Histopathological study of soft tissue tumours in a tertiary health centre in southern part of Assam

Background: Soft tissue tumors are defined as mesenchymal proliferations which occur in the extraskeletal non-epithelial tissues of the body, excluding the viscera, coverings of brain and lymphoreticular system. The objective of this study was to study the histopathological features of soft tissue tumors and to study the occurrence of soft tissue tumors in relation to age, sex and anatomical site.Methods: This study comprised of 89 cases studied over a period of two years. All soft tissue tumors, their gross features, microscopic findings were analysed in detail. Soft tissue tumors were divided into benign and malignant categories and further sub typing were done according to World Health Organization (WHO) classification. The distribution of soft tissue tumors according to the age, sex and site of occurrence was studied.Results: Out of 89 cases of soft tissue tumors, 76 cases were benign, 4 cases belonged to intermediate category and 9 cases were malignant. Adipocytic tumors formed the largest group constituting 39 cases. Vascular tumors were the second commonest (26 cases) followed by peripheral nerve sheath tumors (11 cases). The benign tumors were seen in younger age as compared to malignant tumors. Malignant soft tissue tumors was seen to be more common in male than female and pleomorphic sarcoma and liposarcoma was commonest (3 cases each).Conclusions: Benign tumors were more common than malignant. The most common benign tumors were lipoma followed by hemangioma and schwannoma. The most common malignant tumor was pleomorphic sarcoma. The benign tumors were seen in younger age as compared to malignant tumors.

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Clinicopathological study of soft tissue sarcoma-retrospective study of tertiary cancer institute in eastern India

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20204907 ◽

2020 ◽

Vol 8 (11) ◽

pp. 4075

Author(s):

Kunhi Mohammed K. P. ◽

Snehasis Pradhan ◽

Supratim Bhattacharyya ◽

Prafulla Kumar Das ◽

Muhammed Navas N. K.

Keyword(s):

Retrospective Study ◽

Soft Tissue ◽

Soft Tissue Sarcoma ◽

Malignant Tumors ◽

Soft Tissue Sarcomas ◽

The Body ◽

Female Ratio ◽

Pleomorphic Sarcoma ◽

Frequent Variety ◽

Male To Female

Background: Soft tissue sarcomas are a rare and heterogeneous group of malignant tumors of mesenchymal origin that comprise less than 1 percent of all adult malignancies. Although they occur anywhere in the body, they involve most commonly in extremities, trunk, retroperitoneum and head and neck. The aim of the study was to analyze clinical and histopathological features of various soft tissue sarcomas.Methods: This was a retrospective study, conducted in tertiary cancer centre in Odisha during the period 2015 to 2018. We collected clinical parameters like age, sex, site of swelling, any associated pain and biopsy reports and these variables were correlated with final histopathology reports.Results: A total of 107 patients were included in the study, with male to female ratio of 2:1(71 and 36) and average age of 43.45 years. All of them presented with a swelling. The lower extremities were the most common sites i.e. 44.62%. Pleomorphic sarcoma was the most frequent histologic variety comprising 43% and less frequent variety were angiosarcoma, and myxoid sarcoma.Conclusions: Soft tissue sarcoma are predominant in males and middle aged population are frequently affected. Most common affected site is lower extremity and pleomorphic sarcoma is the prominent histologic type.

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PEComa: A Perivascular Epithelioid Cell Tumor in the Liver—A Case Report and Review of the Literature

Case Reports in Medicine ◽

10.1155/2013/904126 ◽

2013 ◽

Vol 2013 ◽

pp. 1-4 ◽

Cited By ~ 15

Author(s):

Faseeh Khaja ◽

Allison Carilli ◽

Said Baidas ◽

Aravindhan Sriharan ◽

Shanedelle Norford

Keyword(s):

Malignant Tumors ◽

Mtor Inhibitors ◽

Epithelioid Cell ◽

Soft Tissue Tumors ◽

Cell Tumor ◽

The Body ◽

Benign Tumors ◽

Review Of The Literature ◽

Perivascular Epithelioid Cell ◽

Perivascular Epithelioid Cell Tumors

Perivascular epithelioid cell tumors are soft tissue tumors that can occur in various locations in the body whose incidence is rising. Hepatic PEComas are quite rare and diagnosis involves positivity of Melan-A and HMB45 on immunohistochemistry. Usual treatment is surgery for benign tumors and chemotherapy including mTOR inhibitors for malignant tumors. Here we discuss the radiological and pathological diagnosis, evaluation, and management of a hepatic PEComa. We describe a 51-year-old patient who was diagnosed incidentally after unusual physical exam findings.

