scholarly journals Off-pump transapical closure of a mitral periprosthetic leak: a new approach to a difficult problem

2013 ◽  
Vol 17 (6) ◽  
pp. 1048-1050 ◽  
Author(s):  
Diego Felipe Gaia ◽  
João Roberto Breda ◽  
Claudio Henrique Fischer ◽  
José Honório Palma
Keyword(s):  
Difficult Problem ◽  
New Approach ◽  
Off Pump ◽  
Periprosthetic Leak

Pharmacology in Medicine

PEDIATRICS ◽  
1955 ◽  
Vol 16 (1) ◽  
pp. 143-143
Keyword(s):  
Subject Matter ◽  
Collaborative Work ◽  
Difficult Problem ◽  
Research Experience ◽  
New Approach ◽  
Comprehensive Treatise ◽  
The Subject

This large book is the collaborative work of 81 persons. Each has described the drugs currently used in a field with which he is well acquainted from clinical or research experience. The list of authors is impressive. The result of their efforts is a semi-comprehensive treatise which should find a place in the libraries of many physicians. This book represents a new approach to the difficult problem of keeping available a fairly current description of the subject matter in a field which advances, as pharmacology does, in a very uneven fashion.

scholarly journals Research on Prediction Model of Prestress Loss of Anchor Cable in Soil-Rock Dual-Structure Slope

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Xuhe Gao ◽  
Weiping Tian ◽  
Jiachun Li ◽  
Hongliang Qi ◽  
Zhipei Zhang
Keyword(s):  
Prediction Model ◽  
Difficult Problem ◽  
Prestress Loss ◽  
New Approach ◽  
Dual Structure ◽  
Anchor Cable ◽  
Loss Prediction ◽  
Slope Treatment ◽  
Improved Model ◽  
Prestressed Anchor

The establishment of the prestressed cable loss prediction model is a difficult problem faced by the popularization and use. This article aims at the problem of the loss of anchor cable prestress over time in the soil-rock dual-structure slope. We relied on the soil-rock dual-structure slope treatment project of section K5 + 220-K5 + 770 of Jiangwen Expressway and monitored the prestress loss of the anchor cable in the slope through the anchor cable meter with built-in vibrating wire sensor. Using regression analysis and segmented modelling methods, we established a comprehensive mathematical improvement model, analyzed the applicability of the improved model, and obtained the error range, 0.04%–8.9%. This work offers a new approach for predicting anchor cable prestress loss, which has certain practical value for the use of prestressed anchor cables.

New Approach to Integrate Planning and Scheduling of Production System: Heuristic Resolution

2018 ◽  
Vol 39 ◽  
pp. 156-169 ◽  
Author(s):  
Zineb Ibn Majdoub Hassani ◽  
Abdellah El Barkany ◽  
Abdelouahhab Jabri ◽  
Ikram El Abbassi ◽  
Abdel Moumen Darcherif
Keyword(s):  
Genetic Algorithm ◽  
Resource Availability ◽  
Job Shop ◽  
Difficult Problem ◽  
Capacity Constraints ◽  
Production Plan ◽  
Planning And Scheduling ◽  
New Approach ◽  
Total Cost ◽  
Integrated Strategy

In general, planning and scheduling of production are treated separately under the hierarchical strategy. Then, over the time, the iterative strategy appeared which partially considers the scheduling constraints during planning, except that the latter remains unsatisfactory because there is no guarantee that these constraints are taken into account. For this, is born the integrated strategy which integrates planning and scheduling and aims to solve the problem and define a feasible production plan. Since capacity constraints don’t reflect reality in terms of resource availability, and they are not always considered, capacity becomes aggregated. To remedy this problem, it is necessary to integrate more precise constraints of scheduling at the planning level. Based on this observation, we propose in this article a new model that integrates planning and scheduling and considers the constraint of resource availability. In our model, the objective function optimizes the total cost of production for a mono-level job-shop problem. To solve this N-P difficult problem we use a stochastic approached method as genetic algorithm (GA).

scholarly journals Robotic intra-abdominal vasectomy reversal: A new approach to a difficult problem

2014 ◽  
Vol 8 (5-6) ◽  
pp. 439 ◽  
Author(s):  
Yagil Barazani ◽  
Jihad Kaouk ◽  
Edmund S. Sabanegh Jr.
Keyword(s):  
Vas Deferens ◽  
Difficult Problem ◽  
Obstructive Azoospermia ◽  
Operating Microscope ◽  
Surgical Experience ◽  
New Approach ◽  
Robotic Assisted ◽  
Novel Approach ◽  
Surgical Methods ◽  
Vasectomy Reversal

The management of obstructive azoospermia resulting from intra-abdominal vasal obstruction poses a formidable surgical challenge. A number of surgical methods have been described to address this problem, including both open and laparoscopic approaches to mobilize and sometimes even re-route the abdominal vas deferens prior to performing a re-anastamosis. We present the first report, to our knowledge, of robotic intra-abdominal vasectomy reversal used to repair obstructive azoospermia resulting from prior laparoscopic vasectomy. In doing so, we summarize the techniques described previously in the literature and build upon this body of surgical experience by combining robotic-assisted laparoscopic mobilization of the vas with robotic vasovasostomy. We believe this novel approach for repairing intra-abdominal vasal defects minimizes morbidity, while at the same time obviating the need for the operating microscope, and thus represents a practical alternative to existing techniques.

