ASSOCIATION BETWEEN FATIGUE AND INCIDENT FALLS IN OLDER MEN: THE OSTEOPOROTIC FRACTURES IN MEN STUDY

Objective.Osteoporotic fractures are associated with significant morbidity and mortality particularly among older men. However, there is little information regarding risk factors among this population. The aims of our study were to determine risk factors for osteoporosis and fragility fractures and the predictive value of bone mineral density (BMD) measurements for development of fragility fractures in a cohort of elderly Caucasian and African American men.Methods.We evaluated 257 men aged 70 years or older for risk factors for osteoporosis and fragility fractures using a detailed questionnaire and BMD assessment. Exclusion criteria included conditions known to cause osteoporosis such as hypogonadism and chronic steroid use, current treatment with bisphosphonates, bilateral hip arthroplasties, and inability to ambulate independently.Results.Age, weight, weight loss, androgen deprivation treatment, duration of use of dairy products, exercise, and fracture within 10 years prior to study entry were associated with osteoporosis (p ≤ 0.05). Fragility fractures were associated with duration of use of dairy products, androgen deprivation treatment, osteoporosis, and history of fracture within 10 years prior to BMD assessment (p ≤ 0.05). There were some differences in risk factors between the Caucasian and African American populations, suggesting that risk factors may vary between ethnic groups.Conclusion.Although men with osteoporosis had a higher rate of fractures, the majority of fractures occurred in men with T-scores > −2.5 standard deviations below the mean, suggesting that factors other than BMD are also important in determining risk.

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0393 The Effect of Trazadone Use on Non-REM Sleep Instability in Community-Dwelling Older Men

SLEEP ◽

10.1093/sleep/zsaa056.390 ◽

2020 ◽

Vol 43 (Supplement_1) ◽

pp. A150-A151

Author(s):

S Hartmann ◽

M Baumert

Keyword(s):

High Performance ◽

Detection System ◽

Antidepressant Medication ◽

Osteoporotic Fractures ◽

Nrem Sleep ◽

Older Men ◽

Community Dwelling ◽

Sleep Study ◽

Significant Difference ◽

Cap Rate

Abstract Introduction With steadily growing numbers of patients with a depressive disorder, the effect of antidepressants on sleep architecture is of increasing concern. One major oral antidepressant medication is trazadone, which has also been prescribed in low doses for sleep insomnia treatment. Here, we investigate the effect of trazadone on NREM sleep instability also known as cyclic alternating pattern (CAP) in community-dwelling older men. Methods CAP was scored in overnight EEG recordings from 41 older men on trazadone (TRZ) and 50 age-matched men who did not use trazadone (NTRZ), participating in the Osteoporotic Fractures in Men Sleep Study. A high performance automated detection system determined the ratio between CAP time and NREM sleep time (CAP rate), the number of A1-phases per hour of NREM sleep (A1 index), and the number of A2+A3-phases per hour of NREM sleep (A2+A3 index). The effect of TRZ on CAP parameters was determined using the Mann-Whitney U test. Results CAP rate was significantly decreased in men using trazadone (NTRZ: 58.2±19.7%, TRZ: 47.9±15.9%) as compared to non-trazadone user (p < 0.01). Subtype indices did not show any significant difference between both groups but to some extent less frequent A2-A3 phases for TRZ user (A1-phases: NTRZ 13.0±18.7 no./h vs. TRZ 10.8±20.4 no./h, p = 0.35; A2+A3-phases: NTRZ 51.5±33.7 no./h vs. TRZ 44.7±23.3 no./h, p = 0.068). Conclusion CAP rate was significantly decreased in older men on trazadone as compared to older men who did not use trazadone, suggesting that trazadone usage has a stabilising effect on sleep micro-structure. Support The National Heart, Lung, and Blood Institute (NHLBI) provides funding for the MrOS Sleep ancillary study “Outcomes of Sleep Disorders in Older Men” under the following grant numbers: R01 HL071194, R01 HL070848, R01 HL070847, R01 HL070842, R01 HL070841, R01 HL070837, R01 HL070838, and R01 HL070839.

