scholarly journals Levels of Thyroid Hormones and Human Chorionic Gonadotropin in Normotensive Pregnant Women

2016 ◽  
Vol 8 (4) ◽  
pp. 324-326
Author(s):  
Akhilesh Kumar Singh ◽  
Bechan Kumar Gautam
Keyword(s):  
Thyroid Hormones ◽  
Pregnant Women ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Thyroid Stimulating Hormone ◽  
Control Group ◽  
Hormonal Changes ◽  
Total Triiodothyronine ◽  
Total Thyroxine ◽  
Chemiluminescent Immunoassay

ABSTRACT During pregnancy the hormonal changes take place, resulting in changes in thyroid functions. The present study was conducted to determine thyroid hormones and human chorionic gonadotropin (hCG) in normotensive pregnancy. Fifty normotensive pregnant subjects were included in the study. Age-matched 50 nonpregnant subjects, not having any disease were taken as control. Total triiodothyronine (total T3), total thyroxine (total T4), thyroid stimulating hormone (TSH), and hCG were estimated by using enzyme amplified chemiluminescent immunoassay. The level of thyroid hormones was found significantly increased in normotensive pregnant subjects as compared to that of control group. We therefore conclude that investigations should be done routinely in pregnancy. How to cite this article Singh AK, Agrawal P, Gautam BK, Garg R. Levels of Thyroid Hormones and Human Chorionic Gonadotropin in Normotensive Pregnant Women. J South Asian Feder Obst Gynae 2016;8(4):324-326.

Lacking evidence for release of thyroid hormones from circulating thyroglobulin during subtotal thyroidectomy

1988 ◽  
Vol 117 (2) ◽  
pp. 219-224 ◽  
Author(s):  
J. Date ◽  
M. Blichert-Toft ◽  
U. Feldt-Rasmussen ◽  
V. Haas
Keyword(s):  
Thyroid Hormones ◽  
Mean Value ◽  
Thyroid Stimulating Hormone ◽  
Mean Values ◽  
Thyroid Resection ◽  
Free Thyroxine Index ◽  
Total Triiodothyronine ◽  
Total Thyroxine ◽  
The Mean ◽  
Peak Value

Abstract. The effect of subtotal thyroid resection for thyrotoxicosis on concentrations of serum thyroid hormones and thyroglobulin (Tg), was determined in 10 patients during operation and the subsequent 18 days. Mean serum Tg responded drastically, increasing from a pre-operative value of 0.30 nmol/l to a peak value of approximately 26 nmol/l during operation followed by a gradual decline to levels lower than before surgery on day 18. Mean serum total thyroxine was 114 nmol/l pre-operatively and free thyroxine index (FT4I) 105 units. Both fluctuated only slightly during operation. Postsurgically, the mean values decreased to below 50% of the pre-operative level. Mean serum total triiodothyronine (TT3) was 1.46 nmol/l pre-operatively. It decreased during operation, reaching a nadir of 0.55 nmol/l on day 2, whereafter the concentration increased slightly. Mean serum reverse T3 (rT3) was 0.45 nmol/l pre-operatively, increased 62% during surgery, and decreased postsurgically. The mean value of serum thyroid stimulating hormone (TSH) was 0.61 mU/l pre-operatively and remained below 1 mU/l during and after operation, but from day 10 concentration began to rise steadily. It is concluded that the vast release of Tg during thyroid resection did not contribute to the concentration of serum T4 to an extent of clinical relevance.

scholarly journals Levels of thyroid-stimulating and thyroid hormones in pregnant women with obesity and their newborns

2019 ◽  
Vol 4 (4) ◽  
pp. 58-63
Author(s):  
O. B. Karelina ◽  
N. V. Artymuk ◽  
O. A. Tachkova ◽  
T. Yu. Marochko ◽  
M. N. Surina
Keyword(s):  
Body Weight ◽  
Thyroid Hormones ◽  
Pregnant Women ◽  
Thyroid Stimulating Hormone ◽  
Obese Women ◽  
Third Trimester ◽  
Normal Body ◽  
Normal Body Weight ◽  
Chemiluminescent Immunoassay ◽  
Stimulating Hormone

