scholarly journals PREDICTORS OF LONGITUDINAL COGNITIVE DECLINE AMONG COMMUNITY-DWELLING KOREAN OLDER ADULTS

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S657-S657
Author(s):  
Jinhee Shin ◽  
Eunhee Cho
Keyword(s):  
Older Adults ◽  
Cognitive Function ◽  
Mixed Models ◽  
Mmse Score ◽  
Social Activity ◽  
Community Dwelling ◽  
Panel Survey ◽  
Old Adults ◽  
Normal Cognition ◽  
Over Time

Abstract Objective This study aims to explore predictors to longitudinal decline of cognitive function in old adults in Korean. Methods The data were derived from the information system of the Korean Longitudinal Study of Aging (KLoSA) which performed nationwide aging panel survey for adults aged over 45 years between 2006 and 2016. The sample consisted of 1,262 older adults who completed K-MMSE. Of the total 1,262 participants, 752 had normal cognition, 243 had mild cognitive impairment, and the rest 267 had dementia. Variables from diverse dimensions were derived from the KLoSA. The linear mixed models were used to predict and explain predictors affecting cognitive function decline over time. Results The ADL and IADL, depression, exercise, and social activity were time-varying variables significantly related to the cognitive function of the older adults. Over time, difference in change of the K-MMSE score between three groups was significant. Conclusions This study identified predictors influencing decrease of cognitive function over time in older adults in Korea. Tailored intervention needs to be developed and implemented in order to delay the cognitive function decline. Improving physical function through regular exercise, increasing social activity, and managing depression by early detection and treatment are recommended according to the cognitive function status. Keywords: old adults, cognitive function, K-MMSE, predictor

scholarly journals Longitudinal relationships between subjective fatigue, cognitive function, and everyday functioning in old age

2012 ◽  
Vol 25 (2) ◽  
pp. 275-285 ◽  
Author(s):  
Feng Lin ◽  
Ding-Geng Chen ◽  
David E. Vance ◽  
Karlene K. Ball ◽  
Mark Mapstone
Keyword(s):  
Older Adults ◽  
Cognitive Function ◽  
Latent Class ◽  
Growth Mixture Modeling ◽  
Community Dwelling ◽  
Everyday Functioning ◽  
Subjective Fatigue ◽  
Community Dwelling Older Adults ◽  
Over Time

ABSTRACTBackground: The present study examined the prospective relationships between subjective fatigue, cognitive function, and everyday functioning.Methods: A cohort study with secondary data analysis was conducted using data from 2,781 community-dwelling older adults without dementia who were enrolled to participate in the Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) randomized intervention trial. Measures included demographic and health information at baseline, and annual assessments of subjective fatigue, cognitive function (i.e. speed of processing, memory, and reasoning), and everyday functioning (i.e. everyday speed and everyday problem-solving) over five years.Results: Four distinct classes of subjective fatigue were identified using growth mixture modeling: one group complaining fatigue “some of the time” at baseline but “most of the time” at five-year follow-up (increased fatigue), one complaining fatigue “a good bit of the time” constantly over time (persistent fatigue), one complaining fatigue “most of the time” at baseline but “some of the time” at five-year follow-up (decreased fatigue), and the fourth complaining fatigue “some of the time” constantly over time (persistent energy). All domains of cognitive function and everyday functioning declined significantly over five years; and the decline rates, but not the baseline levels, differed by the latent class of subjective fatigue. Except for the decreased fatigue class, there were different degrees of significant associations between the decline rates of subjective fatigue and all domains of cognitive function and everyday functioning in other classes of subjective fatigue.Conclusion: Future interventions should address subjective fatigue when managing cognitive and functional abilities in community-dwelling older adults.

scholarly journals Tea consumption and measures of attention and psychomotor speed in the very old: the Newcastle 85+ longitudinal study

