Systemic infection

2021 ◽  
pp. 345-350
Author(s):  
Michael Obladen

In antiquity, transmission of disease was attributed to the miasma or contagion theory. In the Middle Ages, living in proximity to domestic animals and flies, the scarce use of soap, and absent sewage augmented the exposure to bacteria. In the early 19th century, Gordon, Holmes, and Semmelweis understood that maternal childbed fever—closely related to neonatal sepsis—was transferred by the physician’s hands to the mother during delivery. Before bacteria were discovered in the mid-19th century, septic infections in the newborn were perceived as different disorders: erysipelas, Buhl’s disease, Winckel’s disease, and so on. With the advent of microbiology, sepsis became heterogeneous and was mainly defined by the causing microorganism. In the 1940s, group B streptococci emerged as a pathogen of newborns and soon became the commonest cause of neonatal sepsis. The discovery of antibiotics made the deadly disease treatable. In the 1970s, resistant bacterial strains emerged and allied dangerously with indwelling devices, especially central venous catheters. In the developing world, neonatal sepsis remains a major cause of infant mortality.

2017 ◽  
pp. 16-33
Author(s):  
Inna Põltsam-Jürjo

From “heathens’ cakes” to “pig’s ears”: tracing a food’s journey across cultures, centuries and cookbooks It is intriguing from the perspective of food history to find in 19th and 20th century Estonian recipe collections the same foods – that is, foods sharing the same names – found back in European cookbooks of the 14th and 15th centuries. It is noteworthy that they have survived this long, and invites a closer study of the phenomenon. For example, 16th century sources contain a record about the frying of heathen cakes, a kind of fritter, in Estonia. A dish by the same name is also found in 18th and 19th century recipe collections. It is a noteworthy phenomenon for a dish to have such a long history in Estonian cuisine, spanning centuries in recipe collections, and merits a closer look. Medieval European cookbooks listed two completely different foods under the name of heathen cakes and both were influenced from foods from the east. It is likely that the cakes made it to Tallinn and finer Estonian cuisine through Hanseatic merchants. It is not ultimately clear whether a single heathen cake recipe became domesticated in these parts already in the Middle Ages. In any case, heathen cakes would remain in Estonian cuisine for several centuries. As late as the early 19th century, the name in the local Baltic German cuisine referred to a delicacy made of egg-based batter fried in oil. Starting from the 18th century, the history of these fritters in Estonian cuisine can be traced through cookbooks. Old recipe collections document the changes and development in the tradition of making these cakes. The traditions of preparing these cakes were not passed on only in time, but circulated within society, crossing social and class lines. Earlier known from the elites’ culture, the dish reached the tables of ordinary people in the late 19th and early 20th century. In Estonian conditions, it meant the dish also crossed ethnic lines – from the German elite to the Estonian common folk’s menus. In the course of adaptation process, which was dictated and guided by cookbooks and cooking courses, the name of the dish changed several times (heydenssche koken, klenätid, Räderkuchen, rattakokid, seakõrvad), and changes also took place in the flavour nuances (a transition from spicier, more robust favours to milder ones) and even the appearance of the cakes. The story of the heathen cakes or pig’s ears in Estonian cuisine demonstrates how long and tortuous an originally elite dish can be as it makes its way to the tables of the common folk. The domestication and adaptation of such international recipes in the historical Estonian cuisine demonstrates the transregional cultural exchange, as well as culinary mobility and communication.


2021 ◽  
pp. 43-55
Author(s):  
S. D. Titarenko ◽  
◽  
M. M. Rusanova ◽  

The article is devoted to the insufficiently studied problem of using intermedial analysis for studying the Gothic tradition in the literature of Russian symbolism (on the example of V. Brusov’s and F. Sologub’s works). We focus our attention on transition a visual image or a medieval art motive from one sign system to another. We analyze how medieval cultural categories correspond to the chronotope and figurative system in the Gothic novels of the 18th - early 19th century. It is concluded that the Symbolists refer to the visual images of the Gothic novel not only as elements of tradition, but also as categories of the culture of the Middle Ages.