Aim: To study the level of thyroid-stimulating and thyroid hormones in pregnant women with obesity and their newborns.Materials and Methods. We consecutively recruited 40 pregnant women and their newborns. Blood sampling in pregnant women was carried out at the end of the third trimester 12 hours after the last meal while in newborns it was conducted immediately after birth. Measurement of serum thyroid-stimulating hormone, thyroxine, triiodothyronine, and free thyroxine was performed using chemiluminescent immunoassay.Results. Thyroid disease was significantly more common in pregnant women with obesity. Clinical and latent hypothyroidism in obese pregnant women was observed 1.5-fold more frequently as compared with those having normal body weight. In keeping with these findings, goiter and elevated thyroxine were also more common in obese pregnant women. Newborns from obese women were more often characterized by a transient hypothyroidism in combination with an augmented thyroid-stimulating hormone.Conclusion. Levels of thyroid-stimulating and thyroid hormones in obese pregnant women and their newborns significantly differ from the patients with normal body weight.

scholarly journals Yoga Intervention as a Potential Countermeasure for Polar T3 Syndrome

2019 ◽  
Vol 4 (3) ◽  
pp. 163-169
Author(s):  
Mohit Nirwan ◽  
K J Jyothish ◽  
Kaushik Halder ◽  
Sutanu Chakraborty ◽  
M Saha ◽  
...  
Keyword(s):  
Thyroid Stimulating Hormone ◽  
Controlled Study ◽  
Control Group ◽  
Yoga Group ◽  
Significant Difference ◽  
Common Ailment ◽  
Total Triiodothyronine ◽  
Total Thyroxine ◽  
Randomised Controlled ◽  
And Control

Polar T3 syndrome is a common ailment for polar sojourners. It is characterised by abnormal fluctuations of thyroid hormones during extended polar winter. A randomised controlled study was conducted on 14 winter expedition members of Indian Scientific Expedition (2016) to Antarctica by introducing customised yoga module. Blood samples were collected during January to October, 2016 at different intervals for the estimation of total thyroxine (TT4), total triiodothyronine (TT3), thyroid stimulating hormone and noradrenaline (NA) by ELISA. In October yoga group showed significant (p = 0.04) higher TT3 values (2.1 ng/ml ± 0.9; mean ± SD) as compared to the control (0.7 ng/ml ± 0.6). In October a significant difference (p=0.0085) was observed between yoga and control group for NA values (47.0 pg/ml ± 22.0 and 107 pg/ml ± 46.0). Thyroid response of control group at the end of the study revealed presence of polar T3 syndrome in control group. Results indicate that regular yoga practice helped mitigating polar T3 syndrome

scholarly journals Prediction of Placenta Accreta Using Hyperglycosylated Human Chorionic Gonadotropin

2018 ◽  
Vol 8 (2) ◽  
pp. 142-146
Author(s):  
Maad Mahdi Shalal ◽  
Shaymaa Kadhim Jasim ◽  
Huda Khalil Abd
Keyword(s):  
Caesarean Section ◽  
Pregnant Women ◽  
Chorionic Gonadotropin ◽  
Gestational Age ◽  
Human Chorionic Gonadotropin ◽  
Placenta Accreta ◽  
Placenta Previa ◽  
Control Group ◽  
Previous Caesarean Section ◽  
Hyperglycosylated Human Chorionic Gonadotropin

