scholarly journals Association of Previous Measles Infection With Markers of Acute Infectious Disease Among 9- to 59-Month-Old Children in the Democratic Republic of the Congo

2018 ◽  
Vol 8 (6) ◽  
pp. 531-538 ◽  
Author(s):  
Hayley R Ashbaugh ◽  
James D Cherry ◽  
Nicole A Hoff ◽  
Reena H Doshi ◽  
Vivian H Alfonso ◽  
...  

Abstract Background Transient immunosuppression and increased susceptibility to other infections after measles infection is well known, but recent studies have suggested the occurrence of an “immune amnesia” that could have long-term immunosuppressive effects. Methods We examined the association between past measles infection and acute episodes of fever, cough, and diarrhea among 2350 children aged 9 to 59 months whose mothers were selected for interview in the 2013–2014 Democratic Republic of the Congo (DRC) Demographic and Health Survey (DHS). Classification of children who had had measles was completed using maternal recall and measles immunoglobulin G serostatus obtained via dried-blood-spot analysis with a multiplex immunoassay. The association with time since measles infection and fever, cough, and diarrhea outcomes was also examined. Results The odds of fever in the previous 2 weeks were 1.80 (95% confidence interval [CI], 1.25–2.60) among children for whom measles was reported compared to children with no history of measles. Measles vaccination demonstrated a protective association against selected clinical markers of acute infectious diseases. Conclusion Our results suggest that measles might have a long-term effect on selected clinical markers of acute infectious diseases among children aged 9 to 59 months in the DRC. These findings support the immune-amnesia hypothesis suggested by others and underscore the need for continued evaluation and improvement of the DRC’s measles vaccination program.

2020 ◽  
Vol 2019 ◽  
pp. vii-xxviii
Author(s):  
Marie-Christin Gabriel ◽  
Carola Lentz

AbstractThe Department of Anthropology and African Studies (ifeas) at Johannes Gutenberg University Mainz hosts a comprehensive archive on African Independence Day celebrations. Created in 2010, the archive is one of the outcomes of a large comparative research project on African national days directed by Carola Lentz. It offers unique insights into practices of as well as debates on national commemoration and political celebrations in Africa. The archive holds more than 28,000 images, including photographs, newspaper articles, documents, and objects from twelve African countries: Benin, Burkina Faso, Cameroon, Côte d'Ivoire, Democratic Republic of the Congo, Gabon, Ghana, Madagascar, Mali, Namibia, Nigeria, and Tanzania. It primarily consists of an online photo and newspaper archive (https://bildarchiv.uni-mainz.de/AUJ/; https://www.blogs.uni-mainz.de/fb07-ifeas-eng/departmental-archives/online-archive-african-independence-days/); some of the material is also stored in the physical archive on African Independence Days at ifeas as well as in the department's ethnographic collection (https://www.blogs.uni-mainz.de/fb07-ifeas-eng/ethnographic-collection/). Most of the material concerns recent celebrations, but the collection has been complemented by some documentation of earlier festivities. Archives hold many stories while they also have a story to tell in their own right. This article discusses both aspects. It first traces the history of the Online Archive African Independence Days at ifeas. It then provides an overview of the different categories of material stored in the archive and tells a few of the many stories that the photos, texts and objects contain. We hope to demonstrate that the archive holds a wealth of sources that can be mined for studies on national commemoration and political celebrations in Africa, and, more generally, on practices and processes of nation-building and state-making.


2018 ◽  
Vol 116 (2) ◽  
pp. 593-598 ◽  
Author(s):  
Lucy van Dorp ◽  
Sara Lowes ◽  
Jonathan L. Weigel ◽  
Naser Ansari-Pour ◽  
Saioa López ◽  
...  