BMC Nutrition ◽  
2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Edward Jonathan Okello ◽  
Nuno Mendonça ◽  
Blossom Stephan ◽  
Graciela Muniz-Terrera ◽  
Keith Wesnes ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cognitive Function ◽  
Sustained Attention ◽  
Community Dwelling ◽  
Tea Consumption ◽  
Psychomotor Speed ◽  
Very Old ◽  
Old Adults ◽  
Global Cognitive Function ◽  
Over Time

Abstract Background A number of studies have indicated a beneficial effect of tea consumption on the reduction of risk of cognitive impairment and dementia in older aged populations. However, there is a paucity of data on these associations in the very old, defined as individuals aged 85 years and over. We investigated the relationship between tea consumption in the very old and measures of global cognitive function, memory, attention and psychomotor speed. Method Longitudinal (5-years), population-based cohort study of individuals aged 85+ years in the North East of England, United Kingdom. Participants were community-dwelling and institutionalized men and women recruited through general medical practices (n = 676). Baseline tea consumption and longitudinal measures of global and domain specific (memory, speed and attention) cognitive function were assessed. Linear mixed models, controlling for demographic (e.g. age, sex and education) and health variables were used to determine whether tea consumption was protective against cognitive decline. Results Tea consumption was not associated with cognitive function at baseline on any measure (unadjusted and adjusted analyses). In the linear mixed effects models adjusted for age, sex, education and disease co-morbidity, higher tea consumption was associated with significantly better attention (focused and sustained attention), and psychomotor speed (complex tasks only) over five-years follow-up. However, there was no association between tea consumption and global cognitive function, memory or performance on simple speed tasks over time. Conclusions In this cohort study of non-demented very old adults we found that higher (vs. lower) tea consumption was associated with better performance over time on measures of focused and sustained attention and some psychomotor speed tasks. No associations with global cognition, memory or easy speed tasks (simple Reaction Time or Word Recognition) were detected. The results have implications for the development of possible diet-based interventions focused on improving cognitive function in the very old age group. These findings need to be confirmed in a sufficiently powered and well-designed RCT with non-demented very old adults.

scholarly journals ASSOCIATION BETWEEN GRIP STRENGTH AND COGNITIVE FUNCTION AMONG COMMUNITY-DWELLING OLDER ADULTS

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S483-S484
Author(s):  
Milan Chang ◽  
Alfons Ramel ◽  
Palmi V Jonsson ◽  
Inga Thorsdottir ◽  
Olof Geirsdottir
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Older Adults ◽  
Cardiovascular Risk ◽  
Cognitive Function ◽  
Grip Strength ◽  
Exercise Intervention ◽  
Mmse Score ◽  
Community Dwelling ◽  
Community Dwelling Older Adults

Abstract Background: Decline in both physical function and cognition among older adults has been associated with increased risk of dementia. Physical activity (PA) is beneficial for the improvement of both physical and cognitive function. The purpose of the study was to investigate the association between baseline physical function and cognitive function after 12 weeks of resistance training among older adults. Methods: Two hundred and thirty-seven community-dwelling older adults (N=237, 73.7±5.7 years, 58.2% female) participated in a 12-week resistance exercise program (3 times/week; 3 sets, 6-8 repetitions at 75-80% of the 1-repetition maximum), designed to increase strength and muscle mass of major muscle groups. Body composition, physical activity status, grip strength, cardiovascular risk factors, 6 minutes walking distance (6MWD), and Mini-Mental State Examination (MMSE) were measured at baseline and endpoint. The linear regression model was used to examine the association. Results: Mean MMSE score was 27.5±2.1 at baseline and 28.1±2.2 after the exercise intervention. After the intervention, 57 declined, 55 remained the same, and 120 have improved in MMSE scores. We found that the MMSE score after the intervention was significantly associated with baseline grip strength (beta=.03, P<.05) among healthy older adults, after adjusting basic characteristics, cardiovascular risk factors and mobility at baseline. Conclusion: Our study found that baseline grip strength was strongly associated with cognitive function after the 12 weeks of resistance training. Muscle power, such as grip strength may play an important role in the effect of exercise intervention on cognition even among healthy independent older adults.

scholarly journals Patterns and risk factors of cognitive decline among community-dwelling Korean older adults: The Korean Longitudinal Study of Aging (2006–2016)

