scholarly journals Adaptive Landscape of Protein Variation in Human Exomes

2018 ◽  
Vol 35 (8) ◽  
pp. 2015-2025 ◽  
Author(s):  
Ravi Patel ◽  
Laura B Scheinfeldt ◽  
Maxwell D Sanderford ◽  
Tamera R Lanham ◽  
Koichiro Tamura ◽  
...  
2019 ◽  
Vol 11 (9) ◽  
pp. 2578
Author(s):  
Jumeniyaz Seydehmet ◽  
Guang-Hui Lv ◽  
Abdugheni Abliz

Irrational use and management of water and land are associated with poor hydro-geological conditions causing water logging and salinization problems, possibly leading to farmland abandonment and economic loss. This poses a great challenge to the sustainability of oasis’ and requires desalinization through reasonable landscape design by multiple crossing studies so we collected traditional knowledge by field interviews and literature schemes, except for the modern desalinization approaches by literature, and we found that the salinization problem has been solved by traditional land reclamation, traditional drainage, natural drainage and flood irrigation, locally. It is worth mentioning that the traditional reclamation in salinized areas requires flood water, sand dunes and a salinized pit area; the sand dunes are used to elevate the pit surface, and water is used to leach salt from the soil. Natural drainage (the depth and width are 4–10 m and 50–100 m, respectively) caused by flash flooding has significant benefits to some salinized villages in the range of 3000–5000 m and ancient groundwater drainage systems, such as Karez are supporting the oasis with drainage water for centuries. In addition landscape characteristics, salinization and hydro-geological conditions of the oasis were studied from Landsat image, DEM, literature and field photos. Then based on the gathered information above, a desalinization model was developed to decrease the groundwater table and salt leaching in the water logging landscape. Then according to landscape characteristics, different desalinization approaches were recommended for different landscapes. To address environmental uncertainties, an adaptive landscape management and refinement approach was developed, and acceptance of the model was validated by stakeholder opinion. The results provide guidelines for sustainable desalinization design and highlight the importance of combining traditional knowledge and modern ecological principles in sustainable landscape design.


2021 ◽  
Author(s):  
Anik Dutta ◽  
Fanny E. Hartmann ◽  
Carolina Sardinha Francisco ◽  
Bruce A. McDonald ◽  
Daniel Croll

AbstractThe adaptive potential of pathogens in novel or heterogeneous environments underpins the risk of disease epidemics. Antagonistic pleiotropy or differential resource allocation among life-history traits can constrain pathogen adaptation. However, we lack understanding of how the genetic architecture of individual traits can generate trade-offs. Here, we report a large-scale study based on 145 global strains of the fungal wheat pathogen Zymoseptoria tritici from four continents. We measured 50 life-history traits, including virulence and reproduction on 12 different wheat hosts and growth responses to several abiotic stressors. To elucidate the genetic basis of adaptation, we used genome-wide association mapping coupled with genetic correlation analyses. We show that most traits are governed by polygenic architectures and are highly heritable suggesting that adaptation proceeds mainly through allele frequency shifts at many loci. We identified negative genetic correlations among traits related to host colonization and survival in stressful environments. Such genetic constraints indicate that pleiotropic effects could limit the pathogen’s ability to cause host damage. In contrast, adaptation to abiotic stress factors was likely facilitated by synergistic pleiotropy. Our study illustrates how comprehensive mapping of life-history trait architectures across diverse environments allows to predict evolutionary trajectories of pathogens confronted with environmental perturbations.


Agronomy ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1001
Author(s):  
Jagadeesh Sundaramoorthy ◽  
Gyu Tae Park ◽  
Hyun Jo ◽  
Jeong-Dong Lee ◽  
Hak Soo Seo ◽  
...  

