scholarly journals Proteome-Wide Analysis Using SOMAscan Identifies and Validates Chitinase-3-Like Protein 1 as a Risk and Disease Marker of Delirium Among Older Adults Undergoing Major Elective Surgery

2021 ◽  
Author(s):  
Sarinnapha M Vasunilashorn ◽  
Simon T Dillon ◽  
Noel Y Chan ◽  
Tamara G Fong ◽  
Marie Joseph ◽  
...  
Keyword(s):  
Older Adults ◽  
Successful Aging ◽  
Postoperative Delirium ◽  
Linear Models ◽  
Elective Surgery ◽  
Protein Modeling ◽  
Full Cohort ◽  
Validation Data ◽  
Age Related

Abstract Background Delirium (an acute change in cognition) is a common, morbid, and costly syndrome seen primarily in aging adults. Despite increasing knowledge of its epidemiology, delirium remains a clinical diagnosis with no established biomarkers to guide diagnosis or management. Advances in proteomics now provide opportunities to identify novel markers of risk and disease progression for postoperative delirium and its associated long-term consequences (eg, long-term cognitive decline and Alzheimer’s disease [AD]). Methods In a nested matched case–control study (18 delirium/no-delirium pairs) within the Successful Aging after Elective Surgery study (N = 556), we evaluated the association of 1305 plasma proteins preoperatively [PREOP] and on postoperative day 2 [POD2]) with delirium using SOMAscan. Generalized linear models were applied to enzyme-linked immunosorbant assay (ELISA) validation data of one protein across the full cohort. Multi-protein modeling included delirium biomarkers identified in prior work (C-reactive protein, interleukin-6 [IL6]). Results We identified chitinase-3-like-protein-1 (CHI3L1/YKL-40) as the sole delirium-associated protein in both a PREOP and a POD2 predictor model, a finding confirmed by ELISA. Multi-protein modeling found high PREOP CHI3L1/YKL-40 and POD2 IL6 increased the risk of delirium (relative risk [95% confidence interval] Quartile [Q]4 vs Q1: 2.4[1.2–5.0] and 2.1[1.1–4.1], respectively). Conclusions Our identification of CHI3L1/YKL-40 in postoperative delirium parallels reports of CHI3L1/YKL-40 and its association with aging, mortality, and age-related conditions including AD onset and progression. This highlights the type 2 innate immune response, involving CHI3L1/YKL-40, as an underlying mechanism of postoperative delirium, a common, morbid, and costly syndrome that threatens the independence of older adults.

scholarly journals AN INFLAMMATORY SIGNATURE OF POSTOPERATIVE DELIRIUM

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S820-S821
Author(s):  
Sarinnapha Vasunilashorn ◽  
Long H Ngo ◽  
Simon Dillon ◽  
Hasan Otu ◽  
Bridget Tripp ◽  
...  
Keyword(s):  
Successful Aging ◽  
Inflammatory Markers ◽  
Postoperative Delirium ◽  
Linear Models ◽  
Elective Surgery ◽  
Geriatric Syndrome ◽  
Reactive Protein ◽  
Increased Risk ◽  
Comorbidity Index ◽  
Inflammatory Proteins

Abstract Delirium is a common, morbid, and costly geriatric syndrome, yet its pathophysiology remains poorly understood. In a nested matched case-control study within the Successful Aging after Elective Surgery (SAGES) study, a cohort of adults age ≥70 without dementia undergoing major non-cardiac surgery, we previously identified inflammatory proteins to be associated with delirium. Using the entire SAGES cohort, the current study examines the independent associations of these inflammatory proteins with postoperative delirium. Plasma was collected preoperatively (PREOP) and on postoperative day 2 (POD2). Neuroinflammatory marker chitinase-3-like protein [CHI3l1 or YKL-40]; PREOP and POD2) and systemic inflammatory markers interleukin [IL]-6 (POD2 only) and C-reactive protein (CRP; PREOP and POD2) were measured using enzyme-linked immunosorbent assays. Generalized linear models were used to determine the independent (multivariable) associations between the inflammatory markers, measured in sample-based quartiles (Q). All models adjusted for age, sex, baseline cognition, surgery type, Charlson comorbidity index, and medical complications. Among the 555 patients (mean age 77 years, standard deviation, SD 5.2), 58% were female and 86% underwent orthopedic surgeries. Postoperative delirium occurred in 24%. High YKL-40 PREOP and IL-6 at POD2 (Q4 vs. Q1) were significantly associated with an increased risk of delirium: relative risk (RR) [95% confidence interval (CI)] 2.2[1.1-4.4] and 2.7[1.3-5.7], respectively. CRP (PREOP and POD2) was not significantly associated with delirium (p=0.37 and p=0.73, respectively). This work underscores the importance of inflammation (YKL-40 and IL-6) in the pathophysiology of postoperative delirium.