2020 ◽  
Author(s):  
Jinhee Shin ◽  
Eunhee Cho
Keyword(s):  
Risk Factors ◽  
Older Adults ◽  
Cognitive Function ◽  
Cognitive Decline ◽  
Daily Living ◽  
Community Dwelling ◽  
Regular Exercise ◽  
Severe Dementia ◽  
Normal Cognitive Function ◽  
Over Time

Abstract Background Dementia prevalence is increasing worldwide, and thus, the global impact of cognitive impairment and dementia has become a priority public health issue. This study aimed to assess the patterns of and risk factors for cognitive decline over time in community-dwelling Korean adults aged ≥ 65 years. Methods Older adults with normal cognitive function at baseline in 2006 were evaluated, and changes in their cognitive function were followed over time. The data were obtained from the 2006–2016 Korean Longitudinal Study of Aging. Cognitive function in 2016 was classified based on the Korean-Mini-Mental State Examination score as normal, mild dementia, and moderate and severe dementia. The t-test, ANOVA, and linear mixed models were used to analyse the patterns and risk factors f cognitive decline over time. Results Of the 1,262 participants examined, 752 maintained normal cognitive function, 267 older adults showed a change from normal cognitive function to mild dementia, and 243 older adults showed a decline from normal cognitive function to moderate and severe dementia between 2006 and 2016. There were significant differences in cognitive function over time among the three groups, and these were influenced by age, gender, education level, religion, activities of daily living, instrumental activities of daily living, regular exercise, number of meetings with friends, and depression. The differences have gradually increased over 10 years. Conclusions This study identified the patterns of cognitive decline over time and important factors related to cognitive decline. Individualised interventions such as improving physical function through regular exercise, increasing social activity, and managing depression by early detection and treatment may contribute to maintain cognitive function.

scholarly journals SERUM 25-HYDROXY VITAMIN D, PHYSICAL ACTIVITY AND COGNITIVE FUNCTION AMONG OLDER ADULTS

2018 ◽  
pp. 1-7
Author(s):  
M. Chang ◽  
H. Eymundsdottir ◽  
O.G. Geirsdottir ◽  
P.V. Jonsson ◽  
V. Gudnason ◽  
...  
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Vitamin D ◽  
Cognitive Function ◽  
Multivariate Logistic Regression Analysis ◽  
Community Dwelling ◽  
Serum 25Ohd ◽  
Old Adults ◽  
High Cognitive Function ◽  
25 Hydroxy Vitamin D

Objective: To investigate the association between 25-hydroxy vitamin D (25OHD) and cognitive function with particular consideration of physical activity (PA) in Icelandic older adults. Design: Cross-sectional study. Setting: Iceland. Participants: Old adults aged 65-96. The final analytical sample included 4304 non-demented participants. Measurements: Serum 25OHD was categorized into deficient (≤ 30 nmol/L, 8%), insufficient (31-49 nmol/L, 25%) and normal-high levels (>50 nmol/L, 67%). Cognitive function assessments included measurements of memory function (MF), speed of processing (SP) and executive function (EF) all categorized as low and high (divided by 50th percentile). Multivariate logistic regression analysis was used to calculate the odds ratio (OR) for having high cognitive function. Results: Serum 25OHD was positively associated with cognitive function. Adjustment for PA and other potential confounders diminished this association only partially. Compared to participants with normal-high levels of 25OHD, those with deficient levels had decreased odds for high SP (OR: 0.74, CI: 0.57-0.97), high MF (OR: 0.55; CI: 0.43-0.71) and high EF (OR: 0.76, CI: 0.57-1.0). Conclusion: Serum 25OHD below ≤30 nmol/L was associated with decreased odds for high cognitive function among community dwelling old adults as compared to those with 25OHD above > 50 nmol/L. Neither PA nor other potential confounders explained the associations between 25OHD and cognitive function. Future studies should explore mechanisms and the potential clinical relevance of this relationship.

