Psychosocial Issues Related to Liquid Biopsy for ctDNA in Individuals at Normal and Elevated Risk

2021 ◽  
pp. 116-118
Author(s):  
Jada G. Hamilton ◽  
Amanda Watsula-Morley ◽  
Alicia Latham
Keyword(s):  
Liquid Biopsy ◽  
Negative Impact ◽  
Medical Application ◽  
Circulating Tumor Dna ◽  
Elevated Risk ◽  
Great Promise ◽  
Disease Outcomes ◽  
Incidental Discovery ◽  
Risk Of Cancer

The use of a liquid biopsy through analysis of circulating tumor DNA, or ctDNA, has received much attention as a potential diagnostic and prognostic tool in oncology. This chapter provides an overview of the medical application of liquid biopsy for ctDNA in individuals at normal and elevated risk of cancer. We discuss the psychosocial implications of ctDNA assays, including the incidental discovery of germline variants, the possibility of increased anxiety and uncertainty, and the potential for negative impact on quality of life. We conclude that although ctDNA shows great promise in improving disease outcomes among patients affected by cancer, further research is needed to establish the clinical validity and clinical utility of ctDNA assays. Additionally, psychosocial outcomes should be included in the balance of risks and benefits of these tests.

scholarly journals Clinical utility of liquid biopsy for the diagnosis and monitoring of EML4-ALK NSCLC patients

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Estela Sánchez-Herrero ◽  
Mariano Provencio ◽  
Atocha Romero
Keyword(s):  
Quality Of Life ◽  
Liquid Biopsy ◽  
Molecular Profiling ◽  
Circulating Tumor Dna ◽  
Content Type ◽  
Anaplastic Lymphoma ◽  
Non Invasive ◽  
Available Technology ◽  
Nsclc Patients

AbstractBackgroundGenomic rearrangement in anaplastic lymphoma kinase (ALK) gene occurs in 3−7% of patients with non-small-cell lung cancer (NSCLC). The detection of this alteration is crucial as ALK positive NSCLC patients benefit from ALK inhibitors, which improve both the patient's quality of life and overall survival (OS) compared to traditional chemotherapy.ContentIn routine clinical practice, ALK rearrangements are detected using tissue biopsy. Nevertheless, the availability of tumor tissue is compromised in NSCLC patients due to surgical complications or difficult access to the cancer lesion. In addition, DNA quality and heterogeneity may impair tumor biopsies testing. These limitations can be overcome by liquid biopsy, which refers to non-invasive approaches for tumor molecular profiling. In this paper we review currently available technology for non-invasive ALK testing, in NSCLC patients, based on the analysis of circulating tumor DNA (ctDNA), circulating tumor RNA (ctRNA), circulating tumor cells (CTCs), tumor-educated platelets (TEPs) and extracellular vesicles (EVs) such as exosomes.Summary and outlookNon-invasive tumor molecular profiling is crucial to improve outcomes and quality of life of NSCLC patients whose tumors harbor a translocation involving ALK locus.

scholarly journals Liquid Biopsy, ctDNA Diagnosis through NGS

Life ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 890
Author(s):  
Chen Lin ◽  
Xuzhu Liu ◽  
Bingyi Zheng ◽  
Rongqin Ke ◽  
Chi-Meng Tzeng
Keyword(s):  
Next Generation Sequencing ◽  
Cancer Diagnosis ◽  
Liquid Biopsy ◽  
Sampling Bias ◽  
Circulating Tumor Dna ◽  
Genetic Alterations ◽  
Great Promise ◽  
Next Generation ◽  
Minimal Invasion ◽  
Generation Sequencing

Liquid biopsy with circulating tumor DNA (ctDNA) profiling by next-generation sequencing holds great promise to revolutionize clinical oncology. It relies on the basis that ctDNA represents the real-time status of the tumor genome which contains information of genetic alterations. Compared to tissue biopsy, liquid biopsy possesses great advantages such as a less demanding procedure, minimal invasion, ease of frequent sampling, and less sampling bias. Next-generation sequencing (NGS) methods have come to a point that both the cost and performance are suitable for clinical diagnosis. Thus, profiling ctDNA by NGS technologies is becoming more and more popular since it can be applied in the whole process of cancer diagnosis and management. Further developments of liquid biopsy ctDNA testing will be beneficial for cancer patients, paving the way for precision medicine. In conclusion, profiling ctDNA with NGS for cancer diagnosis is both biologically sound and technically convenient.

Green Beans Cultivation Using Mice Pets Control to Improve the Quality of Bintaro Fruit Extract

2018 ◽  
Vol 1 (1) ◽  
pp. 38
Author(s):  
Ajeng Embri Legawati ◽  
Nur Azizah ◽  
Achmad Ramadhan
Keyword(s):  
Natural Resources ◽  
Negative Impact ◽  
Green Beans ◽  
Fruit Extract ◽  
Bean Plants ◽  
Cultivation Technology ◽  
Environmental Balance ◽  
The Impact ◽  
Chemical Pesticides

Green beans cultivation technology using mice pets control has been implemented in the Gluranploso village, Benjeng Gresik. The implementation of the technology performed for 2.5 months from August to October 2017. The purpose of the implementation is aimed to reduce the dependence of farmers on the use of chemical pesticides so that the farmers are aware of the negative impact of chemical pesticides. Assessing the impact of the utilization of Bintaro fruit and fruit extracts to explore ways of making Bintaro as a natural biopesticide to overcome rat attack on green bean plants in the Gluranploso village. Pest control mice can reduce the rate of loss of the crops more effectively and efficiently. Finally, with the use of those natural resources as a biopesticide material can also maintain the environmental balance

