scholarly journals Is Lung Cancer Incidence Increasing in Never-Smokers?

2015 ◽  
Vol 108 (1) ◽  
pp. djv418 ◽  
Author(s):  
Susan Jenks
Keyword(s):  
Lung Cancer ◽  
Cancer Incidence ◽  
Lung Cancer Incidence ◽  
Never Smokers

scholarly journals Chronic obstructive pulmonary disease and lung cancer incidence in never smokers: a cohort study

Thorax ◽  
2020 ◽  
Vol 75 (6) ◽  
pp. 506-509 ◽  
Author(s):  
Hye Yun Park ◽  
Danbee Kang ◽  
Sun Hye Shin ◽  
Kwang-Ha Yoo ◽  
Chin Kook Rhee ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Chronic Obstructive Pulmonary Disease ◽  
Cohort Study ◽  
Pulmonary Disease ◽  
Cancer Incidence ◽  
Chronic Obstructive ◽  
Lung Cancer Incidence ◽  
Obstructive Pulmonary Disease ◽  
Never Smokers

There has been limited evidence for the association between chronic obstructive pulmonary disease (COPD) and the incidence of lung cancer among never smokers. We aimed to estimate the risk of lung cancer incidence in never smokers with COPD, and to compare it with the risk associated with smoking. This cohort study involved 338 548 subjects, 40 to 84 years of age with no history of lung cancer at baseline, enrolled in the National Health Insurance Service National Sample Cohort. During 2 355 005 person-years of follow-up (median follow-up 7.0 years), 1834 participants developed lung cancer. Compared with never smokers without COPD, the fully-adjusted hazard ratios (95% CI) for lung cancer in never smokers with COPD, ever smokers without COPD, and ever smokers with COPD were 2.67 (2.09 to 3.40), 1.97 (1.75 to 2.21), and 6.19 (5.04 to 7.61), respectively. In this large national cohort study, COPD was also a strong independent risk factor for lung cancer incidence in never smokers, implying that COPD patients are at high risk of lung cancer, irrespective of smoking status.

Lung cancer incidence in never smokers in the Southeast of Brazil: 10 years analysis.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e13571-e13571
Author(s):  
Jose Zago Pulido ◽  
Sabina B. Aleixo ◽  
Narelle Parmanhane
Keyword(s):  
Public Health ◽  
Lung Cancer ◽  
Cell Carcinoma ◽  
Cancer Incidence ◽  
Health Problem ◽  
Public Health Problem ◽  
Management Tool ◽  
Clinical Staging ◽  
Lung Cancer Incidence ◽  
Never Smokers

e13571 Background: Lung cancer is a leading cause of cancer death worldwide. In Brazil, the Ministry of Health estimated an absolute incidence of 30,200 cases of lung cancer in 2020. Eighty-five percent of diagnosed cases are associated with consumption of tobacco products. Although smoking remains the predominant cause, lung cancer in never smokers is an increasingly prominent public health problem. However, data on this topic, particularly lung cancer incidence rates in developing countries in never smokers are limited. Methods: The data presented in this work correspond to the period from 2007 to 2017 and were extracted from the database of the Hospital Cancer Registry of the Evangelical Hospital of Cachoeiro de Itapemirim (RHC / HECI) through SisRHC, a computerized database management tool for Hospital Cancer Records. Results: Of the 494 patients who were diagnosed with lung cancer aged 18 years or over, 395 (80%) had complete information on a history of tobacco use, of which 68 patients denied smoking. Based on data from 68 patients, the years 2011 and 2012 had the lowest incidence, 6%, of non-smokers with lung cancer. 2009 and 2007 were the years with the highest incidence, 24 and 33% respectively. In the remaining years, the percentage varied between 15 and 23%. Regarding gender, 47 (69%) of the cases were women and 21 (31%) were men. Adenocarcinoma without a specific origin (NOS) was the most frequent histological type in non-smoking patients, with 33 (48.5%) of the cases, followed by malignant neoplasia 10 (14.7%), squamous cell carcinoma NOS 8 (11, 8%) and NOS carcinoma 7 (10.3%), the types of NOS large cell carcinoma, NOS small cell carcinoma, NOS papillary carcinoma, NOS bronchioloalveolar adenocarcinoma and adenosquamous carcinoma account for 10 (14.7%) cases. Analyzing the clinical staging (CE) at the time of diagnosis, 1 (1.5%) had EC 1, 4 (5.9%) EC 2, 12 (17.6%) EC 3, 42 (61.8%) EC 4 and 9 (13.2%) had no reports of staging. The median incidence rate was 17%, confirming that smoking remains the biggest cause of lung cancer, and reinforcing the need for more comprehensive epidemiological analyzes for this population. As the data can reach even higher percentages, as the information is provided by patients, without an available reliability assessment method. Conclusions: Lung cancer in never smokers is a major public health problem and further exploration of its patterns of incidence, etiology and biology is needed.

