scholarly journals Telomere shortening and aortic plaque progression in Apoliprotein E knockout mice after pulmonary exposure to candle light combustion particles

Mutagenesis ◽  
2018 ◽  
Vol 33 (3) ◽  
pp. 253-261 ◽  
Author(s):  
Ana Cecilia Damiao Gouveia ◽  
Astrid Skovman ◽  
Annie Jensen ◽  
Ismo Kalevi Koponen ◽  
Steffen Loft ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Plaque Progression ◽  
Telomere Shortening ◽  
Pulmonary Exposure ◽  
Aortic Plaque ◽  
Combustion Particles ◽  
Candle Light

Lung inflammation and genotoxicity in mice lungs after pulmonary exposure to candle light combustion particles

2017 ◽  
Vol 276 ◽  
pp. 31-38 ◽  
Author(s):  
Astrid Skovmand ◽  
Ana Cecilia Damiao Gouveia ◽  
Ismo Kalevi Koponen ◽  
Peter Møller ◽  
Steffen Loft ◽  
...  
Keyword(s):  
Lung Inflammation ◽  
Pulmonary Exposure ◽  
Combustion Particles ◽  
Candle Light

scholarly journals Pwp1 regulates telomere length by stabilizing shelterin complex and maintaining histone H4K20 trimethylation

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Yangyang Yu ◽  
Wenwen Jia ◽  
Yao Lyu ◽  
Dingwen Su ◽  
Mingliang Bai ◽  
...  
Keyword(s):  
Telomere Length ◽  
Knockout Mice ◽  
Embryonic Stem ◽  
Telomere Maintenance ◽  
Reproductive Capacity ◽  
Mouse Development ◽  
Telomere Shortening ◽  
Shelterin Complex ◽  
Telomere Homeostasis ◽  
Novel Protein

Abstract Telomere maintenance is critical for chromosome stability. Here we report that periodic tryptophan protein 1 (PWP1) is involved in regulating telomere length homeostasis. Pwp1 appears to be essential for mouse development and embryonic stem cell (ESC) survival, as homozygous Pwp1-knockout mice and ESCs have never been obtained. Heterozygous Pwp1-knockout mice had shorter telomeres and decreased reproductive capacity. Pwp1 depletion induced rapid telomere shortening accompanied by reduced shelterin complex and increased DNA damage in telomeric regions. Mechanistically, PWP1 bound and stabilized the shelterin complex via its WD40 domains and regulated the overall level of H4K20me3. The rescue of telomere length in Pwp1-deficient cells by PWP1 overexpression depended on SUV4-20H2 co-expression and increased H4K20me3. Therefore, our study revealed a novel protein involved in telomere homeostasis in both mouse and human cells. This knowledge will improve our understanding of how chromatin structure and histone modifications are involved in maintaining telomere integrity.

Risk Factors of Aortic Plaque Progression Evaluated by Long-Term Follow-Up Data With Transesophageal Echocardiography

2017 ◽  
Vol 119 (11) ◽  
pp. 1872-1876 ◽  
Author(s):  
Chisato Izumi ◽  
Makoto Miyake ◽  
Masashi Amano ◽  
Hayato Matsutani ◽  
Sumiyo Hashiwada ◽  
...  
Keyword(s):  
Risk Factors ◽  
Transesophageal Echocardiography ◽  
Plaque Progression ◽  
Aortic Plaque ◽  
Long Term Follow Up

scholarly journals Reversibility of Defective Hematopoiesis Caused by Telomere Shortening in Telomerase Knockout Mice

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0131722 ◽  
Author(s):  
Aparna Raval ◽  
Gregory K. Behbehani ◽  
Le Xuan Truong Nguyen ◽  
Daniel Thomas ◽  
Brenda Kusler ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Telomere Shortening

scholarly journals AORTIC PLAQUE PROGRESSION IN PATIENTS TREATED WITH IMMUNE CHECKPOINT INHIBITORS

2020 ◽  
Vol 75 (11) ◽  
pp. 1715
Author(s):  
Lili Zhang ◽  
Jana Taron ◽  
Zsofia Drobni ◽  
Raza Alvi ◽  
Amna Zafar ◽  
...  
Keyword(s):  
Immune Checkpoint ◽  
Immune Checkpoint Inhibitors ◽  
Checkpoint Inhibitors ◽  
Plaque Progression ◽  
Aortic Plaque

Cardiovascular Effects of Pulmonary Exposure to Titanium Dioxide Nanoparticles in ApoE Knockout Mice

2013 ◽  
Vol 13 (5) ◽  
pp. 3214-3222 ◽  
Author(s):  
Tian Chen ◽  
Jieqiong Hu ◽  
Chunying Chen ◽  
Ji Pu ◽  
Xiaoxing Cui ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Knockout Mice ◽  
Titanium Dioxide Nanoparticles ◽  
Cardiovascular Effects ◽  
Pulmonary Exposure ◽  
Apoe Knockout Mice

Rapamycin Attenuates Atherosclerotic Plaque Progression in Apolipoprotein E Knockout Mice

2005 ◽  
Vol 46 (4) ◽  
pp. 481-486 ◽  
Author(s):  
Rajbabu Pakala ◽  
Eugenio Stabile ◽  
Gil Jin Jang ◽  
Leonardo Clavijo ◽  
Ron Waksman
Keyword(s):  
Apolipoprotein E ◽  
Atherosclerotic Plaque ◽  
Knockout Mice ◽  
Plaque Progression ◽  
Apolipoprotein E Knockout Mice
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