scholarly journals 476Associations between prenatal perfluoroalkyl substance exposure and cord thyroid hormones using BKMR model

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Hong Liang
Keyword(s):  
Thyroid Hormones ◽  
Maternal Plasma ◽  
Thyroid Stimulating Hormone ◽  
Birth Cohort Study ◽  
Free T4 ◽  
Exposure Effect ◽  
Substance Exposure ◽  
Total Triiodothyronine ◽  
Total Thyroxine ◽  
Highly Correlated

Abstract Background Perfluoroalkyl substances (PFASs) are a class of synthetic compounds widely detected in humans. We aimed to examine associations between prenatal PFAS exposure and cord thyroid hormones levels. Methods We studied 300 mother-infant pairs in Shanghai-Minhang Birth Cohort Study. We measured eight PFASs in maternal plasma samples collected at 12-16 gestational weeks, and total thyroxine (T4), free T4 (FT4), total triiodothyronine (T3), free T3 (FT3), and thyroid stimulating hormone (TSH) in cord plasma. Bayesian kernel machine regression (BKMR) model was used addressing high correlations between PFAS mixture. Results Maternal PFAS mixture was positively associated with cord T3/FT3 concentrations, such that the 75th percentile of PFAS mixture was associated with 0.074 (95%CI: 0.037, 0.146) nmol/l increase in T3 and 0.095 (95%CI: -0.005, 0.195) pmol/l increase in FT3, compared with the 25th percentile. Regarding single-exposure effect, PFOA at 75th percentile was associated with increased T3 (0.0396 nmol/l, 95%CI: 0.007, 0.072), FT3 (0.159 pmol/l, 95%CI: 0.055, 0.264) and TSH (1.50 uIU/ml, 95%CI: 0.379, 2.621), while PFNA was associated with decreased FT3 (-0.148 pmol/l, 95%CI -0.271, -0.0253) and TSH (-1.621 uIU/ml, 95%CI: -2.959, -0.2835). PFDA was associated with increased FT3 (0.112 pmol/l, 95%CI: -0.0311, 0.2559). Conclusions Prenatal FPAS exposure was positively associated with T3/FT3 with predominant compounds of PFOA, PFNA, and PFDA. Key messages Using BKMR addressing highly correlated PFASs, prenatal exposure to eight PFASs was associated with increased cord T3/FT3 levels with PFOA, PFNA, and PFDA being predominant compounds.

Lacking evidence for release of thyroid hormones from circulating thyroglobulin during subtotal thyroidectomy

1988 ◽  
Vol 117 (2) ◽  
pp. 219-224 ◽  
Author(s):  
J. Date ◽  
M. Blichert-Toft ◽  
U. Feldt-Rasmussen ◽  
V. Haas
Keyword(s):  
Thyroid Hormones ◽  
Mean Value ◽  
Thyroid Stimulating Hormone ◽  
Mean Values ◽  
Thyroid Resection ◽  
Free Thyroxine Index ◽  
Total Triiodothyronine ◽  
Total Thyroxine ◽  
The Mean ◽  
Peak Value

Abstract. The effect of subtotal thyroid resection for thyrotoxicosis on concentrations of serum thyroid hormones and thyroglobulin (Tg), was determined in 10 patients during operation and the subsequent 18 days. Mean serum Tg responded drastically, increasing from a pre-operative value of 0.30 nmol/l to a peak value of approximately 26 nmol/l during operation followed by a gradual decline to levels lower than before surgery on day 18. Mean serum total thyroxine was 114 nmol/l pre-operatively and free thyroxine index (FT4I) 105 units. Both fluctuated only slightly during operation. Postsurgically, the mean values decreased to below 50% of the pre-operative level. Mean serum total triiodothyronine (TT3) was 1.46 nmol/l pre-operatively. It decreased during operation, reaching a nadir of 0.55 nmol/l on day 2, whereafter the concentration increased slightly. Mean serum reverse T3 (rT3) was 0.45 nmol/l pre-operatively, increased 62% during surgery, and decreased postsurgically. The mean value of serum thyroid stimulating hormone (TSH) was 0.61 mU/l pre-operatively and remained below 1 mU/l during and after operation, but from day 10 concentration began to rise steadily. It is concluded that the vast release of Tg during thyroid resection did not contribute to the concentration of serum T4 to an extent of clinical relevance.