Smoking and estrogen plus progestin (E+P) and lung cancer incidence and mortality.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 1524-1524
Author(s):  
Rowan T. Chlebowski ◽  
Heather A. Wakelee ◽  
Thomas E Rohan ◽  
Jingmin Liu ◽  
Michael S. Simon ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Clinical Trial ◽  
Cancer Incidence ◽  
Smoking Status ◽  
Controlled Clinical Trial ◽  
Lung Cancer Incidence ◽  
Lung Cancers ◽  
Risk Of Death ◽  
Incidence And Mortality ◽  
Never Smokers

1524 Background: In the Women’s Health Initiative (WHI) randomized, placebo-controlled clinical trial, E+P increased deaths from lung cancer (those cancer-attributed) and after lung cancer (regardless of cause) (Lancet 2009:374:1243). To examine smoking status influence on this process, a cohort combining WHI clinical trial (CT) and observational study (OS) participants, the latter meeting criteria as in the CT, was identified to examine E+P associations with lung cancer incidence and outcome. Methods: 31,966 postmenopausal women (12,299 CT, 19,668 OS) with no prior hysterectomy and no prior hormone therapy use were classified at baseline as not hormone users or E+P users and as current or never smokers. Lung cancers were verified by medical record review. Multi-variant adjusted Cox proportional hazards regression, including pack-year use, calculated hazard ratios (HRs, 95% confidence intervals [CI]) for groups defined by smoking status and E+P use for lung cancer incidence, deaths from lung cancer and deaths after lung cancer. Results: After 12 years mean follow-up, 664 lung cancers were diagnosed with 444 deaths from lung cancer and 513 deaths after lung cancer. Analyzed from cohort entry; see Table. In nonusers of E+P, lung cancer incidence, deaths from lung cancer, and deaths after lung cancer were significantly and substantially greater in current smokers vs never smokers (p< .0001 for all comparisons). In current smokers, lung cancer incidence, deaths from lung cancer and deaths after lung cancer were significantly and substantially greater in E+P users vs non-users (p=.0021, .0005 and .0002, respectively). Conclusions: E+P use in current smokers nearly doubles their already high risk of death from and after lung cancer. Based on this risk, current smokers should not use E+P. [Table: see text]

COPD and lung cancer incidence in never smokers

2019 ◽  
Author(s):  
Hye Yun Park ◽  
Sun Hye Shin ◽  
Danbee Kang ◽  
Kwang Ha Yoo ◽  
Chin Kook Rhee ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Incidence ◽  
Lung Cancer Incidence ◽  
Never Smokers

Active and passive smoking in relation to lung cancer incidence in the Women's Health Initiative prospective cohort study.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 1504-1504
Author(s):  
Ange Wang ◽  
Jessica Kubo ◽  
Juhua Luo ◽  
Manisha Desai ◽  
Michael T Henderson ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Cancer Incidence ◽  
Passive Smoking ◽  
Prospective Cohort ◽  
Lung Cancer Risk ◽  
Lung Cancer Incidence ◽  
Cancer Subtypes ◽  
Former Smokers ◽  
Never Smokers

1504 Background: The relationship between both active and passive smoking and lung cancer incidence in post-menopausal women was examined in theWomen’s Health Initiative Observational Study (WHI-OS). Methods: The WHI-OS, a prospective cohort study conducted at 40 U.S. centers, enrolled women ages 50-79 from 1993-1998.Among 93,676 participants, 76,304 women with complete smoking and covariate data comprised the analytic cohort, in which the association of lung cancer incidence with active and passive (childhood, adult home, and work) smoking exposure was studied. Results: Over 10.5 meanyears of follow-up with 901 lung cancer cases, lung cancer incidence was higher in current smokers (HR 13.44, 95% CI 10.80-16.75) and former smokers (HR 4.20, 95% CI 3.48-5.08), compared to never smokers. This relationship was dose-dependent for both current and former smokers. Risk of all lung cancer subtypes, particularly small cell lung cancer (SCLC) and squamous cell carcinoma (SqCC), was higher in smokers. Among never smokers, any passive smoking exposure (HR 0.88, 95% CI 0.52-1.49) and most passive smoking categories did not significantly increase lung cancer risk, compared to no passive exposure; however, passive exposure as an adult at home for >=30 years was associated with increased risk, of borderline significance (HR 1.61, 95% CI 1.00-2.58). Current smokers had an annualized lung cancer incidence rate of 472.9 cases/100,000 person-years, compared to 158.1 for former smokers and 36.2 for never smokers (112.3 overall). Conclusions: To our knowledge, this is the first study to examine both active and passive smoking in relation to lung cancer incidence in a complete prospective cohort of U.S. women. Active smoking is associated with significant increases in incidence of all lung cancer subtypes in post-menopausal women, particularly SCLC and SqCC. Smoking cessation decreases lung cancer risk. Prolonged exposure as an adult at home may be the strongest passive smoking contributor to lung cancer risk in this cohort. The findings support continued need for investment in smoking prevention and cessation, research on passive smoking, and understanding of lung cancer risk factors other than smoking.

