ALCOHOL CONSUMPTION AND RISK OF DEMENTIA UP TO 27 YEARS LATER IN A LARGE, POPULATION-BASED SAMPLE: THE HUNT STUDY, NORWAY

SummaryModerate alcohol consumption is associated with lower levels of several coagulation factors. It is an established protective factor for cardiovascular disease; however, the effect on venous thrombosis is unknown. In a large population-based case-control study, we evaluated the association between alcohol consumption and the risk of venous thrombosis. The MEGA study included consecutive patients with a first venous thrombosis between March 1999 and September 2004 from six anticoagulation clinics in the Netherlands. Partners of patients were asked to participate, and additional controls were recruited using a random digit dialling method. All participants completed a standardized questionnaire, and blood samples were collected. A total of 4,423 patients and 5,235 controls were included in the analyses. Alcohol consumption was associated with a reduced risk of venous thrombosis, with 2–4 glasses per day resulting in the largest beneficial effect (odds ratio [OR] 0.67, 95% confidence interval [CI95] 0.58–0.77) compared to abstainers. The effect was more pronounced in women (OR 0.66, CI95 0.53–0.84) than men (OR 0.82, CI95 0.63–1.07) and also more striking for pulmonary embolism (OR 0.56, CI95 0.46–0.70) than for deep venous thrombosis of the leg (OR 0.74, CI95 0.63–0.88). Compared to abstainers, fibrinogen levels were decreased in individuals who consumed alcohol (maximum decrease: 0.30 g/l). FactorVII and vonWillebrand levels were mildly decreased in these individuals but not consistently over the categories of alcohol consumption. In conclusion, alcohol consumption is associated with a reduced risk of venous thrombosis, which may be in part mediated by decreased fibrinogen levels. Thromb

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Alcohol Consumption Is Associated with Poor Prognosis in Obese Patients with COVID-19: A Mendelian Randomization Study Using UK Biobank

Nutrients ◽

10.3390/nu13051592 ◽

2021 ◽

Vol 13 (5) ◽

pp. 1592

Author(s):

Xiude Fan ◽

Zhengwen Liu ◽

Kyle L. Poulsen ◽

Xiaoqin Wu ◽

Tatsunori Miyata ◽

...

Keyword(s):

Alcohol Consumption ◽

Mendelian Randomization ◽

Large Population ◽

Heavy Drinking ◽

Adaptive Immune Response ◽

Population Based ◽

Uk Biobank ◽

Chronic Alcohol Abuse ◽

Risk Of Death ◽

Using Data

Background: Acute and chronic alcohol abuse has adverse impacts on both the innate and adaptive immune response, which may result in reduced resistance to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and promote the progression of coronavirus disease 2019 (COVID-19). However, there are no large population-based data evaluating potential causal associations between alcohol consumption and COVID-19. Methods: We conducted a Mendelian randomization study using data from UK Biobank to explore the association between alcohol consumption and risk of SARS-CoV-2 infection and serious clinical outcomes in patients with COVID-19. A total of 12,937 participants aged 50–83 who tested for SARS-CoV-2 between 16 March to 27 July 2020 (12.1% tested positive) were included in the analysis. The exposure factor was alcohol consumption. Main outcomes were SARS-CoV-2 positivity and death in COVID-19 patients. We generated allele scores using three genetic variants (rs1229984 (Alcohol Dehydrogenase 1B, ADH1B), rs1260326 (Glucokinase Regulator, GCKR), and rs13107325 (Solute Carrier Family 39 Member 8, SLC39A8)) and applied the allele scores as the instrumental variables to assess the effect of alcohol consumption on outcomes. Analyses were conducted separately for white participants with and without obesity. Results: Of the 12,937 participants, 4496 were never or infrequent drinkers and 8441 were frequent drinkers. Both logistic regression and Mendelian randomization analyses found no evidence that alcohol consumption was associated with risk of SARS-CoV-2 infection in participants either with or without obesity (All q > 0.10). However, frequent drinking, especially heavy drinking (HR = 2.07, 95%CI 1.24–3.47; q = 0.054), was associated with higher risk of death in patients with obesity and COVID-19, but not in patients without obesity. Notably, the risk of death in frequent drinkers with obesity increased slightly with the average amount of alcohol consumed weekly (All q < 0.10). Conclusions: Our findings suggest that alcohol consumption has adverse effects on the progression of COVID-19 in white participants with obesity, but was not associated with susceptibility to SARS-CoV-2 infection.

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Insomnia as a risk factor for ill health: results from the large population-based prospective HUNT Study in Norway

Journal of Sleep Research ◽

10.1111/jsr.12102 ◽

2013 ◽

Vol 23 (2) ◽

pp. 124-132 ◽

Cited By ~ 114

Author(s):

Børge Sivertsen ◽

Tea Lallukka ◽

Paula Salo ◽

Ståle Pallesen ◽

Mari Hysing ◽

...