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The First Case Treated with Larotrectinib of a Novel TMTC2-NTRK3 Fusion Undifferentiated High-Grade Pleomorphic Sarcoma of the Chest

10.21203/rs.3.rs-843043/v1 ◽

2021 ◽

Author(s):

Chujie Bai ◽

Lu Zhang ◽

Yaohui Wang ◽

Taiyan Guo ◽

Xia You ◽

...

Keyword(s):

Soft Tissue ◽

Clinical Manifestations ◽

Soft Tissue Tumors ◽

The Body ◽

High Grade ◽

Pleomorphic Sarcoma ◽

First Case ◽

Painless Mass ◽

Almost All ◽

Next Generation Sequencing Ngs

Abstract Undifferentiated high-grade pleomorphic sarcoma (UPS) is a rare soft tissue sarcoma (STS) of mesenchymal origin, particularly the extremities and retroperitoneum, meanwhile it has been reported in almost all parts of the body. UPS is highly invasive and has a poor prognosis due to its clinical manifestations of painless mass and deep tumor site, which are usually found at an advanced stage. Patients with UPS tend to have a lower 5-year survival rate than patients with other types of STS. Recently, NTRK fusions were detected in many cancer types, such as thyroid cancer, colorectal cancer, non-small cell lung cancer, soft tissue tumors, uterine sarcomas, and melanomas. However, the mutation frequency of NTRK fusion in all cancers is only 0.1-1%. Targeted therapy with NTRK inhibitors, such as Larotrectinib and Entrectinib, leads to a response in most patients with NTRK1/2/3 gene fusion-positive tumors. Herein, we present a 68-years old man diagnosed with stage IIIA (T2N0M0G3) UPS. Next-generation sequencing (NGS) revealed a novel TMTC2-NTRK3 fusion. The NTRK3 positivity was also detected by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). He had a response to Larotrectinib. This report broadens the spectrum of NTRK fusions in UPS and highlights a new target for treatment.

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Significance of Coagulation and Fibrinolysis Markers for Benign and Malignant Soft Tissue Tumors

10.21203/rs.3.rs-46074/v1 ◽

2020 ◽

Author(s):

Kunihiro Asanuma ◽

Tomoki Nakamura ◽

Tomohito Hagi ◽

Takayuki Okamoto ◽

Kouji Kita ◽

...

Keyword(s):

Soft Tissue ◽

Malignant Tumors ◽

Characteristic Curve ◽

Soft Tissue Tumors ◽

Clinicopathological Parameters ◽

Diagnostic Tools ◽

Benign Tumors ◽

Benign Soft Tissue Tumors ◽

Significant Difference ◽

Coagulation And Fibrinolysis

Abstract Background: The intimate relationship between coagulation and fibrinolysis in malignant tumors is a well-known phenomena, with the malignant phenotype enhancing coagulation and fibrinolysis. We hypothesized that soft tissue sarcoma (STS) affects the expression of coagulation and fibrinolysis markers, which could be used to distinguish STS from benign soft tissue tumors. We analyzed the correlations between plasma levels of D-dimer (DD), plasmin-α2 plasmin inhibitor complex (PIC), soluble fibrin (SF), and thrombin-antithrombin III complex (TAT) in benign soft tissue tumors and STS to elucidate whether these markers can be used to predict STS.Methods: Plasma DD, PIC, SF and TAT levels in primary soft tissue tumors (benign, 67, STS 68) were measured before biopsy or treatment. The marker levels were analyzed and compared to various clinicopathological parameters.Results: In malignancy (STS), the average DD, PIC and SF levels were significantly higher than in benign tumors. Multivariate logistic analysis of continuous variables indicated that only PIC exhibited a significant difference (OR: 24.5, 95%CI: 3.55-170, p=0.0012). Receiver operating characteristic curve analysis produced area under the curve values for DD: 0.691, PIC: 0.784, SF: 0.734 and TAT: 0.588. Youden’s index was used to establish thresholds of 0.37 (DD), 0.80 (PIC), 0.90 (SF) and 0.82 (TAT). Threshold values for PIC and SF indicated high specificity (0.881, 0.791) and high positive predictive value (0.818, 0.745), respectively The highest accuracy value among the markers was observed for PIC (0.704). Significant differences in multivariate analysis of binary variables were demonstrated by categorizing low and high groups based on their threshold, PIC (≥0.80) (OR: 3.36, 95%CI: 1.19-9.43, p=0.0212) and SF (≥0.90) (OR: 2.63, 95%CI: 1.04-6.66, p=0.0404) . Conclusions: Of the coagulation and fibrinolysis markers studied, increased PIC levels were related to STS and over 0.80 PIC was the most suitable for the prediction of STS, which, along with other diagnostic tools, represents a helpful subsidiary tool for the prediction of STS.

