The present is a single-centre prospective study enrolling 30 patients with low cardiovascular risk profile (SCORE risk, cardiovascular disease risk <10% at 10 years). Patients were consecutive enrolled from March 2019 to February 2020 (recruitment period). The average follow-up was 14 weeks, from intaking monacolin K 10 mg + Coenzyme Q10 10 mg. The scheduled evaluations of the enrolled population were: before the beginning of the therapy and after a period of 14 weeks. Results After 14 weeks of treatment we demonstrated a statistically significant reduction in total cholesterol (P 0.015) and LDL (P 0.003). An important effect on the inflammatory profile was highlighted, resulting in a decrease in Hs-CRP at 12-weeks (P 0.052), associated with a progressive reduction of arterial stiffness (P 0.063) and an improvement in endothelial function (P 0.048). Conclusions Data obtained suggest that formulations with natural nutraceuticals, especially fermented red rice, have a protective cardiovascular effect, not also through reduction of plasma lipids but in endothelial function and arterial stiffness improvement.

scholarly journals Determinants of attaining and maintaining a low cardiovascular risk profile—the Doetinchem Cohort Study

2015 ◽  
Vol 26 (1) ◽  
pp. 135-140 ◽  
Author(s):  
Gerben Hulsegge ◽  
Yvonne T. van der Schouw ◽  
Martha L. Daviglus ◽  
Henriëtte A. Smit ◽  
W.M. Monique Verschuren
Keyword(s):  
Cohort Study ◽  
Cardiovascular Risk ◽  
Risk Profile ◽  
Cardiovascular Risk Profile ◽  
Low Cardiovascular Risk

scholarly journals Normalized endothelial function but sustained cardiovascular risk profile 11 years following a pregnancy complicated by preeclampsia

2013 ◽  
Vol 36 (12) ◽  
pp. 1081-1087 ◽  
Author(s):  
Eva Östlund ◽  
Maha Al-Nashi ◽  
Rangeen Rafik Hamad ◽  
Anders Larsson ◽  
Maria Eriksson ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Endothelial Function ◽  
Risk Profile ◽  
Cardiovascular Risk Profile

scholarly journals A T1 and DTI fused 3D corpus callosum analysis in MCI subjects with high and low cardiovascular risk profile

2017 ◽  
Vol 14 ◽  
pp. 298-307 ◽  
Author(s):  
Yi Lao ◽  
Binh Nguyen ◽  
Sinchai Tsao ◽  
Niharika Gajawelli ◽  
Meng Law ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Corpus Callosum ◽  
Risk Profile ◽  
Cardiovascular Risk Profile ◽  
Low Cardiovascular Risk

scholarly journals Heart failure in low risk patients with atrial fibrillation, nationwide registry case-control study based on 227811 patients

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
C Basic ◽  
P Hansson ◽  
T Zverkova-Sandstrom ◽  
B Johansson ◽  
M Fu ◽  
...  
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Heart Disease ◽  
Cardiovascular Risk ◽  
Incidence Rate ◽  
Prediction Models ◽  
Risk Profile ◽  
Cardiovascular Risk Profile ◽  
One Year ◽  
Low Cardiovascular Risk

