Longitudinal Profiling in Phenotypic Metric of Aging: Insights From the Baltimore Longitudinal Study of Aging

Abstract It remains challenging to quantify the pace of aging across lifespan due to lack of comprehensive longitudinal measurements across wide range of age. In Baltimore Longitudinal Study of Aging, we have measured the longitudinal trajectories of more than 30 phenotypes across four pre-identified domain - body composition, energy regulation, homeostatic mechanisms and neurodegeneration/neuroplasticity, among participants with age between 20+ and 90+. We implemented a two-stage approach to summarize the longitudinal trajectories of these phenotypes across four domains into a summarized score. We demonstrated that higher summarized score (denoting for slower longitudinal phenotypic decline) is associated with slower decline in both cognitive and physical functions, across different stages of adulthood. Our results imply that deep longitudinal profiling contains rich information and may potentially replace diseases as an early endpoint in trials targeting at aging. Further, understanding the underpinning of longitudinal phenotypic trajectories may provide clues to the biological mechanisms of aging.

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Factors affecting longitudinal trajectories of plasma sphingomyelins: the Baltimore Longitudinal Study of Aging

Aging Cell ◽

10.1111/acel.12275 ◽

2014 ◽

Vol 14 (1) ◽

pp. 112-121 ◽

Cited By ~ 43

Author(s):

Michelle M. Mielke ◽

Veera Venkata Ratnam Bandaru ◽

Dingfen Han ◽

Yang An ◽

Susan M. Resnick ◽

...

Keyword(s):

Longitudinal Study ◽

Factors Affecting ◽

Longitudinal Trajectories ◽

Baltimore Longitudinal Study

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Longitudinal Trajectories in Guilford-Zimmerman Temperament Survey Data: Results From the Baltimore Longitudinal Study of Aging

The Journals of Gerontology Series B ◽

10.1093/geronb/61.2.p108 ◽

2006 ◽

Vol 61 (2) ◽

pp. P108-P116 ◽

Cited By ~ 36

Author(s):

A. Terracciano ◽

R. R. McCrae ◽

P. T. Costa

Keyword(s):

Longitudinal Study ◽

Survey Data ◽

Longitudinal Trajectories ◽

Baltimore Longitudinal Study

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1344: Metabolic Factors Associated with Benign Prostatic Hyperplasia: The Baltimore Longitudinal Study of Aging

The Journal of Urology ◽

10.1016/s0022-5347(18)33557-2 ◽

2006 ◽

Vol 175 (4S) ◽

pp. 432-433 ◽

Cited By ~ 4

Author(s):

J. Kellogg Parsons ◽

H. Ballentine Carter ◽

Alan W. Partin ◽

B. Gwen Windham ◽

E. Jeffrey Metter ◽

...

Keyword(s):

Longitudinal Study ◽

Benign Prostatic Hyperplasia ◽

Prostatic Hyperplasia ◽

Metabolic Factors ◽

Factors Associated ◽

Baltimore Longitudinal Study

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Faculty Opinions recommendation of Serum testosterone is associated with aggressive prostate cancer in older men: results from the Baltimore Longitudinal Study of Aging.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1166133.627551 ◽

2009 ◽

Author(s):

Noelle LoConte ◽

Ticiana Leal

Keyword(s):

Prostate Cancer ◽

Longitudinal Study ◽

Serum Testosterone ◽

Older Men ◽

Aggressive Prostate Cancer ◽

Baltimore Longitudinal Study

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Faculty Opinions recommendation of Prevalence and prognostic significance of exercise-induced nonsustained ventricular tachycardia in asymptomatic volunteers: BLSA (Baltimore Longitudinal Study of Aging).

