Smoking and estrogen plus progestin (E+P) and lung cancer incidence and mortality.

1524 Background: In the Women’s Health Initiative (WHI) randomized, placebo-controlled clinical trial, E+P increased deaths from lung cancer (those cancer-attributed) and after lung cancer (regardless of cause) (Lancet 2009:374:1243). To examine smoking status influence on this process, a cohort combining WHI clinical trial (CT) and observational study (OS) participants, the latter meeting criteria as in the CT, was identified to examine E+P associations with lung cancer incidence and outcome. Methods: 31,966 postmenopausal women (12,299 CT, 19,668 OS) with no prior hysterectomy and no prior hormone therapy use were classified at baseline as not hormone users or E+P users and as current or never smokers. Lung cancers were verified by medical record review. Multi-variant adjusted Cox proportional hazards regression, including pack-year use, calculated hazard ratios (HRs, 95% confidence intervals [CI]) for groups defined by smoking status and E+P use for lung cancer incidence, deaths from lung cancer and deaths after lung cancer. Results: After 12 years mean follow-up, 664 lung cancers were diagnosed with 444 deaths from lung cancer and 513 deaths after lung cancer. Analyzed from cohort entry; see Table. In nonusers of E+P, lung cancer incidence, deaths from lung cancer, and deaths after lung cancer were significantly and substantially greater in current smokers vs never smokers (p< .0001 for all comparisons). In current smokers, lung cancer incidence, deaths from lung cancer and deaths after lung cancer were significantly and substantially greater in E+P users vs non-users (p=.0021, .0005 and .0002, respectively). Conclusions: E+P use in current smokers nearly doubles their already high risk of death from and after lung cancer. Based on this risk, current smokers should not use E+P. [Table: see text]

Download Full-text

Five vitamin D receptor polymorphisms (FokI, BsmI, Apa1, Taq1, and Cdx2) and lung cancer risk.

Journal of Clinical Oncology ◽

10.1200/jco.2012.30.15_suppl.e12013 ◽

2012 ◽

Vol 30 (15_suppl) ◽

pp. e12013-e12013

Author(s):

Rong Li ◽

Ming Tian ◽

Meili Ma ◽

Jun Pei ◽

Yiyi Song ◽

...

Keyword(s):

Lung Cancer ◽

Vitamin D ◽

Cancer Patients ◽

Cancer Incidence ◽

Smoking Status ◽

Chinese Patients ◽

Healthy Controls ◽

Lung Cancer Incidence ◽

Lung Cancer Patients ◽

Incidence And Mortality

e12013 Background: Vitamin D and its receptor (VDR) have been implicated in lung cancer incidence and mortality. Here we assess the relationships between VDR single nucleotide polymorphisms (SNPs) (FokI, BsmI, ApaI, Taq, Cdx2) and lung cancer incidence in Chinese patients. Methods: Genomic DNA was extracted from peripheral blood samples. Five VDR SNPs (FokI, BsmI, ApaI, Taq, Cdx2) were detected by polymerase chain reaction. Genotype analysis was conducted using mass spectrograph. Results: A total of 67 lung cancer patients and 72 healthy controls participated in the study. There were more males and current smokers among the lung cancer patients than among healthy controls. Lung cancer patients were much older than controls. Age and smoking status were included in the equation for predicting disease status. The CC-AA (Apa1-Cdx2) and the CC-AA-CC (ApaI-Cdx2- FokI) haplotypes were associated with higher lung cancer incidence. The rs1544410 (BsmI) and rs731236 (TaqI) were not associated with higher lung cancer incidence, but they were associated with rs797523 (ApaI). Conclusions: There is a significant correlation between certain VDR SNPs (FokI, ApaI, Cdx2) and lung cancer incidence in Chinese people.

Download Full-text

Sex Difference and Smoking Effect of Lung Cancer Incidence in Asian Population

Cancers ◽

10.3390/cancers13010113 ◽

2020 ◽

Vol 13 (1) ◽

pp. 113

Author(s):

Boyoung Park ◽

Yeol Kim ◽

Jaeho Lee ◽

Nayoung Lee ◽

Seung Hun Jang

Keyword(s):