Keyword(s):

Risk Factor ◽

Large Population ◽

Population Based ◽

Hunt Study

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Alcohol consumption and suicide among middle-aged men in Japan

The British Journal of Psychiatry ◽

10.1192/bjp.188.3.231 ◽

2006 ◽

Vol 188 (3) ◽

pp. 231-236 ◽

Cited By ~ 34

Author(s):

Tatsuo Akechi ◽

Motoki Iwasaki ◽

Yosuke Uchitomi ◽

Shoichiro Tsugane

Keyword(s):

Alcohol Consumption ◽

Alcohol Intake ◽

Large Population ◽

Health Centre ◽

Population Based ◽

Study Cohort ◽

Public Health Centre ◽

Heavy Drinkers ◽

Icd 10

BackgroundFew studies have investigated large population-based cohorts for an association between alcohol consumption and suicide.AimsTo investigate the possible association between alcohol intake and suicide.MethodWe used nationwide population-based cohort data from the Japan Public Health Centre-Based Prospective Study cohort. Atotal of 43 383 men aged 40–69 years participated. Death from suicide was defined according to ICD–10 as codes X60-X84.ResultsDuringthe367817person-years of follow-up, there were 168 suicides. Compared with occasional drinkers, the pooled multivariate relative risk (RR; with 95% CI) of suicide for non-drinkers and regular heavy drinkers was 2.3 (1.2–4.6) and 2.3 (1.2–4.7) respectively. The RR increased with the amount of alcohol consumed (P for trend =0.004).ConclusionsThere is a U-shaped association between alcohol consumption and subsequent suicide.

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Multiple lifestyle behaviours and mortality, findings from a large population-based Norwegian cohort study - The HUNT Study

BMC Public Health ◽

10.1186/s12889-016-3993-x ◽

2017 ◽

Vol 17 (1) ◽

Cited By ~ 32

Author(s):

Steinar Krokstad ◽

Ding Ding ◽

Anne C. Grunseit ◽

Erik R. Sund ◽

Turid Lingaas Holmen ◽

...

Keyword(s):

Cohort Study ◽

Large Population ◽

Population Based ◽

Lifestyle Behaviours ◽

Hunt Study

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Parental migraine in relation to migraine in offspring: Family linkage analyses from the HUNT Study

Cephalalgia ◽

10.1177/0333102419828989 ◽

2019 ◽

Vol 39 (7) ◽

pp. 854-862 ◽

Cited By ~ 6

Author(s):

Sigrid Børte ◽

John-Anker Zwart ◽

Synne Øien Stensland ◽

Knut Hagen ◽

Bendik S Winsvold

Keyword(s):

Cohort Study ◽

Confidence Interval ◽

Odds Ratio ◽

Large Population ◽

Population Based ◽

Cross Sectional ◽

Maternal Line ◽

Hunt Study ◽

Cross Sectional Design ◽

Migrainous Headache

Background Migraine is known to run in families. While some clinical studies have indicated that migraine is disproportionally transmitted through the maternal line, this has not been examined in a population-based setting. Methods We utilized a large, population-based cohort study from Norway, the HUNT Study. Using a cross-sectional design, our sample consisted of 13,731 parents and 8970 offspring. Logistic regression was used to calculate odds ratios with 95% confidence intervals for active migraine and non-migrainous headache in offspring, given active maternal or paternal headache. Results There was a significant association between maternal migraine and offspring migraine (odds ratio 2.76, 95% confidence interval 2.18–3.51). A weaker association ( p = 0.004 for comparison with maternal migraine) was found between paternal migraine and offspring migraine (odds ratio 1.67, 95% confidence interval 1.33–2.28). For non-migrainous headache, there was a significant association between mothers and offspring (odds ratio 1.25, 95% confidence interval 1.10–1.43), but not between fathers and offspring. Conclusions Parental migraine is associated with offspring migraine, with a stronger association for maternal migraine. This may indicate maternal-specific transmission.

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Alcohol Consumption is Associated with Poor Prognosis in Obese Patients with COVID-19: a Mendelian Randomization Study using UK Biobank

10.1101/2020.11.25.20238915 ◽

2020 ◽

Author(s):

Xiude Fan ◽

Zhengwen Liu ◽

Kyle L Poulsen ◽

Xiaoqin Wu ◽

Tatsunori Miyata ◽

...

