P–024 Health and lifestyle detrimental conditions may impact the association between patient age and semen parameters in male populations

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
M C Guglielmo ◽  
M Vitali ◽  
R Iemmello ◽  
I Caliari ◽  
S Maruccia ◽  
...  
Keyword(s):  
Semen Quality ◽  
Age Groups ◽  
Sperm Concentration ◽  
Quality Parameters ◽  
Paternal Age ◽  
Semen Parameters ◽  
Male Population ◽  
Semen Volume ◽  
Fertility Clinic ◽  
The Impact

Abstract Study question Can health and lifestyle detrimental conditions impact the relationship between paternal age and semen quality parameters in a male population? Summary answer Health and lifestyle detrimental conditions can attenuate the negative relationship between age and sperm concentration in a male population. What is known already Paternal age has increased in parallel with maternal age but its contribution in couple subfertility deserves further investigation. Previous studies suggest that paternal ageing is associated with reduced semen volume and impaired sperm morphology and motility, but not with reduced sperm concentration. Several health and lifestyle conditions such as diabetes, hypertension and smoking can negatively affect semen quality. Since the distribution of these conditions is not homogeneous throughout men’s reproductive life, one can hypothesize that their presence may confound the association between paternal age and semen quality parameters in male populations. Study design, size, duration This is a retrospective study with data from 5565 men examined in a single fertility clinic between 2015 and 2020. The impact of health and lifestyle conditions was assessed by comparing the effects of age on semen parameters in two different patient populations: the overall patient population and a subpopulation excluding patients with detrimental health or lifestyle characteristics, both divided in 4 age groups (A: 25–34, B: 35–39, C: 40–44 and D: ≥45 years). Participants/materials, setting, methods The study includes 5565 men aged 24 to 72 years providing semen samples to assess volume, progressive motility and concentration (WHO) in a single fertility clinic. Patients presenting diabetes, heart/circulatory diseases, andrological disorders, genital neoplasms, cystic fibrosis, Y microdeletions, abusive alcohol intake, smoking and/or recreational use of drugs were excluded from the healthy subpopulation. The effect of age on semen parameters was assessed by ANOVA (motility and volume) or Kruskal-Wallis one-way ANOVA (concentration). Main results and the role of chance: Of 5565 men included in the study, 2150 (38.6%) did not present any of the detrimental health and lifestyle conditions described above. In the overall patient population, semen volume [Mean±SD (mL); A: 3.14 ± 1.55, B: 3.01 ± 1.53, C: 2.83 ± 1.52, D: 2.65 ± 1.58; p < 0.001] and sperm progressive motility [Mean±SD (%); A: 33.1 ± 18.0, B: 31.7 ± 17.7, C: 31.4 ± 17.5, D: 28.4 ± 17.5; p < 0.001] gradually and significantly decreased with paternal age. The same effect was observed in the patient subpopulation excluding detrimental health and lifestyle conditions [(mL; A: 3.21 ± 1.58, B: 3.05 ± 1.51, C: 2.89 ± 1.59, D: 2.78 ± 1.50; p < 0.001); (%; A: 35.85 ± 17.4, B: 33.7 ± 17.4, C: 32.2 ± 17.1, D: 30.3 ± 16.5; p < 0.001)]. However, sperm concentration significantly decreased with paternal age in the subpopulation excluding detrimental health and lifestyle conditions [(Mean±SD) million/mL; A: 43.19 ± 41.0, B: 38.8 ± 38.6, C: 38.4 ± 34.6, D: 36.6 ± 33.9; p < 0.001], but not in the overall population (million/mL; A: 38.17 ± 40.9, B: 36.7 ± 34.7, C: 35.3 ± 35.1, D: 35. 1± 37.5; p = 0.088). Limitations, reasons for caution This study is limited by its retrospective nature and by the accuracy of data on health and lifestyle conditions provided by the patients. Differences between age groups not controlled for in the study could also impact the results. Wider implications of the findings: Ours findings suggest that health and lifestyle conditions may confound the effects of age on semen and sperm quality. Therefore, these data constitute a useful reference for the accurate assessment of the impact of male age on fertility. Trial registration number Not applicable

scholarly journals ASSOCIATIONS BETWEEN PITUITARY-GONADAL AXIS PARAMETERS AND SEMEN QUALITY IN YOUNG, HEALTHY MEN (AndroLS)