2017 ◽  
Vol 1 (37) ◽  
Author(s):  
Andreas Zajic

Pöggstall castle in Lower Austria has long been renowned to a national public for its ostensibly “authentic” medieval torture chamber located in an upper floor room of the 13th century keep. As recent investigations disclosed, the whole arrangement was not installed before the early 19th century when the Austrian Emperor Francis I owned the estate. The re-assessment of the interior betrays a “romantic” idea of pre-modern torture and punishment that imagined the “dark” Middle Ages as a “counter-draft” to “enlightened” practices of justice and criminal law. Whereas the allegedly “original” torture chamber is in fact an imaginative construction of historicism and romanticism, an inventory of the castle from 1548 lists, among other devices of torture and punishment, a curious item that might theoretically have served the same function. The object is referred to as a prison or a lock called an “iron cow” or “brazen bull”, a term that evokes associations with the legendary antique motive of the bull of Phalaris. The article seeks to examine the object in the light of the literary and iconographic tradition of the “brazen bull” and argues that – whether the Pöggstall bull was really intended to be used as a torture instrument or not – it proves, in any case, that the owners were well-acquainted with “humanistic” traditions of torture in antiquity.


2005 ◽  
Vol 12 (04) ◽  
pp. 451-456
Author(s):  
RIZWAN WASEEM ◽  
MUHAMMAD KHAN ◽  
TAHIRA S. IZHAR ◽  
Abdul Waheed Qureshi

Objective: To find out the bacterial pathogens in neonatal sepsis and todetermine antimicrobial sensitivity patterns of these pathogens. Place and Duration: At the Neonatal Unit of GhurkiTrust Teaching Hospital Lahore, from February 2003 to December 2004. Design: It was an analytical comparativestudy, done in prospective fashion. Subjects and Methods: A total of 100 culture proven neonates of sepsis wereincluded. Clinical data including neonatal and maternal history, physical examination and laboratory data includingblood counts and cultures were recorded. The cases that have already been given antibiotics were excluded. Standarddisc-diffusion method was used to assess the sensitivity pattern for the antibiotics (ampicillin, gentamicin, cefotaxime,ceftazidime, amikacin and imipenem). Results: Out of total of 100 cases, 64 belonged to Early onset Sepsis (EOS)and 36 belonged to Late onset Sepsis (LOS). Gram negative organisms were isolated from more than 80% of thecases. E. Coli was the commonest isolate (n=34), followed by Klebsiella (n=30) and Pseudomonas (n=13), involvingboth early and late onset groups. No isolate of group B streptococci (GBS) was found. Out of 34 isolates ofE.Coli,14.70%(n=5),17.6%(n=6),41.17%(n=14),61.76%(n=21),79.4%(n=27) and 97.05%(n=33) were sensitive toampicillin, gentamicin, cefotaxime, amikacin, ceftazidime and imipenem respectively. Klebsiella and Pseudomonas alsoshowed a low sensitivity to ampicillin, gentamicin, and cefotaxime, while good sensitivity to amikacin, ceftazidime andimipenem. The mortality was significantly high (P<0.05) in low birth weight infants. Conclusion: Improvement inantenatal and natal services is mandatory to reduce incidence of neonatal sepsis and related mortality. Most of theorganisms are resistant to commonly used drugs. Surveillance is required on regular basis.