scholarly journals Sex Difference and Smoking Effect of Lung Cancer Incidence in Asian Population

Cancers ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 113
Author(s):  
Boyoung Park ◽  
Yeol Kim ◽  
Jaeho Lee ◽  
Nayoung Lee ◽  
Seung Hun Jang
Keyword(s):  
Lung Cancer ◽  
Sex Difference ◽  
Cancer Incidence ◽  
Screening Program ◽  
Smoking Status ◽  
Asian Population ◽  
Smoking History ◽  
Lung Cancer Incidence ◽  
Male And Female ◽  
Never Smokers

This study analyzed the sex difference in the effect of smoking exposure on lung cancer in terms of absolute and relative risks despite the increasing lung cancer incidence in Asian female never smokers. A retrospective cohort study was conducted on individuals aged 40–79 years who participated in the national health screening program in 2007 and 2008 with linkage to the Korea Central Cancer Registry records. We evaluated sex differences in the age-standardized incidence rate (ASR) of lung cancer by smoking history and the hazard ratio (HR) after adjusting for potential confounders. ASRs for male and female never smokers were 92.5 and 38.3 per 100,000 person-years, respectively (rate ratio (RR) = 2.4; 95% confidence interval (CI) = 2.3–2.5). ASRs for male and female current smokers with a 30 pack-year smoking history were 305.3 and 188.4 per 100,000 person-years, respectively (RR = 1.6; 95% CI = 1.3–2.0). Smoking was significantly associated with lung cancer risk for both sexes. HRs for former smokers versus never smokers were 1.27 (95% CI = 1.23–1.33) for men and 1.43 (95% CI = 1.16–1.81) for women. HRs for current smokers versus never smokers were 2.71 (95% CI = 2.63–2.79) for men and 2.70 (95% CI = 2.48–2.94) for women. HRs for lung cancer increased similarly in both men and women according to smoking status. However, among Korean individuals with comparable smoking statuses, lung cancer incidence is higher in men than in women. Sex should be considered in combination with smoking history in the selection of a lung cancer screening target population.

scholarly journals Lung Cancer Incidence in Never Smokers

2007 ◽  
Vol 25 (5) ◽  
pp. 472-478 ◽  
Author(s):  
Heather A. Wakelee ◽  
Ellen T. Chang ◽  
Scarlett L. Gomez ◽  
Theresa H. Keegan ◽  
Diane Feskanich ◽  
...  
Keyword(s):  
Public Health ◽  
Lung Cancer ◽  
Cancer Incidence ◽  
Incidence Rates ◽  
Health Issue ◽  
Public Health Issue ◽  
Lung Cancer Incidence ◽  
Follow Up Study ◽  
Never Smokers

Purpose Lung cancer is a leading cause of cancer death worldwide. Although smoking remains the predominant cause of lung cancer, lung cancer in never smokers is an increasingly prominent public health issue. However, data on this topic, particularly lung cancer incidence rates in never smokers, are limited. Methods We reviewed the existing literature on lung cancer incidence and mortality rates among never smokers and present new data regarding rates in never smokers from the following large, prospective cohorts: Nurses’ Health Study; Health Professionals Follow-Up Study; California Teachers Study; Multiethnic Cohort Study; Swedish Lung Cancer Register in the Uppsala/Örebro region; and First National Health and Nutrition Examination Survey Epidemiologic Follow-Up Study. Results Truncated age-adjusted incidence rates of lung cancer among never smokers age 40 to 79 years in these six cohorts ranged from 14.4 to 20.8 per 100,000 person-years in women and 4.8 to 13.7 per 100,000 person-years in men, supporting earlier observations that women are more likely than men to have non–smoking-associated lung cancer. The distinct biology of lung cancer in never smokers is apparent in differential responses to epidermal growth factor receptor inhibitors and an increased prevalence of adenocarcinoma histology in never smokers. Conclusion Lung cancer in never smokers is an important public health issue, and further exploration of its incidence patterns, etiology, and biology is needed.

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