Few phenomena have had as profound or long-lasting consequences in human history as the emergence of large-scale centralized states in the place of smaller scale and more local societies. This study examines a fundamental, and yet unexplored, consequence of state formation: its genetic legacy. We studied the genetic impact of state centralization during the formation of the eminent precolonial Kuba Kingdom of the Democratic Republic of the Congo (DRC) in the 17th century. We analyzed genome-wide data from over 690 individuals sampled from 27 different ethnic groups from the Kasai Central Province of the DRC. By comparing genetic patterns in the present-day Kuba, whose ancestors were part of the Kuba Kingdom, with those in neighboring non-Kuba groups, we show that the Kuba today are more genetically diverse and more similar to other groups in the region than expected, consistent with the historical unification of distinct subgroups during state centralization. We also found evidence of genetic mixing dating to the time of the Kingdom at its most prominent. Using this unique dataset, we characterize the genetic history of the Kasai Central Province and describe the historic late wave of migrations into the region that contributed to a Bantu-like ancestry component found across large parts of Africa today. Taken together, we show the power of genetics to evidence events of sociopolitical importance and highlight how DNA can be used to better understand the behaviors of both people and institutions in the past.


2020 ◽  
Vol 9 (4) ◽  
pp. 135-147
Author(s):  
Kim Lah ◽  
Anthony Collins

This paper explores the 2004 Kilwa massacre in the Democratic Republic of the Congo (DRC) through a decolonial perspective, explaining how the massacre is situated within the history of colonial power and global capitalist relations. As such, the convergence of mining and political interests that created the context in which this violence was possible is examined, rather than the specific human rights abuses committed during the massacre. This approach highlights how such acts of violence are an ongoing factor of colonial and postcolonial exploitation, as well as the difficulties in holding the responsible parties accountable. This investigation shows the importance of developing a decolonial Southern criminology that contextualizes human rights abuses within local and international systems of power and locates acts of criminal violence within the broader networks of structural violence.


2017 ◽  
Vol 13 (11) ◽  
pp. 92
Author(s):  
Mampeta Wabasa Salomon

In the Democratic Republic of the Congo (DRC), the protectionist conservatism influenced by colonialism, which exploited African countries for the prosperity of the colonizing countries, still has a high visibility in the Salonga National Park (PNS). If, in theory, the Central Africans seem to free themselves from the colonial powers on their land, in practice they are still there. The hostility of settlers who have become neo-colonists to the development of Central Africa remains intact, he adds (Ndinga, 2003). This reflects a "logic from above" that has disregarded local values. Yet, in the era of sustainable development and globalization, African protected areas appear to be essential tools for States to reposition themselves in a complex set of actors with the aim of capturing and using the new environmental rent (Giraut, Guyot, & Houssay-Holzschuch, 2003). This is a "bottom-up logic", placing people at the heart of all activities and aiming to reorganize their long-term relationships with the environment. From these two logics, a third "logic from the other side" emerges, reflecting a collective awareness of the fragility of the planet. The restoration of the rights of Africans in the various national frameworks constitutes a major challenge for the contemporary management of African protected areas. Because the protected areas inherited from the different colonial systems must accompany the change in management methods and the redefinition of their functions in order to better serve the local community in the long-term.


2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S323-S323 ◽  
Author(s):  
Hayley Ashbaugh ◽  
James D Cherry ◽  
Sue Gerber ◽  
Stephen G Higgins ◽  
Adva Gadoth ◽  
...  

