Photosensitivity

2020 ◽  
pp. 5688-5694
Author(s):  
Hiva Fassihi ◽  
Jane McGregor
Keyword(s):  
Skin Cancer ◽  
Inflammatory Responses ◽  
Sun Exposure ◽  
Sunlight Exposure ◽  
Normal Human Skin ◽  
Non Melanoma Skin Cancer ◽  
Normal Individuals ◽  
Cutaneous Reactions ◽  
Skin Conditions ◽  
Photosensitivity Disorders

Normal human skin is photosensitive in that it reddens following acute sunlight exposure and tans and thickens following chronic sunlight exposure. Skin cancer, particularly non-melanoma skin cancer, is also a consequence of high cumulative sun exposure in genetically predisposed normal individuals (predominantly those with fair skin). Outside the range of normal photosensitivity, there are several conditions in which patients exhibit diverse abnormal cutaneous reactions to sunlight. These are broadly described together as the photosensitivity disorders, but in fact they comprise a very heterogeneous group of skin conditions. Abnormal cutaneous photosensitive responses range from easy sunburn (as in drug phototoxicity and the DNA repair photodermatoses) and pain (erythropoietic protoporphyria), through to complex inflammatory responses such as urticaria, eczema, or epidermal necrosis induced by specific wavelengths of sunlight, the so-called idiopathic photodermatoses.

Photosensitivity

2010 ◽  
pp. 4665-4671
Author(s):  
Jane McGregor
Keyword(s):  
Skin Cancer ◽  
Human Skin ◽  
Sun Exposure ◽  
Nonmelanoma Skin Cancer ◽  
Sunlight Exposure ◽  
Normal Human Skin ◽  
Normal Individuals ◽  
Normal Human ◽  
Fair Skin

Normal human skin is photosensitive in that it reddens following acute sunlight exposure and tans and thickens following chronic sunlight exposure. Skin cancer, particularly nonmelanoma skin cancer, is also a consequence of high cumulative sun exposure in genetically predisposed normal individuals (predominantly those with fair skin)....

scholarly journals Ultradeep sequencing differentiates patterns of skin clonal mutations associated with sun-exposure status and skin cancer burden

2021 ◽  
Vol 7 (1) ◽  
pp. eabd7703
Author(s):  
Lei Wei ◽  
Sean R. Christensen ◽  
Megan E. Fitzgerald ◽  
James Graham ◽  
Nicholas D. Hutson ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Cancer Risk ◽  
Normal Skin ◽  
Sun Exposure ◽  
Uv Exposure ◽  
Induced Mutations ◽  
Carcinogenic Effect ◽  
Normal Human Skin ◽  
Cancer Burden ◽  
Skin Cancer Risk

In ultraviolet (UV) radiation–exposed skin, mutations fuel clonal cell growth. The relationship between UV exposure and the accumulation of clonal mutations (CMs) and the correlation between CMs and skin cancer risk are largely unexplored. We characterized 450 individual-matched sun-exposed (SE) and non-SE (NE) normal human skin samples. The number and relative contribution of CMs were significantly different between SE and NE areas. Furthermore, we identified hotspots in TP53, NOTCH1, and GRM3 where mutations were significantly associated with UV exposure. In the normal skin from patients with cutaneous squamous cell carcinoma, we found that the cancer burden was associated with the UV-induced mutations, with the difference mostly conferred by the low-frequency CMs. These findings provide previously unknown information on UV’s carcinogenic effect and pave the road for future development of quantitative assessment of subclinical UV damage and skin cancer risk.

scholarly journals Vitamin D status and its relation with insulin resistance and VDR-FokI polymorphism in Iranian non-melanoma skin cancer (NMSC) patients: a case-control study

2019 ◽  
Author(s):  
Fatemeh Rezaiian ◽  
Sayed Hossein Davoodi ◽  
Bahareh Nikooyeh ◽  
Amir Houshang Ehsani ◽  
Ali Kalayi ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Vitamin D ◽  
Skin Cancer ◽  
Case Control Study ◽  
Sunlight Exposure ◽  
Vitamin D Status ◽  
Fasting Serum ◽  
Non Melanoma Skin Cancer ◽  
Control Study ◽  
Melanoma Skin

Abstract Background: Sunlight exposure, the main source of endogenous vitamin D synthesis, may increase the risk of non-melanoma skin cancer (NMSC) development. Vitamin D receptor (VDR) polymorphisms are associated with 25(OH)D levels, cancer development and insulin resistance. This study was aimed to examine the associations among vitamin D status, VDR FokI polymorphism, insulin resistance and NMSC. Methods: This case-control study included 73 diagnosed cases of NMSC and 72 healthy controls from dermatology clinics at Razi Hospital, Tehran, Iran. A questionnaire was used to assess sunlight exposure. The extracted DNA from whole blood samples were genotyped. Fasting serum 25-hydroxyvitaminD (25(OH)D)), lipid profile, glucose, and insulin were measured. To evaluate insulin resistance, HOMA-IR formula was used. Results: We found a significant higher duration of cumulative sunlight exposure in cases compared with controls (p<0.001). However, 25(OH)D concentrations were not significantly different between cases and controls (30±15 vs. 29±15 ng/mL, p=0.78). Higher levels of insulin (p = 0.004) and HOMA-IR score (p= 0.019) were observed in Ff and ff genotype of FokI. We did not observe any significant increased risk of NMSC due to f allele, as compared with FF (OR =2.33, 95% CI 0.81-6.75, p=0.12). The components of lipid profile, fasting serum glucose, iPTH and anthropometric measures did not differ significantly across VDR genotypes. Conclusion: In conclusion, sunlight exposure was associated with NMSC risk. VDR FokI polymorphisms appears to influence insulin resistance in the NMSC patients. Keywords: sun exposure; non-melanoma skin cancer; polymorphisms; insulin resistance

Burden of non-melanoma skin cancer attributable to occupational sun exposure in Canada

2019 ◽  
Vol 92 (8) ◽  
pp. 1151-1157 ◽  
Author(s):  
Cheryl E. Peters ◽  
J. Kim ◽  
C. Song ◽  
E. Heer ◽  
V. H. Arrandale ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Sun Exposure ◽  
Non Melanoma Skin Cancer ◽  
Melanoma Skin

scholarly journals Sternectomy for Treating Advanced Non-Melanoma Skin Cancer

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Victor Emmanuel Gadelha Pinheiro ◽  
Bianca Rohsner Bezerra ◽  
Luís Arthur Brasil Gadelha Farias ◽  
Irapuan Teles de Araujo Filho ◽  
Marcio Ribeiro Studart da Fonseca
Keyword(s):  
Skin Cancer ◽  
Survey Data ◽  
Medical Records ◽  
Clinical Course ◽  
Locally Advanced ◽  
Sunlight Exposure ◽  
Prolonged Survival ◽  
Non Melanoma Skin Cancer ◽  
Melanoma Skin

Introduction. Skin cancer is a rare indication of sternectomy. Our goal is to report the clinical course of seven patients who underwent sternectomy for skin cancer. Methods. The survey data were collected from medical records of patients treated between 2008 and 2018 at Ceará Cancer Institute. Results. All patients had prolonged sunlight exposure and average disease time of two years and age of 60 years. Most patients recovered favorably after treatment with prolonged survival. Conclusion. Sternectomy remains an option with curative purposes for locally advanced skin cancer.

Sign in / Sign up

Export Citation Format

Share Document