DC Polarography of Cephradine and Its Application to Capsules

1979 ◽  
Vol 62 (3) ◽  
pp. 556-559
Author(s):  
Luis J Nuñez-Vergara ◽  
Juan A Squella ◽  
Ernesto M Gonzalez
Keyword(s):  
Quantitative Analysis ◽  
Spectral Data ◽  
Linear Relation ◽  
Dosage Forms ◽  
Polarographic Method ◽  
Acidic Hydrolysis ◽  
Diffusion Controlled ◽  
Dc Polarography ◽  
Coloring Matter

Abstract A polarographic method has been developed for the quantitative analysis of cephradine and its dosage forms. Direct determinations on capsules are carried out; excipients and coloring matter do not interfere in the determination. The electroactive product is formed by acidic hydrolysis with 5.0N HCl and heating at 80°C for 60 min. Two polarographic waves are obtained: I = - 0.46 v and II = - 0.78 v vs. SCE. Both reduction waves are diffusion controlled. Wave I is preferred for analytical purposes. The precise chemical identity of the electroactive product has not been determined, but UV spectral data and the TLC Rf value are reported. A linear relation is established for levels of cephradine between 10-2 and 10-5M in 5.0N HCl.

Quantitative surface damage studies by H.R.E.M.

1989 ◽  
Vol 47 ◽  
pp. 632-633
Author(s):  
S. R. Singh ◽  
H. J. Fan ◽  
L. D. Marks
Keyword(s):  
Solar Wind ◽  
Quantitative Analysis ◽  
Surface Science ◽  
Surface Damage ◽  
Space Environment ◽  
Oxygen Desorption ◽  
The Past ◽  
Diffusion Controlled ◽  
Original Observation ◽  
Substantial Interest

Since the original observation that the surfaces of materials undergo radiation damage in the electron microscope similar to that observed by more conventional surface science techniques there has been substantial interest in understanding these phenomena in more detail; for a review see. For instance, surface damage in a microscope mimics damage in the space environment due to the solar wind and electron beam lithographic operations.However, purely qualitative experiments that have been done in the past are inadequate. In addition, many experiments performed in conventional microscopes may be inaccurate. What is needed is careful quantitative analysis including comparisons of the behavior in UHV versus that in a conventional microscope. In this paper we will present results of quantitative analysis which clearly demonstrate that the phenomena of importance are diffusion controlled; more detailed presentations of the data have been published elsewhere.As an illustration of the results, Figure 1 shows a plot of the shrinkage of a single, roughly spherical particle of WO3 versus time (dose) driven by oxygen desorption from the surface.

scholarly journals Electrochemical Behaviour of N′-(p-toluenesulphonyl)-3-methyl-4-(4′-substituted arylhydrazono) pyrazolin-5-ones

2012 ◽  
Vol 9 (4) ◽  
pp. 1864-1874
Author(s):  
V. Nagaraju ◽  
R. Sreenivasulu ◽  
P. Venkata Ramana
Keyword(s):  
Electrochemical Behaviour ◽  
Reduction Process ◽  
Effect Of Solvent ◽  
Buffer Solutions ◽  
Diffusion Controlled ◽  
Controlled Potential Electrolysis ◽  
Dc Polarography ◽  
Controlled Potential ◽  
Ph Range ◽  
And Diffusion

The electrochemical behaviour of N′-(p-toluenesulphonyl)-3-methyl-4-(4′-substituted arylhydrazono) pyrazolin-5-ones has been investigated at dme and gc electrodes in buffer solutions of pH 2.0, 4.0, 6.0, 8.0 and 10.0 using dc polarography and cyclic voltammetry and coulometry. The compounds exhibit one well defined wave in the entire pH range of study. The process is irreversible and diffusion controlled. Controlled potential electrolysis indicates the involvement of four electrons in the reduction process. The effect of solvent, cations and anions, temperature and substitutents on the mechanism of reduction has been studied. Based on the results obtained the mechanism of reduction has been suggested.

scholarly journals Pretreatment of the spectral data in PLS1 quantitative analysis.