The enzyme flavonoid 3′,5′-hydroxylase (F3′5′H) plays an important role in producing anthocyanin pigments in soybean. Loss of function of the W1 locus encoding F3′5′H always produces white flowers. However, few color variations have been reported in wild soybean. In the present study, we isolated a new color variant of wild soybean accession (IT261811) with pinkish-white flowers. We found that the flower’s pinkish-white color is caused by w1-s3, a single recessive allele of W1. The SNP detected in the mutant caused amino acid substitution (A304S) in a highly conserved SRS4 domain of F3′5′H proteins. On the basis of the results of the protein variation effect analyzer (PROVEAN) tool, we suggest that this mutation may lead to hypofunctional F3′5′H activity rather than non-functional activity, which thereby results in its pinkish-white color.


2018 ◽  
Vol 49 (1) ◽  
pp. 379-408 ◽  
Author(s):  
Roger B.J. Benson

Dinosaurs were large-bodied land animals of the Mesozoic that gave rise to birds. They played a fundamental role in structuring Jurassic–Cretaceous ecosystems and had physiology, growth, and reproductive biology unlike those of extant animals. These features have made them targets of theoretical macroecology. Dinosaurs achieved substantial structural diversity, and their fossil record documents the evolutionary assembly of the avian body plan. Phylogeny-based research has allowed new insights into dinosaur macroevolution, including the adaptive landscape of their body size evolution, patterns of species diversification, and the origins of birds and bird-like traits. Nevertheless, much remains unknown due to incompleteness of the fossil record at both local and global scales. This presents major challenges at the frontier of paleobiological research regarding tests of macroecological hypotheses and the effects of dinosaur biology, ecology, and life history on their macroevolution.


Author(s):  
Anja Brüll ◽  
Timo Matti Wirth ◽  
Frank Lohrberg ◽  
Annet Kempenaar ◽  
Marlies Brinkhuijsen ◽  
...  

AbstractLandscapes can be understood as socialecological systems under constant change. In Europe various territorial dynamics pose persistent challenges to maintaining diverse landscapes both as European heritage and in their capacity to provide vital functions and services. Concurrently, under the competence of cohesion policy, the EU is attempting to improve policy making by better policy coordination and respecting regional specifics. This paper explores the question how a policy dedicated to landscape can help to handle territorial change and support territorial cohesion. It presents results and performances of the ESPON applied research study LP3LP: (1) a common landscape policy for the Three Countries Park, across the Dutch, German and Belgium borders, including a spatial landscape vision, a governance proposal of adaptive landscape management, and thematic strategies dealing with green infrastructure, cultural heritage, complementary biomass and quality production; (2) recommendations at the EU level. In discussing the significance of a landscape approach for EU policy,three dimensions of landscape are linked withimportant aspects of territorial cohesion: ‘landscape as asset’ addressing natural-cultural territorial capital as an indigenous base forsmart, sustainable, and inclusivedevelopment;‘landscape as place’ stressing the relevance of landscape for place-based policies; and ‘landscape as common ground’ highlighting its potential for horizontal, vertical, and territorial integration.


2021 ◽  
Author(s):  
James Lyons-Weiler

AbstractHuman evolution sits at several important thresholds. In organic evolution, interplay between exogenous environmental and genetic factors rendered new phenotypes at rates limited by genetic variation. The interplay took place on adaptive fitness landscapes determined by correspondence of genetic and environmental relationships. Human evolution involved important emergences that altered the adaptive landscape: language, writing, organized societies, science, and the internet. These endogenous factors ushered in transformative periods leading to more rapidly evolving emergences. I explore the impact of development of emerging biotransformative technologies capable of being applied to effect self-genetic modification and artificial intelligence-augmented cognition on the evolutionary landscape of phenotypes important to cognitive plasticity. Interaction effects will yield unanticipated emergences resulting in hyperrealm adaptive landscapes with more rapid evolutionary processes that feed back upon more fundamental levels while vastly outpacing organic evolution. Emerging technologies exist that are likely to impact the evolution of cognitive plasticity in humans in ways and at rates that will lead to societal upheaval. I show that the theoretical contribution of organic evolution in future human evolution is expected to become comparatively insignificant relative to that made by endogenous environmental factors such as external cognition aids and manipulation of the human genome. The results support the conclusion of a strong recommendation of a moratorium on the adoption of any technology capable of completely altering the course of human evolution.


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