Aging of Competitive Athletes

Gerontology ◽  
2017 ◽  
Vol 63 (5) ◽  
pp. 488-494 ◽  
Author(s):  
Hirofumi Tanaka
Keyword(s):  
Older Adults ◽  
Poor Quality ◽  
Negative Stereotypes ◽  
Age Related ◽  
Masters Athletes ◽  
Competitive Athletes ◽  
Vascular Stiffening ◽  
High Motivation ◽  
Clinical Conditions

Demographics of human aging are rapidly changing. As illustrated in the biomedicalization of aging, an ever increasing number of older adults is affected by a variety of clinical conditions and diseases, including vascular stiffening, sarcopenia, physical disability, and poor quality of life. One population that is situated in the opposite end of the health and functional spectrum to the sedentary frail elderly is Masters athletes. These older competitive athletes are endowed with substantial functional capacity, overall long-term health, high motivation, and psychosocial outlook. Masters athletes are combating the dogma and negative stereotypes of older adults and aging. From the scientific standpoint, examining Masters athletes can provide insight into preventive gerontology, primary prevention of age-related diseases and dysfunctions, and exercise-based medical practices. Moreover, the study on Masters athletes is simply joyous and entertaining as they often remind us what can be possible in aging.

scholarly journals Dissociating refreshing and elaboration and their impacts on memory

2018 ◽  
Author(s):  
Lea M. Bartsch ◽  
Vanessa M. Loaiza ◽  
Lutz Jäncke ◽  
Klaus Oberauer ◽  
Jarrod A. Lewis-Peacock
Keyword(s):  
Older Adults ◽  
Memory Performance ◽  
Ethics Committees ◽  
Fmri Data ◽  
Ethical Review ◽  
Long Term Memory ◽  
List Type ◽  
Term Memory ◽  
Age Related

AbstractMaintenance of information in working memory (WM) is assumed to rely on refreshing and elaboration, but clear mechanistic descriptions of these cognitive processes are lacking, and it is unclear whether they are simply two labels for the same process. This fMRI study investigated the extent to which refreshing, elaboration, and repeating of items in WM are distinct neural processes with dissociable behavioral outcomes in WM and long-term memory (LTM). Multivariate pattern analyses of fMRI data revealed differentiable neural signatures for these processes, which we also replicated in an independent sample of older adults. In some cases, the degree of neural separation within an individual predicted their memory performance. Elaboration improved LTM, but not WM, and this benefit increased as its neural signature became more distinct from repetition. Refreshing had no impact on LTM, but did improve WM, although the neural discrimination of this process was not predictive of the degree of improvement. These results demonstrate that refreshing and elaboration are separate processes that differently contribute to memory performance.HighlightsRepeated reading, refreshing, and elaboration are differentiable in brain activation patterns in both young and older adults.Elaboration selectively improved long-term memory for young adults, and the size of the benefit was related to the neural separability of elaboration from other processes.Older adults implemented a sub-optimal form of elaboration, and this may be a factor contributing to age-related deficits in long-term memory.Ethics statementThe study was approved by the ethical review board of the canton of Zurich (BASEC-No. 2017-00190) and all subjects gave informed written consent in accordance with the Declaration of Helsinki.Data and code availability statementAll behavioral data and analysis scripts can be assessed on the Open Science Framework (osf.io/p2h8b/). The fMRI data that support the findings of this study are available on request from the corresponding author, LMB. The fMRI data are not publicly available due to restrictions of the Swiss Ethics Committees on research involving humans regarding data containing information that could compromise the privacy of research participants.