Dual Modality Management of Symptomatic Organized Pancreatic Necrosis: A New Approach to a Difficult Problem

2009 ◽  
Vol 69 (5) ◽  
pp. AB326
Author(s):  
Andrew S. Ross ◽  
Michael Gluck ◽  
Shayan Irani ◽  
Ellen Hauptmann ◽  
Robert Crane ◽  
...  
Keyword(s):  
Pancreatic Necrosis ◽  
Difficult Problem ◽  
New Approach ◽  
Dual Modality

Step Vibration Drilling for Micro Inclined Hole

2011 ◽  
Vol 199-200 ◽  
pp. 1857-1860
Author(s):  
Peng Zhang ◽  
Xing Yu Guo ◽  
De Yuan Zhang
Keyword(s):  
Manufacturing Industry ◽  
Difficult Problem ◽  
Hole Drilling ◽  
Drill Bit ◽  
New Approach ◽  
Hole Drilling Method ◽  
Drilling Method ◽  
Modern Manufacturing ◽  
Vibration Drilling

In modern manufacturing industry, there are a great deal of micro inclined holes, which is a difficult problem to machining. A novel micro inclined hole drilling method, step vibration drilling, is adopted. The experiments are carried that 45 degrees inclined hole is drilled into the 45 steel workpiece with Φ0.5mm carbide drill bit. The notable result was obtained with the method of step vibration drilling for drilling 45 degrees inclined holes on 45 steel, which break the restriction of drill jig. The new approach is put forward for micro inclined hole.

“Cartesian Theatre” in American Analytic Philosophy and in Orthodox Anthropology and Culturology

2021 ◽  
Vol 64 ◽  
pp. 208-245
Author(s):  
Svetlana V. Lourie
Keyword(s):  
Free Will ◽  
20Th Century ◽  
Analytic Philosophy ◽  
Human Mind ◽  
Difficult Problem ◽  
Point Of View ◽  
Analytical Philosophy ◽  
New Approach ◽  
Human Subjectivity ◽  
Key Concepts

The article is devoted to the analysis of American analytic philosophy – the science mostly focused on the problem of the philosophy of conscience since the end of the 20th century, - in the perspective of the Orthodox anthropology and culturology. The author studies the key concepts of analytic philosophy, first of all qualia and the so-called difficult problem of conscience related to it. The author analyzes how and why the physicalism (materialism) of analytic philosophy took the form of illusionism, - the concept of the illusionary character of conscience, free will, human subjectivity and of mental in general. The article develops a new approach to these problems from the point of view of the Orthodox anthropology. In the perspective of Orthodox anthropology and considering the achievements of analytical philosophy the author analyzes the key concepts of the last, including its main stumbling block – the problem of homunculus as “a character” of the so-called Cartesian theatre, that involves the presence of an “observer” in the human mind, which controls the processes of perception and thinking and constitutes the basis of human subjectivity. And finally, the author analyzes the consequences of the Orthodox approach to the problem of conscience for the theory of culture.

scholarly journals Fast and scalable genome-wide inference of local tree topologies from large number of haplotypes based on tree consistent PBWT data structure

2019 ◽  
Author(s):  
Vladimir Shchur ◽  
Liliia Ziganurova ◽  
Richard Durbin
Keyword(s):  
Data Structure ◽  
Dna Sequences ◽  
Difficult Problem ◽  
New Approach ◽  
Large Numbers ◽  
Genome Wide ◽  
Tree Topologies ◽  
Demographic Inference ◽  
The Relationship

Estimation of the relationship between DNA sequences is one of the most important problems in genomics. Understanding these relationships is central to demographic inference, correction of population structure in GWAS, identifying signals of selection etc. The data structure containing the full information about sample genealogy is called the ancestral recombination graph (ARG). However, ARG inference is a very difficult problem, not least due to a very complex state space. In this work we describe a new approach for fast and scalable generation of local tree topologies relating large numbers of haplotypes. Our method is closely related to the estimation of ARG, and captures both local and global properties of an ARG. It is based on a data structure which we call tree consistent PBWT, a modification of PBWT data structure introduced by R. Durbin (2014). We also explore some methods to estimate the quality of the generated tree topologies and to make inferences based on them. At the end we discuss a probabilistic model which could potentially lead to the estimation of ARG node times.

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