2019 ◽  
Vol 15 (3) ◽  
pp. e11-e24
Author(s):  
Józków Paweł ◽  
Medras Marek ◽  
Szmigiero Leszek ◽  
Słowinska-Lisowska Małgorzata ◽  
Lwow Felicja
Keyword(s):  
Sperm Morphology ◽  
Semen Quality ◽  
Sperm Count ◽  
Sperm Concentration ◽  
Free Testosterone ◽  
Quality Parameters ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Semen Volume ◽  
The Impact

Background and ObjectiveHormonal measurements play an important role in the evaluation of male fertility potential. In men without hypogonadism, the impact of androgen status on semen is rarely analyzed.Material and MethodsWe evaluated associations between parameters of the pituitary-gonadal axis: luteinizing hormone (LH), follicle-stimulating hormone (FSH), total testosterone (T), free testosterone (FT), calculated testosterone (TC), bioavailable testosterone (TB), sex hormone-binding globulin (SHBG), free androgen index, and semen quality parameters in healthy young men.ResultsIn our study group, sperm concentration and sperm count were associated with FSH and FT. The percentage of immotile sperm was associated with LH and T. The percentage of vital sperm was negatively related to LH. We identified negative, independent associations between T and semen volume (p<0.026) and TC and semen volume (p<0.025). We observed negative, independent association between FSH, FT, and total sperm count (both P<0.002) and between FT and the percentage of normal forms (P<0.012). There were positive associations between LH and T and the percentage of immotile sperm (P<0.007 and P<0.034, respectively). There were no relationships between sperm morphology parameters and the parameters of the pituitary-gonadal axis.ConclusionIn healthy eugonadal men, variations in FSH, LH, T, and FT (within normal limits) are reflected in semen characteristics but not in sperm morphology features.

scholarly journals What Is the Impact of Excessive Iodine and Semen Quality in Fertile Men of China: An Association Study 

2021 ◽  
Author(s):  
Ning Wang ◽  
Fang Lv ◽  
Ge Yu ◽  
Cuige Shi ◽  
Shangming Wang ◽  
...  
Keyword(s):  
Semen Quality ◽  
Sperm Count ◽  
Sperm Concentration ◽  
Urinary Iodine ◽  
Iodine Concentration ◽  
Male Reproduction ◽  
Semen Parameters ◽  
Human Thyroid ◽  
Urinary Iodine Concentration ◽  
The Impact

Abstract Background: Iodine is an essential element for hormones synthesized by the human thyroid gland. Thyroid hormone deficiency affects all body tissues, including multiple endocrine changes that alter growth hormones, corticotrophin, glucocorticoids, and gonadal function. In many countries, subfertility is an important problem affecting about 10–15% of all couples trying to conceive. Male subfertile factors have accounted for 25–30% of all cases in their studies. The aim of this study was to study the correlation between urinary iodine concentration (UIC) and semen quality of fertile male in China.Methods: semen and urine samples were collected from males who attended a survey for the reproductive physiological constants of male and female in China. All participants were fertile and they should be free from diseases of male reproductive system and thyroid related diseases. We studied the correlation between UIC and semen quality parameters in fertile males and the effect of iodine concentration on male reproduction. Participants were divided into six groups based on UIC. We measured semen parameters and UIC. Semen parameters or time-to-pregnancy (TTP) were analyzed by Spearman correlation, linear regression and multivariable logistic regression. Results: 1089 men were recruited in the study. The mean and median age of participants were 27.46±0.12 and 27±3.88 years, respectively. UIC of 274 (25.16%) men was lower than the UIC of WHO recommended. UIC of 405 men located in the region of WHO recommended. 62.35% of them were not located in the optimal region. Semen concentration and total sperm count were found to decrease when UIC increases when the UIC≥100 ug/L. Conclusions: A male with deficient UIC or excessive UIC has more risk of lower semen quality such as sperm concentration and total sperm count. In addition, if a male with deficient UIC or excessive UIC, his wife has longer TTP than the males who had normal UIC. Deficient UIC associated with lower semen quality and TTP than excessive UIC.

scholarly journals Evaluating bull fertility based on non-return method

2012 ◽  
Vol 66 (1-2) ◽  
pp. 27-40
Author(s):  
Igor Prka ◽  
Dragan Vukovic ◽  
Stevan Perkovic
Keyword(s):  
Semen Quality ◽  
Sperm Quality ◽  
Quality Parameters ◽  
Semen Parameters ◽  
Service Period ◽  
Microscopic Evaluation ◽  
Live Sperm ◽  
Return Method ◽  
The Impact ◽  
First Time

