Familial Risks and Mortality in Second Primary Cancers in Melanoma

AbstractBackgroundMalignant melanoma (MM) patients are at increasing risk of developing second primary cancers (SPCs). We assessed mortality and risk of SPCs in MM patients with siblings or parents affected with same cancer compared with that of the general population.MethodsWe used the Swedish Family-Cancer Database to assess relative risks (RRs) and causes of death in SPCs until 2015 in patients with a MM diagnosis between 1958 and 2015. We identified 35 451patients with MM among whom 3212 received a subsequent diagnosis of SPC. RRs of SPCs after MM diagnosis were calculated stratifying over concordant family history of cancer in first-degree relatives.ResultsFamilial RRs were increased for second melanoma (RR = 19.28, 95% CI = 16.71 to 22.25), squamous cell skin cancer (RR = 7.58, 95% CI = 5.57 to 10.29), leukemia (RR = 5.69, 95% CI = 2.96 to 10.94), bladder (RR = 4.15, 95% CI = 2.50 to 6.89), ovarian (RR = 3.89, 95% CI = 1.46 to 10.37), kidney cancer (RR = 3.77, 95% CI = 1.57 to 9.06), cancer of unknown primary (RR = 3.67, 95% CI = 1.65 to 8.16), nervous system (RR = 2.88, 95% CI = 1.20 to 6.93), breast (RR = 2.34, 95% CI = 1.92 to 2.84), lung (RR = 2.24, 95% CI = 1.50 to 3.35), and prostate cancer (RR = 2.22, 95% CI = 1.89 to 2.61) with statistical significance. For all cancers, familial RR was in excess (2.09, 95% CI = 2.02 to 2.16 vs 1.78, 95% CI = 1.69 to 1.87; Ptrend < .0001). Cause of death in MM patients with SPC is shown to be dependent on the cancer site though SPCs contributed to majority of deaths.ConclusionsSPCs appear higher with prior family history of cancer and contribute to mortality. SPC was the most common cause of death in patients with SPC and is almost uniformly the major contributing cause of death for all cancer sites. For improved survival in MM patients, prevention and early detection of SPCs would be important.

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Family history of cancer in first degree relatives and risk of cancer of unknown primary

European Journal of Cancer Care ◽

10.1111/ecc.13485 ◽

2021 ◽

Author(s):

Alexander L. R. Grewcock ◽

Karlijn E. P. E. Hermans ◽

Matty P. Weijenberg ◽

Piet A. Brandt ◽

Caroline Loef ◽

...

Keyword(s):

Family History ◽

Cancer Of Unknown Primary ◽

Unknown Primary ◽

Family History Of Cancer ◽

First Degree Relatives ◽

History Of ◽

Risk Of Cancer ◽

History Of Cancer

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Risk factors for early-onset colorectal cancer in China.

Journal of Clinical Oncology ◽

10.1200/jco.2021.39.15_suppl.10542 ◽

2021 ◽

Vol 39 (15_suppl) ◽

pp. 10542-10542

Author(s):

Zhe Pan ◽

Junfeng Huang ◽

Mingkai Huang ◽

Zhiyuan Yao ◽

Jiongqiang Huang ◽

...

Keyword(s):

