scholarly journals POOR SLEEP QUALITY IS RELATED TO DECREASED WHITE MATTER INTEGRITY IN BRAIN NOCICEPTIVE PATHWAYS IN OLDER ADULTS

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S367-S368
Author(s):  
Anna R Egbert ◽  
Ryan S Falck ◽  
John R Best ◽  
Linda Li ◽  
Lynne Feehan ◽  
...  
Keyword(s):  
Older Adults ◽  
White Matter ◽  
Sleep Quality ◽  
Sleep Efficiency ◽  
Sensor Data ◽  
White Matter Integrity ◽  
Poor Sleep ◽  
Accelerometer Data ◽  
Poor Sleep Quality ◽  
Brain White Matter

Abstract Poor sleep quality, decreased physical activity (PA) and increased sedentary behavior (SB) are common characteristics of older adults. Notably, these factors play an important role in brain health. We examined the relationship between sleep quality, PA, SB and brain white matter integrity (WM) in older adults with osteoarthritis (OA). We retained data on 16 participants (mean age 60, SD=7.7) from a larger Monitor-OA cohort recruited from Metro Vancouver, BC, Canada. Sleep efficiency and duration, amount of time spent on PA and SB daily over a period of one week was acquired with an objective measure – the multi-sensor monitor SenseWear Mini which integrates tri-axial accelerometer data, physiological sensor data and personal demographic information. Brain WM tractography was calculated from fractional anisotropy data obtained with diffusion weighted magnetic resonance imaging. Voxelwise group-level statistics examined the effects of our variables of interest on the integrity of brain WM tracts while controlling for participants age. We found that lower sleep efficiency was related to decreased integrity in WM tracts of frontal, temporal lobes, precuneus and thalamus (Bonferroni corrected p<0.05). Shorter sleep was related to lower WM integrity in frontal regions, posterior cingulate and insula radiations (Bonferroni corrected p<0.05). No significant effects were noted for PA or SB. The identified brain regions are involved in sleep processes but further overlap with the nociceptive brain network. Our findings suggest that neural mechanisms related to sleep disturbance may also involve pain-related processing in older adults.

778 Poor Sleep Quality is Associated with Reduced Myelination in Patients with Psychotic Disorders

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A303-A303
Author(s):  
Cagri Yuksel ◽  
Xi Chen ◽  
Lauren Watford ◽  
Margaret Gardner ◽  
Kathryn Lewandowski ◽  
...  
Keyword(s):  
White Matter ◽  
Sleep Quality ◽  
Psychotic Disorders ◽  
Sleep Onset ◽  
Sleep Loss ◽  
Magnetization Transfer Ratio ◽  
Poor Sleep ◽  
Sleep Onset Latency ◽  
Healthy Controls ◽  
Poor Sleep Quality

Abstract Introduction Recent studies show that sleep favors oligodendrocyte proliferation and myelination, and sleep loss is associated with alterations in white matter structure and decreased myelination. Psychotic disorders are characterized by disrupted white matter integrity, and abnormal axon and myelin structure. Despite common sleep disturbances in these disorders, little is known about the relationship between sleep quality and white matter findings. A novel in vivo neuroimaging technique that combines diffusion tensor spectroscopy (DTS) and magnetization transfer ratio (MTR) allows separately examining the axon structure and glial function, and myelin content, respectively. Using this method, we examined the association of sleep quality with white matter biology in a sample of patients with psychotic disorders and matched healthy controls. Methods Participants included patients diagnosed with bipolar disorder with psychotic features (euthymic or depressed, n=12) and schizophrenia spectrum disorders (n=9), and age and sex matched healthy controls (n=20). DTS and MTR data was collected from the right prefrontal white matter at 4T. DTS measures included apparent diffusion coefficients of water, NAA, creatine and choline. Sleep quality was measured using Pittsburgh Sleep Quality Index (PSQI). Results PSQI total score was significantly higher in patients. and patient sample included a higher percentage of poor sleepers (PSQI total score>5). In patients, total PSQI score and sleep onset latency were significantly and negatively associated with MTR (F=6.9, p=0.02 and F=9.7, p=0.007, respectively). There was no difference in any DTS measures between groups. Conclusion Our preliminary results show that poor sleep quality is associated with decreased myelin content in the frontal lobe, in patients with psychotic disorders. This finding suggests that sleep loss may be a mediator of white matter alterations in psychosis. Support (if any) This work is supported by National Institute of Mental Health K23MH119322 to Cagri Yuksel