Objectives: Hyperglycosylated human chorionic gonadotropin (hCG) is a variant of hCG. In addition, it has a different oligosaccharide structure compared to the regular hCG and promotes the invasion and differentiation of peripheral cytotrophoblast. This study aimed to measure hyperglycosylated hCG as a predictor in the diagnosis of placenta accreta. Materials and Methods: In general, 90 pregnant women were involved in this case-control study among which, 30 ladies (control group) were pregnant within the gestational age of ≥36 weeks with at least one previous caesarean section and a normal sited placenta in transabdominal ultrasound (TAU). The other 60 pregnant women (case group) were within a gestational age of ≥36 weeks at least, one previous caesarean section and placenta previa with or without signs of placenta accreta in TAU. Hyperglycosylated hCG and total hCG were measured in each group and the results of the surgery were followed up. Results: Hyperglycosylated hCG showed higher serum levels in patients with placenta accreta compared to those with placenta previa and control women. Hyperglycosylated hCG with an optimal cut point of (3) IU/L predicted placenta accreta in pregnant women with 90% specificity, 76.7% sensitivity, and 81.1% accuracy. Conclusions: The high specificity of the above approach makes it a good diagnostic tool (as a single test) for confirming placenta accreta in clinical settings. When this test is added to our established workup, its high positive predictive value makes it a suitable method within the algorithm of accreta confirmation when there is a high suspicion or insufficient evidence to the diagnosis of placenta accreta.

scholarly journals Study on Serum Levels of Thyroid Hormones and Thyroid Stimulating Hormone in Different Trimester of Normal Pregnancy

2012 ◽  
Vol 2 (2) ◽  
pp. 19-23
Author(s):  
Zinat Begum ◽  
Rezina Akhtar Banu ◽  
TH Zahra Moon Moon
Keyword(s):  
Thyroid Hormones ◽  
Pregnant Women ◽  
Serum Levels ◽  
Normal Pregnancy ◽  
Thyroid Stimulating Hormone ◽  
Control Group ◽  
Serum T3 ◽  
Serum T4 ◽  
The Mean ◽  
And Control

Objective: The present study was conducted to study the changes in serum levels of thyroid hormones and thyroid stimulating hormone (TSH) in different trimesters of normal pregnancy. Methods: This cross-sectional study was conducted in the Department of Physiology, Rangpur Medical College Hospital over a period 1 year from July 2008 to June 2009. Apparently healthy pregnant women aged between 20 - 35 years were consecutively included in the study. Patients suffering from thyroid disorders or any other systemic diseases and lactating mothers were excluded from the study. A total of 100 subjects - 75 pregnant women (25 selected from each trimester of pregnancy) and 25 non-pregnant women were purposively selected as case and control groups respectively. Result: The mean age was almost identically distributed between the two groups (23.8 ± 3.9 vs. 24.9 ±4.6, p = 0.343). Lower class patient was predominant in case and control group (68% vs. 64%, p =0.756). The mean serum T3 level was higher in case group compared to control group. The mean serum T3 level was identically distributed in 1st and 3rd trimester (p = 0.536 and p = 0.145 respectively) but significant difference was found in 2nd trimester (p = 0.001). The mean serum T4 level of control group did not experience any change throughout the whole observation period. The serum T4 level was 210 nmol/L at 1st trimester then it began to increase almost a plateau at 2nd   trimester and then gradually dropped 232.2 nmol/L at third trimester. The mean serum TSH level was 1.1 mIU/L at 1st trimester then it began to increase sharply assumed a mean score 1.3 mIU/L at 2nd trimester. From 2nd trimester onwards it began to decrease upto the end of observation when no change in the non-pregnant women in 1st, 2nd & 3rd trimester. Conclusion: Thyroid hormones (T3, T4) increase in the 2nd trimester of pregnancy and fall again in the 3rdtrimester but TSH does not experience any significant change throughout the pregnancy. Ibrahim Cardiac Med J 2012; 2(2): 19-23

EVALUATION OF HUMAN CHORIONIC GONADOTROPIN IN VAGINAL WASHINGS FOR THE EARLY DIAGNOSIS OF PREMATURE RUPTURE OF FOETAL MEMBRANES: A CLINICAL STUDY

2021 ◽  
pp. 49-50
Author(s):  
Komal Yadav ◽  
Sadhna Mathur ◽  
Surabhi Tomar ◽  
Faizah Yousuf
Keyword(s):  
Pregnant Women ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Demographic Data ◽  
Control Group ◽  
Premature Rupture ◽  
Beta Hcg ◽  
Group 2 ◽  
Group B ◽  
Group 1

