Links of Sleep Duration with Biomarkers of Accelerated Aging: the Baltimore Longitudinal Study of Aging

Abstract Sleep disorders and sleep deprivation have been linked to markers of biological aging, including methylation change and increases in white blood cell and neutrophil counts. However, little is known regarding the association of sleep duration with biological markers of aging. We investigated links of self-reported sleep duration with biological aging markers in 615 participants in the Baltimore Longitudinal Study of Aging (BLSA) aged ≥50 years (mean = 71.0 ± 11.2, 49.6% women, 68.8% white) with data on self-reported sleep duration in hours (i.e., ≤6 (n=131), >6 to 7 (n=234), >7 (n=250)), demographics, and genetic and methylation data (mDNA). Our aging biomarker outcomes were four epigenetic clocks (Horvath, Hannum, PhenoAge, and GrimAge), mDNA-estimated PAI1, and estimated granulocyte count. After adjustment for age, sex, and race, compared to those sleeping ≤6 hours, those reporting >7 hours of sleep had faster biological aging according to Hannum age-acceleration, PhenoAge, GrimAge, mDNA-estimated PAI1, and granulocyte count. In addition, sleep duration interacted with age, such that compared to individuals reporting ≤6 hours of sleep, individuals reporting >6 to 7 hours showed lower GrimAge with increasing age, and with sex, such that males with longer sleep duration (>6 to 7 and >7 hours) showed a lower granulocyte count compared to females. Findings suggest that both short and long sleep duration are associated with and may contribute to accelerated aging. Prospective studies in larger samples are needed to examine whether changes in sleep duration precede changes in aging biomarkers.

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White Blood Cell Count and Mortality in the Baltimore Longitudinal Study of Aging

Journal of the American College of Cardiology ◽

10.1016/j.jacc.2007.01.076 ◽

2007 ◽

Vol 49 (18) ◽

pp. 1841-1850 ◽

Cited By ~ 93

Author(s):

Carmelinda Ruggiero ◽

E. Jeffrey Metter ◽

Antonio Cherubini ◽

Marcello Maggio ◽

Ranjan Sen ◽

...

Keyword(s):

Longitudinal Study ◽

Blood Cell ◽

Cell Count ◽

White Blood Cell Count ◽

White Blood Cell ◽

Blood Cell Count ◽

Baltimore Longitudinal Study

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Bidirectional Associations between Short or Long Sleep Duration and Cognitive Function: the China Health and Retirement Longitudinal Study

10.1101/2021.01.23.21250015 ◽

2021 ◽

Author(s):

Jianian Hua ◽

Hongpeng Sun ◽

Qi Fang

Keyword(s):

Longitudinal Study ◽

Cognitive Function ◽

Sleep Duration ◽

Short Sleep Duration ◽

Short Sleep ◽

Bidirectional Association ◽

Long Sleep ◽

Global Cognition ◽

Bidirectional Associations ◽

Prospective Longitudinal

AbstractIMPORTANCEThe bidirectional association between sleep duration and cognitive function has not been conclusively demonstrated.OBJECTIVETo investigate the longitudinal association between sleep duration and cognitive function among middle-aged and elderly Chinese participants.Design, SETTING, AND PARTICIPANTSA national representative and prospective longitudinal study in China. 7984 participants aged 45 years and above were assessed at baseline between June 2011 and March 2012 (wave 1) and 2013 (wave 2), 2015 (wave 3) and 2018 (wave4).MAIN OUCOMES AND MEASURESSelf-reported nighttime sleep duration was evaluated by interview. Cognitive function was evaluated via assessments of global cognition, which reflected the ability of episodic memory, visuospatial construction, calculation, orientation and attention.ResultsRegarding the 7984 participants in wave 4, the mean (SD) age was 64.7 (8.4), 3862 (48.4) were male, and 6453 (80.7) lived in rural area. There were 14981, 11768 (78.6%), 10192 (68.0%), 7984 (53.3%) participants in the four waves of the study, respectively. Latent growth models showed both sleep duration and global cognition worsen over time. Cross-lagged models indicated that long or short sleep duration in the previous wave was associated lower global cognition in the next wave (standardized β=-0.066; 95%CI: −0.073, −0.059; P<0.001; Wave 1 to 2), and lower global cognition in the previous wave was associated with long or short sleep duration in the next wave (standardized β=-0.106; 95%CI: −0.116, −0.096; P<0.001; Wave 1 to 2). Global cognition was probably the major driver in this reciprocal associations.CONCLUSIONS AND REVELANCEThere were bidirectional associations between long or short sleep duration and cognitive function. Lower cognitive function had a stronger association with worse cognitive function than the reverse. A moderate sleep duration is always recommended. Moreover, attention should be paid on the declined cognition and cognitive therapy among older adults with short or long sleep duration.