Decreased free fraction of thyroid hormones after prolonged Antarctic residence

1990 ◽  
Vol 69 (4) ◽  
pp. 1467-1472 ◽  
Author(s):  
H. L. Reed ◽  
D. Brice ◽  
K. M. Shakir ◽  
K. D. Burman ◽  
M. M. D'Alesandro ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Free Fraction ◽  
Cardiovascular Responses ◽  
Free T4 ◽  
Before And After ◽  
Total Triiodothyronine ◽  
Serum T3 ◽  
Total Thyroxine ◽  
Normal Men ◽  
First Time

We investigated the effects of Antarctic residence (AR) on serum thyroid hormone and cardiovascular responses to a 60-min standard cold air (0 degree C) test (SCAT). Serum total thyroxine (TT4) and serum total triiodothyronine (TT3), free T4 (FT4) and T3 (FT3), thyrotropin (TSH), and percent free fraction of T4 (%FT4) and T3 (%FT3) were measured in normal men (n = 15) before and after each of three SCATs. The SCAT was first carried out in California and then repeated after 24 and 44 wk AR. Mean arterial pressure (MAP) and sublingual oral temperature (Tor) were measured before and during each SCAT. The SCAT did not alter thyroid hormones before or after AR. The %FT4 decreased from 0.0334 +/- 0.0017 to 0.0295 +/- 0.0007% (P less than 0.002) with 44 wk AR but without a significant change in TT4 or FT4 for the same period. The %FT3 also decreased from 0.2812 +/- 0.0128 to 0.2458 +/- 0.0067% (P less than 0.005) after 44 wk AR. FT3 decreased (P less than 0.003) but TT3 and TSH were unchanged with 44 wk AR. The decrease in %FT4 and %FT3 may be theoretically accounted for by a 10% increase in either the capacity or the affinity of the serum binding proteins. The SCAT in California increased MAP and did not change Tor. After 44 wk AR, the SCAT no longer increased MAP but did lower Tor. The shift in the Tor and MAP response to the SCAT is consistent with the associated occurrence of cold adaptation during AR. We describe for the first time a decrease in the free fraction of both serum T3 and T4 present with extended polar residence and independent of a SCAT, further characterizing the recently reported “polar T3 syndrome.”

scholarly journals Levels of Thyroid Hormones and Human Chorionic Gonadotropin in Normotensive Pregnant Women

2016 ◽  
Vol 8 (4) ◽  
pp. 324-326
Author(s):  
Akhilesh Kumar Singh ◽  
Bechan Kumar Gautam
Keyword(s):  
Thyroid Hormones ◽  
Pregnant Women ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Thyroid Stimulating Hormone ◽  
Control Group ◽  
Hormonal Changes ◽  
Total Triiodothyronine ◽  
Total Thyroxine ◽  
Chemiluminescent Immunoassay

ABSTRACT During pregnancy the hormonal changes take place, resulting in changes in thyroid functions. The present study was conducted to determine thyroid hormones and human chorionic gonadotropin (hCG) in normotensive pregnancy. Fifty normotensive pregnant subjects were included in the study. Age-matched 50 nonpregnant subjects, not having any disease were taken as control. Total triiodothyronine (total T3), total thyroxine (total T4), thyroid stimulating hormone (TSH), and hCG were estimated by using enzyme amplified chemiluminescent immunoassay. The level of thyroid hormones was found significantly increased in normotensive pregnant subjects as compared to that of control group. We therefore conclude that investigations should be done routinely in pregnancy. How to cite this article Singh AK, Agrawal P, Gautam BK, Garg R. Levels of Thyroid Hormones and Human Chorionic Gonadotropin in Normotensive Pregnant Women. J South Asian Feder Obst Gynae 2016;8(4):324-326.

Changes in serum triiodothyronine kinetics and hepatic type I 5'-deiodinase activity of cold-exposed swine

1994 ◽  
Vol 266 (5) ◽  
pp. E786-E795 ◽  
Author(s):  
H. L. Reed ◽  
M. Quesada ◽  
R. L. Hesslink ◽  
M. M. D'Alesandro ◽  
M. T. Hays ◽  
...  
Keyword(s):  
Elevated Serum ◽  
Total Body Weight ◽  
Weight Percent ◽  
Type I ◽  
Free T4 ◽  
Gland Weight ◽  
Total Triiodothyronine ◽  
Total Thyroxine