Author(s):  
Kenneth Seeskin

Although Jewish philosophy flourished in the Middle Ages, it underwent a serious decline in 1492, when the Jews were expelled from Spain. The period following Kant and Mendelssohn witnessed an attempt to reintegrate Jewish philosophy into the mainstream of Western culture. The strategy of reintegration consisted of two elements: (1) showing that there is more to Judaism than the study of Scripture and (2) arguing that some of the ideas that won favour in the Enlightenment were anticipated by Jews centuries earlier. The most central idea that Jewish thinkers claimed as their own is a shift in focus from theoretical issues to practical ones. As important features of the medieval worldview fell into disrepute, many philosophers began to ask whether there are limits to what human reason can know. Can it really prove that God exists or that the soul is immortal? One response was to argue that even if no proof can be found, there are still grounds for believing, particularly if our understanding of ourselves as moral agents makes no sense without them. But it did not take long for people to argue that moral agency requires not just a God but a free and transcendent God capable of issuing commands to free agents created in the divine image. Here too, Jewish thinkers claimed that the idea of a God who is not limited by nature and insists on mercy and justice for all people was an integral part of monotheism as understood by the Hebrew prophets.


PEDIATRICS ◽  
1981 ◽  
Vol 68 (4) ◽  
pp. 544-549 ◽  
Author(s):  
Carol J. Baker ◽  
Morven S. Edwards ◽  
Dennis L. Kasper

The role of maternally acquired antibody to native type III polysacchande of group B Streptococcus as a determinant of susceptibility for infant systemic infection was investigated. Sera from 11 1 acutely ill infants with type III group B streptococcal bacteremia and/or meningitis and their mothers, and cord sera from 45 healthy neonates and their mothers who had type III group B streptococcal vaginal colonization at delivery were studied. Sera from each of 111 acutely ill infants contained very low levels ofantibody (sjlt 1.7 µg/ml, median 0.4 µg/ml), and a significant correlation with maternal levels was tested for early onset infection (median 0.6 µg/ml; r = .76; P sjlt .01). Women whose infants remained well had antibody levels sjgt 2 µg/ml in their sera (73%) more often than those whose infants developed symptomatic infection (17%) (P sjlt .001), and the median level in their sera (12.6 µg/ml) was considerably higher. Study of sera obtained during convalescence from 86 surviving infants indicated a poor antibody response to infection. In contrast, high levels of antibody were detected in sera from each of five convalescent women with postpartum bacteremia. These data extend earlier observations suggesting the correlation between low levels of type-specific antibody in serum and risk for systemic infection with type III strains of group B streptococci.


2009 ◽  
Vol 53 (6) ◽  
pp. 2342-2345 ◽  
Author(s):  
Jacques Lepercq ◽  
Jean Marc Treluyer ◽  
Christelle Auger ◽  
Josette Raymond ◽  
Elisabeth Rey ◽  
...  

ABSTRACT Preterm premature rupture of the membranes is associated with a high risk of neonatal sepsis. An increase in the incidence of early-onset neonatal sepsis due to ampicillin-resistant Escherichia coli in premature infants has been observed in the past few years. Intrapartum prophylaxis with ampicillin has proven to be efficient for the prevention of early neonatal sepsis due to group B streptococci. To date, there is no strategy for the prevention of early neonatal sepsis due to ampicillin-resistant E. coli. Our aim was to investigate whether a standardized dosage regimen of intrapartum cefotaxime could provide concentrations in the cord blood greater than the cefotaxime MIC90 for E. coli. Seven pregnant women hospitalized with preterm premature rupture of the membranes and colonized with ampicillin-resistant isolates of the family Enterobacteriaceae were included. Cefotaxime was given intravenously during delivery, as follows: 2 g at the onset of labor and then 1 g every 4 h until delivery. Blood specimens were collected from the mother 30 min after the first injection and just before the second injection, and at birth, blood specimens were simultaneously collected from the mother and the umbilical cord. The concentrations of cefotaxime in the cord blood ranged from 0.5 to 8.5 mg/liter. The MIC90 of cefotaxime for E. coli strains (0.125 mg/liter) was achieved in all cases. This preliminary study supports the use of cefotaxime for intrapartum prophylaxis in women colonized with ampicillin-resistant isolates of Enterobacteriaceae. The effectiveness of this regimen for the prevention of neonatal sepsis needs to be evaluated with a larger population.


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