scholarly journals Mapping Epistatic Quantitative Trait Loci With One-Dimensional Genome Searches

Genetics ◽  
2001 ◽  
Vol 157 (1) ◽  
pp. 445-454 ◽  
Author(s):  
Jean-Luc Jannink ◽  
Ritsert Jansen
Keyword(s):  
Maximum Likelihood ◽  
Doubled Haploid ◽  
Quantitative Trait ◽  
Genetic Background ◽  
Two Dimensional ◽  
Qtl Detection ◽  
One Dimensional ◽  
First Order ◽  
Large Populations ◽  
Different Levels

AbstractThe discovery of epistatically interacting QTL is hampered by the intractability and low power to detect QTL in multidimensional genome searches. We describe a new method that maps epistatic QTL by identifying loci of high QTL by genetic background interaction. This approach allows detection of QTL involved not only in pairwise but also higher-order interaction, and does so with one-dimensional genome searches. The approach requires large populations derived from multiple related inbred-line crosses as is more typically available for plants. Using maximum likelihood, the method contrasts models in which QTL allelic values are either nested within, or fixed over, populations. We apply the method to simulated doubled-haploid populations derived from a diallel among three inbred parents and illustrate the power of the method to detect QTL of different effect size and different levels of QTL by genetic background interaction. Further, we show how the method can be used in conjunction with standard two-locus QTL detection models that use two-dimensional genome searches and find that the method may double the power to detect first-order epistasis.

scholarly journals Two-dimensional ground-state mapping of a Mott-Hubbard system in a flexible field-effect device

2019 ◽  
Vol 5 (5) ◽  
pp. eaav7282 ◽  
Author(s):  
Yoshitaka Kawasugi ◽  
Kazuhiro Seki ◽  
Satoshi Tajima ◽  
Jiang Pu ◽  
Taishi Takenobu ◽  
...  
Keyword(s):  
Phase Diagram ◽  
Ground State ◽  
Field Effect ◽  
Mott Insulator ◽  
Two Dimensional ◽  
Superconducting Transition ◽  
Microscopic Mechanism ◽  
One Dimensional ◽  
First Order ◽  
Insulating Phase

A Mott insulator sometimes induces unconventional superconductivity in its neighbors when doped and/or pressurized. Because the phase diagram should be strongly related to the microscopic mechanism of the superconductivity, it is important to obtain the global phase diagram surrounding the Mott insulating state. However, the parameter available for controlling the ground state of most Mott insulating materials is one-dimensional owing to technical limitations. Here, we present a two-dimensional ground-state mapping for a Mott insulator using an organic field-effect device by simultaneously tuning the bandwidth and bandfilling. The observed phase diagram showed many unexpected features such as an abrupt first-order superconducting transition under electron doping, a recurrent insulating phase in the heavily electron-doped region, and a nearly constant superconducting transition temperature in a wide parameter range. These results are expected to contribute toward elucidating one of the standard solutions for the Mott-Hubbard model.

scholarly journals A multi-marker model for detecting chromosomal segments displaying QTL activity.

Genetics ◽  
1993 ◽  
Vol 134 (4) ◽  
pp. 1277-1288 ◽  
Author(s):  
F Rodolphe ◽  
M Lefort
Keyword(s):  
Quantitative Trait Loci ◽  
Genetic Analysis ◽  
Statistical Method ◽  
Linear Model ◽  
Genetic Markers ◽  
Doubled Haploid ◽  
Quantitative Trait ◽  
Asymptotic Properties ◽  
Genetic Determinism ◽  
Qtl Detection

Abstract A statistical method is presented for detecting quantitative trait loci (QTLs), based on the linear model. Unlike methods able to detect a few well separated QTLs and to estimate their effects and positions, this method considers the genome as a whole and enables the detection of chromosomal segments involved in the differences between two homozygous lines, and their backcross, doubled haploid, or F2 progenies, for a quantitative trait. Genetic markers must be codominant, but missing markers are accepted, provided they are missing independently from the experiment. Asymptotic properties, which are of practical use, are developed. This method does not rely on strong genetic hypotheses, and thus does not permit any precise genetic analysis of the trait under study, but it does assess which regions of the genome are involved, whatever the complexity of the genetic determinism (number, effects and interactions among QTLs). Simultaneous use of several methods, including this one, should lead to better efficiency in QTL detection.

