Seizures and Epilepsy in Preterm and Term Neonates, Infants, Children, and Adolescents

2017 ◽  
Author(s):  
Jules C. Beal ◽  
Monika Eisermann ◽  
Sunita Misra ◽  
Phillip L. Pearl ◽  
Perrine Plouin ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Adult Population ◽  
Juvenile Myoclonic Epilepsy ◽  
Myoclonic Epilepsy ◽  
Age Group ◽  
Eeg Monitoring ◽  
Term Neonates ◽  
Seizure Semiology ◽  
Genetic Abnormalities

Children are often affected by seizure types and epilepsy syndromes that are specific to their age group and distinct from those seen in adults. At the same time, certain epilepsy syndromes affecting the adult population, such as Lennox–Gastaut syndrome and juvenile myoclonic epilepsy, often begin during childhood, as do seizures related to genetic abnormalities. The use of electroencephalography (EEG) and prolonged EEG monitoring has allowed for further insight and greater specificity in identifying and understanding seizures and epilepsy syndromes in children. This chapter reviews the role of EEG in pediatric seizures and the pediatric epilepsies, including electrographic findings in the ictal state and in the interictal period, as well as the correlation with clinical seizure semiology as it contributes to the diagnosis of epileptic phenomena. The chapter discusses EEG patterns, seizure types, and epilepsy syndromes specific to neonates, infants, children, and adolescents.

scholarly journals The role of intestinal cell kinase in interneurons, a protein mutated in Juvenile Myoclonic Epilepsy

2018 ◽  
Vol 12 ◽  
Author(s):  
Maxime Gilsoul ◽  
Laurence De Nijs ◽  
Bernard Lakaye
Keyword(s):  
Juvenile Myoclonic Epilepsy ◽  
Myoclonic Epilepsy ◽  
Intestinal Cell ◽  
Intestinal Cell Kinase

scholarly journals GABAergic Neuron Deficit As An Idiopathic Generalized Epilepsy Mechanism: The Role Of BRD2 Haploinsufficiency In Juvenile Myoclonic Epilepsy

PLoS ONE ◽  
2011 ◽  
Vol 6 (8) ◽  
pp. e23656 ◽  
Author(s):  
Libor Velíšek ◽  
Enyuan Shang ◽  
Jana Velíšková ◽  
Tamar Chachua ◽  
Stephania Macchiarulo ◽  
...  
Keyword(s):  
Juvenile Myoclonic Epilepsy ◽  
Myoclonic Epilepsy ◽  
Gabaergic Neuron ◽  
Idiopathic Generalized Epilepsy ◽  
Generalized Epilepsy

scholarly journals Immunopathogenesis and Treatment of Rheumatoid Arthritis: Recent Developments

2015 ◽  
Vol 7 (2) ◽  
pp. 62-67
Author(s):  
ASM Giasuddin ◽  
KA Jhuma ◽  
AMM Haq ◽  
MM Haque
Keyword(s):  
Rheumatoid Arthritis ◽  
Adult Population ◽  
Chronic Inflammatory Disease ◽  
Age Group ◽  
T Helper ◽  
T Helper Lymphocytes ◽  
Th17 Lymphocytes ◽  
Recent Developments ◽  
Cytokine Cascade

Rheumatoid arthritis (RA) is a chronic inflammatory disease occurring three times more in females throughout the world affecting 1-2% of the adult population in all ethnic groups, usually in the age group of 25-60 years. Although the role of CD4 + T helper lymphocytes in the aetiopathogenesis has been studied for more than three decades, the focus on CD4 + T helper type 17 (Th17) lymphocytes and its associated cytokines is much more recent. The cytokines such as IL-17 and IFN-g induce secondary cytokines such as IL-1, TNF-a , etc which possibly cause inflammation in joints. This cytokine cascade, therefore, offers a number of points and opportunities for immunointervention in RA. The present review article highlights some of the major aspects of the immunopathogenesis that involve Th17 cells and their association relevant to recent developments in the treatment of RA. DOI: http://dx.doi.org/10.3329/bjmb.v7i2.22415 Bangladesh J Med Biochem 2014; 7(2): 62-67

Aberrant Thalamocortical Connectivity in Juvenile Myoclonic Epilepsy

2017 ◽  
Vol 28 (01) ◽  
pp. 1750034 ◽  
Author(s):  
S. Jiang ◽  
C. Luo ◽  
J. Gong ◽  
R. Peng ◽  
S. Ma ◽  
...  
Keyword(s):  
Diffusion Tensor ◽  
Network Connectivity ◽  
Epileptic Activity ◽  
Juvenile Myoclonic Epilepsy ◽  
Myoclonic Epilepsy ◽  
Healthy Controls ◽  
Posterior Thalamus ◽  
Duration Of Disease ◽  
Subcortical Nuclei