Colorectal Cancer ◽

Risk Factors ◽

Cohort Study ◽

Family History ◽

Early Onset ◽

Cancer Site ◽

Family History Of Cancer ◽

History Of ◽

Early Onset Colorectal Cancer ◽

History Of Cancer

10542 Background: The incidence of colorectal cancer among persons aged < 50 years (early-onset colorectal cancer, EOCRC) has increased since the early 1990s. However, the risk factors contributing to this trend remain largely unknown. Methods: We conducted a retrospective study of participants who were aged < 50 years and without a previous cancer history, using the China Kadoorie Biobank cohort study. We analyzed data related to demographics, lifestyle habits, family history, and comorbidities of EOCRC cases with participants without colorectal cancer in this age group (controls). Univariate and multivariate-adjusted cox regression models were used to estimate the associations with risk factors. Results: We identified 225 EOCRC cases and 88842 controls that include the final analyses. Of the 225 EOCRC patients, 105 (46.7%) were colon cancers and 120 (53.3%) were rectum cancers. EOCRC cases were older, have more intake of fish and eggs, have higher BMIs, diabetes, and family history of cancer compared with controls (P < 0.05). After adjustment for potential confounding factors, increasing age (HR 2.18, 95%CI 2.05-2.31), BMI (HR 1.06, 95%CI 1.01-1.11), family history of cancer (HR 1.41, 95%CI 1.00-1.98), and more intake of fish (HR 1.54, 95%CI 1.09-2.19) were significantly associated with a higher risk of EOCRC. In sensitivity analyses stratified by cancer site (colon and rectum), the results remained consistent. Conclusions: Based on the large Chinese cohort study, we found increasing age, higher BMI or obesity, family history of cancer, and more intake of fish were independent risk factors for EOCRC. Further studies are needed to identify factors that cause the increasing incidence of EOCRC in China and other countries, and explore the potential mechanism behind.[Table: see text]

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Breast Cancer as a Second Primary in Patients With Prostate Cancer—Estrogen Treatment or Association With Family History of Cancer?

The Journal of Urology ◽

10.1016/j.juro.2006.03.036 ◽

2006 ◽

Vol 176 (2) ◽

pp. 538-543 ◽

Cited By ~ 20

Author(s):

Camilla Thellenberg Karlsson ◽

Beatrice Malmer ◽

Fredrik Wiklund ◽

Henrik Grönberg

Keyword(s):

Breast Cancer ◽

Prostate Cancer ◽

Family History ◽

Estrogen Treatment ◽

Second Primary ◽

Family History Of Cancer ◽

History Of ◽

History Of Cancer

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Racial/Ethnic Differences in the Association Between Family History of Cancer and Smoking Status Among US Adults

Annals of Epidemiology ◽

10.1016/j.annepidem.2020.08.025 ◽

2020 ◽

Vol 52 ◽

pp. 103-104

Author(s):

I. Jackson ◽

K. Okhawere ◽

G. Oboli ◽

A. Opiegbe ◽

O. Eromosele

Keyword(s):

Family History ◽

Ethnic Differences ◽

Smoking Status ◽

Family History Of Cancer ◽

History Of ◽

Racial Ethnic ◽

History Of Cancer

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Clinical, Pathological and Molecular Characteristics of Chilean Patients with Early-, Intermediate- and Late-Onset Colorectal Cancer

Cells ◽

10.3390/cells10030631 ◽

2021 ◽

Vol 10 (3) ◽

pp. 631

Author(s):

Karin Alvarez ◽

Alessandra Cassana ◽

Marjorie De La Fuente ◽

Tamara Canales ◽

Mario Abedrapo ◽

...

Keyword(s):

Colorectal Cancer ◽

Family History ◽

Age Of Onset ◽

Late Onset ◽

Molecular Characteristics ◽

Family History Of Cancer ◽

Molecular Features ◽

Age Of Diagnosis ◽

History Of ◽

History Of Cancer

Colorectal cancer (CRC) is the second most frequent neoplasm in Chile and its mortality rate is rising in all ages. However, studies characterizing CRC according to the age of onset are still lacking. This study aimed to identify clinical, pathological, and molecular features of CRC in Chilean patients according to the age of diagnosis: early- (≤50 years; EOCRC), intermediate- (51–69 years; IOCRC), and late-onset (≥70 years; LOCRC). The study included 426 CRC patients from Clinica Las Condes, between 2007 and 2019. A chi-square test was applied to explore associations between age of onset and clinicopathological characteristics. Body Mass Index (BMI) differences according to age of diagnosis was evaluated through t-test. Overall (OS) and cancer-specific survival (CSS) were estimated by the Kaplan–Meier method. We found significant differences between the age of onset, and gender, BMI, family history of cancer, TNM Classification of Malignant Tumors stage, OS, and CSS. EOCRC category was characterized by a family history of cancer, left-sided tumors with a more advanced stage of the disease but better survival at 10 years, and lower microsatellite instability (MSI), with predominant germline mutations. IOCRC has shown clinical similarities with the EOCRC and molecular similarities to the LOCRC, which agrees with other reports.

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