In order to evaluate the results of reproductive cows and heifers, different parameters of fertility are used, such as the service period, insemination index, intercalving time and others, and of the breeding bulls the values obtained through non-return. An ejaculate is taken up for further processing by veterinary centres only provided it meets the prescribed quality parameters. Rating semen parameters includes a macroscopic (volume, colour, consistency, smell and pH) and a microscopic evaluation (mobility, density, percentage of live sperm and abnormal and damaged sperm). In addition to sperm quality and the fertility of the female animal, the results of the non-return method are also influenced by a number of exogenous causes (season, age, race, insemination techniques) that have no small impact on the end result of insemination - pregnancy. In order to obtain more objective results of the fertility of bulls the following tasks were undertaken, namely: 1. to calculate with the non-return method the fertility of bulls in over 10,000 cows inseminated for the first time during a period of 6 years; and 2. to analyze the impact of semen quality, season, age of cow and bull, and the bull breed on the results of fertility.

scholarly journals Influence of age on the spermiogramic parameters of native sheep

1970 ◽  
Vol 7 (2) ◽  
pp. 301-304 ◽  
Author(s):  
MR Hassan ◽  
S Pervage ◽  
M Ershaduzzaman ◽  
MAI Talukder
Keyword(s):  
Semen Quality ◽  
Age Groups ◽  
Sperm Concentration ◽  
Live Weight ◽  
Scrotal Circumference ◽  
Semen Volume ◽  
Native Sheep

The study was conducted to evaluate the qualities of ram semen in different age groups (one to four years) were evaluated. The parameters included testes length (cm), testes breadth (cm), scrotal circumference (cm), live weight (kg), semen volume (ml), PH, sperm concentration (x109), motility (%), percentage of live, dead and normal, abnormal spermatozoa of native sheep. The average semen volume (ml) found to be 0.60, 0.91, 0.85 and 0.87; sperm concentration (109/ml) 1.03, 3.27, 4.45 and 4.17 and finally motility (%) were found to be 68.07, 75.03, 75.01 and 76.25 respectively for the 1st, 2nd, 3rd and 4th year age of native ram. The effects of age on all parameters (testes length, semen volume, semen pH, sperm concentration, motility, viability, normal spermatozoa) were significant except testes breadth and scrotal circumference. The value of all of these parameters increased linearly up to three years with the increase of age except PH. The result of the present study indicated that scrotal diameter, serving capacity; normal and live spermatozoa were comparatively better during the 3rd year than the 1st and 2nd year of age while the values were almost similar at 3rd and 4th year of age. With the increasing of age, the semen quality improved and stabilized up to at the age of 3 years. Keywords: Native sheep; Spermiogramic parameter; Age DOI: 10.3329/jbau.v7i2.4738 J. Bangladesh Agril. Univ. 7(2): 301-304, 2009

scholarly journals An age-based sperm nomogram: the McGill reference guide

2020 ◽  
Vol 35 (10) ◽  
pp. 2213-2225
Author(s):  
Mali Salmon-Divon ◽  
Guy Shrem ◽  
Jacques Balayla ◽  
Tamar Nehushtan ◽  
Alexander Volodarsky-Perel ◽  
...  
Keyword(s):  
Significant Influence ◽  
Semen Quality ◽  
Sperm Concentration ◽  
Semen Parameters ◽  
Progressive Motility ◽  
Semen Volume ◽  
Fourth Decade ◽  
Reference Limits ◽  
Age Dependent ◽  
Entire Dataset