1996 ◽  
Vol 45 (1) ◽  
pp. 85-89 ◽  
Author(s):  
Tetsuo IWATA ◽  
Jun KOSHOUBU
Keyword(s):  
Quantitative Analysis ◽  
Spectral Data

A quantitative analysis about the prevalence of PTSD after the chemical attack in halabja

2011 ◽  
Vol 26 (S2) ◽  
pp. 164-164
Author(s):  
F. M-Hasan
Keyword(s):  
Social Support ◽  
Quantitative Analysis ◽  
Linear Relation ◽  
Ptsd Symptoms ◽  
Lower Prevalence ◽  
The Third ◽  
Chemical Attack ◽  
Kurdish Women ◽  
The World ◽  
Primary Hypothesis

The March 1988 genocide in Halabja, in which 4000–7000 Kurdish women, children and men were killed by the then Iraqi regime, was the most brutal gas attack on a civil population in modern history. This study challenges currently held understandings of PTSD and how traumatic transformations are expressed in other parts of the world; thereby contributing to the new field of traumatology. The study is quantitative analysis of the prevalence of PTSD, measured using (IES), in two Kurdish towns; Halabja and Suleimaniyah, encompassing 110 participants. The study's primary aim was to compare the prevalence of PTSD in Halabja with that in Suleimaniyah which was not attacked, the expectation being that PTSD would be more prevalent in Halabja than in Suleimaniyah. secondly, that women and those with shorter education would report a higher prevalence of PTSD symptoms, and thirdly that participants with higher levels of social support would report a lower prevalence of PTSD symptoms. The results showed that the prevalence of PTSD symptoms in total, of reliving and of hyperarousal in the trauma exposed town was significantly higher than in Suleimaniyah, thus supporting the primary hypothesis. The results further showed a significant connection between sex and PTSD symptoms and a clear linear relation between education and prevalence of PTSD symptoms, thus supporting the second hypothesis. However, the results showed no support for the third hypothesis. The study thus indicates that researchers and practitioners working with PTSD need a broader cultural understanding to carry out studies in best possible manner.

Quantification Of Novel Dpp4 Inhibitor - Vildagliptin By Spectrophotometric And Chromatographic Techniques: Brief Review

2021 ◽  
pp. 5603-5610
Author(s):  
Gnanasekaran D. ◽  
Gandhimathi R.
Keyword(s):  
Quantitative Analysis ◽  
Analytical Techniques ◽  
Dosage Forms ◽  
Major Focus ◽  
Pharmaceutical Dosage Forms ◽  
Dipeptidyl Peptidase 4 ◽  
Chromatographic Techniques ◽  
Dipeptidyl Peptidase 4 Inhibitor ◽  
Pros And Cons

A review is presented on different analytical techniques used for quantitative analysis of novel Dipeptidyl peptidase-4 inhibitor (DPP-4) - Vildagliptin. Endeavours have been made to examine all the pertinent references to the degree conceivable. The review discusses the pros and cons of the cited analytical techniques, which will aid to give understand into the methods used for determination of Vildagliptin, from clinical isolates and from its pharmaceutical dosage forms. The major focus of this review is the basic as well as advanced analytical techniques established for determination of Vildagliptin. The procedures outlined here have been exhibited to be helpful for assessment of Vildagliptin and may discover application in dissecting other related properties.

scholarly journals Quantitative Analysis of Sulpiride and Impurities of 2-Aminomethyl-1-Ethylpyrrolidine and Methyl-5-Sulphamoyl-2-Methoxybenzoate in Pharmaceuticals by High-Performance Thin-Layer Chromatography and Scanning Densitometry

1999 ◽  
Vol 82 (4) ◽  
pp. 825-829 ◽  
Author(s):  
Danica Agbaba ◽  
Tatjana Miljkovic ◽  
Valentina Marinkovic ◽  
Dobrila Zivanov-Stakic ◽  
Sote Vladimirov
Keyword(s):  
Quantitative Analysis ◽  
Thin Layer ◽  
High Performance ◽  
Methylene Chloride ◽  
Solvent System ◽  
Ammonia Solution ◽  
Dosage Forms ◽  
Raw Material ◽  
Layer Chromatography

Abstract A simple and reliable thin-layer chromatographic method for determining sulpiride and impurities of 2-aminomethyl-1-ethylpyrrolidine and methyl-5-sulphamoyl-2-methoxybenzoate was developed and validated. A methylene chloride–methanol–ammonia solution (25%; 18 + 2.8 + 0.4, v/v) solvent system is used for separation and quantitative evaluation of chromatograms. The chromatographic plate is first scanned at 240 nm to locate chromatographic zones corresponding to sulpiride and methyl-5-sulphamoyl-2-methoxybenzoate. Then 2-aminomethyl-1-ethylpyrrolidine is derivatized in situ with ninhydrin, and resulting colored spots are measured at 500 nm. The method is reproducible and convenient for quantitative analysis and purity control of sulpiride in its raw material and in its dosage forms.

Quantitative analysis of mebeverine in dosage forms by HPLC

1997 ◽  
Vol 44 (7-8) ◽  
pp. 427-430 ◽  
Author(s):  
O. Al-Deeb ◽  
B. M. Al-Hadiya ◽  
N. H. Foda
Keyword(s):  
Quantitative Analysis ◽  
Dosage Forms
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