Swine exposed to cold air have elevated serum values of total triiodothyronine (TT3) and free T3 (FT3). To characterize the mechanism of these increases, we measured in vivo kinetic parameters after a bolus intravenous injection of 125I-labeled T3 by use of both multicompartmental (MC) and noncompartmental (NC) methods and in vitro hepatic type I iodothyronine 5'-deiodinase (5'D-I) activity. Ten ad libitum-fed 5-mo-old boars were divided into two groups, living for 25 days in either control (22 degrees C) or cold (4 degrees C) conditions. Cold-exposed animals consumed 50% more calories than control animals but showed no difference in total body weight, percent body fat, or plasma volume. Thyroid gland weight was increased 86% (P < 0.004), as was serum total thyroxine (TT4) (48%), free T4 (FT4) (61%), TT3 (103%), and FT3 (107%), whereas serum thyrotropin (TSH) was not different in cold-exposed compared with control animals. The T3 plasma clearance rate was similar between groups when both MC and NC techniques were used. However, T3 plasma appearance rate (PAR) was elevated in cold-treated animals 110% over controls by MC (P < 0.001) and 83% by NC methods (P < 0.001). The animal total hormone pool of T3 was increased 76% (MC) and 53% (NC) compared with control (P < 0.01). The Michaelis constant of hepatic 5'D-I was not different between groups, but the maximum enzyme velocity increased (106%; P < 0.02). Therefore cold exposure for 25 days is associated with increased energy intake, thyroid size, T3 PAR, and hepatic 5'D-I activity with little change in serum TSH.

scholarly journals Impact of thyroid hormones on asthma in older adults

2019 ◽  
Vol 47 (9) ◽  
pp. 4114-4125 ◽  
Author(s):  
Zhan Bingyan ◽  
Wei Dong
Keyword(s):  
Respiratory Failure ◽  
Thyroid Hormones ◽  
Pulmonary Function ◽  
Correlation Coefficients ◽  
Forced Expiratory Volume ◽  
Thyroid Stimulating Hormone ◽  
Type I ◽  
Free Triiodothyronine ◽  
Specific Effects ◽  
Total Thyroxine

Objective Thyroid hormones affect airway contraction, but the specific effects of thyroid hormones on airways are controversial. Methods We divided 78 advanced-age men with asthma into 3 groups: type I respiratory failure (RF1), type II respiratory failure (RF2), and no respiratory failure (NRF). Pulmonary function was measured after asthma stabilization. Results The free triiodothyronine (FT3) level was significantly higher in the RF1 than RF2 group, but the free thyroxine (FT4), total thyroxine (TT4), and thyroid-stimulating hormone (TSH) levels were not significantly different. In the RF1, RF2, and NRF groups, the correlation coefficients between FT3 and the forced expiratory volume in1 s (FEV1) were 0.317, 0.627, and 0.213; those between FT3 and the FEV1/forced vital capacity (FVC) ratio were 0.287, 0.412, and 0.156; those between FT4 and FEV1 were 0.214, 0.231, and 0.167; and those between FT4 and the FEV1/FVC ratio were 0.211, 0.215, and 0.218, respectively. In the RF1 and RF2 groups, the correlation coefficients between the sum activity of peripheral deiodinases (SPINA-GD) and the FEV1/FVC ratio were 0.164 and 0.421, and those between SPINA-GD and FEV1 were 0.284 and 0.491, respectively. Conclusion The correlation between FT3 and pulmonary function is likely caused by changes in thyroid enzymology.

scholarly journals Marked Biological Variance in Endocrine and Biochemical Markers in Childhood: Establishment of Pediatric Reference Intervals Using Healthy Community Children from the CALIPER Cohort

2013 ◽  
Vol 59 (9) ◽  
pp. 1393-1405 ◽  
Author(s):  
Dana Bailey ◽  
David Colantonio ◽  
Lianna Kyriakopoulou ◽  
Ashley H Cohen ◽  
Man Khun Chan ◽  
...  
Keyword(s):  
Reference Values ◽  
Biochemical Markers ◽  
Troponin I ◽  
Reference Intervals ◽  
Thyroid Stimulating Hormone ◽  
Healthy Children ◽  
Free Triiodothyronine ◽  
Laboratory Test Results ◽  
Total Triiodothyronine ◽  
Total Thyroxine

