SP830A BEHAVIOUR CHANGE INTERVENTION DESIGNED TO REDUCE THE RISK OF ABNORMAL GLUCOSE METABOLISM AFTER RENAL TRANSPLANTATION: METHODOLOGY FROM THE CAVIAR STUDY

2019 ◽  
Vol 34 (Supplement_1) ◽  
Author(s):  
Reena Mair ◽  
Joanne Driscoll ◽  
Ed Day ◽  
Adnan Sharif
Keyword(s):  
Renal Transplantation ◽  
Glucose Metabolism ◽  
Behaviour Change ◽  
Behaviour Change Intervention ◽  
Abnormal Glucose Metabolism

scholarly journals Two Japanese patients with stage G3b chronic kidney disease and impaired glucose metabolism after renal transplantation successfully treated with empagliflozin

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Ryoichi Miyazaki ◽  
Kyoko Miyagi ◽  
Misaki Yoshida
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Transplantation ◽  
Renal Transplant ◽  
Glucose Metabolism ◽  
Kidney Disease ◽  
Transplant Recipient ◽  
Sglt2 Inhibitors ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Abnormal Glucose Metabolism

Abstract Background Renal transplant recipients with chronic kidney disease (CKD) often develop abnormal glucose metabolism. Although recent studies have reported the protective effects of sodium-glucose transport protein 2 (SGLT2) inhibitors on the heart and kidneys, few have assessed their effect in renal transplant patients. Moreover, to our knowledge, there have been no studies on the effects of SGLT2 inhibitors in renal transplant recipients in Japan. Case presentation Case 1 was a 67-year-old male renal transplant recipient with post-transplant diabetes mellitus. He was administered empagliflozin 10 mg once a day for 9 months. Over time, his HbA1c levels decreased from 6.8 to 6.0%. Case 2 was a 56-year-old male renal transplant recipient with fatty liver disease. He was administered empagliflozin 10 mg once a day for 9 months. His ALT, γ-GTP, and LDL-cholesterol levels all decreased. In both patients, body weight and the urine albumin to creatinine ratio (UACR) decreased after empagliflozin administration, but there were no changes in the estimated glomerular filtration rate. No adverse events occurred in either case. Conclusions Administration of empagliflozin had favorable outcomes in two patients with stage G3b CKD and abnormal glucose metabolism after renal transplantation. Further studies will be required to clarify the efficacy and safety of SGLT2 inhibitors in a larger population of patients with similar medical conditions.

scholarly journals Metabolic signatures in the conversion from gestational diabetes mellitus to postpartum abnormal glucose metabolism: a pilot study in Asian women

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xi-Meng Wang ◽  
Yan Gao ◽  
Johan G. Eriksson ◽  
Weiqing Chen ◽  
Yap Seng Chong ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Glucose Metabolism ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Post Partum ◽  
Diagnostic Biomarkers ◽  
Serum Metabolites ◽  
Abnormal Glucose Metabolism ◽  
Metabolic Signatures

AbstractWe aimed to identify serum metabolites related to abnormal glucose metabolism (AGM) among women with gestational diabetes mellitus (GDM). The study recruited 50 women diagnosed with GDM during mid-late pregnancy and 50 non-GDM matchees in a Singapore birth cohort. At the 5-year post-partum follow-up, we applied an untargeted approach to investigate the profiles of serum metabolites among all participants. We first employed OPLS-DA and logistic regression to discriminate women with and without follow-up AGM, and then applied area under the curve (AUC) to assess the incremental indicative value of metabolic signatures on AGM. We identified 23 candidate metabolites that were associated with postpartum AGM among all participants. We then narrowed down to five metabolites [p-cresol sulfate, linoleic acid, glycocholic acid, lysoPC(16:1) and lysoPC(20:3)] specifically associating with both GDM and postpartum AGM. The combined metabolites in addition to traditional risks showed a higher indicative value in AUC (0.92–0.94 vs. 0.74 of traditional risks and 0.77 of baseline diagnostic biomarkers) and R2 (0.67–0.70 vs. 0.25 of traditional risks and 0.32 of baseline diagnostic biomarkers) in terms of AGM indication, compared with the traditional risks model and traditional risks and diagnostic biomarkers combined model. These metabolic signatures significantly increased the AUC value of AGM indication in addition to traditional risks, and might shed light on the pathophysiology underlying the transition from GDM to AGM.

scholarly journals A behaviour change intervention to reduce home exposure to second hand smoke during pregnancy in India and Bangladesh: a theory and evidence-based approach to development

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Veena A. Satyanarayana ◽  
Cath Jackson ◽  
Kamran Siddiqi ◽  
Prabha S. Chandra ◽  
Rumana Huque ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Behaviour Change ◽  
Delphi Survey ◽  
Behaviour Change Techniques ◽  
Evidence Based ◽  
Behaviour Change Intervention ◽  
Behaviour Change Interventions ◽  
Modified Delphi ◽  
Qualitative Interview Study ◽  
At Home

Abstract Background Home exposure to secondhand smoke (SHS) is highly prevalent amongst pregnant women in low- and middle-income countries like India and Bangladesh. The literature on the efficacy of behaviour change interventions to reduce home exposure to SHS in pregnancy is scarce. Methods We employed a theory and evidence-based approach to develop an intervention using pregnant women as agents of change for their husband’s smoking behaviours at home. A systematic review of SHS behaviour change interventions led us to focus on developing a multicomponent intervention and informed selection of behaviour change techniques (BCTs) for review in a modified Delphi survey. The modified Delphi survey provided expert consensus on the most effective BCTs in reducing home exposure to SHS. Finally, a qualitative interview study provided context and detailed understanding of knowledge, attitudes and practices around SHS. This insight informed the content and delivery of the proposed intervention components. Results The final intervention consisted of four components: a report on saliva cotinine levels of the pregnant woman, a picture booklet containing information about SHS and its impact on health as well strategies to negotiate a smoke-free home, a letter from the future baby to their father encouraging him to provide a smoke-free home, and automated voice reminder and motivational messages delivered to husbands on their mobile phone. Intervention delivery was in a single face-to-face session with a research assistant who explained the cotinine report, discussed key strategies for ensuring a smoke-free environment at home and practised with pregnant women how they would share the booklet and letter with their husband and supportive family members. Conclusion A theory and evidence-based approach informed the development of a multicomponent behaviour change intervention, described here. The acceptability and feasibility of the intervention which was subsequently tested in a pilot RCT in India and Bangladesh will be published later.

Correlation of Pretransplant Glucose Metabolism With the development of New Onset Diabetes After Renal Transplantation

2017 ◽  
Vol 101 ◽  
pp. S53
Author(s):  
Sahil Bagai ◽  
Namrata Rao ◽  
Ashish Sharma ◽  
Naresh Sachdeva ◽  
Manish Rathi
Keyword(s):  
Renal Transplantation ◽  
Glucose Metabolism ◽  
Onset Diabetes ◽  
New Onset

scholarly journals Dietary antioxidants: Do they have a role to play in the ongoing fight against abnormal glucose metabolism?

Nutrition ◽  
2012 ◽  
Vol 28 (7-8) ◽  
pp. 715-721 ◽  
Author(s):  
Antoine Avignon ◽  
Marie Hokayem ◽  
Catherine Bisbal ◽  
Karen Lambert
Keyword(s):  
Glucose Metabolism ◽  
Dietary Antioxidants ◽  
Abnormal Glucose Metabolism
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