scholarly journals Tea consumption and measures of attention and psychomotor speed in the very old: The Newcastle 85+ Longitudinal Study

2020 ◽  
Author(s):  
Edward Jonathan Okello ◽  
Nuno Mendonça ◽  
Blossom Stephan ◽  
Graciela Muniz-Terrera ◽  
Keith Wesnes ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cognitive Function ◽  
Sustained Attention ◽  
Community Dwelling ◽  
Tea Consumption ◽  
Psychomotor Speed ◽  
Very Old ◽  
Old Adults ◽  
Global Cognitive Function ◽  
Over Time

Abstract Background: A number of studies have indicated a beneficial effect of tea consumption on the reduction of risk of cognitive impairment and dementia in older aged populations. However, there is a paucity of data on these associations in the very old, defined as individuals aged 85 years and over. We investigated the relationship between tea consumption in the very old and measures of global cognitive function, memory, attention and psychomotor speed.Method: Longitudinal (5-years), population-based cohort study of individuals aged 85+ years in the North East of England, United Kingdom. Participants were community-dwelling and institutionalized men and women recruited through general medical practices (n=676). Baseline tea consumption and longitudinal measures of global and domain specific (memory, speed and attention) cognitive function were assessed. Linear mixed models, controlling for demographic (e.g. age, sex and education) and health variables were used to determine whether tea consumption was protective against cognitive decline.Results: Tea consumption was not associated with cognitive function at baseline on any measure (unadjusted and adjusted analyses). In the linear mixed effects models adjusted for age, sex, education and disease co-morbidity, higher tea consumption was associated with significantly better attention (focused and sustained attention), and psychomotor speed (complex tasks only) over five-years follow-up. However, there was no association between tea consumption and global cognitive function, memory or performance on simple speed tasks over time.Conclusions: In this cohort study of non-demented very old adults we found that higher (vs. lower) tea consumption was associated with better performance over time on measures of focused and sustained attention and some psychomotor speed tasks. No associations with global cognition, memory or easy speed tasks (simple Reaction Time or Word Recognition) were detected. The results have implications for the development of possible diet-based interventions focused on improving cognitive function in the very old age group. These findings need to be confirmed in a sufficiently powered and well-designed RCT with non-demented very old adults.

scholarly journals Do Communication Patterns Affect the Association between Cognitive Impairment and Hearing Loss among Older Adults in Vietnam?

2021 ◽  
Vol 18 (4) ◽  
pp. 1603
Author(s):  
Tran Dai Tri Han ◽  
Keiko Nakamura ◽  
Kaoruko Seino ◽  
Vo Nu Hong Duc ◽  
Thang Van Vo
Keyword(s):  
Older Adults ◽  
Hearing Loss ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Vision Loss ◽  
Community Dwelling ◽  
Cross Sectional ◽  
Ordinal Logistic Regression Analysis ◽  
Communication Devices ◽  
Community Dwelling Older Adults

This study examined the prevalence of cognitive impairment among older adults in central Vietnam and the roles of communication (with or without communication devices) in the association between cognitive impairment and hearing loss. This cross-sectional study was performed on 725 randomly selected community-dwelling older adults aged ≥60 years from Thua Thien Hue province, Vietnam. Participants attended a face-to-face survey. Sociodemographic characteristics, social interaction with or without communication devices, health status and cognitive function using the Mini-Mental State Examination were reported. Ordinal logistic regression analysis was performed to quantify the association between hearing loss and cognitive function by frequency of communication with and without devices. Mild and severe cognitive impairment had prevalence rates of 23.6% and 19.3%, respectively. Cognitive impairment was more prevalent among older adults with hearing-loss, vision loss and difficulties with instrumental activities of daily living (IADL). The association between hearing loss and cognitive impairment was not significant when older adults had frequent communication with others using devices. This study presented the relatively high prevalence of cognitive impairment in community-dwelling older adults in Vietnam. Frequent communication using devices attenuated the association between hearing loss and cognitive impairment.

scholarly journals Functional Constipation and Anorexia in Community-Dwelling Older Adults: Korean Frailty and Aging Cohort Study (KFACS)