Keyword(s):

Alcohol Consumption ◽

Mendelian Randomization ◽

Large Population ◽

Heavy Drinking ◽

Adaptive Immune Response ◽

Population Based ◽

Uk Biobank ◽

Chronic Alcohol Abuse ◽

Risk Of Death ◽

Using Data

AbstractBackgroundAcute and chronic alcohol abuse have adverse impacts on both the innate and adaptive immune response, which may result in reduced resistance to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and promote the progression of coronavirus disease 2019 (COVID-19). However, there are no large population-based data evaluating potential causal associations between alcohol consumption and COVID-19.MethodWe conducted a Mendelian randomization study using data from UK Biobank to explore the association between alcohol consumption and risk of SARS-CoV-2 infection and serious clinical outcomes in patients with COVID-19. A total of 12,937 participants aged 50-83 who tested for SARS-CoV-2 between 16 March to 27 July 2020 (12.1% tested positive) were included in the analysis. The exposure factor was alcohol consumption. Main outcomes were SARS-CoV-2 positivity and death in COVID-19 patients. We generated weighted and unweighted allele scores using three genetic variants (rs1229984, rs1260326, and rs13107325) and applied the allele scores as the instrumental variables to assess the effect of alcohol consumption on outcomes. Analyses were conducted separately for white participates with and without obesity.ResultsOf the 12,937 participants, 4,496 were never or infrequent drinkers and 8,441 were frequent drinkers. (including 1,156 light drinkers, 3,795 moderate drinkers, and 3,490 heavy drinkers). Both logistic regression and Mendelian randomization analyses found no evidence that alcohol consumption was associated with risk of SARS-CoV-2 infection in participants either with (OR=0.963, 95%CI 0.800-1.159; q =1.000) or without obesity (OR=0.891, 95%CI 0.755-1.053; q =.319). However, frequent drinking (HR=1.565, 95%CI 1.012-2.419; q =.079), especially heavy drinking (HR=2.071, 95%CI 1.235-3.472; q =.054), was associated with higher risk of death in patients with obesity and COVID-19, but not in patients without obesity. Notably, the risk of death in frequent drinkers with obesity increased slightly with the average amount of alcohol consumed weekly (HR=1.480, 95%CI 1.059-2.069; q =.099).ConclusionsOur findings suggested alcohol consumption may had adverse effects on the progression of COVID-19 in white participants with obesity, but was not associate with susceptibility to SARS-CoV-2 infection.

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Arterial waveform parameters in a large, population-based sample of adults: relationships with ethnicity and lifestyle factors

Journal of Human Hypertension ◽

10.1038/jhh.2016.78 ◽

2016 ◽

Vol 31 (5) ◽

pp. 305-312 ◽

Cited By ~ 1

Author(s):

J D Sluyter ◽

A D Hughes ◽

S A McG Thom ◽

A Lowe ◽

C A Camargo Jr ◽

...

Keyword(s):

Alcohol Consumption ◽

Augmentation Index ◽

Large Population ◽

Population Based ◽

Lifestyle Factors ◽

Pressure Amplitude ◽

Cross Sectional ◽

Heavy Alcohol ◽

Pacific People ◽

Heavy Alcohol Consumption

Abstract Little is known about how aortic waveform parameters vary with ethnicity and lifestyle factors. We investigated these issues in a large, population-based sample. We carried out a cross-sectional analysis of 4798 men and women, aged 50–84 years from Auckland, New Zealand. Participants were 3961 European, 321 Pacific, 266 Maori and 250 South Asian people. We assessed modifiable lifestyle factors via questionnaires, and measured body mass index (BMI) and brachial blood pressure (BP). Suprasystolic oscillometry was used to derive aortic pressure, from which several haemodynamic parameters were calculated. Heavy alcohol consumption and BMI were positively related to most waveform parameters. Current smokers had higher levels of aortic augmentation index than non-smokers (difference=3.7%, P<0.0001). Aortic waveform parameters, controlling for demographics, antihypertensives, diabetes and cardiovascular disease (CVD), were higher in non-Europeans than in Europeans. Further adjustment for brachial BP or lifestyle factors (particularly BMI) reduced many differences but several remained. Despite even further adjustment for mean arterial pressure, pulse rate, height and total:high-density lipoprotein cholesterol, compared with Europeans, South Asians had higher levels of all measured aortic waveform parameters (for example, for backward pressure amplitude: β=1.5 mm Hg; P<0.0001), whereas Pacific people had 9% higher loge (excess pressure integral) (P<0.0001). In conclusion, aortic waveform parameters varied with ethnicity in line with the greater prevalence of CVD among non-white populations. Generally, this was true even after accounting for brachial BP, suggesting that waveform parameters may have increased usefulness in capturing ethnic variations in cardiovascular risk. Heavy alcohol consumption, smoking and especially BMI may partially contribute to elevated levels of these parameters.

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