scholarly journals UTILIZING TECHNOLOGY NETWORKS TO SUPPORT SOCIAL NETWORKS FOR PEOPLE AGING WITH DISABILITY

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S758-S759
Author(s):  
Elena T Remillard ◽  
Wendy Rogers ◽  
Sarah Ruiz
Keyword(s):  
Older Adults ◽  
Successful Aging ◽  
Independent Living ◽  
Large Scale ◽  
Tai Chi ◽  
New Technologies ◽  
Great Promise ◽  
Ongoing Research ◽  
Engineering Research

Abstract A growing number of new smart, internet-enabled technologies from smart phone applications, to teleconferencing, to the Internet of Things (IoT), provide great promise and potential to support successful aging-in-place for people with long-term disabilities. This symposium highlights ongoing research at the TechSAge Rehabilitation Engineering Research Center to identify technology needs and develop/adapt new technologies to promote independence, health, and participation of this population. To understand user needs, Harris et al. will present findings from a large-scale interview study with older adults with long-term vision and mobility disabilities (N=120) that explored specific task-based challenges with community activities (e.g., going to entertainment events, volunteering) as well as solutions and strategies to overcome them. Koon et al. will present findings on perceived facilitators and barriers to using digital assistants (e.g., Amazon Alexa) to facilitate a variety of everyday tasks at home, from shopping to communicating with others, among adults aging with mobility disabilities. Levy et al. will discuss findings from research driving the creation of augmented reality tools that can enable individuals to experience how IoT devices, such as smart thermostats and lightbulbs, could be used within the context of one’s own abilities and home. Mitzner et al., will describe the development of a Tele Tai Chi intervention for older adults with long-term mobility disabilities that employs teleconferencing software to translate an in-person, evidence-based class to an online, social experience. TechSAge Program Officer, Sarah Ruiz (National Institute on Disability, Independent Living, and Rehabilitation Research), will serve as the discussant.

Older Adults’ Recalled Memorable Messages about Aging and Their Associations with Successful Aging

2019 ◽  
Vol 45 (4) ◽  
pp. 474-507 ◽  
Author(s):  
Quinten S Bernhold ◽  
Howard Giles
Keyword(s):  
Older Adults ◽  
Successful Aging ◽  
Hope Theory ◽  
Memorable Messages ◽  
Subjective State ◽  
Age Related ◽  
Dispositional Hope ◽  
The Right ◽  
Memorable Message

Abstract Using the Communicative Ecology Model of Successful Aging (CEMSA), this study examined how one’s own age-related communication and memorable message characteristics indirectly predict successful aging, via aging efficacy. Older adults with higher dispositional hope recalled memorable messages as (a) higher in positivity, (b) higher in efficacy, and (c) more likely to contain a theme of aging not being important or being a subjective state that can be overcome with the right mindset. Older adults were classified as engaged, bantering, or disengaged agers, based on their own age-related communication. Uniquely for CEMSA’s development and the blended role of hope theory within it, memorable message efficacy indirectly predicted greater successful aging, via heightened aging efficacy.

scholarly journals Individual and Environmental Barriers to Successful Aging

2016 ◽  
Vol 11 (1) ◽  
pp. 21-23 ◽  
Author(s):  
Daphne C. Hernandez ◽  
Craig A. Johnston
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Low Income ◽  
Successful Aging ◽  
Healthy Lifestyle ◽  
Behavioral Changes ◽  
Healthy Diet ◽  
Environmental Barriers ◽  
Aging Adults

The cornerstone to successful aging is maintaining a consistent physical activity routine and healthy diet. This is particular important for aging adults to preserve their independence. However, for low-income aging adults there are significant individual and environmental barriers that reduce their ability to maintain a healthy lifestyle. Understanding how environmental supports can be found in existing programs geared toward older adults is a way to insure long-term behavioral changes.

scholarly journals Prediction of Long-term Cognitive Decline Following Postoperative Delirium in Older Adults