CHRONOBIOLOGICAL AND PSYCHOEMOTIONAL STATUS IN WOMEN WITH CHRONIC RECURRENT BACTERIAL CYSTITIS AND CARBOHYDRATE METABOLISM DISORDER

2020 ◽  
pp. 56-59
Author(s):  
Мария Николаевна Химичева ◽  
Андрей Владимирович Кузьменко ◽  
Владимир Васильевич Кузьменко ◽  
Тимур Асланбекович Гяургиев
Keyword(s):  
Chronic Disease ◽  
Carbohydrate Metabolism ◽  
Negative Impact ◽  
High Risk Group ◽  
Chronic Complications ◽  
Course Of Disease ◽  
Metabolism Disorder ◽  
Common Group ◽  
Tract Infections

Инфекции мочевых путей - наиболее распространённая группа заболеваний в практике врача уролога. Один из представителей является хронический рецидивирующий бактериальный цистит. Данное заболевание встречается во всех возрастных категориях и затрагивает все сферы жизни пациентов. Симптомы, возникающие при обострении хронического бактериального цистита, оказывают негативное влияние на качество жизни, что может приводить к нарушению психоэмоционального состояния больных. Отдельную группу высокого риска в отношении ИНМП составляют пациенты с нарушением углеводного обмена, у которых риск развития различных инфекций выше, чем у людей без подобных нарушений. К факторам, повышающим риск развития ИНМП у больных с нарушением углеводного обмена, относят возраст, компенсацию и наличие хронических осложнений, в первую очередь нефропатии и цистопатии. Человеческий организм функционирует циклически в соответствии с определенными индивидуальными ритмами. Любое хроническое заболевание приводит к рассогласованию процессов, протекающих в различных системах организма, вызывая развитие десинхроноза. Наличие у человека более 1 хронического заболевания утяжеляет течение болезни и приводит к снижению восстановительных способностей организма и сокращению его адаптационного потенциала Urinary tract Infections are the most common group of diseases in the practice of a urologist. One of the representatives is chronic recurrent bacterial cystitis. This disease occurs in all age categories and affects all areas of life of patients. Symptoms that occur with the exacerbation of chronic bacterial cystitis have a negative impact on the quality of life, which can lead to a violation of the psychoemotional state of patients. A separate high-risk group for INMP is patients with impaired carbohydrate metabolism, who have a higher risk of developing various infections than people without such disorders. Factors that increase the risk of developing INMP in patients with impaired carbohydrate metabolism include age, compensation, and the presence of chronic complications, primarily nephropathy and cystopathy. The human body functions cyclically in accordance with certain individual rhythms. Any chronic disease leads to misalignment of the processes occurring in various body systems, causing the development of DS, the Presence of more than 1 chronic disease complicates the course of disease and leads to a decrease in regenerative abilities of the organism and reduce its adaptive capacity

Modern challenges of border areas development in the context of decentralization reform

2019 ◽  
pp. 79-89
Author(s):  
Khrystyna Prytula ◽  
Yaroslava Kalat ◽  
Iryna Kyryk
Keyword(s):  
Ethnic Minorities ◽  
Negative Impact ◽  
Local Development ◽  
Economic Security ◽  
Uneven Development ◽  
Scientific Article ◽  
Border Regions ◽  
Border Areas ◽  
Decentralization Reform

An integral part of the implementation of any reform is the emergence of the risks of its negative impact on one or another area of region development. The decentralization reform in Ukraine is not an exception. In its the context the most probable occurrence of negative phenomena is in the border regions, which could be prevented by first detecting them. In the scientific article, the authors focus on the analysis of a number of challenges for the development of border regions in the context of decentralization reform. Given the territorial remoteness of the central regions of the country and the capital, which today serve as areas of concentration of investment and economic activity, the border regions traditionally (this is typical for the border areas of the EU member states) lag behind the rest of the regions by the main socio-economic indicators of development. Among the main challenges facing the border regions of Ukraine today are the following: the provision of competitiveness in the context of European integration processes and reduction of the border barrier function; low level of economic security; the outflow of human capital and the issue of ethnic minorities. Based on an expert survey of representatives of the fifteen united territorial communities (UTCs), the possibility of such risks of decentralization in the border regions were defined as following: groundless use of local budget funds; emergence of significant imbalances between delegated new authority and available financial resources of the community; increasing uneven development of territories within the community; increasing uneven development of communities within the country; deterioration of the availability and quality of providing educational and medical services; deterioration of the quality of local government; reducing of the state influence on the management of local development processes; radicalization of political unions representing the interests of ethnic minorities in places of their compact residence; further economic decline of the territory of communities and so on.

Perianal Hyperhidrosis Successfully Treated with Botulinum Toxin A

2021 ◽  
pp. 1-4
Author(s):  
Leandra Reguero del Cura ◽  
Marta Drake Monfort ◽  
Adrian De Quintana Sancho ◽  
Marcos Antonio González López
Keyword(s):  
Botulinum Toxin ◽  
Negative Impact ◽  
Botulinum Toxin A ◽  
Psychosocial Burden ◽  
Toxin A ◽  
Rare Form ◽  
Good Safety Profile ◽  
Degree Of Satisfaction ◽  
Botulinum Toxin Injections

Perianal hyperhidrosis (HH) is a rare form of primary focal HH and may become a major problem for the patient with a significant psychosocial burden and negative impact on the quality of life. Botulinum toxin injections are widely used as a second-line treatment option for axillary, palmar, and plantar HH with a good safety profile. Herein, we pre­sent a case of primary perianal HH successfully treated with Botulinum toxin A at a dose higher than that previously reported in literature, with a longer response, a higher degree of satisfaction, and no adverse effects. Moreover, we review the main aspects of the perianal anatomy that are essential to carry out the technique correctly and make dermatologists achieve expertise with the procedure.

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