BACKGROUND Reference intervals are indispensable in evaluating laboratory test results; however, appropriately partitioned pediatric reference values are not readily available. The Canadian Laboratory Initiative for Pediatric Reference Intervals (CALIPER) program is aimed at establishing the influence of age, sex, ethnicity, and body mass index on biochemical markers and developing a comprehensive database of pediatric reference intervals using an a posteriori approach. METHODS A total of 1482 samples were collected from ethnically diverse healthy children ages 2 days to 18 years and analyzed on the Abbott ARCHITECT i2000. Following the CLSI C28-A3 guidelines, age- and sex-specific partitioning was determined for each analyte. Nonparametric and robust methods were used to establish the 2.5th and 97.5th percentiles for the reference intervals as well as the 90% CIs. RESULTS New pediatric reference intervals were generated for 14 biomarkers, including α-fetoprotein, cobalamin (vitamin B12), folate, homocysteine, ferritin, cortisol, troponin I, 25(OH)-vitamin D [25(OH)D], intact parathyroid hormone (iPTH), thyroid-stimulating hormone, total thyroxine (TT4), total triiodothyronine (TT3), free thyroxine (FT4), and free triiodothyronine. The influence of ethnicity on reference values was also examined, and statistically significant differences were found between ethnic groups for FT4, TT3, TT4, cobalamin, ferritin, iPTH, and 25(OH)D. CONCLUSIONS This study establishes comprehensive pediatric reference intervals for several common endocrine and immunochemical biomarkers obtained in a large cohort of healthy children. The new database will be of global benefit, ensuring appropriate interpretation of pediatric disease biomarkers, but will need further validation for specific immunoassay platforms and in local populations as recommended by the CLSI.

scholarly journals Evaluation of thyroid function status in patients with alopecia areata

2018 ◽  
Vol 4 (3) ◽  
pp. 277
Author(s):  
Ehimen P. Odum ◽  
Collins Amadi ◽  
Bolaji I. Otike-Odibi
Keyword(s):  
Thyroid Function ◽  
Alopecia Areata ◽  
Clinical Status ◽  
Thyroid Stimulating Hormone ◽  
Port Harcourt ◽  
High Prevalence ◽  
Total Triiodothyronine ◽  
Total Thyroxine ◽  
The Mean ◽  
The University

<p class="abstract"><strong>Background:</strong> Epidemiologic reports suggest a high prevalence of thyroid function abnormalities among patients with alopecia areata. Hence, this study was designed to investigate this hypothesis among indigenous Nigeria patients with alopecia areata.</p><p class="abstract"><strong>Methods:</strong> The study was a retrospective analysis of records of thyroid function investigations of patients with alopecia areata who had presented to the Department of Chemical Pathology and Metabolic Medicine of the University of Port Harcourt Teaching Hospital (UPTH), Nigeria over a 10-year period (1<sup>st</sup> January 2007 and 31<sup>st</sup> December 2016). Records of patients’ age, sex, thyroid stimulating hormone (TSH), total thyroxine (T4), and total triiodothyronine (T3) were acquired from laboratory records and analyzed using SPSS version 15. A p&lt;0.05 was applied as being significant.<strong></strong></p><p class="abstract"><strong>Results:</strong> One hundred and thirteen (113) records of patients with alopecia areata were reviewed, among them 55 (48.7%) males and 58 (51.3%) females with no sex difference (p=0.778). The mean age of study cohorts was 29.42±10.27 (range 16–63) with the majority (61.9%) between the age group 20 to 40 years. No difference in the mean age, TSH, and T3 levels were observed between the males and females. Thyroid function abnormalities were observed in 27.3% of study cohorts and the most prevalent abnormality was hypothyroidism (16.8% subclinical and 4.4% primary) with a female preponderance.</p><p><strong>Conclusions:</strong> The study suggests an association of alopecia areata with thyroid function abnormalities. Patients with alopecia areata should be screened for thyroid function abnormalities irrespective of clinical status.</p>

scholarly journals Haematological and biochemical parameters in Churra-da-Terra-Quente ewes from the northeast of Portugal

2010 ◽  
Vol 62 (2) ◽  
pp. 265-272 ◽  
Author(s):  
I.R. Dias ◽  
C.A. Viegas ◽  
A.M. Silva ◽  
H.F. Pereira ◽  
C.P. Sousa ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Biochemical Parameters ◽  
Reference Intervals ◽  
Thyroid Stimulating Hormone ◽  
Thrombin Time ◽  
Free T4 ◽  
Indigenous Breed ◽  
Plasma Electrolytes ◽  
Hematological And Biochemical Parameters ◽  
Glutamyl Transferase

