Tumours

2011 ◽  
Author(s):  
David Warwick ◽  
Roderick Dunn ◽  
Erman Melikyan ◽  
Jane Vadher
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Osteoid Osteoma ◽  
Malignant Tumours ◽  
Periosteal Chondroma ◽  
Benign Tumours ◽  
And Cartilage

Types of tumour 574Benign tumours of bone and cartilage 575Ganglia 578Benign tumours of soft tissue 582Malignant tumours 584Malignant tumours of bone and cartilage 585Soft tissue sarcoma (STS) 586Metastatic tumours 590• Osteoid osteoma• Osteoblastoma• Chondroma (enchondroma, periosteal chondroma = ecchondroma)...

scholarly journals Role of FNAC in soft tissue tumors and its histopathological correlation

2017 ◽  
Vol 4 (8) ◽  
pp. 2632
Author(s):  
Veenu Jain ◽  
Tarun Agarwal
Keyword(s):  
Soft Tissue ◽  
Diagnostic Accuracy ◽  
Paraffin Section ◽  
Needle Aspiration ◽  
Soft Tissue Tumors ◽  
Age Group ◽  
Malignant Tumours ◽  
Soft Tissue Tumours ◽  
Histopathological Correlation ◽  
Benign Tumours

Background: Soft tissue tumours are very rare. They are diagnosed initially by Fine needle aspiration cytology (FNAC). The present study was conducted with the aim to study the acceptability and diagnostic accuracy of cytodiagnosis in soft tissue lesions, to evaluate the reliability of cytodianosis as compared conventional histological paraffin section and to assess nuclear grade in various soft tissue lesions.Methods: The present study was conducted on 140 patients of soft tissue tumours during the period from August 2002 to July 2003 in the Department of pathology and microbiology, LLRM medical college, Meerut. FNAC was done in 132 cases and histopathology was conducted in 86 cases and correlation of those results was done.Results: Diagnosis of STT by FNAC was done in 132 cases. In benign tumours maximum number of cases (28) was in the age group of 20-29 years and in malignant tumours maximum number of cases (7) was in the age group of 40-49 years. 110 (83.3%) cases were benign and 22 (16.7%) cases were found to be malignant. Maximum number of STT was observed in trunk followed by limb extremities. Male preponderance was observed in the study. The overall accuracy of the present study was 97.7%. Accuracy for diagnosing benign soft tissue tumours was 100% and for malignant STT was 94.5%. The sensitivity, specificity and predictive value of the present study was 100%, 98.6% and 93.3%.Conclusions: FNAC plays a very important role in initial diagnosis of soft tissue tumours. It provided acceptable diagnostic accuracy when supported by histopathology.

scholarly journals The Effectiveness of “Two-Week” Referrals for Suspected Bone and Soft Tissue Sarcoma

Sarcoma ◽  
2007 ◽  
Vol 2007 ◽  
pp. 1-3 ◽  
Author(s):  
A. Malik ◽  
L. Wigney ◽  
S. Murray ◽  
C. H. Gerrand
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
General Practitioners ◽  
Diagnosis And Treatment ◽  
Soft Tissue Tumour ◽  
Malignant Tumours ◽  
Urgent Referral ◽  
The North ◽  
Tissue Tumour ◽  
Time To Diagnosis

The two-week “wait” target introduced in 2000 requires that patients with suspected cancer referred by general practitioners should be seen within two weeks. We reviewed patients who had been referred under this standard to the North of England Bone and Soft Tissue Tumour Service, to determine if the referral guidelines had been followed, and what proportion of patients referred under the guideline had malignant tumours. 40 patients were referred under the guideline between January 2004 and December 2005. Ten of these patients (2548%) had malignant tumours, compared with 243 of 507 (48%) of those referred from other sources. In 9 of the 40 cases, the patient did not meet the criteria for urgent referral. Although this target has focussed attention on shortening the time to diagnosis and treatment, prioritising patients referred from general practitioners has the potential to disadvantage those with malignant tumours referred from other sources.

scholarly journals Prevalence of Soft Tissue Tumours in Duhok-Iraq: A Practical Immunohistochemical Approach

2020 ◽  
Author(s):  
Intisar Salim Pity ◽  
Omar Salim Muhi
Keyword(s):  
Soft Tissue ◽  
Dermatofibrosarcoma Protuberans ◽  
Cross Sectional Study ◽  
Malignant Tumours ◽  
Soft Tissue Tumours ◽  
Cross Sectional ◽  
Not Otherwise Specified ◽  
Diagnosis And Classification ◽  
Benign Tumours ◽  
Age Range