2017 ◽  
Vol 72 (12) ◽  
pp. 1697-1702 ◽  
Author(s):  
Elizabeth E Devore ◽  
Tamara G Fong ◽  
Edward R Marcantonio ◽  
Eva M Schmitt ◽  
Thomas G Travison ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Decline ◽  
Postoperative Delirium

scholarly journals Moving toward a neuroplasticity view of bilingualism, executive control, and aging

2014 ◽  
Vol 35 (5) ◽  
pp. 857-894 ◽  
Author(s):  
SHARI BAUM ◽  
DEBRA TITONE
Keyword(s):  
Older Adults ◽  
Language Processing ◽  
Executive Control ◽  
Cognitive Aging ◽  
Successful Aging ◽  
Empirical Support ◽  
Individual Variability ◽  
Cognitive Capacity ◽  
Neurocognitive Functions ◽  
Age Related

ABSTRACTNormal aging is an inevitable race between increasing knowledge and decreasing cognitive capacity. Crucial to understanding and promoting successful aging is determining which of these factors dominates for particular neurocognitive functions. Here, we focus on the human capacity for language, for which healthy older adults are simultaneously advantaged and disadvantaged. In recent years, a more hopeful view of cognitive aging has emerged from work suggesting that age-related declines in executive control functions are buffered by life-long bilingualism. In this paper, we selectively review what is currently known and unknown about bilingualism, executive control, and aging. Our ultimate goal is to advance the views that these issues should be reframed as a specific instance of neuroplasticity more generally and, in particular, that researchers should embrace the individual variability among bilinguals by adopting experimental and statistical approaches that respect the complexity of the questions addressed. In what follows, we set out the theoretical assumptions and empirical support of the bilingual advantages perspective, review what we know about language, cognitive control, and aging generally, and then highlight several of the relatively few studies that have investigated bilingual language processing in older adults, either on their own or in comparison with monolingual older adults. We conclude with several recommendations for how the field ought to proceed to achieve a more multifactorial view of bilingualism that emphasizes the notion of neuroplasticity over that of simple bilingual versus monolingual group comparisons.

scholarly journals Development of a Comprehensive Chinese Successful Aging Scale: Incorporating the Viewpoints of Older Adults

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 215-216
Author(s):  
Edwin K H Chung ◽  
Dannii Yeung
Keyword(s):  
Older Adults ◽  
Successful Aging ◽  
Well Being ◽  
Community Dwelling ◽  
Survey Study ◽  
Age Related ◽  
Initial Item ◽  
Civic Awareness ◽  
Definition Of ◽  
Community Dwelling Older Adults

Abstract Inspiring by Martinson and Berridge’s (2015) systematic review, the current definition of successful aging (SA) fails to acknowledge the laypeople’s conceptualization of SA. Adopting a mixed-method approach, two studies were conducted with the aim of soliciting older adults’ perceptions of SA and to develop a multidimensional instrument for assessing SA. Study 1 was a qualitative study and 27 community-dwelling older adults (Mage=68.07 years, SD=7.10, range=60–83; 56.3% females) were interviewed. Interview transcripts were analyzed, and seven themes were emerged. An initial item pool for the Successful Aging Scale (SAS) was then established based on these themes as well as those in the SA literature, such as acceptance and independence. Study 2 was a survey study which was conducted among 414 community-dwelling older adults (Mage=64.50 years, SD=4.01, range=60–82; 55.3% females) to identify optimal items for constitution of the SAS. Exploratory factor analysis revealed a 12-factor solution, accounting for 62% of the variance. The 12 factors are adequate health, perceived constraints, flexible attitudes toward life, acceptance of age-related change, life embracement, active engagement, harmonious family, supportive friendship, civic awareness, social contribution, living independently, and adaptive coping strategies. The 12 factors exhibit similar strength of associations with most of the well-being measures, but certain factors show stronger correlation with depressive symptoms and social relationship, suggesting the uniqueness of each factor. Overall, the SAS demonstrates promising psychometric properties. These findings disclose that the older adults’ perceptions of SA could cover broader dimensions than those in Rowe and Kahn’s model (1997).

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