CHRONOBIOLOGICAL AND PSYCHOEMOTIONAL STATUS IN WOMEN WITH CHRONIC RECURRENT BACTERIAL CYSTITIS AND CARBOHYDRATE METABOLISM DISORDER

Author(s):  
Мария Николаевна Химичева ◽  
Андрей Владимирович Кузьменко ◽  
Владимир Васильевич Кузьменко ◽  
Тимур Асланбекович Гяургиев

Инфекции мочевых путей - наиболее распространённая группа заболеваний в практике врача уролога. Один из представителей является хронический рецидивирующий бактериальный цистит. Данное заболевание встречается во всех возрастных категориях и затрагивает все сферы жизни пациентов. Симптомы, возникающие при обострении хронического бактериального цистита, оказывают негативное влияние на качество жизни, что может приводить к нарушению психоэмоционального состояния больных. Отдельную группу высокого риска в отношении ИНМП составляют пациенты с нарушением углеводного обмена, у которых риск развития различных инфекций выше, чем у людей без подобных нарушений. К факторам, повышающим риск развития ИНМП у больных с нарушением углеводного обмена, относят возраст, компенсацию и наличие хронических осложнений, в первую очередь нефропатии и цистопатии. Человеческий организм функционирует циклически в соответствии с определенными индивидуальными ритмами. Любое хроническое заболевание приводит к рассогласованию процессов, протекающих в различных системах организма, вызывая развитие десинхроноза. Наличие у человека более 1 хронического заболевания утяжеляет течение болезни и приводит к снижению восстановительных способностей организма и сокращению его адаптационного потенциала Urinary tract Infections are the most common group of diseases in the practice of a urologist. One of the representatives is chronic recurrent bacterial cystitis. This disease occurs in all age categories and affects all areas of life of patients. Symptoms that occur with the exacerbation of chronic bacterial cystitis have a negative impact on the quality of life, which can lead to a violation of the psychoemotional state of patients. A separate high-risk group for INMP is patients with impaired carbohydrate metabolism, who have a higher risk of developing various infections than people without such disorders. Factors that increase the risk of developing INMP in patients with impaired carbohydrate metabolism include age, compensation, and the presence of chronic complications, primarily nephropathy and cystopathy. The human body functions cyclically in accordance with certain individual rhythms. Any chronic disease leads to misalignment of the processes occurring in various body systems, causing the development of DS, the Presence of more than 1 chronic disease complicates the course of disease and leads to a decrease in regenerative abilities of the organism and reduce its adaptive capacity

Author(s):  
Barbara Gryglewska ◽  
Karolina Piotrowicz ◽  
Tomasz Grodzicki

Multimorbidity is defined as any combination of a chronic disease with at least one other acute or chronic disease or biopsychosocial or somatic risk factor. Old age is a leading risk factor for multimorbidity. It has a negative impact on short- and long-term prognosis, patients’ cognitive and functional performance, self-care, independence, and quality of life. It substantially influences patients’ clinical management and increases healthcare-related costs. There is a great variety of clinical measures to assess multimorbidity; some are presented in this chapter. Despite its high prevalence in older adults, clinical guidelines for physicians managing patients with multimorbidity are underdeveloped and insufficient.


2011 ◽  
Vol 23 (1) ◽  
pp. 102-116
Author(s):  
Ralph-Michael Karrasch ◽  
Monika Reichert

This study shows that caregiving for a spouse with a chronic disease or disability can be a difficult task in many ways and can have a negative impact (e.g. lack of intimacity, sexual problems) on the quality of the relationship between the couple. With regard to sexual problems, for example, insufficient ways to handle sexual dysfunction of the (male) partner, the avoidance of talking about sexuality, a misleading perception of each other’s sexual needs and jealousy can be experienced as especially burdensome. As a consequence, very often caregivers and care receivers report a lower marital satisfaction compared to the time before the caregiving situation set in. In order to reduce the negative impact caregiving may have on the partnership, changes in everyday life and in the relationship have to be accepted and, adequate coping strategies have to be used or learned, respectively (e.g. improvement of verbal communication skills). Zusammenfassung: Diese Studie zeigt, dass die Pflege eines Partners mit chronischer Erkrankung oder Einschränkung in vielerlei Hinsicht eine schwierige Aufgabe darstellt und negative Auswirkungen – wie einen Mangel an Zärtlichkeit oder sexuelle Probleme – auf die Partnerschaftsqualität haben kann. In Hinblick auf sexuelle Probleme können unzureichende Wege mit sexueller Dysfunktion des (männlichen) Partners umzugehen, das Vermeiden von Gesprächen über Sexualität, eine irreführende Wahrnehmung der gegenseitigen sexuellen Bedürfnisse und Eifersucht als besonders belastend erlebt werden. Als Folge berichten Pflegende und Gepflegte über eine geringere Zufriedenheit mit der Partnerschaft als in der Zeit, bevor die Pflegesituation auftrat. Um die möglichen negativen Auswirkungen einer Pflegesituation auf die Partnerschaft zu verringern, müssen Veränderungen im alltäglichen Leben und in der Partnerschaft besser angenommen und adäquate Bewältigungsstrategien wie z.B. eine Verbesserung der verbalen Kommunikation genutzt bzw. erlernt werden.