Abstract STUDY QUESTION How does age affect various semen parameters? SUMMARY ANSWER For most semen parameters, the nomogram of the entire population was biphasic, peaking around the fourth decade of life. WHAT IS KNOWN ALREADY In clinical practice, semen quality is examined by using the WHO 2010 reference limits but these limits do not account for male age. A percentile-based, large-scale nomogram describing how different semen parameters change throughout reproductive life has been lacking. STUDY DESIGN, SIZE, DURATION A retrospective study was conducted with 12 188 sperm samples, obtained from individuals who attended the McGill University Health Centre reproductive clinic between 2009 and 2018. PARTICIPANTS/MATERIALS, SETTING, METHODS One sample from each individual who attended the clinic during the study period was analysed by using computer-assisted sperm analysis (CASA). The analysed parameters were human-verified and included sperm concentration, motility, progressive motility, total count, morphology and semen volume. Based on this analysis, the entire dataset (n = 12 188) was further divided into two groups of samples: samples that surpassed the WHO 2010 lower reference limits (‘above reference limits’ group, ARL; n = 6305), and samples that did not (‘below reference limit’ group, BRL; n = 5883). Regression quantiles were fitted as a function of age to generate age-dependent nomograms, and these quantiles were divided into 5th, 25th, 50th, 75th and 95th percentiles. MAIN RESULTS AND THE ROLE OF CHANCE In the entire dataset, age had a significant influence (P &lt; 0.001) on all parameters (except morphology) which demonstrated a biphasic trend peaking in the fourth decade of life. In the ARL group, age had a significant influence (P &lt; 0.01) on all semen parameters except sperm concentration and morphology. However, unlike in the entire dataset, only semen volume demonstrated a biphasic trend in the ARL group (peaking in the fourth decade of life), whereas other parameters either remained unchanged (concentration and morphology) or consistently declined with age (sperm motility, progressive motility and total sperm count). Percentile-based nomograms were generated for individuals between the ages of 20 and 60 years in the entire dataset and in the ARL group. LIMITATIONS, REASONS FOR CAUTION First, the semen samples were obtained from individuals who were referred to a fertility clinic, such that the entire dataset does not necessarily represent the general population. Second, the cross-sectional sampling design increases variance, and the nomograms are less accurate in the 5th and 95th percentiles and at the extremes of the age distributions. Third, the observed age-dependent changes in semen parameters do not necessarily indicate changes in fertility, as not all factors that affect male fertility were analysed. Fourth, some of our semen analyses employed CASA, which can have variability issues. Finally, our models did not incorporate possible secular trends. WIDER IMPLICATIONS OF THE FINDINGS We provide the first nomogram that correlates age with semen quality parameters in different population percentiles, thus complementing the current reference limits set by the WHO in 2010. Most examined semen parameters in our study changed non-linearly with age; therefore, age should be regularly employed as a factor in the clinical analysis of semen samples. STUDY FUNDING/COMPETING INTEREST(S) The authors have not received any funding to support this study. There are no conflicts of interest to declare. TRIAL REGISTRATION NUMBER N/A.

scholarly journals Association between obesity-associated markers and semen quality parameters and serum reproductive hormones in Chinese infertile men

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Jian-Xiong Ma ◽  
Bin Wang ◽  
Hai-Song Li ◽  
Xue-Juan Jiang ◽  
Jia Yu ◽  
...  
Keyword(s):  
Semen Quality ◽  
Sperm Concentration ◽  
Density Lipoprotein ◽  
Quality Parameters ◽  
Reproductive Hormones ◽  
Normal Group ◽  
Semen Parameters ◽  
Progressive Motility ◽  
Infertile Men ◽  
The Relationship

Abstract Background The current evidence on the association between obesity-associated markers and semen quality, serum reproductive hormones and lipids remains inconsistent. In this study, we tested the hypothesis that, in infertile Chinese men, body mass index (BMI) negatively correlates with sperm concentration, serum total testosterone (TT), and high-density lipoprotein cholesterol (HDL-C). The relationship between other obesity-associated markers and semen quality parameters, serum reproductive hormones, lipids and leptin were also investigated. Methods 181 Chinese infertile men were recruited from September 2018 to September 2019. Their obesity-associated markers, semen parameters, and serum reproductive hormones, lipids and leptin were detected. Statistical analysis was performed to assess the relationship between obesity-associated markers and semen quality, serum reproductive hormones, lipids and leptin. Result(s) Statistically negative correlation was found between other obesity-associated markers (e.g. waist-to-hip ratio and waist-to-height ratio) and semen parameters (e.g. sperm concentration, ratio of progressive motility and ratio of non-progressive motility), while no significant correlation was found between BMI and semen quality, serum reproductive hormones, lipids and leptin. Ratio of morphologically normal sperm was negatively correlated with serum lipids including total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C), leptin and seminal superoxide dismutase. Ratio of progressive sperm, sperm concentration and ratio of morphologically normal sperm exhibited significantly lower values in overweight group than normal group. Estradiol (E2) and E2/TT were significantly higher in obese group than normal group, while TT level was significantly lower in obese group than normal group. Univariate and multivariate analysis indicated that TC was significantly associated with BMI. Serum leptin concentration was positively correlated with seminal leptin concentration in overweight and obese groups. Conclusion(s) No significant correlation was found between BMI and sperm concentration, serum TT and HDL-C, while other obesity-associated markers were found to negatively correlate with sperm concentration, ratio of progressive motility and ratio of non-progressive motility. Statistically significant correlations between serum reproductive hormones, lipids and leptin also existed in Chinese infertile men.