Introduction: The field of Soft Tissue Tumours (STT) is enormously vast, and yet histologically and relatively vague. Although benign tumours are more common than malignant tumours, the relative rarity of sarcomas, little knowledge, and insufficient local studies, made the authors eager to search more through this field and explore the hidden and unobvious features of these tumours in our locality. Aim: The study aimed to apply traditional and updated antibodies to characterise STT in Duhok-Iraq, morphologically and immunohistochemically. Materials and Methods: In this cross-sectional study, 886 STT were received in the Department of Histopathology in Central General Laboratories and Vin Private Laboratories, Duhok-Iraq, over a period of 11 consecutive years (January, 2009 to December, 2019). Cases were studied clinically and then, morphologically categorised. Immunohistochemical workup was performed when needed, to sub-classify undifferentiated tumours. Results: Benign tumours (n=768) ovarian sarcomas (n=118) by a ratio of 6.5:1, both showed a wide age range (1 month to 82 years), with peak in the fourth decade and with no sex predilection. Also, limbs were more commonly affected by both benign and malignant tumours.Lipomas topped the benign STT 328 (42.7%) followed by vascular tumours 178 (23.2%). Regarding sarcomas, 29 (24.5%) remained unclassifiable and were typed as Sarcoma Not Otherwise Specified (NOS). For the specifically diagnosed malignancies, leiomyosarcoma 24 (20.3%) topped the list, followed by rhabdomyosarcoma and Ewing’s/Primitive Neuroectodermal Tumour (PNET) 12 (10.1%) each, Dermatofibrosarcoma Protuberans (DFSP) and liposarcoma 11 (9.4%) each and synovial sarcoma 6 (5.1%). Conclusion: Benign STT were more common than sarcomas. Diagnosis and classification of STT should be based on acumen histologic grounds which is sufficient for most benign tumours and to some extent for sarcomas. Undifferentiated sarcomas cannot be categorised without immunohistochemistry. However, loss of some differentiation antigens in undifferentiated cancers often necessitate the use of panels of antibodies, and considerable cases even need further evaluation, like molecular studies.

scholarly journals Amplification and Over-Expression of theMDM2Gene in Human Soft Tissue Tumours

Sarcoma ◽  
1997 ◽  
Vol 1 (1) ◽  
pp. 17-22 ◽  
Author(s):  
Helen Patterson ◽  
Diana Barnes ◽  
Sandra Gill ◽  
James Spicer ◽  
Cyril Fisher ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Gene Amplification ◽  
Soft Tissue Sarcomas ◽  
Clear Correlation ◽  
Malignant Tumours ◽  
Soft Tissue Tumours ◽  
Over Expression ◽  
Human Soft Tissue ◽  
Genetic Sequences ◽  
Benign Tumours

Purpose. Amplification of genetic sequences on chromosome 12q13 is frequently found in soft tissue tumours. However, for theMDM2gene, over-expression of the MDM2 protein has not always been shown to accompany gene amplification, raising the possibility that amplification of genetic sequences targets alternative genes on chromosome 12q13 for over-expression. To investigate this discrepancy, we have examined 129 soft tissue tumours for amplification of theMDM2gene using Southern analysis, and 39 of these tumours were also examined by immunohistochemical staining for MDM2 over-expression.Results. Gene amplification was identified in 14/114 (12.3%) of the malignant tumours, but was not identified in any of the benign tumours; 21/39 (54%) of the malignant tumours also demonstrated MDM2 over-expression. Within this group theMDM2gene was over-expressed in every tumour in which the gene amplification was found, and over-expression in the absence of gene amplification was also found in an additional 10 tumours.Discussion. These data demonstrate a clear correlation between the presence ofMDM2amplification and MDM2 over-expression, and provide persuasive evidence therefore that the amplification of genetic sequences on chromosome 12q13 in soft tissue sarcomas targets theMDM2gene for over-expression. These data also indicate that alternative mechanisms may contribute to MDM2 over-expression within some tumours.

Morphological Examination of a Herpes-type Virus Indigenous for Tree Shrews

1970 ◽  
Vol 28 ◽  
pp. 160-161
Author(s):  
J. P. Brunschwig ◽  
R. M. McCombs ◽  
R. Mirkovic ◽  
M. Benyesh-Melnick
Keyword(s):  
Electron Microscopy ◽  
Soft Tissue ◽  
Chick Embryo ◽  
Soft Tissue Sarcoma ◽  
Cell Cultures ◽  
Tree Shrew ◽  
Type Virus ◽  
Morphological Examination ◽  
Tree Shrews ◽  
Embryo Cells

A new virus, established as a member of the herpesvirus group by electron microscopy, was isolated from spontaneously degenerating cell cultures derived from the kidneys and lungs of two normal tree shrews. The virus was found to replicate best in cells derived from the homologous species. The cells used were a tree shrew cell line, T-23, which was derived from a spontaneous soft tissue sarcoma. The virus did not multiply or did so poorly for a limited number of passages in human, monkey, rodent, rabbit or chick embryo cells. In the T-23 cells, the virus behaved as members of the subgroup B of herpesvirus, in that the virus remained primarily cell associated.

Soft Tissue Sarcoma: The Important Role of Initial MRI Reports for Disease Control

2020 ◽  
Author(s):  
S Weiß ◽  
A Korthaus ◽  
K-H Frosch ◽  
C Schlickewei ◽  
M Priemel
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Disease Control
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