Hematological and biochemical parameters, including plasma electrolytes and thyroid hormones, were determined in 73 clinically healthy Churra-da-Terra-Quente ewes, a typical breed from the northeast of Portugal. The hemogram values were: erythrocytes 9.8±1.5×10(12)/L; haemoglobin 118.1±19.1g/L; haematocrit 40.8±5.9%; leukocytes 5.7±1.8×10(9)/L; and platelets 544.3±177.2×10(9)/L. The thrombin time was 17.3±1.7 seconds. The values of biochemical parameters were: total protein 76.4±6.1g/L; glucose 2.87±0.60mmol/L; total cholesterol 1.65±0.33mmol/L; aspartate aminotransferase 155.9±49.2U/L; alanine aminotransferase 23.2±9.6U/L; γ-glutamyl transferase 48.0±18.7U/L; total alkaline phosphatase 121.6±76.1U/L; glutamate dehydrogenase 6.4±3.7U/L; urea 7.32±2.22mmol/L; creatinine 123.0±54.1μmol/L; total calcium 2.53±0.25mmol/L; phosphorus 2.10±0.46mmol/L; magnesium 1.01±0.09mmol/L; sodium 152.04±3.65mmol/L; potassium 4.7±0.4mmol/L; ionized calcium 1.32±0.07mmol/L; total thyroxine 111.75±42.29nmol/L; total triiodothyronine 1.01±0.28nmol/L; free T4 11.93±1.78pmol/L; free T3 4.22±1.33pmol/L; and thyroid-stimulating hormone 0.18±0.19μIU/mL. Although differences among the Churra-da-Terra-Quente breed and other breeds may occur, the hematological and biochemical parameters, plasma electrolytes, and thyroid hormones, for this indigenous breed, were generally situated within the reference intervals previously reported for sheep.

scholarly journals Soluble Interleukin 2 Receptors' Levels Versus Thyroid Hormones Levels in Nonthyroidal Disease

1999 ◽  
Vol 42 (1) ◽  
pp. 13-14
Author(s):  
Ioannis Ilias ◽  
Georgios Panoutsopoulos ◽  
Nikiforos Filippou ◽  
Anna Dima ◽  
Ioulia Christakopoulou ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Thyroid Hormones ◽  
Interleukin 2 ◽  
Tuberculosis Treatment ◽  
Interleukin 2 Receptor ◽  
Total Triiodothyronine ◽  
Total Thyroxine ◽  
Soluble Interleukin 2 Receptor ◽  
Tuberculosis Therapy ◽  
The Relationship

Serum soluble interleukin-2 receptor levels, basal thyrotropin, total thyroxine, total triiodothyronine and free triodothyronine were assayed in 29 - otherwise healthy - patients with pulmonary tuberculosis before initiation of anti-tuberculosis treatment and after two weeks of therapy. Twenty seven out of 29 patients presented low-normal total triiodothyronine levels, showing a statistical elevation after anti-tuberculosis therapy. Total triiodothyronine levels before anti-tuberculosis therapy were inversely correlated with levels of serum soluble interleukin-2 receptors. Further investigation on the relationship between soluble interleukin-2 receptorÕs levels and thyroid hormones in non-thyroidal disease can be envisaged.

Population-specific reference values for thyroid hormones on the Abbott ARCHITECT i2000 analyzer

2004 ◽  
Vol 42 (5) ◽  
Author(s):  
Manuel González-Sagrado ◽  
Francisco Javier Martín-Gil
Keyword(s):  
Thyroid Hormones ◽  
Reference Values ◽  
Patient Population ◽  
Laboratory Data ◽  
Thyroid Stimulating Hormone ◽  
Specific Reference ◽  
Reference Ranges ◽  
Free Triiodothyronine ◽  
Total Triiodothyronine ◽  
Abbott Architect

AbstractReliable reference ranges are important in the interpretation of laboratory data, and it is incumbent on each laboratory to verify that the ranges they use are appropriate for the patient population they serve. The objective of this study was to determine population-specific reference ranges for thyroid stimulating hormone (TSH), free thyroxine (fT4), free triiodothyronine (fT3) and total triiodothyronine (TT3) on the Abbott ARCHITECT

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