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Statistically Based Survival Rate Estimation in Patients with Soft Tissue Tumors

Romanian Journal of Orthopaedic Surgery and Traumatology ◽

10.2478/rojost-2018-0018 ◽

2018 ◽

Vol 1 (Supplement) ◽

pp. 7

Author(s):

B. Şerban ◽

Z. Panti ◽

M. Nica ◽

M. Pleniceanu ◽

M. Popa ◽

...

Keyword(s):

Survival Rate ◽

Soft Tissue ◽

Healing Rate ◽

Malignant Tumors ◽

Surgical Excision ◽

Soft Tissue Tumors ◽

Benign Tumors ◽

Rate Estimation ◽

Differentiation Degree ◽

Histopathological Type

Abstract Introduction. Although most soft tissue tumors are benign, with a high healing rate after surgical excision, there is a variety of malignant tumors with differences in progression and prognosis. The study aims to assess the survival rate in patients diagnosed with this pathology, based on the patient’s characteristics (age, gender, race), as well as the tumor’s (histological type, differentiation degree, location and size). Materials and methods. The retrospective study included a group of 103 patients diagnosed in our department during 2010 and 2017. Considering the high healing rate of benign tumors, only the group of neoplastic patients (45 cases) was involved in the survival rate estimation, assessing tumor characteristics and individual comorbidities. Within this lot, we emphasized a predominance of neoplasm in patients aged over 50 years (32 cases), men (29 cases), and localization of the neoplasm in the thigh (23 cases). The predominant histopathological type, liposarcoma, was diagnosed in 67% of the cases, with dimensions over 6 cm and with local extension. Results. There have been significant variations in mortality between the different histological subtypes (liposarcoma vs. synovial sarcoma). Local recurrences were shown in 18 cases of liposarcoma in the first 2 years after the surgical excision, with an increased aggressiveness of this neoplasm in men over 50 years. 12 cases developed distant metastasis, and, until the end of the study, 7 deaths were reported in 3 cases involving associated comorbidities. Conclusions. The five-year survival is inversely proportional to the extent of the tumor and the local invasion, as well as to the age of the patient. It is difficult to appreciate an overall survival rate in the context of a heterogeneous group of tumors so it must be evaluated for every histological subtype taking into account the patient’s particularities.

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Statistically based survival rate estimation in patients with soft tissue tumors

Romanian Journal of Orthopaedic Surgery and Traumatology ◽

10.2478/rojost-2018-0085 ◽

2018 ◽

Vol 1 (2) ◽

pp. 84-89

Author(s):

Bogdan Serban ◽

Zsombor Panti ◽

Mihai Nica ◽

Marian Pleniceanu ◽

Mihnea Popa ◽

...

Keyword(s):

Survival Rate ◽

Soft Tissue ◽

Healing Rate ◽

Malignant Tumors ◽

Surgical Excision ◽

Soft Tissue Tumors ◽

Benign Tumors ◽

Rate Estimation ◽

Differentiation Degree ◽

Histopathological Type

Abstract Although most soft tissue tumors are benign, with a high healing rate after surgical excision, there is a variety of malignant tumors with differences in progression and prognosis. The study aimed to assess the survival rate in patients diagnosed with this pathology, based on the patient’s characteristics (age, gender, race), as well as the tumor’s histological type, differentiation degree, location and size. The retrospective study included a group of 103 patients diagnosed during 2010 and 2017 in our department. Considering the high healing rate of benign tumors, only the group of neoplastic patients (45 cases) was involved in the survival rate estimation, assessing tumor characteristics and individual comorbidities. Within this lot, we emphasized a predominance of neoplasm in patients aged over 50 years (32 cases), men (29 cases), and localization of the neoplasm in the thigh (23 cases). The predominant histopathological type, liposarcoma, was diagnosed in 67% of the cases, with dimensions over 6 cm and with local extension. There have been significant variations in mortality between the different histological subtypes (liposarcoma vs. synovial sarcoma). Local recurrences were showed in 18 cases of liposarcoma in the first 2 years after the surgical excision, with an increased aggressiveness of this neoplasm in men over 50 years. 12 cases developed distant metastasis, and until the end of the study, 7 deaths were reported in 3 cases involving associated comorbidities. The five-year survival is inversely proportional to the extent of the tumor and the local invasion, as well as to the age of the patient. An overall survival rate is difficult to appreciate in the context of a heterogeneous group of tumors so it must be evaluated for every histological subtype taking into account the patient’s particularities.