Effect of dietary ellagic acid supplementation on semen quality parameters in chickens

2015 ◽  
Vol 55 (1) ◽  
pp. 107 ◽  
Author(s):  
M. Shanmugam ◽  
S. V. Rama Rao
Keyword(s):  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Seminal Plasma ◽  
Ellagic Acid ◽  
Semen Quality ◽  
Sperm Concentration ◽  
Quality Parameters ◽  
Superoxide Dismutase Activity ◽  
Semen Parameters ◽  
Reducing Ability

Ellagic acid (EA), a polyphenoloic constituent in fruits and nuts, has been shown to have antioxidant and antiapoptotic properties. The aim of this study was to investigate the effect of dietary EA supplementation on semen quality parameters in chickens. Forty roosters (Dahlem Red breed), 28 weeks of age, were randomly assigned to four groups and fed diets containing EA at 0, 25, 50, or 75 mg/kg for 8 weeks. Semen was evaluated for volume, appearance, individual motility, sperm concentration, 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) dye reduction test, and live, dead and abnormal sperm counts. The seminal plasma was separated and evaluated for protein, alkaline phosphatase, and lipid peroxidation. At the end of the experiment, blood from individual birds was collected, and serum was separated and evaluated for superoxide dismutase activity, lipid peroxidation, and ferric-reducing ability of plasma. Supplementation with EA had no effect (P > 0.05) on gross semen parameters. Seminal plasma protein and lipid peroxidation were different (P < 0.01) between the treatment groups. The group fed EA at 75 mg/kg had high (P < 0.01) seminal plasma lipid peroxidation and lower (P < 0.05) serum superoxide dismutase activity. In conclusion, dietary supplementation of EA in chickens had no effect on the gross semen qualities and increased lipid peroxidation in seminal plasma.

Sexual Behavior and its Relationship with Semen QualityParameters in Jaffrabadi Breeding Bulls

2019 ◽  
Vol 15 (01) ◽  
pp. 57-60
Author(s):  
J K Chaudhary ◽  
G B Solanki ◽  
H P Vijyeta ◽  
P M Gamit ◽  
K S Murthy
Keyword(s):  
Sexual Behavior ◽  
Sperm Motility ◽  
Semen Quality ◽  
Sperm Concentration ◽  
Quality Parameters ◽  
Mating Ability ◽  
Mean Values ◽  
Semen Volume ◽  
Mass Activity ◽  
Live Sperm

The present study was carried out on 80 ejaculates, 20 each from four healthy Jaffrabadi breeding bulls to see the relationship betweensexual behavior and semen quality parameters. The results depicted that the overall mean values of libido score, mating ability score andsexual libido score between bulls. The overall color of semen ranged from thin white to very thick creamy. The overall values for semen volume(ml), pH, sperm concentration (million/mL), mass activity, individual sperm motility (%) and live spermatozoa (%) were 2.99 ± 0.12, 6.80 ± 0.01, 1439.68 ± 48.46, 3.94 ± 0.03, 89.51 ± 0.21 and 95.00 ± 0.19, respectively. The values for semen volume, sperm concentration,mass activity (%) and live sperm (%) differed significantly (p less than 0.05) between bulls. There were significant positive correlations (p LESS THAN 0.01)of libido with mating ability, sexual behavior score and ejaculate volume of semen (r = 0.37 to 0.87), while a negative correlation wasfound with sperm concentration (-0.30). Mating ability was significantly (p less than 0.01) correlated with sexual behavior score and ejaculatevolume (0.78, 0.67), and sexual behavior was correlated with semen volume (0.84). Sperm concentration was significantly (p less than 0.05 correlated with mass activity (0.29), while individual sperm motility was positively (p less than 0.05) correlated with live sperm percentage (0.25).Correlations of libido, reflected the importance of sexual behavior of Jaffrabadi bulls in predicting their future utility as a proficient breeder under AI program.

scholarly journals Sexually transmitted infections and semen quality from subfertile men with and without leukocytospermia