scholarly journals THE MODERATING EFFECT OF RAISING ONE’S GRANDCHILDREN ON THE RELATION BETWEEN SLEEP AND DEPRESSION

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S678-S678
Author(s):  
Melanie Stearns ◽  
Danielle K Nadorff
Keyword(s):  
Older Adults ◽  
Risk Factor ◽  
Depressive Symptoms ◽  
Sleep Quality ◽  
Sleep Problems ◽  
Depression Scale ◽  
Poor Sleep ◽  
Older Individuals ◽  
Poor Sleep Quality ◽  
Custodial Grandparents

Abstract Recent evidence has shown that poor quality sleep is associated with depression, particularly among older individuals (Bao et al., 2017; Nadorff, Fiske, Sperry, & Petts, 2012). Moreover, given the high prevalence of depressive symptoms among older adults, it is important to identify possible risk factors of poor sleep quality. One possible risk factor is being a custodial grandparent (raising one’s grandchildren), as increased caregiving responsivities are associated with increased depressive symptoms (Brand-Winterstein, Edelstein, & Bachner, 2018). Based upon these previous findings, the current study examines the effect of custodial status on the relation between sleep quality and depressive symptoms. The sample (N = 466) was a subset of individuals recruited in the second wave of the MIDUS biomarkers project completed in 2009 who answered the sleep, caregiving, and depressive symptoms variables of interest. Measures included the Center for Epidemiological Studies Depression Scale (CESD), the Pittsburgh Sleep Quality Index (PSQI), and a question regarding custodial grandparent status. The current study aimed to examine whether poor sleep quality might serve as a risk factor for experiencing depressive symptoms and how custodial grandparents might differ from other older adults. Moderation analyses were conducted using SPSS’ Process macro on the sample. The interaction between global sleep quality and custodial grandparent status was significant in predicting depressive symptoms, t (1, 465) = 3.90, p = .04, such that custodial grandparents reported a stronger positive correlation between greater global sleep problems and depressive symptoms than non-custodial grandparents. Implications, future directions, and limitations are discussed.

scholarly journals Poor sleep quality and physical performance in older adults

Sleep Health ◽  
2020 ◽  
Author(s):  
Hayley J. Denison ◽  
Karen A. Jameson ◽  
Avan A. Sayer ◽  
Harnish P. Patel ◽  
Mark H. Edwards ◽  
...  
Keyword(s):  
Older Adults ◽  
Sleep Quality ◽  
Physical Performance ◽  
Poor Sleep ◽  
Poor Sleep Quality

Sleep patterns and physical function in older adults attending primary health care

2020 ◽  
Author(s):  
Lucía Arias-Fernández ◽  
Andrea M Smith-Plaza ◽  
María Barrera-Castillo ◽  
Jessica Prado-Suárez ◽  
Esther Lopez-Garcia ◽  
...  
Keyword(s):  
Older Adults ◽  
Health Care ◽  
Sleep Quality ◽  
Physical Function ◽  
Muscle Weakness ◽  
Sleep Disturbances ◽  
Poor Sleep ◽  
Poor Sleep Quality ◽  
Physical Frailty ◽  
Primary Health