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Spectrum of bone and soft tissue tumors in a tertiary cancer institute in Eastern india

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20183252 ◽

2018 ◽

Vol 6 (8) ◽

pp. 2686

Author(s):

Ashwini Natekar ◽

Shubasis Basu ◽

Gavruv Gupta ◽

Maruti Pujari

Keyword(s):

Soft Tissue ◽

Malignant Tumors ◽

Soft Tissue Tumors ◽

Benign Tumors ◽

Age Group ◽

Eastern India ◽

Female Ratio ◽

True Incidence ◽

Site Distribution ◽

Male Female Ratio

Background: Bone and soft tissue tumours are uncommon tumours that can affect any age group. Soft tissue tumors are said to be heterogeneous group of mesenchymal malignancies. Primary bone sarcomas are rare tumors, comprising approximately 0.2% of all cancers. Their true incidence is difficult to estimate because of their rarity. The outcome of the disease depends on the age and time at diagnosis.Methods: A study was carried out in department of pathology in tertiary cancer institute in East India from December 2015 to September 2017. A total of 60 cases were included in the study. All age group patients with indoor admissions and review cases were included in this study. Only soft tissue and bone tumors were included in the study. Epithelial tumors metastasis to bone were excluded from our study. Clinical and radiological details of patients were noted along with gross specimen findings and microscopic examination of H and E stained slides. IHC was also carried out for confirmatory diagnosis. Aims and objectives was to study the histological spectrum of bone and soft tissue tumors in a tertiary cancer institute in Eastern India. Also, to study gender distribution and site distribution of bone and soft tissue tumors.Results: Out of the total 60 cases studied 24 cases were of bone and cartilaginous tumours and 36 cases included were of soft tissue tumors. Benign tumors comprised of 08 cases (13.3%) and malignant tumors accounted to 52 cases (86.7%). Age of the patients ranged from 10 to 80 years. Male female ratio was 1.4:1.Conclusions: Multimodal therapies of treatment are practiced for bone and soft tissue tumors. Early detection and treatment is essential for diagnosis of these malignant tumors. Molecular studies are most important in diagnosing, classifying and also prognosticating bone and soft tissue tumors.

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Navigation-assisted surgery for bone and soft tissue tumors with bony extension.

Journal of Clinical Oncology ◽

10.1200/jco.2012.30.15_suppl.10073 ◽

2012 ◽

Vol 30 (15_suppl) ◽

pp. 10073-10073

Author(s):

Makoto Ieguchi ◽

Manabu Hoshi ◽

Jun Takada ◽

Noriaki Hidaka ◽

Yasushi Shigeoka ◽

...

Keyword(s):

Soft Tissue ◽

Minimally Invasive ◽

Malignant Tumors ◽

Soft Tissue Tumors ◽

Benign Tumors ◽

Navigation Systems ◽

Extraskeletal Osteosarcoma ◽

Registration Method ◽

Joint Replacement Surgery ◽

The Mean

10073 Background: In recent times,minimally invasive surgery, such as endoscopic surgery, has gained a lot of popularity.The navigation system was introduced to orthopedic surgery in the 1990s. These days, computed tomography (CT)-based navigation systems are commonly used in spine and joint replacement surgery because of their precision. The aim of our study was to evaluate the accuracy and efficacy of navigation-assisted excision of bone and soft tissue tumors. Methods: From January 2006 to December 2009, we performed navigation-assisted surgery in 16 patients (11 men and 5 women; mean age, 39 years; range, 13-70 years). We diagnosed 9 benign bone tumors and 7 malignant bone and soft tissue tumors. In 2 patients, the malignant soft tissue tumors infiltrated the adjacent bones. We performed excisional biopsies for the benign tumors and en bloc excisions for the malignant tumors. In all the cases, the point registration method was used with 10 skin markers that were placed around the tumor. Each excisional difference between the preoperative and postoperative plans was evaluated histologically or by postoperative CT. Results: The mean preoperative registration matching time was 12.8 min (range, 8-25 min). The total mean preparation time was 24 min (range, 16-35 min). The mean accuracy of this system, which was determined using the skin markers, was 0.93 mm (range, 0.6-1.5 mm). All biopsied and excised specimens were evaluated by pathologic examination and postoperative CT imaging. The mean difference between the planned margin and postoperative CT or the excised histological specimen was 0 to 4 mm. The mean follow-up period was 53.2 months (range, 10-70 months). There were no local recurrences, except for a case of chordoma that required excision of skip metastases and a case of extraskeletal osteosarcoma, in which the patient died from the disease. Conclusions: We report our experience with navigation-assisted surgery for bone and soft tissue tumors performed using skin markers. Navigation-assisted surgery was indicated in the case of sufficiently reliable, accurate, and minimally invasive resections.