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718071487.793484424 ◽

2013 ◽

Author(s):

Wilbert Aronow

Keyword(s):

Ventricular Tachycardia ◽

Longitudinal Study ◽

Prognostic Significance ◽

Nonsustained Ventricular Tachycardia ◽

Asymptomatic Volunteers ◽

Baltimore Longitudinal Study ◽

Exercise Induced

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Personality and Insomnia Symptoms in Older Adults: The Baltimore Longitudinal Study of Aging

Innovation in Aging ◽

10.1093/geroni/igaa057.1925 ◽

2020 ◽

Vol 4 (Supplement_1) ◽

pp. 578-579

Author(s):

Darlynn Rojo-Wissar ◽

Amal Wanigatunga ◽

Eleanor Simonsick ◽

Antonio Terracciano ◽

Jennifer Schrack ◽

...

Keyword(s):

Older Adults ◽

Longitudinal Study ◽

Sleep Disturbances ◽

Positive Emotions ◽

Rating Scale ◽

Factor Model ◽

Five Factor Model ◽

Baltimore Longitudinal Study ◽

Insomnia Symptoms ◽

Insomnia Severity

Abstract Personality and disturbed sleep are tied to medical morbidity in older adults. We examined associations of personality dimensions and facets from the five-factor model with reports of insomnia symptoms in 1,069 well-functioning older adults 60-97 (SD=8.64) years (51% women) from the Baltimore Longitudinal Study of Aging. Personality was assessed by the Revised NEO Personality Inventory, and insomnia symptoms measured by the Women’s Health Initiative Insomnia Rating Scale. Adjusting for demographics and depressive symptoms, higher neuroticism (B=0.05, SE=-0.01, p<.001) and lower conscientiousness (B=-0.03, SE=-0.01, p<.05) were associated with greater insomnia severity. Although openness, extraversion and agreeableness were not associated with insomnia, a facet of each was. Higher scores on the “positive emotions” facet of extraversion (B =-0.03, SE=-0.01, p<.05) “ideas” facet of openness (B=-0.03, SE=-0.01, p<.05) and altruism facet of agreeableness (B=-0.03, SE=-0.01, p<.05) were associated with lower insomnia severity. Sleep disturbances may partially mediate personality’s influence on health. Part of a symposium sponsored by the Sleep, Circadian Rhythms and Aging Interest Group.

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A longitudinal study of suicide and suicide attempt in northwest of Iran: incidence, predictors, and socioeconomic status and the role of sociocultural status

BMC Public Health ◽

10.1186/s12889-021-11527-9 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Ali Fakhari ◽

Mostafa Farahbakhsh ◽

Elham Davtalab Esmaeili ◽

Hosein Azizi

Keyword(s):

Socioeconomic Status ◽

Longitudinal Study ◽

Religious Commitment ◽

Incidence Rates ◽

Demographic Characteristics ◽

Protective Effects ◽

Wide Range ◽

Multiple Variable ◽

History Of

Abstract Background A detailed community-level understanding of socioeconomic status (SES) and sociocultural status (SCS) of suicides and suicide attempters (SAs) in a prospective design could have significant implications for policymakers at the local prevention and treatment levels. The effect of SCS and SES on SAs is poorly understood and investigated in Iran. The present study aimed to investigate the incidence, trend, and role of SES and SCS on suicide and SAs. Methods A longitudinal study was conducted based on the registry for SAs in Malekan County, Iran, from 2015 to 2018. Demographic characteristics, SES, SCS, incidence rates, and predictors of suicidal behaviors were measured via structured instruments. Simple and multiple logistic regressions were used to estimate crude and adjusted odds ratios (ORs) and 95% confidence intervals (CIs). Results A total of 853 SAs (32 suicides and 821 attempts) were identified during the study. Trend analysis revealed that the suicide rate significantly decreased from 2014 (10.28) to 2018 (1.75) per 100,000. In the final multiple variable models, age (26–40), male sex, unemployment, antisocial activities, history of SA, hanging method, and season (spring) increased the suicide risk while religious commitment had protective effects on suicide. Conclusions Our findings indicated that demographic characteristics, low SES, and SCS are associated with suicide. In this county, trend of suicide and SA were decreased from 2014 to 2018. This study findings highlight the need to consider a wide range of contextual variables, socio-demographic, SES, and SCS in suicide prevention strategies. Improving inter-sectoral collaborations and policymakers’ attitudes are imperative for SA reduction.

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