Author(s):  
Agatha Mary John ◽  
Angitha Saji ◽  
Krupa Ann Sunil ◽  
Abel Abraham Thomas ◽  
Abhilash B. Kumar

Background: The poor knowledge and understanding of menstruation may lead to unsafe hygienic practice that in turn increases the risk of reproductive and genito-urinary tract infections and leads to overall poor quality of life. The food we consume have a complementary relationship with the pattern of menstrual cycle and so is the involvement of exercises. The study focused on understanding the relationship between effect of diet, exercise and other contributing factors on menstruation.Methods: The study was a prospective observational study done with a sample size of 650 subjects of 9 to 18 age group in whom menstruation already occurred who were recruited from five different schools in regions of Pathanamthitta and Alappuzha.Results: It was found that lack of exercise before and during menstruation has caused increased cramps and mood instability in girls. As well as skipping of breakfast and consumption of junk food was found to elevate pain, eventually affecting daily activities.Conclusions: The importance of counselling to all girls from the age of 9 was found to be necessary through the study and thereby adequate changes for a healthy future. Lack of exercise, unhealthy food habits and delayed identification of menstrual problems can have a negative impact on health.


2020 ◽  
Vol 99 (11) ◽  
pp. 1263-1270
Author(s):  
Konstantin P. Luzhetskiy ◽  
Vladimir M. Chigvintsev ◽  
Svetlana A. Vekovshinina ◽  
Alexandra Yu. Vandysheva ◽  
Daria A. Eisfeld

Introduction. The authors performed a hygienic and epidemiological study of the Perm Territory areas with unfavorable sanitary and hygienic indices. Material and methods. The study involved 7,775 children aged from 4 to 14 years (9.2 ± 3.7 years) living in territories using sodium hypochlorite or liquid chlorine (Perm, Krasnokamsky, Nytvensky districts). The comparison group consisted of 425 children (average age 9.3 ± 2.5 years) consuming drinking water that complies with hygienic standards (Sivinsky, Karagai districts). Results. Identified areas with low quality of drinking water supply due to the content of organochlorine compounds (OCS) appeared to have an increased prevalence of obesity, diabetes, ischemic, and hypertensive disease. The authors developed and tested the critical assessment of the risk of formation disorders of fat and carbohydrate metabolism in children consuming drinking water with a high content of organochlorine compounds. Under conditions of oral exposure to OCS (0.43-0.64 mg / l, more than 3 MPC), the index of the risk of impaired fat and carbohydrate metabolism in children (IPI 0.55) was 1.3 times higher than the corresponding levels in the territory of comparison (IPI 0,42). Conclusion. The main markers for the indices of the negative impact of HOS (primarily chloroform) include an increase in the blood level of triglycerides (PS 0.41), LDL (PS 0.25) and a decrease in HDL (PS 0.18), exceeding 1, 2-1.6 times the territory of comparison.


BMJ Open ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. e037128
Author(s):  
Marloes Franssen ◽  
Johanna Cook ◽  
Jared Robinson ◽  
Nicola Williams ◽  
Margaret Glogowska ◽  
...  

IntroductionRecurrent urinary tract infections (RUTIs) have a significant negative impact on quality of life and healthcare costs. To date, daily prophylactic antibiotics are the only treatment which have been shown to help prevent RUTIs. D-mannose is a type of sugar which is believed to inhibit bacterial adherence to uroepithelial cells, and is already being used by some women in an attempt to prevent RUTIs. There is currently insufficient rigorous evidence on which to base decisions about its use. The D-mannose to prevent recurrent urinary tract infections (MERIT) study will evaluate whether D-mannose is clinically and cost-effective in reducing frequency of infection and symptom burden for women presenting to UK primary care with RUTI.Methods and analysisMERIT will be a two-arm, individually randomised, double blind placebo controlled, pragmatic trial. Participants will be randomised to take D-mannose powder or placebo powder daily for 6 months. The primary outcome will be the number of medical attendances attributable to symptoms of RUTI. With 508 participants we will have 90% power to detect a 50% reduction in the chance of a further clinically suspected UTI, assuming 20% lost to follow-up. Secondary outcomes will include: number of days of moderately bad symptoms of UTI; time to next consultation; number of clinically suspected UTIs; number of microbiologically proven UTIs; number of antibiotic courses for UTI; quality of life and healthcare utilisation related to UTI. A within trial economic evaluation will be conducted to examine cost-effectiveness of D-mannose in comparison with placebo. A nested qualitative study will explore participants’ experiences and perceptions of recruitment to, and participation in a study requiring a daily treatment.Ethics and disseminationEthical approval has been obtained from South West-Central Bristol Research Ethics Committee. Publication of the MERIT study is anticipated to occur in 2021.Trial registration numberISRCTN 13283516.


