Smoking and Serum Vitamin D in Older Chinese people: Guangzhou Biobank Cohort Study.

SUMMARYThe objective of this study was to estimate the relationship between serum vitamin D (VitD) status and tuberculosis (TB) infection conversion (TBIC), measured by the tuberculin skin test (TST) and an interferon-gamma release assay, the QuantiFERON-TB Gold In-Tube (QFT-GIT) test, in the contacts of pulmonary TB patients in Castellon (Spain) in a prospective cohort study from 2010 to 2012. Initially, the participants were negative to latent TB infection after a screening that included TST and QFT-GIT tests, and other examinations. A baseline determination of 25-hydroxyvitamin D [25(OH)D] was obtained by chemiluminescence immunoassay. After 8–10 weeks, participants were screened for a second time to determine TB infection conversion (TBIC). Poisson regression models were used in the statistical analysis. Of the 247 participants in the cohort, 198 (80·2%) were screened twice and 18 (9·1%) were TBIC cases. The means of VitD concentration in the TBIC cases and the non-cases were 20·7±11·9 and 27·2±11·4 ng/ml (P = 0·028), respectively. Adjusted for high exposure and TB sputum acid-fast bacilli (AFB)-positive index case, higher serum VitD concentration was associated with low incidence of TBIC (Ptrend = 0·005), and an increase of 1 ng/ml VitD concentration decreased the incidence of TBIC by 6% (relative risk 0·94, 95% confidence interval 0·90–0·99, P = 0·015). The results suggest that sufficient VitD level could be a protective factor of TBIC.

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Vitamin D status in infants during the first 9 months of age and its effect on growth and other biochemical markers: A Prospective Cohort Study

Problems of Endocrinology ◽

10.14341/probl201662519 ◽

2016 ◽

Vol 62 (5) ◽

pp. 19

Author(s):

Manish Gutch ◽

Sukriti Kumar ◽

Uday Kumar Mandal

Keyword(s):

Vitamin D ◽

Cohort Study ◽

Vitamin D Deficiency ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Serum Vitamin ◽

Vitamin D Supplementation ◽

The Body ◽

Serum 25Ohd ◽

Serum Vitamin D

Background and aim. We planned this prospective cohort study in term newborn babies, with the objective to determine the incidence of vitamin D deficiency in infancy and to determine the level of vitamin D which triggers the physiological PTH axis of the body so as to differentiate truly deficient from sufficient vitamin D status.Methods. 96 participants at birth were enrolled and followed up till 9 months of age. Serum25OHD was estimated in cord blood at birth and at 14 ± 1 weeks of life. 77 participants were followed up at 9 months for estimation of serum 25OHD, PTH, Alkaline phosphatase (ALP), calcium and phosphorus. Vitamin D deficiency was defined as serum 25OHD <15 ng/mL as per USIOM guidelines.Results. Serum 25OHD levels at 9 months of age (15.78±8.97ng/mL) were significantly increased in comparison to the level of 3 months of age (14.04±7.10ng/mL) and at birth (8.94±2.24ng/mL).At birth all the participants (77) were deficient in 25OHD levels. It was found that 16/94 (17%)and 19/77 (24.7%) participants at 3 and 9 months of age respectively became vitamin D sufficient without any vitamin D supplementation. There was a significant inverse correlation between serum 25OHD and PTH concentration (r=-0.522, p<0.001), serum 25OHD and ALP(r=-.501, p<0.001). It was found that reduction in serum vitamin D level to below 10.25 ng/mL results in surge of serum PTH.Conclusion: Vitamin D deficiency is common from birth to 9 months of age but incidence decreases spontaneously even without supplementation. Also large number of babies may be falsely labelled as vitamin D deficient with currently followed cutoffs. So a new cutoff for vitamin D deficiency needs to be established for neonates and infants.

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Low serum vitamin D levels are not associated with increased postoperative pain and opioid requirements: a historical cohort study

Canadian Journal of Anesthesia/Journal canadien d anesthésie ◽

10.1007/s12630-015-0357-4 ◽

2015 ◽

Vol 62 (7) ◽

pp. 770-776 ◽

Cited By ~ 4

Author(s):

Somnath Bose ◽

Ashish Khanna ◽

Jing You ◽

Lovkesh Arora ◽

Shahbaz Qavi ◽

...

Keyword(s):

Vitamin D ◽

Cohort Study ◽

Postoperative Pain ◽

Serum Vitamin ◽

Historical Cohort ◽

Serum Vitamin D ◽

Historical Cohort Study ◽

Vitamin D Levels ◽

Low Serum

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Do sufficient vitamin D levels at the end of summer in children and adolescents provide an assurance of vitamin D sufficiency at the end of winter? A cohort study

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2017-0132 ◽

2017 ◽

Vol 30 (10) ◽

Cited By ~ 1

Author(s):

Habibesadat Shakeri ◽

Seyed-Javad Pournaghi ◽

Javad Hashemi ◽

Mohammad Mohammad-Zadeh ◽

Arash Akaberi

Keyword(s):

Vitamin D ◽

Cohort Study ◽

Serum Vitamin ◽

Cutoff Point ◽

Optimal Cutoff ◽

Hydroxyvitamin D ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Optimal Cutoff Point ◽

Sufficient Vitamin

AbstractBackground:The changes in serum 25-hydroxyvitamin D (25(OH)D) in adolescents from summer to winter and optimal serum vitamin D levels in the summer to ensure adequate vitamin D levels at the end of winter are currently unknown. This study was conducted to address this knowledge gap.Methods:The study was conducted as a cohort study. Sixty-eight participants aged 7–18 years and who had sufficient vitamin D levels at the end of the summer in 2011 were selected using stratified random sampling. Subsequently, the participants’ vitamin D levels were measured at the end of the winter in 2012. A receiver operating characteristic (ROC) curve was used to determine optimal cutoff points for vitamin D at the end of the summer to predict sufficient vitamin D levels at the end of the winter.Results:The results indicated that 89.7% of all the participants had a decrease in vitamin D levels from summer to winter: 14.7% of them were vitamin D-deficient, 36.8% had insufficient vitamin D concentrations and only 48.5% where able to maintain sufficient vitamin D. The optimal cutoff point to provide assurance of sufficient serum vitamin D at the end of the winter was 40 ng/mL at the end of the summer. Sex, age and vitamin D levels at the end of the summer were significant predictors of non-sufficient vitamin D at the end of the winter.Conclusions:In this age group, a dramatic reduction in vitamin D was observed over the follow-up period. Sufficient vitamin D at the end of the summer did not guarantee vitamin D sufficiency at the end of the winter. We found 40 ng/mL as an optimal cutoff point.

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