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Sex, Sleep Duration, and the Association of Cognition: Findings from the China Health and Retirement Longitudinal Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph181910140 ◽

2021 ◽

Vol 18 (19) ◽

pp. 10140

Author(s):

Wei Li ◽

Ning Sun ◽

Anthony Kondracki ◽

Wenjie Sun

Keyword(s):

Cognitive Impairment ◽

Longitudinal Study ◽

Sleep Duration ◽

Mental Status ◽

Rural Areas ◽

Chinese People ◽

Linear Modeling ◽

Short Sleep Duration ◽

Long Sleep ◽

Elderly Chinese

Background: We aimed to examine the association between sleep duration and cognitive impairment among elderly Chinese people. Methods: generalized linear modeling was used to analyze the baseline data for adults aged 65 years and over (n = 4785) selected from the 2011 China Health and Retirement Longitudinal Study (CHARLS). The two aspects of cognitive impairment assessed in the study were mental status and memory. Sex-stratified logistic regression models were conducted to identify the effect of sleep duration in the different gender groups. Results: of all the participants, 49.8% were females and 32.5% aged 75 years and over. Of the participants, 59.7% had short sleep duration (<7 h/day), and 9.0% of them had long sleep duration (>8 h/day). Compared to normal sleep duration, long sleep duration was associated with lower mental status scores (β = −0.43, p = 0.001) and lower memory scores (β = −0.26, p = 0.006). Long sleep duration was associated with lower mental status in both men (β = −0.37, p = 0.033) and women (β = −0.46, p = 0.025), however, only in men was long sleep duration found to be associated with low memory scores (β = −0.26, p = 0.047). Conclusions: Our study showed that long sleep duration was significantly associated with poorer mental status and memory scores in elderly Chinese people. Paying greater attention to the effects of sleep patterns on the risk of cognitive decline may yield practical implications for dementia prevention and health promotion, especially among older women with lower educational attainment, living in rural areas, and those who have long sleep duration.

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Depressive symptoms are associated with short and long sleep duration: A longitudinal study of Chinese adolescents

Journal of Affective Disorders ◽

10.1016/j.jad.2019.11.113 ◽

2020 ◽

Vol 263 ◽

pp. 267-273 ◽

Cited By ~ 4

Author(s):

Bao-Peng Liu ◽

Xin-Ting Wang ◽

Zhen-Zhen Liu ◽

Ze-Ying Wang ◽

Di An ◽

...

Keyword(s):

Depressive Symptoms ◽

Longitudinal Study ◽

Sleep Duration ◽

Chinese Adolescents ◽

Long Sleep

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The Association of Sleep Duration With Vision Impairment in Middle-Aged and Elderly Adults: Evidence From the China Health and Retirement Longitudinal Study

Frontiers in Medicine ◽

10.3389/fmed.2021.778117 ◽

2021 ◽

Vol 8 ◽

Author(s):

Mengsha Sun ◽

Qiyu Bo ◽

Bing Lu ◽

Xiaodong Sun ◽

Minwen Zhou

Keyword(s):

Logistic Regression ◽

Longitudinal Study ◽

Sleep Duration ◽

Regression Models ◽

Vision Impairment ◽

Multilevel Logistic Regression ◽

Elderly Adults ◽

Middle Aged ◽

Logistic Regression Models ◽

Long Sleep

Objective: This study aims to investigate the association of sleep duration with vision impairment (VI) in middle-aged and elderly adults.Methods: This cross-sectional study used the data from the baseline survey of the China Health and Retirement Longitudinal Study (CHARLS) 2011–2012, a national survey of adults aged 45 years or older. Weighted multilevel logistic regression models were used to evaluate the association between self-reported sleep duration and VI.Results: Of the 13,959 survey respondents, a total of 4,776 (34.2%) reported VI. The prevalence of short (≤6 h/night) and long (>8 h/night) sleep durations was higher among respondents with VI than those without VI (P < 0.001). Multilevel logistic regression models showed that compared with a sleep duration of 6–8 h/night, a sleep duration of ≤6 h/night was associated with a 1.45-fold [95% confidence interval (CI) = 1.34–1.56] higher VI risk, and a sleep duration of >8 h/night was associated with a 1.18-fold (95% CI = 1.03–1.34) higher VI risk, after adjusting for sociodemographic data, lifestyle factors, and health conditions. Vision impairment was associated with short sleep duration in respondents from all age or gender categories. However, VI was associated with long sleep duration in respondents from the elderly or female categories. The association between VI and long sleep duration disappeared in respondents of middle-aged or male categories.Conclusions: The potential impact of sleep on the risk of visual functions requires further attention. A more comprehensive and integrated health care and rehabilitation system covering vision and sleep is also needed.

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