Lung Cancer ◽

Sex Difference ◽

Cancer Incidence ◽

Screening Program ◽

Smoking Status ◽

Asian Population ◽

Smoking History ◽

Lung Cancer Incidence ◽

Male And Female ◽

Never Smokers

This study analyzed the sex difference in the effect of smoking exposure on lung cancer in terms of absolute and relative risks despite the increasing lung cancer incidence in Asian female never smokers. A retrospective cohort study was conducted on individuals aged 40–79 years who participated in the national health screening program in 2007 and 2008 with linkage to the Korea Central Cancer Registry records. We evaluated sex differences in the age-standardized incidence rate (ASR) of lung cancer by smoking history and the hazard ratio (HR) after adjusting for potential confounders. ASRs for male and female never smokers were 92.5 and 38.3 per 100,000 person-years, respectively (rate ratio (RR) = 2.4; 95% confidence interval (CI) = 2.3–2.5). ASRs for male and female current smokers with a 30 pack-year smoking history were 305.3 and 188.4 per 100,000 person-years, respectively (RR = 1.6; 95% CI = 1.3–2.0). Smoking was significantly associated with lung cancer risk for both sexes. HRs for former smokers versus never smokers were 1.27 (95% CI = 1.23–1.33) for men and 1.43 (95% CI = 1.16–1.81) for women. HRs for current smokers versus never smokers were 2.71 (95% CI = 2.63–2.79) for men and 2.70 (95% CI = 2.48–2.94) for women. HRs for lung cancer increased similarly in both men and women according to smoking status. However, among Korean individuals with comparable smoking statuses, lung cancer incidence is higher in men than in women. Sex should be considered in combination with smoking history in the selection of a lung cancer screening target population.

Download Full-text

Relation Between Lung Cancer Incidence and Mortality Rates with Human Development Index and Its Components: A Global Ecological Study

Iranian Journal of Cancer Prevention ◽

10.17795/ijcp-5310 ◽

2016 ◽

Vol In Press (In Press) ◽

Cited By ~ 2

Author(s):

Mokhtar Soheylizad ◽

Salman Khazaei ◽

Somayeh Khazaei ◽

Shahab Rezaeian

Keyword(s):

Lung Cancer ◽

Human Development ◽

Cancer Incidence ◽

Human Development Index ◽

Ecological Study ◽

Mortality Rates ◽

Lung Cancer Incidence ◽

Development Index ◽

Incidence And Mortality

Download Full-text

Lung cancer incidence and mortality with extended follow-up in the National Lung Screening Trial

Breathe ◽

10.1183/20734735.0322-2019 ◽

2020 ◽

Vol 16 (1) ◽

pp. 190322 ◽

Cited By ~ 1

Author(s):

Armin Frille ◽

Georgia Hardavella ◽

Richard Lee

Keyword(s):

Lung Cancer ◽

Cancer Incidence ◽

Lung Cancer Incidence ◽

National Lung Screening Trial ◽

Incidence And Mortality ◽

Lung Screening ◽

Screening Trial

Download Full-text

Chronic obstructive pulmonary disease and lung cancer incidence in never smokers: a cohort study

Thorax ◽

10.1136/thoraxjnl-2019-213732 ◽

2020 ◽

Vol 75 (6) ◽

pp. 506-509 ◽

Cited By ~ 3

Author(s):

Hye Yun Park ◽

Danbee Kang ◽

Sun Hye Shin ◽

Kwang-Ha Yoo ◽

Chin Kook Rhee ◽

...

Keyword(s):

Lung Cancer ◽

Chronic Obstructive Pulmonary Disease ◽

Cohort Study ◽

Pulmonary Disease ◽

Cancer Incidence ◽

Chronic Obstructive ◽

Lung Cancer Incidence ◽

Obstructive Pulmonary Disease ◽

Never Smokers

There has been limited evidence for the association between chronic obstructive pulmonary disease (COPD) and the incidence of lung cancer among never smokers. We aimed to estimate the risk of lung cancer incidence in never smokers with COPD, and to compare it with the risk associated with smoking. This cohort study involved 338 548 subjects, 40 to 84 years of age with no history of lung cancer at baseline, enrolled in the National Health Insurance Service National Sample Cohort. During 2 355 005 person-years of follow-up (median follow-up 7.0 years), 1834 participants developed lung cancer. Compared with never smokers without COPD, the fully-adjusted hazard ratios (95% CI) for lung cancer in never smokers with COPD, ever smokers without COPD, and ever smokers with COPD were 2.67 (2.09 to 3.40), 1.97 (1.75 to 2.21), and 6.19 (5.04 to 7.61), respectively. In this large national cohort study, COPD was also a strong independent risk factor for lung cancer incidence in never smokers, implying that COPD patients are at high risk of lung cancer, irrespective of smoking status.

Download Full-text