Improvement on Spherical Symmetry in Two-Dimensional Cylindrical Coordinates for a Class of Control Volume Lagrangian Schemes

2012 ◽  
Vol 11 (4) ◽  
pp. 1144-1168 ◽  
Author(s):  
Juan Cheng ◽  
Chi-Wang Shu
Keyword(s):  
Spherical Symmetry ◽  
Gas Dynamics ◽  
Control Volume ◽  
Two Dimensional ◽  
Cylindrical Coordinates ◽  
One Dimensional ◽  
First Order ◽  
Conservation Of Momentum ◽  
Numerical Fluxes ◽  
Geometric Conservation Law

AbstractIn, Maire developed a class of cell-centered Lagrangian schemes for solving Euler equations of compressible gas dynamics in cylindrical coordinates. These schemes use a node-based discretization of the numerical fluxes. The control volume version has several distinguished properties, including the conservation of mass, momentum and total energy and compatibility with the geometric conservation law (GCL). However it also has a limitation in that it cannot preserve spherical symmetry for one-dimensional spherical flow. An alternative is also given to use the first order area-weighted approach which can ensure spherical symmetry, at the price of sacrificing conservation of momentum. In this paper, we apply the methodology proposed in our recent work to the first order control volume scheme of Maire in to obtain the spherical symmetry property. The modified scheme can preserve one-dimensional spherical symmetry in a two-dimensional cylindrical geometry when computed on an equal-angle-zoned initial grid, and meanwhile it maintains its original good properties such as conservation and GCL. Several two-dimensional numerical examples in cylindrical coordinates are presented to demonstrate the good performance of the scheme in terms of symmetry, non-oscillation and robustness properties.

scholarly journals Die Zeit in zweidimensionaler Betrachtung

2016 ◽  
Vol 64 (6) ◽  
Author(s):  
Anton Friedrich Koch
Keyword(s):  
Second Order ◽  
Temporal Scale ◽  
Two Dimensional ◽  
Temporal Scales ◽  
One Dimensional ◽  
First Order ◽  
The Past ◽  
The Future

AbstractB-time, i. e. the temporal scale of the B-series of events, is one and the same for all times, while A-times (the temporal scales of A-series) are as many as there are moments of time. This means that A-theorists will have to consider one-dimensional time two-dimensionally: as changing within itself at every moment. The two-dimensional view is here put to service for a meta-compatibilist theory of freedom, a theory, that is, which reconciles freedom, determinism and their first order incompatibility at the second order. Kant’s position is interpreted as meta-compatibilist as well, but as having the drawback of separating time and freedom. In order to appreciate the connection of time and freedom, one has to acknowledge that in free acts the future is determined further according to plan, while at the same time the past is (with nomological necessity) co-determined further in countless unclear and inscrutable ways. A free act thus consumes its own range of freedom by positing retroactively the sufficient causal antecedents for its taking place: It was free before it occurred and is part of nature after.

Equivalent Composite Laminated Beams With Various Elastic Constitutive Models

1999 ◽  
Author(s):  
Izhak Sheinman ◽  
Yeoshua Frostig
Keyword(s):  
Lower Bounds ◽  
Plane Stress ◽  
Constitutive Models ◽  
Upper And Lower Bounds ◽  
Two Dimensional ◽  
Laminated Beams ◽  
Cylindrical Bending ◽  
One Dimensional ◽  
First Order ◽  
Shear Deformable

Abstract Equivalent one-dimensional constitutive models of composite laminated beams with shear deformation are derived from the classical laminate two-dimensional using first-order shear deformable theory. The present cylindrical bending constitutive models can be used — with much greater accuracy than their well known plane-strain and plane-stress counterparts — as upper and lower bounds, to one of which the behavior tends depending on the width-to-length ratio; this aspect was investigated and results are presented.