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Shun Bai ◽  
Yuan Li ◽  
Yangyang Wan ◽  
Tonghang Guo ◽  
Qi Jin ◽  
...  
Keyword(s):  
Sexually Transmitted Infections ◽  
Semen Quality ◽  
Ureaplasma Urealyticum ◽  
Sperm Quality ◽  
Sperm Concentration ◽  
Semen Parameters ◽  
Detection Rates ◽  
Sexually Transmitted ◽  
Semen Volume ◽  
Significant Difference

Abstract Background The role of sexually transmitted infections (STIs) in semen parameters and male infertility is still a controversial area. Previous studies have found bacterial infection in a minority of infertile leukocytospermic males. This study aims to investigate the prevalence of STIs in semen from subfertile men with leukocytospermia (LCS) and without leukocytospermia (non-LCS) and their associations with sperm quality. Methods Semen samples were collected from 195 men who asked for a fertility evaluation. Infection with the above 6 pathogens was assessed in each sample. Sperm quality was compared in subfertile men with and without LCS. Results The LCS group had significantly decreased semen volume, sperm concentration, progressive motility, total motility and normal morphology. The infection rates of Ureaplasma urealyticum (Uuu), Ureaplasma parvum (Uup), Mycoplasma hominis (MH), Mycoplasma genitalium (MG), Chlamydia trachomatis (CT), herpes simplex virus-2 (HSV-2) and Neisseria gonorrhoeae (NG) were 8.7 %, 21.0 %, 8.2 %, 2.1 %, 3.6 %, 1.0 and 0 %, respectively. The STI detection rates of patients with LCS were higher than those of the non-LCS group (52.3 % vs. 39.3 %), although there was no statistically significant difference between the two groups (P = 0.07). All semen parameters were not significantly different between LCS with STIs and without STIs, except the semen volume in the MG-infected patients with LCS was significantly lower than that in the noninfected group. Conclusions LCS was associated with a reduction in semen quality, but was not associated with STIs.

Impact of Male Aging on Semen Parameters

2021 ◽  
Vol 5 (2) ◽  
Author(s):  
Arzu Yurci ◽  
Nur Dokuzeylul Gungor
Keyword(s):  
Regression Analysis ◽  
Sperm Motility ◽  
Sperm Concentration ◽  
Paternal Age ◽  
World Health ◽  
Semen Parameters ◽  
Age Group ◽  
Male Age ◽  
Semen Volume ◽  
The Mean

Aim: To investigate the effect of increasing male age on the semen parameters including semen volume, sperm concentration, and progressive sperm motility. Materials and Methods: 1038 patients who applied to our IVF clinic for semen analysis or for infertility treatment were included in the study. The participants were divided into three age categories as follows: 680 participants (65.5%) aged 22-30, 139 participants (13.4%) aged 31-45 years, and 219 participants (21.1%) aged ≥45 years. Demographic and baseline clinical characteristics were recorded. The variables considered in this study were age and the following semen parameters: volume (ml); sperm concentration (millions/ml); and progressive sperm motility A+B (%). Normal semen values were defined based on the WHO criteria (World Health Organization, 2010). Results: The mean age of the participants was 33.1(± 4.8). The mean BMI of the participants was 24.1(± 2.8). The mean semen volume was 3.3 (± 1.5), the mean semen concentration was 43.6 (± 31.7), and the mean progressive sperm motility was 43.6 (± 10.1). There was a moderate negative correlation between paternal age and semen volume (r=-0.13) and sperm motility (r=-0.32), while there was a moderate positive correlation between paternal age and sperm concentration (r=0.24). The proportion of likelihood ratio measured between semen volume, sperm concentration, sperm motility and age was found to be 1 in patients between the ages of 22-30. The 22-30 age group does not have a decreasing or increasing effect on semen volume (OR: 1), sperm concentration (OR: 1) and motility (OR: 1). Regression analysis of patients in the 31-45 age group revealed no change in semen volume (OR: 0.99, 95% CI: 0.43-2.3, p <0.9), but an increase in sperm concentration (OR: 1.74, 95% CI: 1.13-2.7, p <0.01), and decreased sperm motility (OR: 0.28, 95% CI: 0.16-0.47, p <0.00). In the regression analysis of participants over the age of 45, semen volume (OR: 0.31, 95% CI: 0.19-0.53, p <0.00) and sperm motility (OR: 0.05, 95% CI: 0.03-0.08, p <0.00) decreased with age. No change was detected in the concentration (OR: 0.87, 95% CI: 0.63- 1.2, p <0.3). Conclusion: With increasing male age, semen volume and sperm motility begin to decrease. However, a significant decrease in sperm concentration does not occur until the age of 45.

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