The purpose of this study was to investigate the functional connectivity (FC) of thalamic subdivisions in patients with juvenile myoclonic epilepsy (JME). Resting state functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) data were acquired from 22 JME and 25 healthy controls. We first divided the thalamus into eight subdivisions by performing independent component analysis on tracking fibers and clustering thalamus-related FC maps. We then analyzed abnormal FC in each subdivision in JME compared with healthy controls, and we investigated their associations with clinical features. Eight thalamic sub-regions identified in the current study showed unbalanced thalamic FC in JME: decreased FC with the superior frontal gyrus and enhanced FC with the supplementary motor area in the posterior thalamus increased thalamic FC with the salience network (SN) and reduced FC with the default mode network (DMN). Abnormalities in thalamo-prefrontocortical networks might be related to the propagation of generalized spikes with frontocentral predominance in JME, and the network connectivity differences with the SN and DMN might be implicated in emotional and cognitive defects in JME. JME was also associated with enhanced FC among thalamic sub-regions and with the basal ganglia and cerebellum, suggesting the regulatory role of subcortical nuclei and the cerebellum on the thalamo-cortical circuit. Additionally, increased FC with the pallidum was positive related with the duration of disease. The present study provides emerging evidence of FC to understand that specific thalamic subdivisions contribute to the abnormalities of thalamic-cortical networks in JME. Moreover, the posterior thalamus could play a crucial role in generalized epileptic activity in JME.

scholarly journals Participation and Performance Analysis in Children and Adolescents Competing in Time-Limited Ultra-Endurance Running Events

2020 ◽  
Vol 17 (5) ◽  
pp. 1628 ◽  
Author(s):  
Volker Scheer ◽  
Stefania Di Gangi ◽  
Elias Villiger ◽  
Thomas Rosemann ◽  
Pantelis T. Nikolaidis ◽  
...  
Keyword(s):  
Performance Analysis ◽  
North America ◽  
Children And Adolescents ◽  
Adult Population ◽  
Age Group ◽  
Endurance Running ◽  
Performance Trends ◽  
Overall Performance ◽  
And Performance ◽  
Ultra Endurance

Ultra-endurance running is of increasing popularity in the adult population, mainly due to master runners older than 35 years of age. However, youth runners younger than 19 years of age are also competing in ultra-endurance events, and an increase has been observed in distance-limited events, but no data is available on time-limited ultra-endurance events in this age group. This study investigated participation and performance trends in time-limited ultra-endurance races, including multi-day events, in runners younger than 19 years of age. Between the period 1990 and 2018, the most popular events recorded a total of 214 finishes (from 166 unique finishers (UF)) for 6-h events, 247 (212 UF) for 12-h events, and 805 (582 UF) for 24-h events, respectively. The majority of athletes originated from Europe and North America. Only a minority participated in multi-day events. Overall, speed increased with age, but the overall performance speed decreased across calendar years for 6- and 24-h events as participation numbers grew. In summary, in youth ultra-endurance runners, differences were observed regarding participation and performance across the different time-limited events, the age of the athletes and their country of origin

The unexpected role of copy number variations in juvenile myoclonic epilepsy

2013 ◽  
Vol 28 ◽  
pp. S66-S68 ◽  
Author(s):  
Ingo Helbig ◽  
Corinna Hartmann ◽  
Heather C. Mefford
Keyword(s):  
Copy Number ◽  
Juvenile Myoclonic Epilepsy ◽  
Copy Number Variations ◽  
Myoclonic Epilepsy

scholarly journals Lantus, the first peakless basal insulin analogue: 10 years of clinical experience in children and adolescents

2014 ◽  
Vol 17 (2) ◽  
pp. 105-115
Author(s):  
Tamara Leonidovna Kuraeva
Keyword(s):  
Glycemic Control ◽  
Children And Adolescents ◽  
Insulin Analogue ◽  
Vascular Complications ◽  
Clinical Use ◽  
Age Group ◽  
Safety And Efficacy ◽  
Glycemic Profile

This review analyses existing literature, including authors' own data, describing the results of clinical trials which assess safety and efficacy of insulin Glargine (Lantus?) in children and adolescents, as well as peculiar features of T1D management in this age group, including the challenge of reducing the rate of hypoglycemia while maintaining adequate glycemic control. The article also discusses various issues in T1D management in children and adolescents, including the role of glycemic control in development of vascular complications, hypoglycemia and the variability of glycemia. The data confirm the high efficacy of Lantus insulin in respect to metabolic control, including the decrease in the incidence of hypoglycemia and in variability of glycemic profile, the safety of its clinical use in treatment of children, including young children, and adolescents, as well as its ability to improve the quality of life for patients and their parents.

scholarly journals Role of Long Term Video-Electroencephalography Monitoring (VEM) in Diagnosis of Juvenile Myoclonic Epilepsy

2013 ◽  
Vol 1 (4) ◽  
pp. 5-8
Author(s):  
Hossein Amiri ◽  
Mehran Homam ◽  
Malihe Mohammadpour ◽  
Behnaz Razavi ◽  
Ham Ashraf ◽  
...  
Keyword(s):  
Juvenile Myoclonic Epilepsy ◽  
Myoclonic Epilepsy

scholarly journals Prognostic role of focal clinical findings and electroencephalographic features of patients with juvenile myoclonic epilepsy

2012 ◽  
Vol 18 (1) ◽  
pp. 19-25 ◽  
Author(s):  
Yasemin Bicer Gomceli ◽  
Gulnihal Kutlu ◽  
Beyhan Gonulal ◽  
Levent Ertugrul Inan
Keyword(s):  
Juvenile Myoclonic Epilepsy ◽  
Clinical Findings ◽  
Myoclonic Epilepsy ◽  
Prognostic Role
Sign in / Sign up

Export Citation Format

Share Document