Associations Between Perceived Physical and Mental Fatigability and Life Space Mobility in Older Men: The MrOS Study

Abstract Physical performance and fatigue can limit mobility within the larger environment (life-space mobility). It is unknown whether perceived fatigability, fatigue anchored to activity intensity and duration, is independently associated with life-space. We assessed this cross-sectionally in the Osteoporotic Fractures in Men Study (MrOS; N=1,681, Meanage=85±4.1). The Pittsburgh Fatigability Scale (PFS, range: 0-50) measured physical (Mean=16.2±9.5) and mental fatigability (Mean=7.5±8.0). Life Space Assessment scores (range: 0-120, higher=greater life-space) incorporated level, frequency, and assistance used for life-space mobility (Mean=84.3±22.0). Compared to the lowest fatigability strata (Physical: PFS 0-4; Mental: PFS 0-3, modeled separately), men in the two highest physical strata (PFS 20-24: B=-4.10±1.67; PFS≥25: B=-6.23±1.72; p’s≤.05) and men in the three highest mental strata reported significantly lower life-space mobility (PFS 13-15: B=-3.42±1.74; PFS 16-19: B=-5.38±1.83; PFS≥20: B=-7.96±1.66, p’s≤.05), adjusted for physical performance and health covariates. Our results provide evidence linking fatigability and real-world mobility, independent of physical health, in older men.

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Life-space Mobility in Older Men: The Role of Perceived Physical and Mental Fatigability

The Journals of Gerontology Series A ◽

10.1093/gerona/glab286 ◽

2021 ◽

Author(s):

Kyle D Moored ◽

Andrea L Rosso ◽

Theresa Gmelin ◽

Yujia (Susanna) Qiao ◽

Michelle C Carlson ◽

...

Keyword(s):

Physical Performance ◽

Performance Measures ◽

Osteoporotic Fractures ◽

Older Men ◽

Life Space ◽

Assessment Scores ◽

Health Lifestyle ◽

Activity Intensity ◽

Increased Risk ◽

And Performance

Abstract Background Physical performance and fatigue can limit mobility within the larger environment (life-space mobility). It is unknown whether perceived fatigability, self-reported fatigue anchored to activity intensity and duration, is independently associated with life-space. Methods We assessed this cross-sectionally in Visit 4 (2014–2016) of the Osteoporotic Fractures in Men Study (MrOS; N = 1 672, Age: Mean = 84.2 ± 4.0 years). The Pittsburgh Fatigability Scale (PFS, range: 0–50; higher = greater fatigability) measured physical (Mean = 16.1 ± 9.4) and mental fatigability (Mean = 7.5 ± 7.9). Life Space Assessment scores incorporated level, frequency, and assistance used for life-space mobility (range: 0–120, higher = greater life-space mobility; life-space constriction: inability to leave neighborhood without assistance). Separate multiple linear and logistic regressions for physical and mental fatigability were sequentially adjusted for demographic, health/lifestyle, and performance measures. Results The mean life-space mobility score was 84.6 ± 21.8, and 18% (n = 296) of men had life-space constriction. Higher physical and mental fatigability were both associated with lower life-space mobility in models adjusted for health and lifestyle factors (Physical PFS: B = −2.37, 95% confidence interval [CI]: [−3.39, −1.35]; Mental PFS: B = −1.79, 95% CI: [−2.73, −0.84]). Men with higher fatigability also had increased risk of life-space constriction (Physical PFS: OR = 1.59, 95% CI: [1.32, 1.92]; Mental PFS: OR = 1.25, 95% CI: [1.08, 1.46]). Associations were larger in magnitude for physical versus mental fatigability. Adjusting for physical performance measures more strongly attenuated associations for physical compared to mental fatigability. Conclusions Fatigability is linked with real-world mobility in older men, independent of their physical health. This association may be driven by separate physical and cognitive mechanisms worth examining further in longitudinal studies.

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Incident Fall Risk and Physical Activity and Physical Performance among Older Men: The Osteoporotic Fractures in Men Study

American Journal of Epidemiology ◽

10.1093/aje/kwk050 ◽

2007 ◽

Vol 165 (6) ◽

pp. 696-703 ◽

Cited By ~ 132

Author(s):

B. K. S. Chan ◽

L. M. Marshall ◽

K. M. Winters ◽

K. A. Faulkner ◽

A. V. Schwartz ◽

...