Abstract Background Sleep disturbances may contribute to physical function impairment among older adults. Objective To examine the associations between sleep quality and duration and impaired physical function among older adults. Methods Cross-sectional study involving 392 non-institutionalized adults aged ≥65 years, who were recruited from primary health care centres in Spain. Sleep quality and duration were assessed with the Pittsburgh Sleep Quality Index (PSQI). The FRAIL scale was used to identify physical frailty, the short physical performance battery to assess lower extremity functional impairment (LEFI) and grip strength was measured using a hand-held dynamometer to assess muscle weakness. Statistical analyses were performed with logistic regression models adjusted for potential confounders. Results Participants with poor sleep quality (PSQI global score ≥10) were more likely to have functional limitations; the odds ratio (95% confidence interval) was 2.90 (1.10–7.64) for physical frailty, 2.73 (1.34–5.58) for LEFI and 2.32 (1.14–4.75) for muscle weakness. Sleep quality components associated with frailty were sleep disturbances, use of sleeping medication and daytime dysfunction. The only quality component associated with LEFI was poor sleep efficiency, while subjective poor sleep quality and daytime dysfunction were linked to muscle weakness. No associations were observed between night-time sleep duration and physical function indicators. Conclusions Poor self-reported sleep quality, but not sleep duration, was associated with an increased frequency of physical frailty, LEFI and muscle weakness. Interventions to improve sleep quality could contribute to healthy ageing.

Sleep quality mediates the relationship between frailty and cognitive dysfunction in non-demented middle aged to older adults

2019 ◽  
Vol 31 (06) ◽  
pp. 779-788 ◽  
Author(s):  
Sonya Kaur ◽  
Nikhil Banerjee ◽  
Michelle Miranda ◽  
Mitchell Slugh ◽  
Ni Sun-Suslow ◽  
...  
Keyword(s):  
Older Adults ◽  
Executive Function ◽  
Sleep Quality ◽  
Cognitive Decline ◽  
Processing Speed ◽  
Poor Sleep ◽  
Poor Sleep Quality ◽  
Subjective Sleep Quality ◽  
Delayed Recall ◽  
The Relationship

ABSTRACTObjectives:Frailty is associated with cognitive decline in older adults. However, the mechanisms explaining this relationship are poorly understood. We hypothesized that sleep quality may mediate the relationship between frailty and cognition.Participants:154 participants aged between 50-90 years (mean = 69.1 years, SD = 9.2 years) from the McKnight Brain Registry were included.Measurements:Participants underwent a full neuropsychological evaluation, frailty and subjective sleep quality assessments. Direct relationships between frailty and cognitive function were assessed using linear regression models. Statistical mediation of these relationships by sleep quality was assessed using nonparametric bootstrapping procedures.Results:Frailty severity predicted weaker executive function (B = −2.77, β = −0.30, 95% CI = −4.05 – −1.29) and processing speed (B = −1.57, β = −0.17, 95% CI = −3.10 – −0.16). Poor sleep quality predicted poorer executive function (B = −0.47, β = −0.21, 95% CI = −0.79 – −0.08), processing speed (B = −0.64, β = −0.28, 95% CI = −0.98 – −0.31), learning (B = −0.42, β = −0.19, 95% CI = −0.76 – −0.05) and delayed recall (B = −0.41, β = −0.16, 95% CI = −0.80 – −0.31). Poor sleep quality mediated the relationships between frailty severity and executive function (B = −0.66, β = −0.07, 95% CI = −1.48 – −0.39), learning (B = −0.85, β = −0.07, 95% CI = −1.85 – −0.12), delayed recall (B = −0.47, β = −0.08, 95% CI = −2.12 – −0.39) and processing speed (B = −0.90, β = −0.09, 95% CI = −1.85 – −0.20).Conclusions:Relationships between frailty severity and several cognitive outcomes were significantly mediated by poor sleep quality. Interventions to improve sleep quality may be promising avenues to prevent cognitive decline in frail older adults.

scholarly journals Sleep quality relates to emotional reactivity via intracortical myelination

SLEEP ◽  
2020 ◽  
Author(s):  
Nicola Toschi ◽  
Luca Passamonti ◽  
Michele Bellesi
Keyword(s):  
White Matter ◽  
Sleep Quality ◽  
Emotional Reactivity ◽  
Temporal Cortex ◽  
Posterior Cingulate Cortex ◽  
Mediating Effect ◽  
White Matter Integrity ◽  
Poor Sleep ◽  
Negative Consequences ◽  
Human Connectome Project