2021 ◽  
Vol 18 (11) ◽  
pp. 5754
Author(s):  
Eunjin Jeong ◽  
Jung A Kim ◽  
Byung Sung Kim ◽  
Chang Kyun Lee ◽  
Miji Kim ◽  
...  
Keyword(s):  
Older Adults ◽  
Cohort Study ◽  
Depressed Mood ◽  
Mmse Score ◽  
Univariate Analysis ◽  
Functional Constipation ◽  
Community Dwelling ◽  
Geriatric Syndrome ◽  
Female Sex ◽  
Community Dwelling Older Adults

Anorexia is a relevant geriatric syndrome because it accounts for most malnutrition in older adults. Constipation has been suggested as a risk factor for anorexia. This study aimed to examine the association between anorexia and functional constipation in community-dwelling older adults. Data on 899 subjects aged 72–86 years were obtained from a follow-up survey of the Korean Frailty and Aging Cohort Study in 2018. Anorexia was assessed using the Simplified Nutritional Appetite Questionnaire (SNAQ), while functional constipation was diagnosed based on Rome IV criteria. Anorexia and functional constipation were present in 30.9% and 19.6% of the participants, respectively. Age, female sex, chewing problems, malnutrition, polypharmacy, low Mini-Mental Status Examination (MMSE) score, depressed mood, low serum albumin, and functional constipation were associated with anorexia in the univariate analysis. In the multivariate logistic regression, functional constipation was associated with anorexia (OR 1.478, 95% CI 1.038–2.104) after adjusting for age, female sex, and MMSE score. However, after further adjusting for depressed mood (OR 2.568) and chewing problems (OR 2.196), the relationship was no longer significant. This study showed that functional constipation is associated with anorexia in community-dwelling older adults, but this association is confounded by depressed mood and chewing problems.

Accelerated Epigenetic Age in Normal Cognitive Aging of Korean Community-Dwelling Older Adults

2021 ◽  
pp. 109980042098389
Author(s):  
Jongmin Park ◽  
Chang Won Won ◽  
Leorey N. Saligan ◽  
Youn-Jung Kim ◽  
Yoonju Kim ◽  
...  
Keyword(s):  
Older Adults ◽  
Dna Methylation ◽  
Cognitive Function ◽  
Cognitive Aging ◽  
Community Dwelling ◽  
Test Results ◽  
Cohen’S D ◽  
Epigenetic Age ◽  
Epigenetic Age Acceleration ◽  
Community Dwelling Older Adults

Background: Epigenetic age acceleration has been studied as a promising biomarker of age-related conditions, including cognitive aging. This pilot study aims to explore potential cognitive aging-related biomarkers by investigating the relationship of epigenetic age acceleration and cognitive function and by examining the epigenetic age acceleration differences between successful cognitive aging (SCA) and normal cognitive aging (NCA) among Korean community-dwelling older adults (CDOAs). Methods: We used data and blood samples of Korean CDOAs from the Korean Frailty and Aging Cohort Study. The participants were classified into two groups, SCA (above the 50th percentile in all domains of cognitive function) and NCA. The genome-wide DNA methylation profiling array using Illumina Infinium MethylationEPIC BeadChip was used to calculate the following: the DNA methylation age, universal epigenetic age acceleration, intrinsic epigenetic age acceleration (IEAA), and extrinsic epigenetic age acceleration (EEAA). We also used Pearson correlation analysis and independent t-tests to analyze the data. Results: Universal age acceleration correlated with the Frontal Assessment Battery test results ( r = −0.42, p = 0.025); the EEAA correlated with the Word List Recognition test results ( r = −0.41, p = 0.027). There was a significant difference between SCA and NCA groups in IEAA ( p = 0.041, Cohen’s d = 0.82) and EEAA ( p = 0.042, Cohen’s d = 0.78). Conclusions: Epigenetic age acceleration can be used as a biomarker for early detection of cognitive decline in Korean community-dwelling older adults. Large longitudinal studies are warranted.

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