Aim: This study is aimed to evaluate and validate the qualitative human chorionic gonadotropin β subunit (β-hCG) test of the vaginal uid washings of pregnant women with premature rupture of fetal membranes (PROM). Materials & Methodology: A total of 60 pregnant women between 26- and 36-weeks' gestation had participated in this study. The patients with leaking from the vagina were designated Group A, the patients with no leaking from the vagina were Group B. After administering 5 cc of normal saline to posterior fornix by sterile injector, a total of 5 cc washing uid was collected. human chorionic gonadotropin were examined on the same day on collected uid and both groups were compared statistically. Result: In the current study 53.4% patients in group 1 and 60.0% patients from control group were between 19-25 years of age group. Majority of patients were unbooked in both groups. 46.6% patients in PROM group and 56.6% patients in control group presents before 34 weeks of gestation. There is no statistical signicance between two groups in terms of demographic data. Beta -HCG values in vaginal uid of Group 1 was signicantly higher than values in Group 2 with cut off value of Beta -HCG as 50mIU/dL. 83.4% patients from Group 1 (PROM Group) shows Beta -HCG value more than 50Miu/dL.

scholarly journals 476Associations between prenatal perfluoroalkyl substance exposure and cord thyroid hormones using BKMR model

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Hong Liang
Keyword(s):  
Thyroid Hormones ◽  
Maternal Plasma ◽  
Thyroid Stimulating Hormone ◽  
Birth Cohort Study ◽  
Free T4 ◽  
Exposure Effect ◽  
Substance Exposure ◽  
Total Triiodothyronine ◽  
Total Thyroxine ◽  
Highly Correlated

Abstract Background Perfluoroalkyl substances (PFASs) are a class of synthetic compounds widely detected in humans. We aimed to examine associations between prenatal PFAS exposure and cord thyroid hormones levels. Methods We studied 300 mother-infant pairs in Shanghai-Minhang Birth Cohort Study. We measured eight PFASs in maternal plasma samples collected at 12-16 gestational weeks, and total thyroxine (T4), free T4 (FT4), total triiodothyronine (T3), free T3 (FT3), and thyroid stimulating hormone (TSH) in cord plasma. Bayesian kernel machine regression (BKMR) model was used addressing high correlations between PFAS mixture. Results Maternal PFAS mixture was positively associated with cord T3/FT3 concentrations, such that the 75th percentile of PFAS mixture was associated with 0.074 (95%CI: 0.037, 0.146) nmol/l increase in T3 and 0.095 (95%CI: -0.005, 0.195) pmol/l increase in FT3, compared with the 25th percentile. Regarding single-exposure effect, PFOA at 75th percentile was associated with increased T3 (0.0396 nmol/l, 95%CI: 0.007, 0.072), FT3 (0.159 pmol/l, 95%CI: 0.055, 0.264) and TSH (1.50 uIU/ml, 95%CI: 0.379, 2.621), while PFNA was associated with decreased FT3 (-0.148 pmol/l, 95%CI -0.271, -0.0253) and TSH (-1.621 uIU/ml, 95%CI: -2.959, -0.2835). PFDA was associated with increased FT3 (0.112 pmol/l, 95%CI: -0.0311, 0.2559). Conclusions Prenatal FPAS exposure was positively associated with T3/FT3 with predominant compounds of PFOA, PFNA, and PFDA. Key messages Using BKMR addressing highly correlated PFASs, prenatal exposure to eight PFASs was associated with increased cord T3/FT3 levels with PFOA, PFNA, and PFDA being predominant compounds.