Abstract A good quality and amount of sleep are fundamental to preserve cognition and affect. New evidence also indicates that poor sleep is detrimental to brain myelination. In this study, we test the hypothesis that sleep quality and/or quantity relate to variability in cognitive and emotional function via the mediating effect of interindividual differences in proxy neuroimaging measures of white matter integrity and intracortical myelination. By employing a demographically and neuropsychologically well-characterized sample of healthy people drawn from the Human Connectome Project (n = 974), we found that quality and amount of sleep were only marginally linked to cognitive performance. In contrast, poor quality and short sleep increased negative affect (i.e. anger, fear, and perceived stress) and reduced life satisfaction and positive emotionality. At the brain level, poorer sleep quality and shorter sleep duration related to lower intracortical myelin in the mid-posterior cingulate cortex (p = 0.038), middle temporal cortex (p = 0.024), and anterior orbitofrontal cortex (OFC, p = 0.034) but did not significantly affect different measures of white matter integrity. Finally, lower intracortical myelin in the OFC mediated the association between poor sleep quality and negative emotionality (p < 0.05). We conclude that intracortical myelination is an important mediator of the negative consequences of poor sleep on affective behavior.

Is Sensory Processing Preference an Indicator for Poor Sleep Quality Among Older Adults?

2018 ◽  
Vol 72 (4_Supplement_1) ◽  
pp. 7211510182p1
Author(s):  
Megan Chang ◽  
Megan Sadou ◽  
Stephanie Loh ◽  
Sarah Mcdonald ◽  
Barbara Moran ◽  
...  
Keyword(s):  
Older Adults ◽  
Sleep Quality ◽  
Sensory Processing ◽  
Poor Sleep ◽  
Poor Sleep Quality

scholarly journals Objective Sleep Quality and the Underlying Functional Neural Correlates Among Older Adults With Probable MCI

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 379-379
Author(s):  
Chun Liang Hsu ◽  
Ryan Falck ◽  
Daniel Backhouse ◽  
Patrick Chan ◽  
Elizabeth Dao ◽  
...  
Keyword(s):  
Older Adults ◽  
Functional Connectivity ◽  
Sleep Quality ◽  
Resting State ◽  
Brain Regions ◽  
Community Dwelling ◽  
Sleep Efficiency ◽  
Sleep Fragmentation ◽  
Poor Sleep ◽  
Attention Network

Abstract Poor sleep is a strong risk factor for dementia and is commonly reported among older adults with mild cognitive impairment (MCI). However, the neural underpinnings of poor sleep among older adults with MCI remains equivocal. The goal of this cross-sectional analysis was to explore the relationship between resting-state functional connectivity in the brain and sleep quality as measured by actigraphy. We hypothesize lower sleep efficiency and higher sleep fragmentation may be associated with aberrant functional connectivity of brain regions involved in somatosensory, somatomotor, and attentional processing. Thirty-six community-dwelling older adults with probable MCI between 65-85 years (mean=71.8 years) were assessed for sleep quality using a motion watch to quantify sleep efficiency and fragmentation over 14 days. All participants completed resting-state functional magnetic resonance imaging (fMRI) within 14 days of sleep monitoring. Independent associations between network connectivity and sleep quality were determined using general linear models. Examined networks included the somatosensory network (SMN), dorsal attention network (DAN), ventral attention network (VAN), frontoparietal network (FPN), and default mode network (DMN). Mean Montreal Cognitive Assessment score was 22.5 (SD=2.7) and Mini-Mental State Examination score was 28.3 (SD=1.5). Mean sleep efficiency and fragmentation index was 80.1% and 31.8 respectively. Higher sleep fragmentation correlated with increased connectivity between the SMN and insula, the SMN and posterior cingulate, as well as FPN and primary motor area (Z=3.1; p<0.05). These results suggest aberrant functional connectivity between brain regions involved in attentional and somatosensory processes may be associated with disrupted sleep mechanisms in older adults with MCI.

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