Abstract Background Heart failure (HF) is common in patients with atrial fibrillation (AF), and also associated with worse outcome. Consequently, it is commonly included in risk prediction models for AF, used in daily clinical praxis. However, knowledge about the association between solely AF and incidental HF is limited. Aim This study aims to evaluate the short and long-term risks for onset of HF in patients with AF and low cardiovascular risk profile. Methods All patients with first recorded hospitalization for AF in the Swedish National Patient Register, were included from the 1St January 1987 to 31st December 2018. Each patient with AF was matched by age, sex and county with two controls from the Swedish Total Population Register. Patients <18 years, or with concomitant hypertension, diabetes mellitus, coronary and periphery artery disease, previous stroke or transitory ischemic attack, cardiomyopathy, pulmonary arterial hypertension, congenital heart disease, valvular heart disease and renal failure prior or at baseline were excluded. Results In total 227 811 patients and 452 712 controls met the inclusion and exclusion criteria and were included in the study. The incidence rate for incidental HF per 1000 person-year within one year after AF diagnosis was 6.2 (95% CI: 4.5–8.6) among patient 18–34, increased with increasing age and was 142.8 (95% CI: 139.4–146.3) among those >80 years. Within five years the incidence rate decreased in all age categories and was 2.4 (95% CI: 1.8–3.0) among the youngest and 94.0 (95% CI: 92.4–95.6) in the oldest age group. When compared to matched controls from the general population patients with AF had a hazard ratio (HR) and CI 95% to develop HF within one year at 103.9 (46.3–233.1), 34.9 (26.5–45.9), 17.5 (15.5–19.8), 10.3 (9.6–11.1) and 6.1 (5.8–6.4) among patients aged 18–34, 35–49, 50–59, 60–69, 70–79 and >80 years, respectively. Conclusion Despite low cardiovascular risk profile AF still carries high risk for developing incidental HF in particular during the first observation year with increasing tendency along with increasing age. Younger patients with AF and without other cardiovascular comorbidities had more than 100 times higher relative risk to develop HF within one year when compared to matched controls. FUNDunding Acknowledgement Type of funding sources: None.

Abstract MP04: Determinants of attaining and maintaining a low cardiovascular risk profile - the Doetinchem Cohort Study

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Gerben Hulsegge ◽  
Martha L Daviglus ◽  
Yvonne T van der Schouw ◽  
Henriëtte A Smit ◽  
W M Verschuren
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
High Risk ◽  
Risk Profile ◽  
Low Risk ◽  
Cardiovascular Risk Profile ◽  
Risk Profiles ◽  
Risk Status ◽  
Low Education ◽  
Low Cardiovascular Risk

Introduction: Increasing the proportion of adults who attain and maintain low cardiovascular risk profile is essential in the prevention of cardiovascular disease (CVD). It is unknown which factors are associated with attaining and maintaining a low risk profile. We investigate the association of 6 demographic, 4 lifestyle, 3 CVD history, and 4 psychosocial determinants with 1) attaining and 2) maintaining a low risk profile. Method: CVD risk factors and determinants were measured at baseline (1987-1991) and 5-year intervals until 2013 among 6,390 adults initially aged 20-59. Participants were categorized into low risk (i.e., ideal levels of blood pressure, cholesterol, and body mass index, not smoking and no diabetes) and medium or high risk profile. Those with low risk profile maintained or lost their low risk status, whereas those with medium/high risk profiles maintained that risk profile or attained a low risk profile during 5 years follow-up. Determinants of change in risk profiles were examined using modified Poisson regression to obtain risk ratios (RR) and 95% confidence intervals (95%CI) and generalized estimating equations to combine multiple 5-year comparisons. Results: A small proportion of participants (3%) with medium/high risk profile attained a low risk profile during the following 5 years. Compared to those who maintained a medium/high risk profile, one unit increment in Mediterranean (healthy) diet score was associated with 9% (RR: 1.09, 95%CI: 1.02-1.16) and being physically active compared to being inactive with a 104% (RR: 2.04, 95%CI: 1.05-4.00) higher likelihood to attain a low risk profile. Older age (RR: 0.66), male gender (RR: 0.46), low (RR: 0.55) and intermediate (RR: 0.77) education, low education of partner (RR: 0.70), and being a homemaker (RR: 0.73) were significantly associated with lower chance to attain low risk status. Of those having a low risk profile, 40% maintained that low risk profile over 5 years. For those with low risk profile, only older age (RR: 0.93) and low educational level (RR: 0.80) were significantly inversely associated with maintaining low risk profile. Conclusion: Low education level had an unfavorable impact on changes in risk profiles. This underscores the need to target preventive efforts at individuals with low education in the prevention of CVD. A healthy diet and physical activity were the only modifiable risk factors that were favorably associated with attaining low risk profile.

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