Abstract Background Recent studies suggest a measles-induced immune amnesia that could have long-term immunosuppressive effects via preferential depletion of memory B and T CD150+ lymphocytes. Methods We examined the association between past measles and tetanus antibody levels among children participating in the 2013–2014 Democratic Republic of Congo (DRC) Demographic and Health Survey (DHS). Our sample consisted of 833 children aged 6–59 months whose mothers were selected for interview. Mothers reported (via recall) history of measles within the lifetime of the child. Classification of children who previously had measles was completed using maternal recall and measles immunoglobulin G (IgG) serostatus obtained via dried blood spot (DBS) analysis. A multiplex chemiluminescent immunoassay platform was used to obtain serologic results and Assay Score (AS) was calculated as a ratio to a positive control included in each run. Tetanus serostatus was categorized as being above or below the sample median serology AS value. Tetanus vaccination status was obtained via dated vaccination card and limited to children receiving the complete 3-dose vaccination series. Results The median AS for tetanus serology among the entire sample of 833 children was 0.085, while children with history of measles had a median AS of 0.053 (N = 41) and children with no history of measles had a median AS of 0.088 (N = 792), chi-square P-value < 0.05. A random intercept logistic regression model was used to examine the association between previous measles disease and odds of having below median levels of tetanus antibody. Controlling for potential confounding variables, the odds of a child with past history of measles having less than the median level of tetanus antibody was 3.86 (95% CI: 1.70, 8.78) among children fully vaccinated for tetanus. Conclusion The results suggest that, among children 6–59 months in DRC, measles may have a long-term impact on levels of pre-existing, vaccine-induced immunity to tetanus. These findings suggest the need for laboratory studies examining measles’ impact on pre-existing, vaccine-induced immunity and underscore the need for continued evaluation and improvement of DRC’s measles vaccination program. Disclosures All authors: No reported disclosures.


2017 ◽  
Vol 92 ◽  
pp. 47-68
Author(s):  
Reuben Loffman

AbstractThe arrival of Belgian rule in the late nineteenth century initiated significant changes in the labor history of Tanganyika, a province in the southeastern Democratic Republic of the Congo (DRC), as well the discursive regimes used to legitimize these transformations. After the colonial conquests, unfree labor was justified by paternalistic rather than mythical discourses. Although unfree labor was less common in the postcolonial period, the state forced farmers to sell crops at low prices and build roads for no remuneration. In the Cold War context, the language and practice of developmentalism mediated the coercive practices of the independent Congolese state (known as Zaïre, 1971–1997). The floundering Zaïrian government expanded its presence in Tanganyika due to its partnership with USAID. USAID's rhetoric and practice was influenced by a “bottom up” approach to agricultural production, but the cuts to its funding in the 1980s meant it struggled to soften Mobutu's coercive administration.


2009 ◽  
Vol 5 (4S_Part_13) ◽  
pp. P387-P388
Author(s):  
Ranjan Duara ◽  
Warren W. Barker ◽  
Elizabeth Potter ◽  
Jason Appel ◽  
Nisha Bhatia ◽  
...  

2009 ◽  
Vol 30 (6) ◽  
pp. 596-599 ◽  
Author(s):  
Patricia Pavese ◽  
Nathalie Saurel ◽  
José Labarère ◽  
Corinne Decouchon ◽  
Jean-Philippe Vittoz ◽  
...  

In this controlled before-and-after study involving 19 departments in a university-affiliated hospital, a single 1-hour educational session delivered by an infectious diseases physician reduced the use of inappropriate antibiotic therapy for inpatients with positive urine culture Results. Further study is warranted to assess the long-term effect of this intervention.


Author(s):  
Cathy Whitlock

The Paleoecologic recod provides unique insights into the response of communities to environmental perturbations of different duration and intensity. Climate is a primary agent of environmental change and its long-term effect on the vegetation of the Yellowstone/Grand Teton region is revealed in a network of pollen records (Whitlock, 1993). Fire frequency is controlled by climate, and as climate changes so too does the importance of fire in shaping spatial patterns of vegetation. The prehistoric record of Yellowstone's Northern Range, for example, shows the response of vegetation to the absence of major fires in the last 150 years (Whitlock et al., 1991; Engstrom et al., 1991). In longer records spanning the last 14,000 years, periods of frequent fire are suggested by sediments containing high percentages of fire-adapted trees, including lodgepole pine and Douglas-fir, and high amounts of charcoal (Bamosky et al., 1987; Millspaugh and Whitlock, 1993; Whitlock, 1993). The primary research objective has been to study the vegetational history of Yellowstone and its sensitivity to hanges in climate and fire frequency. This information is necessary to understand better the relative effects of climate, natural disturbance, and human perturbation on the Yellowstone landscape. Fossil pollen and plant macrofossils from dated-lake sediment cores provide information on past vegetation and climate. The frequency of charcoal particles and other fire indicators in dated lake-sediment cores offer evidence of past fires.


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