Keyword(s):

Physical Activity ◽

Physical Performance ◽

Fall Risk ◽

Osteoporotic Fractures ◽

Older Men

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Characteristics Associated With Migration Among Older Women and Men in Rural Malawi

Illness Crisis & Loss ◽

10.1177/1054137317723102 ◽

2017 ◽

Vol 25 (4) ◽

pp. 283-308 ◽

Cited By ~ 2

Author(s):

Jacob Kendall ◽

Philip Anglewicz

Keyword(s):

Physical Health ◽

Older Women ◽

Religious Affiliation ◽

Older Men ◽

Household Size ◽

Sub Saharan Africa ◽

Older Individuals ◽

Before And After ◽

Sub Saharan ◽

And Migration

The older population in sub-Saharan Africa is growing rapidly, but little is known about the migration patterns of older individuals in this setting. In this article, we identify the determinants of migration for older individuals in a rural African setting. To do so, we use rare longitudinal data with information for older individuals both before and after migration. We first identify premigration factors associated with moving in the future and then identify differences in characteristics between migrants and nonmigrants after migration. In addition to basic sociodemographic information, we examine differences between migrants and nonmigrants in land ownership, number of lifetime marriages, number of living offspring, previous migration experience, household size, social and religious participation, and religious affiliation. Results show that (a) migration in older age is related to marriage, health and HIV status, household size, and religion; (b) older women who are HIV-positive are more likely to move, and older men with better physical health are more likely to move; (c) older female migrants have worse postmigration physical health; and (d) the relationship between health and migration for older men disappears after migration.

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Risk Factors for the Development of Osteoporosis and Osteoporotic Fractures Among Older Men

The Journal of Rheumatology ◽

10.3899/jrheum.080527 ◽

2009 ◽

Vol 36 (9) ◽

pp. 1947-1952 ◽

Cited By ~ 19

Author(s):

MARIA THOMAS-JOHN ◽

MARY B. CODD ◽

SIALAJA MANNE ◽

NELSON B. WATTS ◽

ANNE-BARBARA MONGEY

Keyword(s):

Risk Factors ◽

African American ◽

Dairy Products ◽

African American Men ◽

Osteoporotic Fractures ◽

Fragility Fractures ◽

Older Men ◽

Current Treatment ◽

Androgen Deprivation ◽

Mineral Density

Objective.Osteoporotic fractures are associated with significant morbidity and mortality particularly among older men. However, there is little information regarding risk factors among this population. The aims of our study were to determine risk factors for osteoporosis and fragility fractures and the predictive value of bone mineral density (BMD) measurements for development of fragility fractures in a cohort of elderly Caucasian and African American men.Methods.We evaluated 257 men aged 70 years or older for risk factors for osteoporosis and fragility fractures using a detailed questionnaire and BMD assessment. Exclusion criteria included conditions known to cause osteoporosis such as hypogonadism and chronic steroid use, current treatment with bisphosphonates, bilateral hip arthroplasties, and inability to ambulate independently.Results.Age, weight, weight loss, androgen deprivation treatment, duration of use of dairy products, exercise, and fracture within 10 years prior to study entry were associated with osteoporosis (p ≤ 0.05). Fragility fractures were associated with duration of use of dairy products, androgen deprivation treatment, osteoporosis, and history of fracture within 10 years prior to BMD assessment (p ≤ 0.05). There were some differences in risk factors between the Caucasian and African American populations, suggesting that risk factors may vary between ethnic groups.Conclusion.Although men with osteoporosis had a higher rate of fractures, the majority of fractures occurred in men with T-scores > −2.5 standard deviations below the mean, suggesting that factors other than BMD are also important in determining risk.

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Clinical relevance of the modified physical performance test versus the short physical performance battery for detecting mobility impairments in older men with peripheral arterial disease

Disability and Rehabilitation ◽

10.1080/09638288.2017.1367966 ◽

2017 ◽

Vol 40 (25) ◽

pp. 3081-3085 ◽

Cited By ~ 3

Author(s):

Odessa Addison ◽

Rishi Kundi ◽

Alice S. Ryan ◽

Andrew P. Goldberg ◽

Richa Patel ◽

...