A one-dimensional self-gravitating stellar gas

1966 ◽  
Vol 25 ◽  
pp. 46-48 ◽  
Author(s):  
M. Lecar
Keyword(s):  
Gravitational Field ◽  
Phase Space ◽  
Motion Picture ◽  
Space Distribution ◽  
Two Dimensional ◽  
One Dimensional ◽  
Phase Space Distribution ◽  
Dimensional Phase Space ◽  
The Mean

“Dynamical mixing”, i.e. relaxation of a stellar phase space distribution through interaction with the mean gravitational field, is numerically investigated for a one-dimensional self-gravitating stellar gas. Qualitative results are presented in the form of a motion picture of the flow of phase points (representing homogeneous slabs of stars) in two-dimensional phase space.

Estimating the Cost of Car Warranty in Indonesia using the Gertsbakh-Kordonsky Method

2020 ◽  
Vol 2 (1) ◽  
pp. 33-40
Author(s):  
Anggis Sagitarisman ◽  
Aceng Komarudin Mutaqin
Keyword(s):  
Maximum Likelihood ◽  
Likelihood Estimation ◽  
Type A ◽  
Claim Data ◽  
Likelihood Method ◽  
Selling Price ◽  
One Dimensional ◽  
Warranty Period ◽  
Kolmogorov Smirnov ◽  
Warranty Costs

AbstractCar manufacturers in Indonesia need to determine reasonable warranty costs that do not burden companies or consumers. Several statistical approaches have been developed to analyze warranty costs. One of them is the Gertsbakh-Kordonsky method which reduces the two-dimensional warranty problem to one dimensional. In this research, we apply the Gertsbakh-Kordonsky method to estimate the warranty cost for car type A in XYZ company. The one-dimensional data will be tested using the Kolmogorov-Smirnov to determine its distribution and the parameter of distribution will be estimated using the maximum likelihood method. There are three approaches to estimate the parameter of the distribution. The difference between these three approaches is in the calculation of mileage for units that do not claim within the warranty period. In the application, we use claim data for the car type A. The data exploration indicates the failure of car type A is mostly due to the age of the vehicle. The Kolmogorov-Smirnov shows that the most appropriate distribution for the claim data is the three-parameter Weibull. Meanwhile, the estimated using the Gertsbakh-Kordonsky method shows that the warranty costs for car type A are around 3.54% from the selling price of this car unit without warranty i.e. around Rp. 4,248,000 per unit.Keywords: warranty costs; the Gertsbakh-Kordonsky method; maximum likelihood estimation; Kolmogorov-Smirnov test.                                   AbstrakPerusahaan produsen mobil di Indonesia perlu menentukan biaya garansi yang bersifat wajar tidak memberatkan perusahaan maupun konsumen. Beberapa pendekatan statistik telah dikembangkan untuk menganalisis biaya garansi. Salah satunya adalah metode Gertsbakh-Kordonsky yang mereduksi masalah garansi dua dimensi menjadi satu dimensi. Pada penelitian ini, metode Gertsbakh-Kordonsky akan digunakan untuk mengestimasi biaya garansi untuk mobil tipe A pada perusahaan XYZ. Data satu dimensi hasil reduksi diuji kecocokan distribusinya menggunakan uji kecocokan Kolmogorov-Smirnov dan taksiran parameter distribusinya menggunakan metode penaksir kemungkinan maksimum. Ada tiga pendekatan yang digunakan untuk menaksir parameter distribusi. Perbedaan dari ketiga pendekatan tersebut terletak pada perhitungan jarak tempuh untuk unit yang tidak melakukan klaim dalam periode garansi. Sebagai bahan aplikasi, kami menggunakan data klaim unit mobil tipe A. Hasil eksplorasi data menunjukkan bahwa kegagalan mobil tipe A lebih banyak disebabkan karena faktor usia kendaraan. Hasil uji kecocokan distribusi untuk data hasil reduksi menunjukkan bahwa distribusi yang cocok adalah distribusi Weibull 3-parameter. Sementara itu, hasil perhitungan taksiran biaya garansi menunjukan bahwa taksiran biaya garansi untuk unit mobil tipe A sekitar 3,54% dari harga jual unit mobil tipe A tanpa garansi, atau sekitar Rp. 4.248.000,- per unit.Kata Kunci: biaya garansi; metode Gertsbakh-Kordonsky; penaksiran kemungkinan maksimum; uji Kolmogorov-Smirnov.

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