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Bone Loss at the Hip and Subsequent Mortality in Older Men: The Osteoporotic Fractures in Men (MrOS) Study

JBMR Plus ◽

10.1002/jbm4.10006 ◽

2017 ◽

Vol 1 (1) ◽

pp. 31-35 ◽

Cited By ~ 2

Author(s):

Peggy M Cawthon ◽

Sheena Patel ◽

Susan K Ewing ◽

Li-Yung Lui ◽

Jane A Cauley ◽

...

Keyword(s):

Bone Loss ◽

Osteoporotic Fractures ◽

Older Men

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Correlates of trabecular and cortical volumetric bone mineral density of the radius and tibia in older men: The osteoporotic fractures in men study

Journal of Bone and Mineral Research ◽

10.1002/jbmr.6 ◽

2010 ◽

Vol 25 (5) ◽

pp. 1017-1028 ◽

Cited By ~ 23

Author(s):

Kamil E Barbour ◽

Joseph M Zmuda ◽

Elsa S Strotmeyer ◽

Mara J Horwitz ◽

Robert Boudreau ◽

...

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Osteoporotic Fractures ◽

Older Men ◽

Volumetric Bone Mineral Density ◽

Mineral Density

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Mean nocturnal respiratory rate predicts cardiovascular and all-cause mortality in community-dwelling older men and women

European Respiratory Journal ◽

10.1183/13993003.02175-2018 ◽

2019 ◽

Vol 54 (1) ◽

pp. 1802175 ◽

Cited By ~ 3

Author(s):

Mathias Baumert ◽

Dominik Linz ◽

Katie Stone ◽

R. Doug McEvoy ◽

Steve Cummings ◽

...

Keyword(s):

Osteoporotic Fractures ◽

Older Men ◽

Community Dwelling ◽

Sleep Study ◽

Men And Women ◽

All Cause Mortality ◽

The Relationship ◽

Older Men And Women

Respiratory frequency (fR) predicts in-hospital and short-term mortality in patients with a variety of pathophysiological conditions, but its predictive value for long-term cardiovascular and all-cause mortality in the general population is unknown. Here, we investigated the relationship between mean nocturnal fR and mortality in community-dwelling older men and women.We measured mean nocturnal fR during sleep from overnight polysomnography in 2686 men participating in the Osteoporotic Fractures in Men Study (MrOS) Sleep study and 406 women participating in the Study of Osteoporotic Fractures (SOF) to investigate the relationship between mean nocturnal fR and long-term cardiovascular and all-cause mortality.166 (6.1%) men in the MrOS cohort (8.9±2.6 years’ follow-up) and 46 (11.2%) women in the SOF cohort (6.4±1.6 years’ follow-up) died from cardiovascular disease. All-cause mortality was 51.2% and 26.1% during 13.7±3.7 and 6.4±1.6 years’ follow-up in the MrOS Sleep study and the SOF cohorts, respectively. Multivariable Cox regression analysis adjusted for significant covariates demonstrated that fR dichotomised at 16 breaths·min−1 was independently associated with cardiovascular mortality (MrOS: hazard ratio (HR) 1.57, 95% CI 1.14–2.15; p=0.005; SOF: HR 2.58, 95% CI 1.41–4.76; p=0.002) and all-cause mortality (MrOS: HR 1.18, 95% CI 1.04–1.32; p=0.007; SOF: HR 1.50, 95% CI 1.02–2.20; p=0.04).In community-dwelling older men and women, polysomnography-derived mean nocturnal fR ≥16 breaths·min−1 is an independent predictor of long-term cardiovascular and all-cause mortality. Whether nocturnal mean fR can be used as a risk marker warrants further prospective studies.

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