Keyword(s):

Peripheral Arterial Disease ◽

Physical Performance ◽

Clinical Relevance ◽

Performance Test ◽

Older Men ◽

Arterial Disease ◽

Short Physical Performance Battery ◽

Physical Performance Test ◽

Mobility Impairments ◽

Peripheral Arterial

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38NEUROMUSCULAR JUNCTION-RELATED GENE EXPRESSION AND PHYSICAL PERFORMANCE IN OLDER MEN: FINDINGS FROM THE HERTFORDSHIRE SARCOPENIA STUDY (HSS)

Age and Ageing ◽

10.1093/ageing/afx110.38 ◽

2017 ◽

Vol 46 (suppl_2) ◽

pp. ii11-ii13

Author(s):

A Granic ◽

L D Westbury ◽

H E Syddall ◽

H P Patel ◽

R Dodds ◽

...

Keyword(s):

Gene Expression ◽

Physical Performance ◽

Older Men ◽

Related Gene

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ASSOCIATION BETWEEN FATIGUE AND INCIDENT FALLS IN OLDER MEN: THE OSTEOPOROTIC FRACTURES IN MEN STUDY

Innovation in Aging ◽

10.1093/geroni/igx004.3645 ◽

2017 ◽

Vol 1 (suppl_1) ◽

pp. 1004-1004

Author(s):

S.C. Welburn ◽

A.J. Santanasto ◽

T. Blackwell ◽

N. Lane ◽

E. Orwoll ◽

...

Keyword(s):

Osteoporotic Fractures ◽

Older Men

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0393 The Effect of Trazadone Use on Non-REM Sleep Instability in Community-Dwelling Older Men

SLEEP ◽

10.1093/sleep/zsaa056.390 ◽

2020 ◽

Vol 43 (Supplement_1) ◽

pp. A150-A151

Author(s):

S Hartmann ◽

M Baumert

Keyword(s):

High Performance ◽

Detection System ◽

Antidepressant Medication ◽

Osteoporotic Fractures ◽

Nrem Sleep ◽

Older Men ◽

Community Dwelling ◽

Sleep Study ◽

Significant Difference ◽

Cap Rate

Abstract Introduction With steadily growing numbers of patients with a depressive disorder, the effect of antidepressants on sleep architecture is of increasing concern. One major oral antidepressant medication is trazadone, which has also been prescribed in low doses for sleep insomnia treatment. Here, we investigate the effect of trazadone on NREM sleep instability also known as cyclic alternating pattern (CAP) in community-dwelling older men. Methods CAP was scored in overnight EEG recordings from 41 older men on trazadone (TRZ) and 50 age-matched men who did not use trazadone (NTRZ), participating in the Osteoporotic Fractures in Men Sleep Study. A high performance automated detection system determined the ratio between CAP time and NREM sleep time (CAP rate), the number of A1-phases per hour of NREM sleep (A1 index), and the number of A2+A3-phases per hour of NREM sleep (A2+A3 index). The effect of TRZ on CAP parameters was determined using the Mann-Whitney U test. Results CAP rate was significantly decreased in men using trazadone (NTRZ: 58.2±19.7%, TRZ: 47.9±15.9%) as compared to non-trazadone user (p < 0.01). Subtype indices did not show any significant difference between both groups but to some extent less frequent A2-A3 phases for TRZ user (A1-phases: NTRZ 13.0±18.7 no./h vs. TRZ 10.8±20.4 no./h, p = 0.35; A2+A3-phases: NTRZ 51.5±33.7 no./h vs. TRZ 44.7±23.3 no./h, p = 0.068). Conclusion CAP rate was significantly decreased in older men on trazadone as compared to older men who did not use trazadone, suggesting that trazadone usage has a stabilising effect on sleep micro-structure. Support The National Heart, Lung, and Blood Institute (NHLBI) provides funding for the MrOS Sleep ancillary study “Outcomes of Sleep Disorders in Older Men” under the following grant numbers: R01 HL071194, R01 HL070848, R01 HL070847, R01 HL070842, R01 HL070841, R01 HL070837, R01 HL070838, and R01 HL070839.

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