Thyroid Function in Gestational Trophoblastic Tumors

1986 ◽  
Vol 72 (2) ◽  
pp. 205-209
Author(s):  
Franca Vergadoro ◽  
Laura Tabacchi ◽  
Pietro Barbacini ◽  
Laura Vassena ◽  
Flavia Zanaboni ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Hydatidiform Mole ◽  
Thyroid Stimulating Hormone ◽  
Control Group ◽  
Free T4 ◽  
Free T3 ◽  
Normal Limits ◽  
Trophoblastic Tumors

Thyroid function was assessed in a total of 15 cases, 7 of whom had choriocarcinoma and 8 hydatidiform mole, by measuring free T3, free T4, thyroxin-binding globulin (TBG), basal thyroid-stimulating hormone (TSH) and after the thyrotropin-releasing hormone test (ΔTSH). Free T3, free T4 and TBG were investigated in the same number of healthy women within the first three months of pregnancy. Only 13.4% of the cases presented elevated levels of free T3 and T4 and TBG; TSH and ΔTSH were within normal limits. Both thyroid hormones and TBG returned to within normal limits when β-human chorionic gonadotropin became undetectable. One patient was found to be hypothyroid. Comparison with the control group showed no significant differences except in TBG levels, which were higher in controls. A significant, direct correlation was found between levels of free T3 and T4 and TBG and the pattern of human chorionic gonadotropin.

scholarly journals Neuroendocrinology of Pregnancy: Participation of Sex Hormones

2021 ◽  
Author(s):  
Luz Irene Pascual Mathey
Keyword(s):  
Immune System ◽  
Thyroid Hormones ◽  
Sex Hormones ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Fetal Development ◽  
Placental Lactogen ◽  
Physiological Adaptation ◽  
Hormonal Changes ◽  
Human Placental Lactogen

Pregnancy is characterized by hormonal changes, critical for the mother’s physiological adaptation, exercising a role in the fetus’s development, maintenance, protection, and nutrition. Since born, the neuroendocrine system’s involvement is necessary to prevent the embryo from being rejected by the mother’s immune system. These changes are regulated by fluctuations in hormones such as Progesterone, Testosterone, Androstenedione, Dehydroepiandrosterone, Estradiol, Prolactin, human Placental Lactogen, human Chorionic Gonadotropin, and Thyroid hormones, which promote the mother’s development and the fetus (maternal-fetal development). Therefore, given the great importance of these hormones during pregnancy, this chapter will explain the preclinical and clinical participation of sex hormones in maternal-fetal development.

Establishment of Early Pregnancy Related Thyroid Hormone Models and Reference Intervals for Pregnant Women in China Based on Real World Data

2021 ◽  
Vol 53 (04) ◽  
pp. 272-279
Author(s):  
Chaochao Ma ◽  
Xiaoqi Li ◽  
Lixin Liu ◽  
Xinqi Cheng ◽  
Fang Xue ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Pregnant Women ◽  
Early Pregnancy ◽  
Gestational Age ◽  
Dynamic Change ◽  
Reference Intervals ◽  
Thyroid Stimulating Hormone ◽  
Free Thyroxine ◽  
Stimulating Hormone

AbstractThyroid hormone reference intervals are crucial for diagnosing and monitoring thyroid dysfunction during early pregnancy, and the dynamic change trend of thyroid hormones during pregnancy can assist clinicians to assess the thyroid function of pregnant women. This study aims to establish early pregnancy related thyroid hormones models and reference intervals for pregnant women. We established two derived databases: derived database* and derived database#. Reference individuals in database* were used to establish gestational age-specific reference intervals for thyroid hormones and early pregnancy related thyroid hormones models for pregnant women. Individuals in database# were apparently healthy non-pregnant women. The thyroid hormones levels of individuals in database# were compared with that of individuals in database* using nonparametric methods and the comparative confidence interval method. The differences in thyroid stimulating hormone and free thyroxine between early pregnant and non-pregnant women were statistically significant (p<0.0001). The reference intervals of thyroid stimulating hormone, free thyroxine and free triiodothyronine for early pregnant women were 0.052–3.393 μIU/ml, 1.01–1.54 ng/dl, and 2.51–3.66 pg/ml, respectively. Results concerning thyroid stimulating hormone and free thyroxine reference intervals of early pregnancy are comparable with those from other studies using the same detection platform. Early pregnancy related thyroid hormones models showed various change patterns with gestational age for thyroid hormones. Early pregnancy related thyroid hormones models and reference intervals for pregnant women were established, so as to provide accurate and reliable reference basis for the diagnosing and monitoring of maternal thyroid disfunction in early pregnancy.

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