Author(s):  
Hanan Al-Juaid ◽  
Aljwharah AlJuaid ◽  
Walaa Abuharba ◽  
Ayman Abouhamda

Background: Nocturnal cough is a common disturbing symptom that affects children during upper respiratory tract infections and can have a major negative impact on child and parents’ sleep quality. Many pharmaceutical medications, herbal regimens, and non-pharmaceutical advice are prescribed to reduce nocturnal cough.  The aim of this research was to study the impact of honey on nocturnal cough in children.Methods: A descriptive study was conducted on 226 children in Taif city, KSA using a pre-prepared questionnaire to assess the cough severity and response to honey in comparison to other treatment modalities.  Data collected were then analyzed using SPSS software.Results: The study was conducted on 226 children (51.77% were females). Children who used honey were significantly older (mean age 7.64±3.8 years) than those who used medications (mean age 6.98±60) (p=0.025). Children who used honey had a higher prevalence of headache (p=0.001) and malaise (p<0.001) than children who did not receive honey. The use of honey was also significantly associated with high cough severity scores. The use of honey seemed to significantly reduce both the cough severity score and combined severity scores, with odd’s ratios of 0.46 and 0.19, respectively (p=0.020 and <0.001). However, it was associated with fewer satisfaction rates and fewer intentions to re-use in next attacks (p=0.025).Conclusions: Honey has a beneficial effect on treating nocturnal cough in children. It decreases the severity of cough as well as the frequency of cough. It is commonly used among older Saudi children who have cough associated with malaise and fever. However, it is not satisfactory for patient and parental relief in Taif city because it doesn’t improve the sleep quality of patients or parents. 


2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
J. Prata ◽  
S. Ramos ◽  
F. Rocha-Gonçalves ◽  
R. Coelho

Background:Acute coronary syndromes (ACS) are a major cause of morbidity and mortality in western industrialized countries and account for disability and loss of productivity. Type D personality and depression are established psychosocial factors with a negative impact on prognosis following acute events.Methods:We evaluated 65 patients admitted to a coronary unit with ACS regarding type D personality (DS-14), depression (BDI-II, HADS), anxiety (HADS), clinical depression (clinical interview following DSM-IV-TR criteria) and quality of life (SF-36). SPSS 12.0 was used for statistical analysis and significance considered for p< 0.05.Results:We found that 38.5% of patients had type D personality and divided the sample into two groups. No significant differences were found regarding social and demographic factors but differences were found regarding diagnosis on admission: type D patients had more AMI with ST elevation (p< 0.05). Type D patients had significantly higher scores in depression and anxiety scales of the HADS (p< 0.01) and worse quality of life in most SF-36 subscales (p< 0.01). There was a negative and significant correlation between the HADS and all the SF-36 subscales, strongest in the mental health subscale (p< 0.01).Conclusions:Type D patients have higher indices of anxiety and depression and worse quality of life when compared with other patients, and constitute a high risk group of worse prognosis. Our results also suggest differences between groups regarding the type of acute event but these results require further confirmation.


VASA ◽  
2011 ◽  
Vol 40 (2) ◽  
pp. 123-130
Author(s):  
Klein-Weigel ◽  
Richter ◽  
Arendt ◽  
Gerdsen ◽  
Härtwig ◽  
...  

Background: We surveyed the quality of risk stratification politics and monitored the rate of entries to our company-wide protocol for venous thrombembolism (VTE) prophylaxis in order to identify safety concerns. Patients and methods: Audit in 464 medical and surgical patients to evaluate quality of VTE prophylaxis. Results: Patients were classified as low 146 (31 %), medium 101 (22 %), and high risk cases 217 (47 %). Of these 262 (56.5 %) were treated according to their risk status and in accordance with our protocol, while 9 more patients were treated according to their risk status but off-protocol. Overtreatment was identified in 73 (15.7 %), undertreatment in 120 (25,9 %) of all patients. The rate of incorrect prophylaxis was significantly different between the risk categories, with more patients of the high-risk group receiving inadequate medical prophylaxis (data not shown; p = 0.038). Renal function was analyzed in 392 (84.5 %) patients. In those patients with known renal function 26 (6.6 %) received improper medical prophylaxis. If cases were added in whom prophylaxis was started without previous creatinine control, renal function was not correctly taken into account in 49 (10.6 %) of all patients. Moreover, deterioration of renal function was not excluded within one week in 78 patients (16.8 %) and blood count was not re-checked in 45 (9.7 %) of all patients after one week. There were more overtreatments in surgical (n = 53/278) and more undertreatments in medical patients (n = 54/186) (p = 0.04). Surgeons neglected renal function and blood controls significantly more often than medical doctors (p-values for both < 0.05). Conclusions: We found a low adherence with our protocol and substantial over- and undertreatment in VTE prophylaxis. Besides, we identified disregarding of renal function and safety laboratory examinations as additional safety concerns. To identify safety problems associated with medical VTE prophylaxis and “hot spots” quality management-audits proved to be valuable instruments.


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