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Schwannoma and Neurofibroma, Originating from the Ulnar Nerve in Neurofibromatosis: A Case Report and Review of the Literature

The Surgery Journal ◽

10.1055/s-0040-1712536 ◽

2020 ◽

Vol 06 (03) ◽

pp. e139-e144

Author(s):

Ali Tabrizi ◽

Ahmadreza Afshar ◽

Iraj Mohebbi ◽

Masoumeh Pourjabali ◽

Hassan Taleb

Keyword(s):

Soft Tissue ◽

Ulnar Nerve ◽

Soft Tissue Tumors ◽

Benign Tumors ◽

En Bloc ◽

Peripheral Nerve Sheath Tumors ◽

Complete Restoration ◽

Soft Tissue Masses ◽

Bloc Excision ◽

The Right

AbstractSchwannomas and neurofibromas are rare benign tumors originating from the peripheral nerve sheath. Tumors in neurofibromatosis are mostly neurofibromas and often appear in the soft tissue of peripheral nerves. In this report, a patient presented with two large adjacent soft tissue tumors in the right wrist and distal forearm which originated from a common nerve. A schwannoma had formed beside a neurofibroma from the ulnar nerve and induced numbness and paresthesia in the little and ring fingers. Although the patient had café au lait spots on the skin, neurofibromatosis was not suspected due to lack of symptoms. The patient was referred to the current research clinic suffering from two soft tissue masses in the wrist and ulnar nerve dysfunction. In neurofibromatosis patients, two tumors of a different nature originating from a common nerve close together have rarely been described in the literature. The patient was treated by en bloc excision of the mass while protecting the nerve fascicles. The follow-up results indicated no neurological symptoms and complete restoration of ulnar nerve function.

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Significance of coagulation and fibrinolysis markers for benign and malignant soft tissue tumors

BMC Cancer ◽

10.1186/s12885-021-08091-1 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Kunihiro Asanuma ◽

Tomoki Nakamura ◽

Tomohito Hagi ◽

Takayuki Okamoto ◽

Kouji Kita ◽

...

Keyword(s):

Soft Tissue ◽

Malignant Tumors ◽

Characteristic Curve ◽

Soft Tissue Tumors ◽

Clinicopathological Parameters ◽

Diagnostic Tools ◽

Benign Tumors ◽

Benign Soft Tissue Tumors ◽

Significant Difference ◽

Coagulation And Fibrinolysis

Abstract Background The intimate relationship between coagulation and fibrinolysis in malignant tumors is a well-known phenomena, with the malignant phenotype enhancing coagulation and fibrinolysis. We hypothesized that soft tissue sarcoma (STS) affects the expression of coagulation and fibrinolysis markers, which could be used to distinguish STS from benign soft tissue tumors. We analyzed the correlations between plasma levels of D-dimer (DD), plasmin-α2 plasmin inhibitor complex (PIC), soluble fibrin (SF), and thrombin-antithrombin III complex (TAT) in benign soft tissue tumors and STS to elucidate whether these markers can be used to predict STS. Methods Plasma DD, PIC, SF and TAT levels in primary soft tissue tumors (benign 67, STS 68) were measured before biopsy or treatment. The marker levels were analyzed and compared to various clinicopathological parameters. Results In malignancy (STS), the average DD, PIC and SF levels were significantly higher than in benign tumors. Multivariate logistic analysis of continuous variables indicated that only PIC exhibited a significant difference (OR: 24.5, 95%CI: 3.55–170, p = 0.0012). Receiver operating characteristic curve analysis produced area under the curve values for DD: 0.691, PIC: 0.784, SF: 0.734 and TAT: 0.588. Youden’s index was used to establish thresholds of 0.37 (DD), 0.80 (PIC), 0.90 (SF) and 0.82 (TAT). Threshold values for PIC and SF indicated high specificity (0.881, 0.791) and high positive predictive value (0.818, 0.745), respectively. The highest accuracy value among the markers was observed for PIC (0.704). Significant differences in multivariate analysis of binary variables were demonstrated by categorizing low and high groups based on their threshold, PIC (≥0.80) (OR: 3.36, 95%CI: 1.19–9.43, p = 0.0212) and SF (≥0.90) (OR: 2.63, 95%CI: 1.04–6.66, p = 0.0404) . Conclusions Of the coagulation and fibrinolysis markers studied, increased PIC levels were related to STS and over 0.80 PIC was the most suitable for the prediction of STS, which, along with other diagnostic tools, represents a helpful subsidiary tool for the prediction of STS.

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